THE RELATIONSHIP OF THE DISTAL DIABETIC POLYNEUROPATHY WITH PARAMETERS OF FOOT BONE MINERAL DENSITY IN PATIENTS WITH DIABETES MELLITUS

The aim of the study was to evaluate foot bone mineral density (BMD) in diabetes mellitus (DM) complicated with distal neuropathy (DN). Materials and methods. 61 patients with DM (DM1-27, DM2-34) were included. 37patients had Charcot osteoarthropathy (the 1st group), the 2nd group (13 patients) with severe DN, the 3rd group (11 patients) with mild DN, and control group consisted of 15 healthy people. All patients underwent dual energy X-ray absorptiometry (DXA) Lunar Prodigy scan. BMD was measured in lumbar spine, hip and radius. Foot BMD was measured using the «Total Body» region’s analysis. Results. There was a significant difference in foot BMD between controls and the 1st (р=0,031) and the 3rd (р=0,027) groups with no significant difference between the groups of patients. Foot BMD significantly correlated with spine, hip and radiusBMD (г=0,5-0,63, р<0,00001), BMI (r=0,4, р=0,000). Negative correlation was found between foot BMD and diabetes duration (r=-0,3, p<0,005) and HbA1c (r=-0,2, р=0,045). No correlation was found between DN and foot BMD. Conclusion. No association between severity of DN and foot BMD was found.

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Peripheral and Central Bone Mineral Density in Charcot’s Neuroarthropathy Compared in Diabetic and Nondiabetic Populations

Journal of the American Podiatric Medical Association ◽

10.7547/1020213 ◽

2012 ◽

Vol 102 (3) ◽

pp. 213-222 ◽

Cited By ~ 7

Author(s):

Robert M. Greenhagen ◽

Dane K. Wukich ◽

Rachel H. Jung ◽

Vassilios Vardaxis ◽

Robert M. Yoho

Keyword(s):

Diabetes Mellitus ◽

Bone Mineral Density ◽

Bone Mineral ◽

Serum Vitamin ◽

Control Group ◽

Mineral Density ◽

X Ray ◽

Serum Vitamin D ◽

Significant Difference ◽

Patients With Diabetes

Background: This prospective study was performed to compare calcaneal and lumbar bone mineral density (BMD) in individuals with and without diabetes mellitus. We compared bone density with the time from onset of Charcot’s neuroarthropathy (CN) in patients with unilateral, nonoperative, reconstructive-stage CN. The final purpose was to investigate the role that sex, age, and serum vitamin D level may have in osseous recovery. Methods: Thirty-three individuals were divided into three groups: controls and patients with diabetes mellitus with and without CN. Peripheral instantaneous x-ray imaging and dual-energy x-ray absorptiometry were performed. Results: The calcaneal BMD of patients with diabetes mellitus and CN was lower than that of the control group (P < .01) but was not significantly lower than that of patients with diabetes mellitus alone. There was no statistically significant difference in lumbar T-scores between groups. Women demonstrated lower BMD than did men (P = .02), but patients 60 years and older did not demonstrate significantly lower BMD than did patients younger than 60 years (P = .135). A negative linear relationship was demonstrated between time and BMD in patients with CN. Conclusions: The results of this study suggest that lumbar BMD does not reflect peripheral BMD in patients with diabetes mellitus and reconstructive-stage CN. This study has clinical implications when reconstructive osseous surgery is planned in patients with CN. (J Am Podiatr Med Assoc 102(3): 213–222, 2012)

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Overexpression of Mig-6 in Cartilage Induces an Osteoarthritis-Like Phenotype in Mice

10.21203/rs.2.24144/v2 ◽

2020 ◽

Author(s):

Melina Bellini ◽

Michael Andrew Pest ◽

Manuela Miranda Rodrigues ◽

Ling Qin ◽

Jae-Wook Jeong ◽

...

