scholarly journals Lipid metabolism and production of incretins in patients with obesity and type 2 diabetes mellitus after biliopancreatic diversion in Hess-Marceau modification at the early stages of follow-up

2016 ◽  
Vol 13 (3) ◽  
pp. 38-44
Author(s):  
Ekaterina Ershova ◽  
Ekaterina Troshina ◽  
Yury Yashkov
Keyword(s):  
Type 2 Diabetes ◽  
Lipid Metabolism ◽  
Total Cholesterol ◽  
Biliopancreatic Diversion ◽  
Positive Impact ◽  
Positive Association ◽  
Hdl Cholesterol ◽  
Atherogenic Index ◽  
Number Of Patients

Objectives: To study the lipid metabolism and secretion of GLP-1 and GIP in obese patients with type 2 diabetes before and 3 months after biliopancreatic diversion (BPD) in Hess-Marceau modification.Materials and methods: 22 patients (44 [38.0; 55.0] years) with morbid obesity (BMI of 50.1 [41.3; 53.8]) and type 2 diabetes were included in the study. Total cholesterol, LDL-C, HDL-C, TG, GLP-1, GIP were evaluated before and 3 months after BPD.Results: At 3 months after BPD there were decreases in weight by 15.8% and a reduction in total cholesterol levels and LDL-C, an increase in the number of patients with a target value of total cholesterol and LDL-C (from 4/22 (18%) to 20/22 (91%, p = 0.0001)). TG levels during the first 3 months after BPD did not change, but there was a trend to an increase in the number of patients with TG target levels (from 8/22 (32%) to 15/22 (68%, p = 0.058)). Due to the reduction of total cholesterol intake after malabsorbtive surgery, we saw a regular decrease in HDL-cholesterol. 3 months after BPD there was an increase in basal secretion of GLP-1 and GIP as compared to preoperative levels, and a strong positive association of the basal GIP with the HDL-C (r = 0,8, p = 0.007) and a strong negative association – with the atherogenic index (r = – 0,7, p = 0.009) at 3 weeks after surgery.Conclusions: The majority of patients with obesity and type 2 diabetes as early as at 3 months after BPD in the modification by Hess-Marceau achieve a significant improvement in the parameters of lipid metabolism; expect positive impact of the GIP on lipid metabolism.

scholarly journals SUN-LB110 The Nutrition Education Using a Health Care Application With Artificial Intelligence in Patients With Diabetes Mellitus

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Takuya Higashitani ◽  
Mitsuhiro Kometani ◽  
Rie Oka ◽  
Yuko Gondo ◽  
Akihiro Nomura ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Total Cholesterol ◽  
Nutrition Education ◽  
Case Reports ◽  
Smart Device ◽  
Number Of Patients ◽  
Diet Control

Abstract Background: Diet control is the basis of the treatment of type 2 diabetes. However, the education and practice of diet control for the patients with type 2 diabetes mellitus (T2DM) need a lot of manpower and time. In 2009, we have developed a telemedicine model that nutritionists analyze photos of T2DM patients’ meal and supervise them remotely. Our system resulted in the improvement of glycemic control of T2DM patients. Recently, the image analysis technology using the artificial intelligence (AI) progresses rapidly. The smart device application “Asken” has an AI-powered photo analysis system which analyzes the photo of the entire meal and identifies the frame of each item as well as its menu and serving amount. In addition, this application delivers individualized dietary messages and feedbacks. Case reports: We report two T2DM cases who conducted nutrient intervention by this application. One case was a 72-year-old man whose HbA1c decreased from 7.2% to 6.6% and weighed from 58.7kg to 57.5kg in 4 months. However, his total cholesterol increased from 119mg/dl to 200mg/dl, and low-density lipoprotein cholesterol (LDL) also increased from 47mg/dl to 106mg/dl. Another case is a 60-year-old man whose HbA1c improved from 7.0% to 6.6% and his weight decreased from 78.0kg to 76.0kg in 3 months. Total cholesterol was 140mg/dl to 128mg/dl, and LDL-cholesterol was from 65mg/dl to 54mg/dl. Conclusion: Using this application might be useful for diet control of T2DM patients. The effects of AI-supported nutrient intervention using application like this should be further clarified in the large number of patients.

scholarly journals Oxidized LDL and lipids as risk factors for ischemic heart disease in type 2 diabetes

