scholarly journals Rapid morphometric method for assessment of thyroid functional activity

1994 ◽  
Vol 40 (4) ◽  
pp. 19-21
Author(s):  
Yu. B. Kirillov ◽  
A. P. Chumachenko ◽  
V. G. Aristarkhov ◽  
A. A. Potapov ◽  
I. V. Panteleyev
Keyword(s):  
Postoperative Period ◽  
Functional Activity ◽  
Thyroid Tissue ◽  
Subtotal Resection ◽  
Morphometric Method ◽  
Euthyroid State ◽  
Active Zones ◽  
Toxic Goiter

The incidence of postoperative hypothyrosis after subtotal resection of the thyroid for diffuse toxic goiter is rather high, 40-50 % according to many authors. A method is suggested permitting assessment of the share of active zones during surgery. A certain amount of thyroid tissue is left with due consideration for this share, this amount being sufficient to attain an euthyroid state in the postoperative period.

scholarly journals Evaluation of morphological parameters in patients operated on for diffuse toxic goiter

2015 ◽  
Vol 22 (1) ◽  
pp. 68-69
Author(s):  
S. V. Dora ◽  
M. G. Rybakova ◽  
M. B. Gudieva ◽  
G. V. Semikova ◽  
A. R. Volkova ◽  
...  
Keyword(s):  
Treatment Outcome ◽  
Surgical Treatment ◽  
Functional Activity ◽  
Significant Contribution ◽  
Thyroid Tissue ◽  
Postoperative Outcomes ◽  
Graves Disease ◽  
Morphological Parameters ◽  
Toxic Goiter

Currently, in a case if the remission of Graves' disease is not achieved during the long-term antithyroid medication, thyroidectomy should be considered as the treatment of choice. However, the predictive criteria of the surgical treatment outcome are not defined. In this regard, it is important to search criteria contributing to prediction of the results of surgical treatment. According to the findings of the study revealed morphological indicators showing a significantly greater functional activity of the thyroid tissue in patients with postoperative thyrotoxicosis. This requires further study, which may have a significant contribution to the prognosis of postoperative outcomes among patients with Graves' disease.

scholarly journals Recurrent goitrous transformation and postoperative hypothyroidism — the arguments to execution of organ-preserving thyroid sergery

2010 ◽  
Vol 9 (5) ◽  
pp. 160-164
Author(s):  
A. N. Galyan ◽  
O. S. Popov ◽  
V. I. Tikhonov ◽  
V. D. Zavadovskaya ◽  
S. N. Gasparyan ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Functional State ◽  
Postoperative Period ◽  
Thyroid Tissue ◽  
Surgical Methods

The study included 557 patients with diffuse nodular colloidal goiter and different functional state of thyroid gland after routine surgeries. In the postoperative period was diagnosed hypothyroidism and in its presence the relapse nodulation in thyroid residue. In order to prevent the development of postoperative hypothyroidism, organopreserve surgical methods of the local cryodestruction of pathologic area thyroid gland and autotransplantation of intact thyroid tissue were suggested.

scholarly journals Assessment of Agreement Between Peak Systolic Velocity of Inferior Thyroid Artery And Thyroid Scan In Differentiating Diffuse Toxic Goiter And Subacute Thyroiditis.

2019 ◽  
Vol 21 (2) ◽  
pp. 97-101
Author(s):  
Khaleda Mushtary ◽  
Nasreen Sultana ◽  
Sharmin Quddus
Keyword(s):  
Thyroid Tissue ◽  
Peak Systolic Velocity ◽  
Inferior Thyroid Artery ◽  
Subacute Thyroiditis ◽  
P Value ◽  
Thyroid Function Tests ◽  
Perfect Agreement ◽  
Color Flow ◽  
Thyroid Scan ◽  
Toxic Goiter