Keyword(s):

Bone Mineral Density ◽

Body Composition ◽

Articular Cartilage ◽

Bone Mineral ◽

Cartilage Degeneration ◽

Negative Regulator ◽

Control Group ◽

Multiple Time ◽

Mineral Density ◽

Significant Difference

Abstract Background: Osteoarthritis (OA) is the most common form of arthritis and characterized by degeneration of articular cartilage. Mitogen-inducible gene 6 (Mig-6) has been identified as a negative regulator of the Epidermal Growth Factor Receptor (EGFR). Cartilage-specific Mig-6 knockout (KO) mice display increased EGFR signaling, an anabolic buildup of articular cartilage and formation of chondro-osseous nodules. Since our understanding of the EGFR/Mig-6 network in cartilage remains incomplete, we characterized mice with cartilage-specific overexpression of Mig-6 in this study. Methods: Utilizing knee joints from cartilage-specific Mig-6 overexpressing (Mig-6over/over) mice (at multiple time points), we evaluated the articular cartilage using histology, immunohistochemical staining and semi-quantitative histopathological scoring (OARSI) at multiple ages. MicroCT analysis was employed to examine skeletal morphometry, body composition, and bone mineral density.Results: Our data show that cartilage-specific Mig-6 overexpression did not cause any major developmental abnormalities in articular cartilage, although Mig-6over/over mice have slightly shorter long bones compared to the control group. Moreover, there was no significant difference in bone mineral density and body composition in any of the groups. However, our results indicate that Mig-6over/over male mice show accelerated cartilage degeneration at 12 and 18 months of age. Immunohistochemistry for SOX9 demonstrated that the number of positively stained cells in Mig-6over/over mice was decreased relative to controls. Immunostaining for MMP13 appeared increased in areas of cartilage degeneration in Mig-6over/over mice. Moreover, staining for phospho-EGFR (Tyr-1173) and lubricin (PRG4) was decreased in the articular cartilage of Mig-6over/over mice. Conclusion: Overexpression of Mig-6 in articular cartilage causes no major developmental phenotype; however, these mice develop earlier OA during aging. These data demonstrate that Mig-6/EGFR pathways is critical for joint homeostasis and might present a promising therapeutic target for OA.

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Overexpression Of Mig-6 In Cartilage Induces An Osteoarthritis-like Phenotype In Mice

10.21203/rs.2.24144/v1 ◽

2020 ◽

Author(s):

Melina Bellini ◽

Michael Andrew Pest ◽

Manuela Miranda Rodrigues ◽

Ling Qin ◽

Jae-Wook Jeong ◽

...

Keyword(s):

Bone Mineral Density ◽

Body Composition ◽

Articular Cartilage ◽

Bone Mineral ◽

Cartilage Degeneration ◽

Negative Regulator ◽

Control Group ◽

Multiple Time ◽

Mineral Density ◽

Significant Difference

Abstract Background: Osteoarthritis (OA) is the most common form of arthritis and characterized by degeneration of articular cartilage. Mitogen-inducible gene 6 (Mig-6) has been identified as a negative regulator of the Epidermal Growth Factor Receptor (EGFR). Cartilage-specific Mig-6 knockout (KO) mice display increased EGFR signaling, an anabolic buildup of articular cartilage and formation of chondro-osseous nodules. Since our understanding of the EGFR/Mig-6 network in cartilage remains incomplete, we characterized mice with cartilage-specific overexpression of Mig-6 in this study. Methods : Utilizing knee joints from cartilage-specific Mig-6 overexpressing ( Mig- 6over/over ) mice (at multiple time points), we evaluated the articular cartilage using histology, immunohistochemical staining and semi-quantitative OARSI scoring at multiple ages. MicroCT analysis was employed to examine skeletal morphometry, body composition, and bone mineral density. Results: Our data show that cartilage-specific Mig-6 overexpression did not cause any major developmental abnormalities in articular cartilage, although Mig-6 over/over mice have slightly shorter long bones compared to the control group. Moreover, there was no significant difference in bone mineral density and body composition in any of the groups. However, our results indicate that Mig-6 over/over male mice show accelerated cartilage degeneration at 12 and 18 months of age. Immunohistochemistry for SOX9 demonstrated that the number of positively stained cells in Mig-6 over/over mice decreased relative to controls. Immunostaining for MMP13 staining is increased in areas of cartilage degeneration in Mig-6 over/over mice. Moreover, staining for phospho-EGFR (Tyr-1173) and lubricin (PRG4) was decreased in the articular cartilage of Mig-6 over/over mice. Conclusion: Overexpression of Mig-6 in articular cartilage causes no major developmental phenotype; however these mice develop earlier OA during aging. These data demonstrate that Mig-6/EGFR pathways is critical for joint homeostasis and might present a promising therapeutic target for OA.