2005 ◽  
Vol 62 (7-8) ◽  
pp. 529-536 ◽  
Author(s):  
Miroslava Zamaklar ◽  
Katarina Lalic ◽  
Natasa Rajkovic ◽  
Danijela Trifunovic ◽  
Mirjana Dragasevic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Oxidized Ldl ◽  
Hdl Cholesterol ◽  
Apo B ◽  
Significant Difference

Background. Abnormal lipid profile is an important risk factor in the development of macrovascular atherosclerotic complications in patients with type 2 diabetes mellitus (T2D). Factors that contribute to endothelial cell dysfunction associated with the initiation of atherosclerosis include oxidative stress. The aim of this study was to investigate the relationship between lipid profile and oxidative stress in type 2 diabetics with and without ischemic heart disease (IHD). Methods. We studied 80 patients with T2D, 40 with IHD (group A1) and 40 without IHD (group A2). We also studied 51 non-diabetics, 31 with IHD (group B1), and 20 without IHD (group B2 - control group). Lipid profile was estimated by the total cholesterol, HDL cholesterol, LDL cholesterol, the level of triglyceride (Tg), lipoproteina a (Lp a), Apo A I, A II, B 100 and E. To evaluate the oxidative status we measured circulating oxidized LDL (ox LDL), erythrocyte antioxidative enzyme activity: superoxide dismutase (E-SOD), glutathione peroxidase (E-GPX), as well as the total antioxidative serum activity (TAS). Inflammatory reaction was estimated by C-reactive protein (CRP) and fibrinogen. Results. No significant difference was found in the lipid profile in groups A1, A2 and B1, but the group B2 had the lowest one. Lp a level was significantly higher in group B1 comparing to other groups (p < 0.05). There was no significant difference in the level of ox LDL between the groups. In diabetics, ox LDL positively correlated with the total cholesterol, LDL cholesterol, non HDL cholesterol, Apo B 100 and the relations between LDL/HDL and Tg/HDL (p < 0.001), as well as with Tg and fibrinogen (p < 0.05). In group B1, ox LDL positively correlated with total cholesterol, Tg (p < 0.01), LDL, and non HDL cholesterol (p < 0.05) and significantly with Apo B 100 (p < 0.001). There was no significant difference in the antioxidant enzyme activities between the groups of diabetics (A1 and A2), but fibrinogen was higher in the group with IHD (group A1, p < 0.05). Group B1 had lower ESOD activity than the groups A1 and A2 (p < 0.05), but CRP was higher (p < 0.05). There were no significant correlations between oxLDL and CRP in groups A1 and A2, but it was statistically significant in the group B1 (p < 0.05). Conclusion. In this study we demonstrated the increased oxidative stress in diabetics compared to non-diabetics regardless of the presence of IHD. Fibrinogen, but not CRP, was higher in diabetics with IHD, compared to diabetics without IHD. The increased oxidative stress, the reduced antioxidative activity E-SOD, and the higher level of CRP were found in non-diabetics with IHD compared to non-diabetics without IHD.

scholarly journals Effect of Fiber-Rich Snacks on C-Reactive Protein and Atherogenic Index in Type 2 Diabetes Patients

2018 ◽  
Vol 25 (4) ◽  
pp. 357-362
Author(s):  
Nartyr Sunarti ◽  
Sri Lestari Sulistyo Rini ◽  
Hemi Sinorita ◽  
Dini Ariani
Keyword(s):  
Type 2 Diabetes ◽  
Hdl Cholesterol ◽  
Atherogenic Index ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Before And After ◽  
Positive Effect ◽  
Hba1c Levels ◽  
Diabetes Patients

Abstract Background and aims: High levels of non-HDL and atherogenic cholesterol can induce inflammation, and as risk factor for cardiovascular diseases. This study was to evaluate the effects of fiber-rich snacks on non-HDL cholesterol, atherogenic index, and Creactive protein (CRP) levels in type 2 diabetes patients (T2DM). Material and Methods: Twenty T2DM patients, were recruited from the Policlinic of Endocrine, Dr. Sardjito General Hospital, Yogyakarta, Indonesia. The subjects received daily 32g fiber-rich snacks made of Dioscorea esculenta, arrowroot, cassava and pumpkin for 4 weeks. Fasting non-HDL cholesterol, atherogenic index, CRP and HbA1c levels were measured before and after intervention. Paired t-test was used to evaluate the results. Results: The fiber-rich snack intervention in T2DM patients significantly reduced levels of non-HDL cholesterol and CRP levels (p<0.05), but the decreased the atherogenic index was not significant (p>0.05). The intervention also significantly reduced the CRP levels (p<0.05) but did not affect HbA1c levels. Body weight, body mass index (BMI), waist circumference decreased significantly after consuming the snacks (p<0.05). Conclusions: This study showed fiber-rich snack has a positive effect in improving non-HDL cholesterol, atherogenic index and CRP levels but does not affect HbA1c levels in T2DM patients.

