scholarly journals Migraine and other headaches in transient ischemic attacks

2019 ◽  
Vol 11 (3S) ◽  
pp. 38-45
Author(s):  
E. R. Lebedeva ◽  
N. M. Gurary ◽  
J. Olesen
Keyword(s):  
Tension Headache ◽  
Cerebrovascular Diseases ◽  
Neurological Dysfunction ◽  
Control Group ◽  
Common Symptom ◽  
Transient Ischemic Attacks ◽  
New Type ◽  
One Year ◽  
The One ◽  
Definition Of

Headache is a common symptom in acute cerebrovascular diseases; however, no studies have evaluated the prevalence of specific headache types in patients with transient ischemic attacks (ТIАs).Objective: to analyze all headaches within the last year and the last week before and during ТIАs.Patients and methods. TIA patients included in the study (female 55% (n=120); mean age, 56.1 years) according to the existing definition of TIAs had a transient neurological dysfunction episode caused by focal brain damage or retinal ischemia for up to 24 hours without forming a new acute heart attack on diffusion-weighted MRI (n=112) or CT (n=8). All the patients were examined by one neurologist within one day after their admission. Patients (female 64% (n=192); mean age, 58.7 years) who had been admitted with a diagnosis of lumbago, lumbar spine osteochondrosis, or gastrointestinal ulcer were examined as a control group. A clinical semistructured face-to-face interview with the patients of both groups was carried out to analyze headache.Results and discussion. The prevalence of migraine without aura during one year before TIA was substantially higher in patients with TIA than in control ones: 20.8 and 7.8%, respectively (p=0.002). Twenty-two (18.3%) patients had sentinel or warning headache within the last week before a TIA that manifested as an increase in and greater frequency of previous headache, as lack of effect of painkillers, and as the emergence of a new type of headaches, which were previously absent. During TIAs, 16 (13.3%) patients developed a new type of headache. Twelve of these 16 patients had migraine-like headache; three patients had headache resembling tension headache; one patient had a thunderclap headache. None of the control patients was found to have a new type of headache. TIAs were significantly more common in the vertebrobasilar basin than in the carotid artery one in patients with headache during the last week before and during TIA.Conclusion. The one year prevalence of migraine was significantly higher in ТIА patients than in control patients, and so was the prevalence of headache within the last week before and during TIA. Migraine-like headache prevailed among the new types of headaches in the development of TIA. A previous headache with a change in characteristics and a new type of headache can be predictors for TIA. 

scholarly journals Real-World Experience of the One-Year Efficacy of Rifaximin Add-On to Lactulose Is Superior to Lactulose Alone in Patients with Cirrhosis Complicated with Recurrent Hepatic Encephalopathy in Taiwan

2021 ◽  
Vol 11 (6) ◽  
pp. 478
Author(s):  
Ching Chang ◽  
Chien-Hao Huang ◽  
Hsiao-Jung Tseng ◽  
Fang-Chen Yang ◽  
Rong-Nan Chien
Keyword(s):  
Hepatic Encephalopathy ◽  
Real World ◽  
Ammonia Level ◽  
Decompensated Cirrhosis ◽  
Control Group ◽  
Multivariable Logistic Regression Model ◽  
Before And After ◽  
One Year ◽  
The One ◽  
Serum Ammonia

