P073 Diagnostic Outcome of Patients With Non-Specific Colitis

AbstractA Bayesian decision support system was developed for the diagnosis of rheumatic disorders. Knowledge in this system is represented as evidential weights of findings. Simple weights were calculated as the logarithm of likelihood ratios on the basis of 1,000 consecutive patients from a rheumatological clinic. The effect of various methods to improve performance of the system by modification of the weights was studied. Three methods had a mathematical basis; a fourth consisted of weights adapted by a human expert, which allowed inclusion of diagnostic rules such as defined in widely accepted criteria sets. The system’s performance was measured in a test population of 570 different cases from the same clinic and compared with predictions of diagnostic outcome made by rheumatologists. The weights from a human expert gave optimal results (sensitivity 65% and specificity 96%), that were close to the physicians’ predictions (sensitivity 64% and specificity 98%). The methods to measure the performance of the various models used in this study emphasize sensitivity, specificity and the use of receiver operating characteristics.

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Endoscopic filter fluorometer for detection of accumulation of Protoporphyrin IX to improve photodynamic diagnostic (PDD)

Current Directions in Biomedical Engineering ◽

10.1515/cdbme-2020-0018 ◽

2020 ◽

Vol 6 (1) ◽

Author(s):

Axel Boese ◽

Alexander Wagner ◽

Alfredo Illanes ◽

Uwe Bernd Liehr ◽

Johann Jakob Wendler ◽

...

Keyword(s):

Imaging System ◽

Time Slot ◽

Protoporphyrin Ix ◽

Optimal Time ◽

Accumulation Process ◽

Technical Feasibility ◽

Filter System ◽

Patient Setup ◽

Diagnostic Outcome ◽

Cell Study

AbstractPhotodynamic diagnostic (PDD) is an optical enhancement option for the endoscope to support the detection of cancer, for example in the bladder. In real application PDD efficiency suffers due to the complex accumulation of the photosensitizing drug inside the tumor and the associated processes of heme syntheses to create the fluorescent components needed. To optimize the diagnostic outcome of PDD it would be helpful to predict the optimal time for diagnosis based on measurable precursors. In a previous cell study, we proposed a new filter fluorometer to image the accumulation of the precursors Coproporphyrin III (CP-III) and Uroporphyrin III (UP-III) that metabolize to Protoporphyrin IX (PP-IX) later. This accumulation process can be used to predict the optimal time slot for diagnostic imaging. Therefore, a new filter system was designed to distinguish between CP-III and PP-IX. In this work we tested this filter system in combination with a standard PDD endoscopic imaging system. Goal of this study was to prove the technical feasibility in a non-patient setup to prepare a later clinical study.

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Relationship Between Cause Of Referral And Diagnostic Outcome In Pigmented Lesion Clinics Aimed To Melanoma Screening: A Multicenter Survey Of The Italian Multidisciplinary Group On Melanoma (Gipme)

Melanoma Research ◽

10.1097/00008390-200404000-00037 ◽

2004 ◽

Vol 14 (2) ◽

pp. S28

Author(s):

P. Carli ◽

V. De Giorgi ◽

R. Betti ◽

R. Vergani ◽

C. Catricalà ◽

...

Keyword(s):

Pigmented Lesion ◽

Multicenter Survey ◽

Multidisciplinary Group ◽

Melanoma Screening ◽

Diagnostic Outcome

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789 HIGH RESOLUTION ESOPHAGEAL MOTILITY: VARIABLE GEOGRAPHIC DISTRIBUTION IN A LARGE MEXICAN COHORT

Diseases of the Esophagus ◽

10.1093/dote/doab052.789 ◽

2021 ◽

Vol 34 (Supplement_1) ◽

Author(s):

Genaro Vazquez-Elizondo ◽

José María Remes-Troche ◽

Enrique Coss-Adame ◽

Edgardo Suárez-Morán ◽

Miguel Ángel Valdovinos-Díaz ◽

...

Keyword(s):