Objective:To analyze agreement between Peak Systolic Velocity (PSV) of inferior thyroid artery (ITA) and Tc99m Thyroid Scan for evaluation of thyrotoxicosis(diffuse toxic goiter and sub-acute thyroiditis)  Patients and Methods: This prospective cross sectional study was conducted in National Institute of Nuclear medicine and Allied sciences (NINMAS)From July 2016 to June 2017.Total sixty four patients with thyrotoxicosis were included in the study. History, clinical examination and thyroid function tests were done for all patients. The thyroid glands of all patients wereevaluated by gray scale ultrasonography for size, shapeand echotexture. Color-flow Doppler ultrasonographyof the thyroid tissue was performed and spectral flowanalysis of both inferior thyroid arteries were assessed. Tc99m Thyroid scan was done for all patients. The patients were divided into two groups. Group A- Diffuse toxic goiter(DTG) and Group B- Subacute thyroiditis(SAT).The diagnosis of diffuse toxic goiter and subacute thyroiditis was supported by the clinical picture, RAIU uptake and Thyroid Scan. Results:All patients had suppressed thyrotropin.Thyroid blood flow, measured by PSV of ITA (CFDS) was highthan normal in DTG patients, while low PSV ofITA than normal was found in SAT.According to Thyroid Scan,Radiotracer concentration (RTC)was diffusely increased with low BKG (background) and almost absent RTC with high BKG was noted in DTG and SAT respectively.In our study Tc99m Thyroid Scan shows agreement with Peak Systolic Velocity of ITA.Here Kappa value was 0.818 and 0.871 in DTG and SAT respectively with P value <0.05 which was statistically significant with almost perfect agreement. Conclusion:An Almost perfect agreement between the two modality (PSV of ITA and Tc99m Thyroid Scan) establishes that they are useful alternativein the differential diagnosis of thyrotoxicosis (Diffuse toxic goiter and Subacute thyroiditis) Bangladesh J. Nuclear Med. 21(2): 97-101, July 2018

scholarly journals INFLUENCE OF ALIMENTARY DEPRIVATION ON MORPHOLOGICAL CHANGES OF RAT'S THYROID GLAND

2021 ◽  
Vol 26 (2(49)) ◽  
pp. 89-97
Author(s):  
R. V. Yanko
Keyword(s):  
Thyroid Gland ◽  
Functional Activity ◽  
Morphological Changes ◽  
Thyroid Tissue ◽  
Digital Camera ◽  
The Body ◽  
Standard Diet ◽  
Thyroid Cells ◽  
Experimental Animals ◽  
The Impact

Introduction: Despite the well-studied effect of alimentary deprivation on the body, the literature data on its effect on functional activity and, in particular, on morphological changes in the thyroid gland are single and often contradictory, which does not allow unambiguous conclusions. All this requires a more detailed study of the role and mechanisms of the impact of restricted nutrition on the thyroid gland. Aim: To investigate the effect of alimentary deprivation on morphological changes in the thyroid gland of young rats. Methods: The study was conducted on 24 male Wistar rats aged 3 months. Rats of all groups were in uniform conditions, on a standard diet. Animals of the experimental group, for 28 days, received a diet reduced by 30 %. Work with rats was carried out in accordance with the principles of the Declaration of Helsinki. Histological preparations were made from the central areas of the thyroid tissue according to the standard method. Using a digital camera, the micropreparations were photographed under a Nikon Eclipse E 100 microscope (Japan). Morphometry was performed using a computer program "Image J". Results: Histological analysis of the rat's thyroid gland affected by alimentary deprivation revealed that it had an unchanged physiological structure. The follicles were mostly of oval shape and of various sizes. Colloid in the follicles of experimental animals is of moderate density and contains numerous resorption vacuoles. Thyroid cells are of prismatic and cubic shape. It was found that in the thyroid gland of experimental rats the area of ​​follicles, colloid, their inner diameter decreases, the height of thyrocytes increases, the stereological resorption index increases and the colloid accumulation index decreases, the number of interfollicular islands increases. Also in experimental animals there was a decrease in the width of the interlobar and interfollicular connective tissue. Conclusion: In rats fed on a reduced diet, morphological signs of increased functional activity of the thyroid gland were found.

Hypothyroidism and Thyrotoxicosis

2019 ◽  
Author(s):  
Paul W. Ladenson
Keyword(s):  
Thyroid Tissue ◽  
Elevated Serum ◽  
Nodular Goiter ◽  
Thyroid Stimulating Hormone ◽  
Graves Disease ◽  
Thyroid Function Tests ◽  
Toxic Nodular Goiter ◽  
Total Thyroxine ◽  
Characteristic Features ◽  
Toxic Goiter

Thyroid disorders are the most common endocrine conditions encountered in clinical practice and can range from clinically obvious to clinically silent. This review provides the definition and epidemiology of the conditions of hypothyroidism and hyperthyroidism. Hypothyroidism can be congenital or acquired, and its pathogenesis, diagnosis, and management are presented. The three most common disorders of thyrotoxicosis (diffuse toxic goiter [Graves disease], toxic nodular goiter, and iatrogenic thyrotoxicosis in thyroid hormone–treated patients are addressed, as well as the many diseases in each of these categories. This review also discusses thyroiditis, goiter, thyroid nodules, and thyroid cancer. Tables list the causes of elevated serum thyroid-stimulating hormone (TSH) levels, the etiologic classification of thyrotoxicosis, characteristic features of thyroiditis, and causes of elevated serum total thyroxine levels. Figures show the prevalence of abnormalities in thyroid function tests in different populations, certain forms of hyperthyroidism that result from pathophysiologic activation of the TSH receptor, and inflammation of thyroid tissue in acute thyroiditis.   This review contains 3 figures, 12 tables, and 61 references. Key Words: Hypothyroidism, Thyrotoxicosis, Thyrotropin, celiac disease, vitiligo, pernicious anemia, Sjögren syndrome, Graves disease, Munchausen syndrome

scholarly journals SERUM AND TISSUE MUCOPROTEINS AND SIALIC ACID IN THYROID DISEASES