Background: Hepatic encephalopathy (HE), a neuropsychiatric complication of decompensated cirrhosis, is associated with high mortality and high risk of recurrence. Rifaximin add-on to lactulose for 3 to 6 months is recommended for the prevention of recurrent episodes of HE after the second episode. However, whether the combination for more than 6 months is superior to lactulose alone in the maintenance of HE remission is less evident. Therefore, the aim of this study is to evaluate the one-year efficacy of rifaximin add-on to lactulose for the maintenance of HE remission in Taiwan. Methods: We conducted a real-world single-center retrospective cohort study to compare the long-term efficacy of rifaximin add-on to lactulose (group R + L) versus lactulose alone (group L, control group). Furthermore, the treatment efficacy before and after rifaximin add-on to lactulose was also analyzed. The primary endpoint of our study was time to first HE recurrence (Conn score ≥ 2). All patients were followed up every three months until death, and censored at one year if still alive. Results and Conclusions: 12 patients were enrolled in group R + L. Another 31 patients were stratified into group L. Sex, comorbidity, ammonia level, and ascites grade were matched while age, HE grade, and model for end-stage liver disease (MELD) score were adjusted in the multivariable logistic regression model. Compared with group L, significant improvement in the maintenance of HE remission and decreased episodes and days of HE-related hospitalizations were demonstrated in group R + L. The serum ammonia levels were significantly lower at the 3rd and 6th month in group 1. Concerning changes before and after rifaximin add-on in group R + L, mini-mental status examination (MMSE), episodes of hospitalization, and variceal bleeding also improved at 6 and 12 months. Days of hospitalization, serum ammonia levels also improved at 6th month. Except for concern over price, no patients discontinued rifaximin due to adverse events or complications. The above results provide evidence for the one-year use of rifaximin add-on to lactulose in reducing HE recurrence and HE-related hospitalization for patients with decompensated cirrhosis.

scholarly journals The Tutte polynomial of symmetric hyperplane arrangements

2020 ◽  
Vol 29 (03) ◽  
pp. 2050004
Author(s):  
Hery Randriamaro
Keyword(s):  
Hyperplane Arrangement ◽  
Dual Graph ◽  
Tutte Polynomial ◽  
Hyperplane Arrangements ◽  
Weyl Groups ◽  
Reflection Groups ◽  
Tutte Polynomials ◽  
One Year ◽  
The One ◽  
Definition Of

The Tutte polynomial is originally a bivariate polynomial which enumerates the colorings of a graph and of its dual graph. Ardila extended in 2007 the definition of the Tutte polynomial on the real hyperplane arrangements. He particularly computed the Tutte polynomials of the hyperplane arrangements associated to the classical Weyl groups. Those associated to the exceptional Weyl groups were computed by De Concini and Procesi one year later. This paper has two objectives: On the one side, we extend the Tutte polynomial computing to the complex hyperplane arrangements. On the other side, we introduce a wider class of hyperplane arrangements which is that of the symmetric hyperplane arrangements. Computing the Tutte polynomial of a symmetric hyperplane arrangement permits us to deduce the Tutte polynomials of some hyperplane arrangements, particularly of those associated to the imprimitive reflection groups.

scholarly journals Meniscus Repair Outcomes with and without Bone Marrow Aspiration Concentrate

2019 ◽  
Vol 7 (7_suppl5) ◽  
pp. 2325967119S0028 ◽  
Author(s):  
Patrick Allan Massey ◽  
Andrew Zhang ◽  
Christine Bayt Stairs ◽  
Stephen Hoge ◽  
Trevor Carroll ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Aspiration ◽  
Meniscus Repair ◽  
Control Group ◽  
Pain Level ◽  
Average Pain ◽  
The Mean ◽  
One Year ◽  
The One