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Quantitative ultrasound assessment of the effect of parity on bone mineral density in females

BMC Women s Health ◽

10.1186/s12905-021-01516-w ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Shahnaz Akil ◽

Huda Al-Mohammed ◽

Norah Al-Batati ◽

Maissa Tirsen ◽

Ahad Al-Otaibi ◽

...

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Quantitative Ultrasound ◽

Screening Method ◽

Broadband Ultrasound Attenuation ◽

Control Group ◽

Mineral Density ◽

Portable Ultrasound ◽

Bone Densitometer ◽

Significant Difference

Abstract Background The effect of pregnancy and breastfeeding on a female’s bone mineral density (BMD) is controversial. This prospective study aims to investigate the effect of parity on BMD among pre-menopausal multiparous females using quantitative ultrasound as a screening method and females with no pregnancies (nulliparous) as a control group. Methods A portable ultrasound-based bone densitometer (DMS PEGASUS SMART, Mauguio, France) was used to indirectly assess the BMD in 51 multiparous (29–45 years) and 51 nulliparous Arabic females (18–35 years) by quantifying the broadband ultrasound attenuation (BUA) from their right calcaneus bone. BUA > 70 db/mhz = normal, BUA 65–69.9 db/mhz = below average, BUA 55–64.9 db/mhz = osteopenia and BUA < 55 db/mhz = osteoporosis. Results There was a significant difference in mean BUA between multiparous and nulliparous females (74.1 db/mhz vs. 69.3 db/mhz, p = 0.006). The prevalence of normal BMD was significantly higher in the nulliparous group than in the multiparous group (70.6% vs. 47.1%, p = 0.02). Osteoporosis was found in the multiparous group only (3/51). Among the multiparous females who breastfed (43/51), a total of 51.2% (22/43) had normal BMD, 25.6% (11/43) had BMD below average, 18.6% (8/43) had osteopenia and 4.7% (2/43) had osteoporosis. No significant differences in mean BUA (p = 0.2) were found between the group of females who breastfed for one year (13/43; BUA: 70.5 ± 9.4), the group of females who breastfed for 6–11 months (8/43; BUA: 70.6 ± 10.0) and those who breastfed for less than six months (22/43; BUA: 71.6 ± 9.4). A binary logistic regression model built for predicting BMD normality showed significance for the variable parity (p = 0.03), while the effect of the possible confounding variables BMI and age on BMD normality was found to be non- significant (p = 0.1 and p = 0.6, respectively). Conclusion Parity affects the BMD, as assessed by a portable ultrasound-based bone densitometer, of young and middle-aged females as compared to the BMD of nulliparous females.

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Clinical effect of Zoledronic Acid in the treatment of Senile Osteoporosis

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.36.7.1964 ◽

2020 ◽

Vol 36 (7) ◽

Author(s):

Li Kong ◽

Kai Zuo ◽

Long Ma

Keyword(s):

