Lithic Technology at Linda's Point, Healy Lake, Alaska

ARCTIC ◽  
2016 ◽  
Vol 69 (1) ◽  
pp. 79 ◽  
Author(s):  
Angela M. Younie ◽  
Thomas E. Gillispie
Keyword(s):  
Time Range ◽  
Lake Area ◽  
Short Term ◽  
Triangular Points ◽  
Culture History ◽  
History Of ◽  
Bone Fragments ◽  
Terminal Pleistocene ◽  
Cultural Component ◽  
Tool Types

<p class="Pa5" style="text-align: justify; text-justify: inter-ideograph;"><span style="font-size: 10.0pt; color: #221e1f;">Interior Alaska’s Healy Lake archaeological locality contains a cultural sequence spanning 13 500 years, beginning with some of the oldest known human occupations in Alaska. From 2011 to 2014, we conducted archaeological excavations at the Linda’s Point site. Detailed recording has clearly separated the lowest cultural component at the site and begun to clarify the contentious culture history of the Healy Lake area. The lower component, associated with a thick paleosol, contains multiple hearths, debitage, and small triangular points similar to those seen at the Healy Lake Village site. The upper silt deposits contain a variety of lithic tool types within a dense scatter of debitage and bone fragments spanning a wide time range. Linda’s Point appears to have been used as a habitation site throughout its history, changing from recurring short-term occupations in the terminal Pleistocene to more intensive site habitation and greater reliance on local lithic resources during the Holocene.</span></p>

ACTION ON MATTER: THE HISTORY OF THE UNIQUELY AFRICAN TAMPER AND CONCAVE ANVIL POT-FORMING TECHNIQUE

2003 ◽  
Vol 1 (1) ◽  
pp. 3-35 ◽  
Author(s):  
Judy Sterner ◽  
Nicholas David
Keyword(s):  
Historical Development ◽  
Weight Ratio ◽  
High Volume ◽  
Efficient Production ◽  
Arid Environments ◽  
Historical Evidence ◽  
Culture History ◽  
History Of ◽  
And Diffusion

The publication, largely by ethnoarchaeologists, of new data on the tamper and concave anvil technique of pot-forming (TCA) permits a reassessment of this uniquely African technique, its toolkit, and its culture history. A survey, inspired by the technologie culturelle school, of its varied expressions in the southern Saharan, Sahelian and northern Sudan zones from Mali to Sudan and extending north into Egypt emphasises the potential of the technique for the efficient production of spherical water jars of high volume to weight ratio, much appreciated in arid environments. The technique is demanding and therefore practised for the most part by specialists. The origins and diffusion of the technique are assessed in the light of the ethnological, archaeological, linguistic, and historical evidence, and a four stage historical development is sketched.

scholarly journals Nanomedicine Reformulation of Chloroquine and Hydroxychloroquine

Molecules ◽  
2020 ◽  
Vol 26 (1) ◽  
pp. 175
Author(s):  
David M. Stevens ◽  
Rachael M. Crist ◽  
Stephan T. Stern
Keyword(s):  
Safety Evaluation ◽  
Therapeutic Index ◽  
Short Term ◽  
Tissue Concentrations ◽  
History Of ◽  
History Of Use ◽  
Novel Applications ◽  
Therapeutic Doses ◽  
Extensive Clinical Experience ◽  
Higher Doses

The chloroquine family of antimalarials has a long history of use, spanning many decades. Despite this extensive clinical experience, novel applications, including use in autoimmune disorders, infectious disease, and cancer, have only recently been identified. While short term use of chloroquine or hydroxychloroquine is safe at traditional therapeutic doses in patients without predisposing conditions, administration of higher doses and for longer durations are associated with toxicity, including retinotoxicity. Additional liabilities of these medications include pharmacokinetic profiles that require extended dosing to achieve therapeutic tissue concentrations. To improve chloroquine therapy, researchers have turned toward nanomedicine reformulation of chloroquine and hydroxychloroquine to increase exposure of target tissues relative to off-target tissues, thereby improving the therapeutic index. This review highlights these reformulation efforts to date, identifying issues in experimental designs leading to ambiguity regarding the nanoformulation improvements and lack of thorough pharmacokinetics and safety evaluation. Gaps in our current understanding of these formulations, as well as recommendations for future formulation efforts, are presented.

scholarly journals Predictors for clinical effectiveness of baricitinib in rheumatoid arthritis patients in routine clinical practice: data from a Japanese multicenter registry

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Nobunori Takahashi ◽  
Shuji Asai ◽  
Tomonori Kobayakawa ◽  
Atsushi Kaneko ◽  
Tatsuo Watanabe ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Practice ◽  
Disease Activity ◽  
Retention Rate ◽  
Oral Prednisone ◽  
Multivariate Logistic Regression Analysis ◽  
Jak Inhibitors ◽  
Short Term ◽  
History Of ◽  
Multicenter Registry