Objectives: The purpose of the current study is to review the results of meniscus repairs with and without bone marrow aspiration concentrate (BMAC). It is hypothesized that with BMAC, meniscus repair outcomes will be improved when compared to without BMAC at 1 year after surgery. Methods: This is a prospective case control study performed from August 2014 until August 2017. Patients were included if they had a meniscus repair performed with no history of prior meniscus surgery to the operative knee. Patients were excluded if there was a full thickness cartilage tear or International Cartilage Repair Society (ICRS) Grade IV cartilage tear not treated in a single staged surgery. Patients were also excluded if they did not reach the one year follow-up, had a multi-ligamentous knee injury requiring multiple staged procedures. From August 2014 until November 2015, patients had meniscus repair without BMA. Menisci were all repaired arthroscopically using inside-out, outside-in and all-inside techniques. After November 2015, all meniscus repairs were augmented with BMAC. In the BMAC group, all bone marrow was obtained from the ipsilateral femur during the time of surgery. The Biocue BMAC system (Zimmer Biomet, Warsaw Indiana) was used for bone marrow aspiration and BMAC was injected directly into the tear site after repair. Numerical data such as VAS, lysholm and IKDC was analyzed using a 2 sample T-test. Categorical data such as sex, tear location, type of tear and zone of tear were analyzed using a chi-square. Results: A total of 150 patients were initially included in the study. The average age in the control group was 26.3 versus 29.4 in the BMAC group (P=0.27). Thirty seven percent of the control group had an ACL reconstruction versus 40% in the BMAC group (P= .77). The control group improved from an average pain level of 6.1 to 1.2 and the BMAC group improved from an average pain level of 5.9 to 0.7 at the 1 year end point. Both the control group and BMAC group improved with respect to pain with no difference at the 1 year end point (P=.19). There was, however a significantly larger reduction in pain at the 6 week and 3 month time point with BMAC compared to the control group (P=.02 and P=.02 respectively). At the 1-year follow-up, the mean lysholm score improved from 43 to 92 in the control group and 43 to 90 in the BMAC group. The mean IKDC score improved from 37 to 87 in the control group and 36 to 83 in the BMAC group at the one year follow-up. Conclusion: Meniscus repair outcomes were improved at 6 weeks and 3 months post-operatively, when BMAC is used to augment meniscus repair compared to repair without BMAC. Both groups, control group and BMAC meniscus repair group had improved outcomes at 1 year post-operatively with respect to VAS, lysholm and IKDC, with no difference in complication rate.

Postoperative Acute Kidney Injury: Focus on Renal Recovery Definitions, Kidney Disease Progression and Survival

2019 ◽  
Vol 49 (3) ◽  
pp. 175-185 ◽  
Author(s):  
Thorir E. Long ◽  
Solveig Helgadottir ◽  
Dadi Helgason ◽  
Gisli H. Sigurdsson ◽  
Tomas Gudbjartsson ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Disease ◽  
Propensity Score ◽  
Matched Control ◽  
Kidney Injury ◽  
Renal Recovery ◽  
University Hospital ◽  
Control Group ◽  
One Year ◽  
Definition Of

Background: The aim of this study was to examine different definitions of renal recovery following postoperative acute kidney injury (AKI) and how these definitions associate with survival and the development and progression of chronic kidney disease (CKD). Methods: This was a retrospective study of all patients who underwent abdominal, cardiothoracic, vascular, or orthopedic surgery at a single university hospital between 1998 and 2015. Recovery of renal function following postoperative AKI was assessed comparing 4 different definitions: serum creatinine (SCr) (i) < 1.1 × baseline, (ii) 1.1–1.25 × baseline, (iii) 1.25–1.5 × baseline, and (iv) > 1.5 × baseline. One-year survival and the development or progression of CKD within 5 years was compared with a propensity score-matched control groups. Results: In total, 2,520 AKI patients were evaluated for renal recovery. Risk of incident and progressive CKD within 5 years was significantly increased if patients did not achieve a reduction in SCr to < 1.5 × baseline (hazard ratio [HR] 1.50; 95% CI 1.29–1.75) and if renal recovery was limited to a fall in SCr to 1.25–1.5 × baseline (HR 1.32; 95% CI 1.12–1.57) within 30 days. The definition of renal recovery that best predicted survival was a reduction in SCr to < 1.5 × baseline within 30 days. One-year survival of patients whose SCr decreased to < 1.5 × baseline within 30 days was significantly better than that of a propensity score-matched control group that did not achieve renal recovery (85 vs. 71%, p < 0.001). Conclusions: These findings should be considered when a consensus definition of renal recovery after AKI is established.

scholarly journals Transient ischemic attacks: their importance in the progression of cerebrovascular diseases and topical issues of medical rehabilitation

2019 ◽  
pp. 22-30
Author(s):  
E. V. Kostenko ◽  
L. V. Petrova
Keyword(s):  
Risk Factors ◽  
Emotional Disorders ◽  
Multidisciplinary Approach ◽  
High Efficiency ◽  
Cerebrovascular Diseases ◽  
Medical Rehabilitation ◽  
Cerebrovascular Event ◽  
Transient Ischemic Attacks ◽  
Ischemic Attack ◽  
Definition Of