scholarly journals Association of the polymorphism in the androgen receptor gene and endothelial function in men with type 2 diabetes

2015 ◽  
Vol 18 (4) ◽  
pp. 35-40 ◽  
Author(s):  
Irina Alekseevna Khripun ◽  
Sergey Vladislavovich Vorobyev ◽  
Michael Iosifovich Kogan
Keyword(s):  
Type 2 Diabetes ◽  
Lipid Metabolism ◽  
Androgen Receptor ◽  
Endothelial Function ◽  
Flow Velocity ◽  
Brachial Artery ◽  
Cag Repeats ◽  
Atherogenic Index ◽  
Brachial Artery Diameter

In recent years, actively studied the effect of androgen deficiency on the cardiovascular system, including endothelial function. Genomic effects of testosterone caused by the length of CAG repeats polymorphism in the androgen receptor (AR) gene.Aim. To examine the association of the polymorphism in the AR gene and carbohydrate, lipid metabolism, endothelial function in men with type 2 diabetes.Materials and methods. We examined 88 men, aged 40-65 years (mean age 53±6,4years) with type 2 diabetes. All patients underwent the study of carbohydrate and lipid metabolism, the assessment of vasomotor endothelial function of the brachial artery by ultrasound sonography, were studied biochemical markers of endothelial dysfunction – ICAM-1, VCAM-1, p-selectin, e-selectin, resistin and number of CAG-repeats in the AR gene. Statistical analysis was performed using the application package SPSS 21,0 using regression analysis.Results. The number of CAG repeats had a significant positive regression to the level of total testosterone, a weak negative regression of the number of CAG repeats in the AR gene and lipid metabolism: triglycerides, LDL, atherogenic index. The assessment of the brachial artery ultrasonography revealed negative regression of the baseline brachial artery diameter and blood flow velocity in the endothelium-dependent vasodilation. The number of CAG repeats was significantly correlated with the levels of p-selectin and resistin. Thus, increasing the number of CAG repeats in the AR gene via a weakening of sensitivity to androgens leads to disruption of endothelial function in men with type 2 diabetes. Increasing the number of CAG repeats in the AR gene leads to deterioration of linear flow velocity during the test with reactive hyperemia with increasing production of p-selectin and resistin.Conclusions. The number of CAG repeats in the AR gene can be regarded as a predictor of the development and progression of cardiovascular lesions in men with type 2 diabetes.

scholarly journals Effect of increased calcium consumption from fat-free milk in an energy-restricted diet on the metabolic syndrome and cardiometabolic outcomes in adults with type 2 diabetes mellitus: a randomised cross-over clinical trial

2018 ◽  
Vol 119 (4) ◽  
pp. 422-430 ◽  
Author(s):  
Junia M. G. Gomes ◽  
Jorge d. A. Costa ◽  
Rita C. G. Alfenas
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Type 2 Diabetes Mellitus ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Restricted Diet ◽  
The Metabolic Syndrome

AbstractWe investigated the effects of high-Ca fat-free milk phase (MD) (prescription of approximately 1500 mg of Ca/d) v. low-Ca phase (CD) (prescription of approximately 800 mg of Ca/d) in an energy-restricted diet on the metabolic syndrome (MetS) and cardiometabolic measures in individuals with type 2 diabetes mellitus (T2DM) and low habitual Ca consumption (<600 mg/d). In this randomised cross-over design, fourteen adults with T2DM (49·5 (sd 8·6) years, BMI 29·4 (sd 4·5) kg/m2) consumed either MD or CD for 12 weeks, with a washout of 18 weeks between phases. A breakfast shake containing 700 mg (MD) or 6·4 mg (CD) of Ca was consumed in the laboratory. In addition, energy-restricted diets were prescribed (800 mg of dietary Ca/d). Waist circumference (WC), fasting glucose, fasting TAG, systolic (SBP) and diastolic blood pressure (DBP), fasting total cholesterol, fasting LDL-cholesterol, fasting HDL-cholesterol, HDL:LDL ratio, HDL:TAG ratio and lipid accumulation product (LAP) index were assessed at baseline and after each phase. Ca consumption during the study was equivalent to 1200 mg/d during MD and 525 mg/d during CD. There was a greater reduction in WC, SBP, DBP and LAP index after MD compared with CD. HDL:LDL ratio increased and total cholesterol, LDL-cholesterol, SBP, DBP and LAP index decreased only in MD. The consumption of approximately 1200 mg of Ca/d (700 mg from fat-free milk+500mg from other dietary sources) associated with an energy-restricted diet decreased some of the MetS components and cardiometabolic measures in adults with T2DM.