Bone Mineral Density ◽

Zoledronic Acid ◽

Bone Mineral ◽

Adverse Reactions ◽

Clinical Effect ◽

Control Group ◽

Observation Group ◽

Mineral Density ◽

Senile Osteoporosis ◽

Significant Difference

Objective: To investigate the clinical efficacy of zoledronic acid in the treatment of senile osteoporosis. Methods: One hundred and six cases of senile osteoporosis who visited to our hospital from August 2017 to December 2018 for treatment were selected and randomly divided into a control group and an observation group. The control group was treated with conventional therapy, while the observation group was treated with zoledronic acid in addition to the treatment of the control group. Bone mineral density, pain degree, therapeutic effect and adverse reactions of the two groups were compared. Results: The total effective rate of the observation group was 96.67%, higher than 80.00% of the control group (P<0.05); the bone mineral density of lumbar vertebrae, femoral neck and Ward’ area in the two groups increased after 6 months of treatment, and the bone mineral density of the observation group increased more than that of the control group (P<0.05); the pain degree of the observation group was lower than that of the control group after 6 months of treatment, and the difference was significant (P<0.05). There was no significant difference in the occurrence of adverse reactions between the two groups (P>0.05). Conclusion: Zoledronic acid is helpful to alleviate clinical symptoms, reduce the degree of bone pain, and promote the increase of bone mass, and has high safety in the treatment of senile osteoporosis, which is worth promotion. doi: https://doi.org/10.12669/pjms.36.7.1964 How to cite this:Kong L, Zuo K, Ma L. Clinical effect of Zoledronic Acid in the treatment of Senile Osteoporosis. Pak J Med Sci. 2020;36(7):1703-1707. doi: https://doi.org/10.12669/pjms.36.7.1964 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of Dried Plum (Prunes) on Bone Density and Strength in Men

Current Developments in Nutrition ◽

10.1093/cdn/nzaa040_021 ◽

2020 ◽

Vol 4 (Supplement_2) ◽

pp. 21-21

Author(s):

Jonnatan Fajardo ◽

Danielle Gaffen ◽

Ashley Eisner ◽

Mark Kern ◽

Shirin Hooshmand

Keyword(s):

Bone Mineral Density ◽

Bone Density ◽

Bone Mineral ◽

Human Study ◽

Control Group ◽

Adult Women ◽

Protective Effects ◽

Mineral Density ◽

Total Body ◽

The Impact

Abstract Objectives Traditionally, osteoporosis has been viewed as a disease mostly affecting women, but cases in men are increasing. Fractures due to osteoporosis can lead to a decreased quality of life in vulnerable populations and lead to increased mortality in men. Although several studies of male and female animals and adult women have demonstrated bone protective effects of dried plum (prunes), no human study has evaluated the effect of dried plum on bone health in men. The objective of the current study was to examine the long-term effects of 100 g dried plum on bone density and strength in men. Methods Sixty-six men (50–79 years old) were randomly assigned into two treatment groups for 12 months: (1) 100 g/day of dried plums; (2) control (0 g/day dried plum). Bone mineral density was measured at baseline, 6- and 12-months at the total body, hip, lumbar spine, and ulna via dual-energy x-ray absorptiometry (DXA). Evaluation of volumetric bone density and strength of the left tibia occurred at baseline, 6- and 12-months using peripheral quantitative computed tomography (pQCT). Results There were no statistically significant changes in bone mineral density (BMD) from baseline to 6 months and 12 months for total body, spine (L1-L4), right and left hip BMD in the control group (0 g/day dried plum) or 100 g/day dried plum group. Modest beneficial effects of dried plums were observed for changes in bone geometry as detected by pQCT including a tendency for BMD to increase as well as increases in periosteal and endosteal circumferences at the 66% region of the tibia, which may promote greater bone strength. Conclusions Dried plums have the potential to improve bone morphometry of the proximal tibia in healthy adult men when consumed for 12 months. Future studies should examine the impact on men with low bone density to further evaluate the bone protective effects of dried plum in male populations. Funding Sources This study was funded by the California Dried Plum Board.