The article deals with the aspects of clinical definition of transient ischemic attack (TIA), the analysis of these risk factors for stroke after TIA and their etiopathogenetic relationship. The features of management of patients with high risk of stroke after TIA are discussed. The issues of interdisciplinary and multidisciplinary approach to medical rehabilitation (MR) of patients with TIA are covered. The results of our own studies of the effectiveness of the MR program in 351 patients with TIA with the inclusion of neurocytoprotectors (choline alfoscerate, Cerepro) are presented. Results and conclusion. Pathogenetically justified is the inclusion in MR of patients with TIA of drugs with neurocalibration effect. The high efficiency of choline alfoscerate (Cerepro) in the form of improving cognitive functions, reducing the severity of emotional disorders and reducing the number of cases of recurrent acute cerebrovascular event is shown.

Gut Microbiota and Urine Metabonomics Alterations in Constitution after Chinese Medicine and Lifestyle Intervention

2021 ◽  
pp. 1-29
Author(s):  
Yuan Jing ◽  
Shuangshuang Han ◽  
Jieyu Chen ◽  
Yigui Lai ◽  
Jingru Cheng ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Gut Microbiota ◽  
Lifestyle Intervention ◽  
Intervention Group ◽  
Urinary Metabolites ◽  
Control Group ◽  
Human Beings ◽  
Before And After ◽  
One Year ◽  
The One

Traditional Chinese Medicine Constitution (TCMC) divides human beings into balanced (ping-he) constitution (PH) and unbalanced constitution. Yang-deficiency (yang-xu) constitution (YAX) is one of the most common unbalanced constitutions in Chinese general population, and it causes susceptibility to particular diseases. However, unbalanced constitutions can be regulated by Chinese medicine and lifestyle intervention in clinical practice. Gui-fu-di-huang-wan (GFDHW) is a well-known Chinese medicine with yang-invigorating activity and is regarded as improving YAX. In this study, 60 healthy YAX students selected from a prospective population of 5185 were enrolled in a randomized clinical trial and completed the study. We compared the gut microbiota and urinary metabolome between individuals with PH and those with YAX before and after one-month-intervention. Compared with the control group, the health status of the intervention group improved significantly, the YAX symptom score was reduced, and the efficacy remained high at the one-year follow-up. The gut microbiota of the healthy PH exhibited greater diversity, and significantly higher species were identified.[Formula: see text]Compared to PH group, YAX individuals showed increased abundance of Bacteroidetes and Bacteroides,also had higher levels of gut microbial-derived urinary metabolites. After one-month-intervention, both GFDHW treatment and lifestyle intervention enriched the diversity and modulated the structure in YAX. The intervention group also partially restored the microbiome and metabolome to healthy PH-like levels. Further, a microbiota co-occurrence network analysis showed that the metabolites enriched in YAX were correlated with microbial community structure. Taken together, our results suggest that Chinese medicine combined with lifestyle intervention benefits YAX individuals. Gut microbiota/metabolite crosstalk might be involved in the Chinese medicine-mediated effects.

A 1-week online self-compassion training reduces self-criticism and pain endurance in people with non-suicidal self-injury ideation – a randomized-waitlist controlled study

2021 ◽  
Author(s):  
Sukriti Drabu ◽  
Oliver Sündermann ◽  
Ryan Y. Hong
Keyword(s):  
Training Group ◽  
Controlled Study ◽  
Control Group ◽  
Single Session ◽  
The Past ◽  
Self Compassion ◽  
Self Injury ◽  
One Year ◽  
The One

Self-criticism has been identified as a key underlying vulnerability that lowers of one’s positive self-regard and pain barriers that prevent individuals from engaging in non-suicidal self-injury (NSSI). Additionally, research suggests that self-compassion may serve as a protective tool in counteracting self-criticism. This study examined the efficacy of a brief online self-compassion training on past year NSSI engagers and ideators in reducing (a) explicit self-criticism, (b) implicit self-criticism, (c) pain endurance and (d) the inclination to engage in NSSI. Sixty-three Singaporean adults who reported the presence of self-injurious thoughts or behaviors in the past one year were randomly assigned to either a 1-week self-compassion training group or a waitlisted control group. As compared to the control group (n = 33), the training group (n = 30) yielded significantly greater reduction in explicit self-criticism after a single session and significantly greater reduction in self-criticism, pain endurance, as well as the explicit inclination to self-injure after the one-week online training. The reduction in explicit self-criticism and inclination to self-injure was maintained at the 2-week follow-up. These findings provide novel evidence supporting the efficacy of using a brief online self-compassion intervention to reduce NSSI correlates and symptoms.