scholarly journals Including Walnuts in a Low-Fat/Modified-Fat Diet Improves HDL Cholesterol-to-Total Cholesterol Ratios in Patients With Type 2 Diabetes

Diabetes Care ◽  
2004 ◽  
Vol 27 (12) ◽  
pp. 2777-2783 ◽  
Author(s):  
L. C. Tapsell ◽  
L. J. Gillen ◽  
C. S. Patch ◽  
M. Batterham ◽  
A. Owen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Total Cholesterol ◽  
Hdl Cholesterol ◽  
Low Fat

scholarly journals A 7-year experience with the surgery of biliopancreatic diversion in the modification of Hess-Marceau for the treatment of morbid obesity and type 2 diabetes

2012 ◽  
Vol 9 (2) ◽  
pp. 43-48 ◽  
Author(s):  
Yu I Yashkov ◽  
A V Nikol'skiy ◽  
D K Bekuzarov ◽  
E V Ershova ◽  
N A Ogneva
Keyword(s):  
Type 2 Diabetes ◽  
Morbid Obesity ◽  
Weight Loss ◽  
Lipid Metabolism ◽  
Biliopancreatic Diversion ◽  
High Efficiency ◽  
Atherogenic Dyslipidemia ◽  
Carbohydrate And Lipid Metabolism ◽  
Before And After

We examined 292 patients (mean age 37,5±9,1 years) with morbid obesity (initial BMI 47,3±7,0 kg/m2), from which 72 patients had type 2 diabetes, before and after biliopancreatic diversion in Hess-Marceau modification, conducted from 2003 to 2010. Along with a significant and steady weight loss, the most important advantage of surgery is its high efficiency in treatment of disturbances in carbohydrate and lipid metabolism in patients with morbid obesity and associated type 2 diabetes and severe atherogenic dyslipidemia.

The epifamin effect on values of immune status, carbohydrate and lipid metabolism in the patients with non-alcoholic steatohepatitis developing at type 2 diabetes mellitus

10.12737/5038 ◽  
2014 ◽  
Vol 8 (1) ◽  
pp. 1-7
Author(s):  
Золоедов ◽  
V. Zoloedov ◽  
Агарков ◽  
A. Agarkov ◽  
Попов ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Lipid Metabolism ◽  
Immune Status ◽  
Atherogenic Index ◽  
Alcoholic Steatohepatitis ◽  
Carbohydrate And Lipid Metabolism ◽  
Basic Treatment

The study is devoted to the Epifamin effect on values of carbohydrate and lipid metabolism, immune status in blood, and also content of 6-sulfatohymelatonin as the main metabolite of melatonin, in urine of the patients with non-alcoholic steatohepatitis developing at type 2 diabetes mellitus. It is shown that fasting glucose, postprandial glucose level and glycated hemoglobin content in the blood of patients decreased significantly during combined treatment with the Epifamin compared to the basic therapy. The results of the Epifamin reception are as follows: more expressed normalization of lipid metabolism, and content of β -lipoproteins, cholesterol, lipoproteins of low density and high density lipoprotein, and atherogenic index in comparison with the results obtained after basic treatment. The obtained results testify to positive Epifamin effect on values of the immune status of patients: level of circulating immune complexes, the main classes of immunoglobulins – IgA, IgM, IgG. It was established that in the patients with non-alcoholic steatohepatitis developing at type 2 diabetes mellitus, 6-sulfatohymelatonin level in urine was lowered on the average by 1,2 times in comparison with control. After basic treatment the reliable changes of the 6-sulfatohymelatonin content in the patients didn’t reveal. After the combined therapy with the Epifamin, the 6-sulfatohymelatonin content in the patients increased on the average for 13.9%. The obtained results allow to conclude about correction the Epifamin effect on melatonin content as a hormone, which able to participate in regulation of carbohydrate and lipid metabolism and to have immune modulating action. The Epifamin use in basic treatment had favorable influence on the immune status, values of carbohydrate and lipid metabolism in blood in the patients with non-alcoholic steatohepatitis developing at type 2 diabetes mellitus that was apparently due to melatonin-corrective effect of this drug.

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