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Bone mineral density in middle-aged women with Turner's syndrome

Acta Endocrinologica ◽

10.1530/eje.0.1320047 ◽

1995 ◽

Vol 132 (1) ◽

pp. 47-52 ◽

Cited By ~ 30

Author(s):

Lisskulla Sylvén ◽

Kerstin Hagenfeldt ◽

Hans Ringertz

Keyword(s):

Bone Mineral Density ◽

Body Fat ◽

Bone Mineral ◽

Turner's Syndrome ◽

Turner’S Syndrome ◽

Middle Aged ◽

Mineral Density ◽

Percentage Body Fat ◽

Significant Difference ◽

Total Body

Sylvén L, Hagenfeldt K, Ringertz H. Bone mineral density in middle-aged women with Turner's syndrome. Eur J Endrocrinol 1995;132:47–52. ISSN 0804–4643 Bone mineral density (BMD), bone mineral content and body composition were determined in 47 middle-aged (mean age 47.9 ± 1.1 years) women with Turner's syndrome. Bone mineral density was measured in the forearm, femoral neck and total body. The women investigated had a BMD lower than the normal mean. When expressed as Z scores (individual values compared to normal reference data matched for age, weight and sex), the median Z score of the total body was −1.23. When comparing women with the karyotype 45,X and mosaic women, the latter showed a higher BMD in all sites of measurement. Duration of hormonal replacement therapy (HRT) differed significantly between the mosaic and the 45,X women, with a longer duration in the mosaic group (20.7 ± 2 vs 12.1 ± 2.6 years; p < 0.01). The duration of HRT was found to be the more important factor to maintain bone mass, not the karyotype. Bone mineral density increased with years of HRT but not until after > 20 years of HRT could a significant difference be shown between the women with HRT ≤ 20 years and those with HRT > 20 years. No correlation was found between BMD and body weight, body fat or percentage body fat. Whether the osteopenia found in women with Turner's syndrome is similar to that found postmenopausally or is a specific form related to the chromosome aberration remains to be investigated further. The present data support a relation to estrogen deficiency. Lisskulla Sylvén, Department of Woman and Child Health, Division for Obstetrics & Gynecology, Karolinska Hospital, S-171 76 Stockholm, Sweden

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Evaluation of Bone Mineral Density in Children with Type I Diabetes Mellitus and Relationship to Serum Levels of Osteopontin

Drug Research ◽

10.1055/s-0043-109001 ◽

2017 ◽

Vol 67 (09) ◽

pp. 527-533 ◽

Cited By ~ 4

Author(s):

Forough Saki ◽

Abdolkarim Sheikhi ◽

Gholam Omrani ◽

Hamid Karimi ◽

Mohammad Dabbaghmanesh ◽

...

Keyword(s):

Diabetes Mellitus ◽

Bone Mineral Density ◽

Bone Mineral ◽

Negative Correlation ◽

Healthy Subjects ◽

Type I Diabetes ◽

Serum Levels ◽

Control Group ◽

Type I ◽

Mineral Density

Abstract Type I diabetes mellitus (T1DM) patients are at risk of osteoporosis and fracture due to the osteoblast and osteoclast malfunction. Osteopontin (OPN) as the major non-collagenous bone matrix protein is produced by osteoblasts and osteoclasts and involve in bone resorption, formation and remodeling. To evaluate the serum levels of OPN, bone mineral density (BMD) and correlation in patients with T1DM this study was designed. In this case-control study, 87 children with T1DM and 87 age/sex-matched healthy subjects were enrolled. Blood samples were tested for OPN levels by ELISA. Dual energy X-ray absorptiometry was used to measure BMD. The mean levels of BMD in patients was significantly lower than control group (p<0.0001). There was no significant difference between patients and healthy subjects regarding the levels of OPN. However, in patients with high levels of OPN (mean+1.5 standard deviation) the BMD was significantly lower than other patients (p<0.0001). Totally there was a negative correlation between serum levels of OPN and BMD in patients with T1DM (p<0.016). These results indicated that the BMD in T1DM is less than healthy children and elevated level of OPN in patients could be associated with low BMD. A linear negative correlation between serum OPN and total BMD of T1DM patients compared to control group was noticed in this study indicating that the amount of serum OPN could be effective on BMD and a good predicting factor for osteoporosis in patients.