Safety Study of AAV hTert and Klotho Gene Transfer Therapy for Dementia

2021 ◽  
Author(s):  
Patrick E Sewell
Keyword(s):  
Gene Transfer ◽  
Randomized Study ◽  
Control Group ◽  
Response Data ◽  
Cognitive Improvement ◽  
Moderate Dementia ◽  
Before And After ◽  
Transfer Method ◽  
One Year ◽  
The One

A sponsored, interventional, non-randomized study without a control group using a novel and proprietary central nervous system gene transfer method to deliver AAV hTert and Klotho genes to five patients with mild or moderate dementia was performed to primarily evaluate safety. Clinical response data was gathered as a secondary interest. The therapy demonstrated a very high safety profile with no serious adverse effects identified. Clinical evaluation of the patients over the course of the one year follow up yielded significant findings with all five patients demonstrating evident reversal of Dementia symptoms such as sustained cognitive improvement as measured by the Folstein exam. Telomere analysis was performed before and after the therapy. A measurable elongation of the participants telomeres was identified, and biological age was reduced as chronological age increased.

scholarly journals One-year mortality among elderly people after hospitalization due to fall-related fractures: comparison with a control group of matched elderly

2012 ◽  
Vol 28 (4) ◽  
pp. 801-805 ◽  
Author(s):  
Evandro Silva Freire Coutinho ◽  
Katia Vergetti Bloch ◽  
Claudia Medina Coeli
Keyword(s):  
Local Community ◽  
Public Health Problem ◽  
The Elderly ◽  
Control Group ◽  
Important Public Health Problem ◽  
Elderly Individuals ◽  
Risk Of Death ◽  
Increased Risk ◽  
One Year ◽  
The One

Fall-related fractures among the elderly represent an important public health problem. Severe fractures have been related to increased risk of death. In order to investigate the mortality profile of elderly individuals with severe fractures, 250 patients aged 60 years and over, hospitalized due to fall-related fractures and 250 elderly without fractures living in the local community were followed-up for one year. They were matched according to sex, age, time of hospitalization and neighborhood. Deaths were identified using probabilistic linkage of the research dataset and the local mortality registry. The one-year cumulative mortality was 25.2% in the case of individuals with severe fractures and 4% for those individuals without. The mortality distribution was not homogeneous across the follow-up period. Two-thirds of deaths among the elderly individuals hospitalized due to fracture occurred within the first 3 months, whereas mortality among those individuals without fractures took place later. Heart disease, pneumonia, GI bleeding, sepsis, and pulmonary embolism, diabetes and stroke were important causes of one-year mortality.

scholarly journals Effect of lip training in children with short upper lip

1984 ◽  
Vol 10 (3) ◽  
pp. 17-26
Author(s):  
Bengt Ingervall ◽  
Gun-Britt Eliasson
Keyword(s):  
Beneficial Effect ◽  
Test Group ◽  
Control Group ◽  
Upper Lip ◽  
Facial Skeleton ◽  
Tooth Position ◽  
One Year ◽  
The One ◽  
Dental Casts

Summary: The effect of lip training was studied in 15 children with incompetent lips, who were compared with a control group of 10 children who also had incompetent lips. Lip function was evaluated by electromyography of the activity of the lips in resting posture and during swallowing and chewing. The morphology of the dentition, facial skeleton and lips were studied on dental casts and profile radiographs. Lip training was performed for one year and was found to maintain lip function in the test group, in contrast to impairment of lip function in the control group. Lip training favorably influenced lip morphology, increasing the height of both lips and decreasing the interlabial gap. In the control group, the interlabial gap increased. The beneficial effect of the training on the function and morphology of the lips could not be shown to affect tooth position during the one-year study period.

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