High Resolution ◽

Data Base ◽

Regional Differences ◽

Outlet Obstruction ◽

Central Mexico ◽

Diverse Population ◽

Chi Square ◽

The North ◽

Available Information ◽

Diagnostic Outcome

Abstract High resolution esophageal manometry (HREM) has been in use for about a decade. However, there is no available information regarding geographical or regional differences in diagnostic outcome. Aim Characterize the indications, demographics and diagnostic outcome of HREM in a diverse population of Mexico. Methods Data was collected from four major referral centers representing diverse geographical areas of Mexico: central—Mexico City (two centers, years 2016-2020), south (Veracruz, years 2015-2020) and north (Monterrey, years 2013—2020). All consecutive cases referred for HREM were entered into a data base and analyzed using Chicago 3 classification. Data was evaluated using chi-square to compare frequencies among groups. Results 2,932 patients included: Central n = 877(29.9), North n = 1003(34.2), South n = 1052(35.9). Mean age 47.9(11-93), women 1,795(61.2), men 1,137(38.8). Nationwide, the most common indications for testing were: GERD n = 1677(57.2), followed by dysphagia 587(20), atypical GERD 244(8.3), post-operative GERD 230(7.9), chest pain 114(3.9), and post-operative dysphagia 78(2.8). HREM was normal in 1,468(49.9) patients. Table shows the diagnostic distribution among centers: Central-Mexico had more abnormal cases 531(60.5) (p < 0.0.001) vs 407(40.6) North and 532(50.6) South. Achalasia was more commonly diagnosed in the South n = 104(19.5) whereas outlet obstruction 39(967) p < 0.001 and spastic disorders were more common in the North 47(11.8) p = 0.002. Weak peristaltic disorders were more common in Central-Mexico 369(78.8) p < 0.001. Conclusion This study represents the first large comparative multicenter HREM data base project in Mexico. In this cohort, most patients receiving HREM are women and those whose indication was GERD. These findings indicate variable regional geographical distribution of HERM diagnosis. Our study suggests that further investigation into the causes and epidemiological distribution of motility disorders is warranted.

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AAA screening in adults with ASD: a retrospective cohort study

Advances in Autism ◽

10.1108/aia-10-2020-0059 ◽

2021 ◽

Vol ahead-of-print (ahead-of-print) ◽

Author(s):

Marios Adamou ◽

Sarah Louise Jones ◽

Stephanie Wetherhill

Keyword(s):

Cohort Study ◽

Clinical Setting ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Autism Spectrum ◽

Specialist Service ◽

Content Type ◽

Empathy Quotient ◽

Adults With Asd ◽

Diagnostic Outcome

Purpose The Adult Asperger Assessment (AAA), comprising the Autism Questionnaire, the Empathy Quiotient and the Relatives Questionnaire is a commonly used screening tool designed to identify adults who may benefit from a further clinical assessment for autism spectrum disorder. The purpose of this paper is to investigate the usefulness of this screening measure in a clinical setting. Design/methodology/approach This retrospective cohort study comprised of 192 service users referred for diagnostic assessment of Autism by a specialist service of the National Health Service. The authors evaluated the diagnostic accuracy of the AAA by investigating if the Autism Questionnaire, the Empathy Quiotient and the Relatives Questionnaire were able to predict the diagnostic outcome of Autism in a clinical setting. Findings Scores from the Relatives Questionnaire can accurately predict diagnostic outcome. No evidence of accuracy for the Autism Questionnaire or the Empathy Quotient was apparent. Based on the findings, the authors recommend clinicians are cautious when interpreting results of the AAA. Research limitations/implications It should be acknowledged that the results may not be generalisable to whole populations. Also, the authors used the full item versions of the scales; therefore, the findings are most applicable to studies which did similar. Originality/value This study highlights the need for investigation into the lack of validation of commonly used screening measures in autistic populations.

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Impact of Voxel Size Variation on CBCT-Based Diagnostic Outcome in Dentistry: a Systematic Review

Journal of Digital Imaging ◽

10.1007/s10278-012-9562-7 ◽

2012 ◽

Vol 26 (4) ◽

pp. 813-820 ◽

Cited By ~ 62

Author(s):

Rubens Spin-Neto ◽

Erik Gotfredsen ◽

Ann Wenzel

Keyword(s):

Systematic Review ◽

Size Variation ◽

Voxel Size ◽

Diagnostic Outcome

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LYMPHATIC DELIVERY: CONCEPT, CHALLENGES AND APPLICATIONS

INDIAN DRUGS ◽

10.53879/id.54.08.11148 ◽

2017 ◽

Vol 54 (08) ◽

pp. 5-22

Author(s):

C. R Bora ◽

◽

R. H. Prabhu ◽

V. B. Patravale

Keyword(s):

Lymphatic System ◽

New Technology ◽

Critical Role ◽

Circulatory System ◽

Drug Carriers ◽

Entire Body ◽

Anatomy And Physiology ◽

Routes Of Administration ◽

Lymphatic Delivery ◽

Diagnostic Outcome

The lymphatic system is an additional circulatory system throughout the entire body. It plays a critical role in the recognition of immune system and response to disease. Lymphatic delivery has attracted a lot of attention for providing preferential chemotherapy and enhancing bioavailability of drugs that undergo hepatic first-pass metabolism. The anatomy and physiology of the lymphatic system, routes of administration and different physicochemical parameters of drug/carriers are overviewed. There are numerous challenges in targeting drugs and bioactives to specific sites, maintaining the desired action and crossing all the physiological barriers. Lymphatic delivery for various diseases employing various nanocarriers emerges as a new technology to provide a better therapeutic and diagnostic outcome.

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