2008 ◽  
Vol 15 (03) ◽  
pp. 309-316
Author(s):  
ZARFAR IQBAL ◽  
TASNEEM ZAFAR
Keyword(s):  
Sialic Acid ◽  
Correlation Coefficient ◽  
Inverse Relationship ◽  
Thyroid Tissue ◽  
Normal Subjects ◽  
Thyroid Diseases ◽  
Pathological State ◽  
Serum Sialic Acid ◽  
Toxic Goiter ◽  
Relationship Of

. Objective: To find the correlation coefficient of serum mucoproteins and sialic acid to thyroid tissuein thyroid diseases. Study Design: The study was carried out at J.P.M.C, Karachi. Materials and Methods: A total oftwenty four thyroid patients and twenty normal subjects were studied. The cases were divided into non toxic goiterfourteen, and toxic goiter ten on the basis of clinical and physical examination, thyroid scanning and hormone analysis.Thyroid hormones were estimated in serum. Mucoproteins and sialic acid were estimated in serum as well as in thyroidtissue. Results: Estimations of thyroid hormones and thyroxine binding globulin (T.B.G.) are useful clinically to evaluatethe functions status and diagnosis of different thyroid disorders. Thyroid tissue is mainly composed of glycoprotein,thyroglobulin, and different studies showed that serum glycoprotein fractions varied in different thyroid diseases.Si 4gnificantly increased levels of T were observed in toxic goiter group. The levels of TBG was significantly increased4in non toxic goiter, toxic goiter patients while T /TBG ratio was significantly decreased in non toxic goiter. Coefficientcorrelation ( r) of serum to tissue mucoproteins shows an inverse relationship in non toxic goiter and toxic goiter patients.In non toxic goiter and toxic goiter patients the serum sialic acid levels to tissue sialic acid levels also shows an inverserelationship. Conclusion: Correlation coefficient analysis showed an inverse relationship of serum mucoproteins andsialic acid to thyroid tissue. It signifies that carbohydrate moieties are increased in the blood when the tissue arehyperactive and in the pathological state. It further concludes that thyrotoxic state might be converted into nodular formeven into cancerous form later on.

scholarly journals Surgical treatment of patients with nodular toxic goiter

2021 ◽  
Vol 23 (3) ◽  
pp. 370-374
Author(s):  
S. M. Zavhorodnii ◽  
M. S. Gatia ◽  
М. А Kubrak ◽  
M. B. Danyliuk
Keyword(s):  
Hormone Replacement ◽  
Comparative Assessment ◽  
Subtotal Resection ◽  
Treatment Results ◽  
Free T3 ◽  
The Mean ◽  
Toxic Goiter ◽  
Diagnostic Criterion ◽  
Late Postoperative Period ◽  
Thyroid Lesions

Nodular toxic goiter (NTG) accounts for 7.3 % to 10.0 % of the goiter population. There are difficulties in the preoperative differential diagnosis between NTG and other thyroid diseases. There is also controversy about the benefits of resection surgery over thyroidectomy in patients with NTG. The aim of the study: a comparative assessment of the diagnosis and treatment results of patients with NTG in the early and late postoperative periods after resection surgery and thyroidectomy. Materials and methods. The study enrolled 51 patients with NTG. The mean age of patients in the group was 51.7 ± 12.9 years. Results. Bilateral multinodular lesions prevailed – 34 (66.7 %) patients. Free T3 level was measured only in 15 (29.4 %) patients, 7 (46.7 %) of them had elevated T3 level. 15 (29.4 %) patients underwent hemithyroidectomy including the isthmus, 2 (3.9 %) had subtotal resection, 34 (66.7 %) patients underwent thyroidectomy. Conclusions. Multinodular bilateral thyroid lesions dominated the structure of NTG – 34 (66.7 %) patients who underwent thyroidectomy. Uninodular and multinodular unilateral pathology was diagnosed only in 17 (33.3 %) patients who underwent organ-preserving surgery. The measurements of free T3 level in patients with NTG allowed the diagnosis of T3-thyrotoxicosis in almost half of patients (46.7 %), which is a diagnostic criterion for detection of functional nodal autonomy. Following the organ-preserving surgery, 17 (33.3 %) patients with NTG required the use of hormone replacement therapy with levothyroxine at a mean dose of 25.0 (25.0; 50.0) mcg/day in the late postoperative period (>1 year).