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The effect of different exercise programs on bone mineral density and physical function in women with osteoporosis: A randomized controlled trial

International Journal of Growth and Development ◽

10.25081/ijgd.2017.v1i1.48 ◽

2017 ◽

Vol 1 (1) ◽

pp. 47

Author(s):

Lumnije Hoxha Kamberi

Keyword(s):

Bone Mineral Density ◽

Muscle Strength ◽

Physical Function ◽

Postmenopausal Women ◽

Bone Mineral ◽

Controlled Trial ◽

Intervention Group ◽

Control Group ◽

Mineral Density ◽

Significant Difference

Aim: Osteoporosis is a multifactorial progressive skeletal disorder characterized by reduced bone mass. Exercise is widely recommended to reduce osteoporosis, falls and related fragility fractures. The purpose of this study was to investigate the effects of land exercise (LE) and aquatic exercise (AE) on physical function and bone mineral density (BMD). Methods: Fifty-eight postmenopausal women, aged 50-70 years, diagnosed with osteoporosis according to BMD measures, enrolled in this study. The subjects were randomly assigned to either the intervention group (LE group) or the control group (AE group). Physical function and BMD were assessed in all subjects in both groups before and after 10 months of intervention. The muscle strength, flexibility, balance, gait time and pain were measured to assess physical function. Bone mineral density at the lumbar spine was measured by dual energy X-ray absorptiometry (DEXA). Results: There were no significant differences between the two groups in the baseline anthropometric data. The two groups were similar with respect to age, weight, height, and body mass index (p>0.05). After the exercise program, muscle strength, flexibility, gait time, pain, and bone density (p<0.001) significantly improved with LE compared to AE. There was no significant difference between the two groups in balance at the 10-month follow-up. Conclusion: Significant improvements in physical function and BMD suggest that LE is a possible alternative for postmenopausal women with OP. Clinical rehabilitation impact: In the current available literature there is insufficient data regarding combined regimens, additionally, conclusions from our research can inspire further studies in order to promote land and water based exercise.

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The effects of a 30-month dietary intervention on bone mineral density: The Postmenopausal Health Study

British Journal Of Nutrition ◽

10.1017/s000711451000019x ◽

2010 ◽

Vol 104 (1) ◽

pp. 100-107 ◽

Cited By ~ 38

Author(s):

George Moschonis ◽

Ioanna Katsaroli ◽

George P. Lyritis ◽

Yannis Manios

Keyword(s):

Bone Mineral Density ◽

Vitamin D ◽

Postmenopausal Women ◽

Bone Mineral ◽

Dairy Products ◽

Dietary Intervention ◽

Control Group ◽

Mineral Density ◽

Nutrition Counselling ◽

Total Body

Low dietary Ca intake and vitamin D insufficiency have been implicated as part of the aetiology leading to osteoporosis. The aim of the present study was to examine the effects of a 30-month dietary intervention that combined supplementation of dairy products fortified with Ca and vitamin D3 and lifestyle and nutrition counselling sessions on bone mineral density (BMD) of postmenopausal women. Sixty-six postmenopausal women (aged 55–65 years) were randomised into a dietary group (DG; n 35), receiving daily and for the first 12 months 1200 mg Ca and 7·5 μg vitamin D3, while for the next 18 months of intervention 1200 mg Ca and 22·5 μg vitamin D3 through fortified dairy products, and a control group (CG; n 31) receiving neither counselling nor dairy products. The DG was found to have more favourable changes in arms (P < 0·001), total spine (P = 0·001) and total body BMD (P < 0·001) compared with the CG. Furthermore, a significant increase was observed for the DG in lumbar spine BMD (0·056; 95 % CI 0·009, 0·103), which was not found to differentiate significantly compared with the change observed in the CG (P = 0·075). In conclusion, the present study showed that intakes of vitamin D of about 22·5 μg/d and of Ca close to the recommended level of 1200 mg from fortified dairy foods for 30 months, with compliance ensured by lifestyle and nutrition counselling sessions, can induce favourable changes in arms, total spine and total body BMD of postmenopausal women.

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