scholarly journals Lipid peroxidation and a-tocopherol in patients with diffuse toxic goiter

2000 ◽  
Vol 46 (6) ◽  
pp. 26-28
Author(s):  
R. S. Tishenin ◽  
T. A. Filonenko ◽  
A. V. Dreval ◽  
T. S. Kamynina
Keyword(s):  
Lipid Peroxidation ◽  
Vitamin E ◽  
Antioxidant Defense ◽  
Malonic Dialdehyde ◽  
Antioxidant Therapy ◽  
Subtotal Resection ◽  
Initial Link ◽  
Before And After ◽  
Toxic Goiter

Plasma and erythrocyte concentrations of lipid acyl hydroperoxides, malonic dialdehyde (MDA), and a-tocopherol were measured in 45patients with diffuse toxic goiter (DTG) before and after thyrostatic therapy and in 26 of these patients 3—6 months after subtotal resection of the thyroid in a state of euthyrosis. The initial link in lipid peroxidation (LPO) was activated in erythrocytes and plasma in hyperthyrosis, while toxic LPO product MDA accumulated only in the plasma. The level of one ofpotent antioxidants a-tocopherol was decreased at all stages of examination in erythrocytes, while in the plasma it was decreased only before therapy. Estimation of the Horvitt index and LPO-antioxidant defense conjugation index (a-tocopherol requirement, content, or insufficiency) in the plasma and erythrocytes showed decreased content of vitamin E in tissues of patients with DTG, which recommends antioxidant therapy to DTG patients.

scholarly journals Dynamics of platelets functional activity data in patients after infrarenal aortic aneurysm stentgrafting

2019 ◽  
Vol 18 (3) ◽  
pp. 44-52
Author(s):  
A. V. Svetlikov ◽  
G. G. Khubulava ◽  
A. I. Ermakov ◽  
L. B. Gaikovaya ◽  
V. S. Gurevich
Keyword(s):  
Postoperative Period ◽  
Functional Activity ◽  
Abdominal Aortic Aneurysms ◽  
Early Postoperative Period ◽  
Aortic Aneurysms ◽  
Long Term Results ◽  
Positive Correlation ◽  
Abdominal Aortic ◽  
Significant Difference ◽  
Late Postoperative Period

It is known that hemostatic, immune and autoimmune reactions can play a role in the development and progression of abdominal aortic aneurysms (AAA), including the activation of platelets and CEC However the role of those in pathogenesis of AAA remains unclear.The aim of this study was to study the influence of EVAR on functional activity of platelets and number of circulating endothelial cells (CEC) in comparison with small abdominal aortic aneurysms – AAA (less than 5 cm)Material and methods. Platelets activity has been analyzed due to the assessment of quantity of GP IIb/IIIa receptors and expression of P-selectin. CD14-FITC/CD16-PE/ HLADR-PC5/CD45-PC7 has been used to assess the monocytes activity CEC were counted by flow cytometry in blood samples of patients before EVAR, within 4 weeks and in 18 months after the operation in comparison with non-operated patients due to small diameter AAA. Markers (CD146 + CD45) were used to identify CEC.Results. The amount of Р-selectin, СD62 in patients with small aneurysms (SAAA) in comparison of aneurysms more the 5 cm (BAAA). has been increased (р<0,05). There was the statistically significant difference in amount of GP IIb/IIIa in SAAA and BAAA(р=0,04). The number of monocytes were less in SAAA Positive correlation between CEC and monocytes and between the size of aneurysms in BAAA before the operation have been revealed. We found the positive correlation between CEC number and P-selectin (CD62), in patients at early postoperative period. The significant difference (р=0,02) (GP) IIb/IIIa receptors in patients before and at late postoperative period has been found ><0,05). There was the statistically significant difference in amount of GP IIb/IIIa in SAAA and BAAA(р=0,04). The number of monocytes were less in SAAA Positive correlation between CEC and monocytes and between the size of aneurysms in BAAA before the operation have been revealed. We found the positive correlation between CEC number and P-selectin (CD62), in patients at early postoperative period. The significant difference (р=0,02) (GP) IIb/IIIa receptors in patients before and at late postoperative period has been found.Conclusion. The change in the quantitative characteristics of CEC, platelets and monocytes during the growth of AAA confirms the idea about the activation of innate immunity as an important pathogenetic link in the development of this disease, closely associated with the destruction of the vascular wall and, in particular, of its endothelial lining. The obtained data partly explain the unsatisfactory long-term results of the EVAR and provide an opportunity for developing new approaches for prevention of postoperative complications and the treatment of AAA. 

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