AbstractThis study aimed to evaluate the short-term effectiveness and safety profiles of baricitinib and explore factors associated with improved short-term effectiveness in patients with rheumatoid arthritis (RA) in clinical settings. A total of 113 consecutive RA patients who had been treated with baricitinib were registered in a Japanese multicenter registry and followed for at least 24 weeks. Mean age was 66.1 years, mean RA disease duration was 14.0 years, 71.1% had a history of use of biologics or JAK inhibitors (targeted DMARDs), and 48.3% and 40.0% were receiving concomitant methotrexate and oral prednisone, respectively. Mean DAS28-CRP significantly decreased from 3.55 at baseline to 2.32 at 24 weeks. At 24 weeks, 68.2% and 64.1% of patients achieved low disease activity (LDA) and moderate or good response, respectively. Multivariate logistic regression analysis revealed that no previous targeted DMARD use and lower DAS28-CRP score at baseline were independently associated with achievement of LDA at 24 weeks. While the effectiveness of baricitinib was similar regardless of whether patients had a history of only one or multiple targeted DMARDs use, patients with previous use of non-TNF inhibitors or JAK inhibitors showed lower rates of improvement in DAS28-CRP. The overall retention rate for baricitinib was 86.5% at 24 weeks, as estimated by Kaplan–Meier analysis. The discontinuation rate due to adverse events was 6.5% at 24 weeks. Baricitinib significantly improved RA disease activity in clinical practice. Baricitinib was significantly more effective when used as a first-line targeted DMARDs.

scholarly journals Actinomyces meyeriEmpyema: A Case Report and Review of the Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Hae Won Jung ◽  
Chong Rae Cho ◽  
Ji Yoon Ryoo ◽  
Hyun Kyo Lee ◽  
So Young Ha ◽  
...  
Keyword(s):  
Pleural Fluid ◽  
Response To Treatment ◽  
Penicillin G ◽  
Review Of The Literature ◽  
Short Term ◽  
Oral Amoxicillin ◽  
History Of ◽  
Multiple Lung Nodules ◽  
The Right ◽  
Radiological Studies

Actinomyces meyeriis an uncommon cause of human actinomycosis. Here, we report a rare case of empyema caused byA. meyeri. A 49-year-old male presented with a history of 10 days of dyspnea and chest pain. A large amount of loculated pleural effusion was present on the right side and multiple lung nodules were documented on radiological studies. A chest tube was inserted and purulent pleural fluid was drained.A. meyeriwas isolated in anaerobic cultures of the pleural fluid. The infection was alleviated in response to treatment with intravenous penicillin G (20 million IU daily) and oral amoxicillin (500 mg every 8 hours) for 4 months, demonstrating that short-term antibiotic treatment was effective.

The Attraction of Literary Local Lore Material and Information from the Native Literature of Students in the Study of A.M. Gorky

2021 ◽  
pp. 137-141
Author(s):  
Zinaida Kh. Tedtoeva
Keyword(s):  
Russian Literature ◽  
Literary Work ◽  
Young Person ◽  
Native People ◽  
Culture History ◽  
Teacher Needs ◽  
Special Area ◽  
History Of ◽  
History Of Culture ◽  
The Aesthetic

The problem of perceiving fiction has aesthetic, sociological, historical and psychological aspects. In this regard, in the methodology of teaching Russian literature to the national audience, special attention is paid to the deep, faithful and subtle reproduction of the literary works of writers, the development of the reader’s talent. Fiction as a form of art is a special area of the aesthetic. In a truly fictional work, all its elements are subordinate to the expression of a certain content, expressive, figurative, therefore, the reader’s understanding of a literary work is not only aesthetic, but also evaluative in nature. There are three stages of students’ perception of the writer’s creation: 1) recreation and experience of images of the work, with the leading process of imagination; 2) understanding of the ideological content; V.G. Belinsky called this stage “true pleasure”; 3) the influence of fiction on the personality of the reader as a result of the perception of the work. Fiction affects the worldview, speech, moral behavior in society, aesthetic and artistic development, in general, the formation of a person’s personality. The teacher tries to ensure that students have the necessary knowledge, developed, recreational imagination, emotional sensitivity, a sense of the poetic word, observation, the ability to make comparisons, comparisons, generalizations, conclusions. Their perception of a work of art is a difficult process that directly depends on previous knowledge of literature, facts of the history of culture, history of society. The complexity of the spiritual world of a modern young person is due to the development of personality in the context of the rapid progress of society. All this poses a difficult task for methodological science - to diversify the means of analysis, its types and techniques, effective ways of influencing art on students. In the national audience, the main problem of studying Russian literature - the teacher needs to reveal Russian-national literary ties with specific examples, based on certain historical conditions, national specifics, use translations of the works of the Russian writer into the native language of students, literary local history material, highlight the attitude of cultural figures of the native people to the work of the Russian writer, to his personality.

Short-Term Retinal Vessel Diameter Variability in Relation to the History of Cold Extremities

2006 ◽  
Vol 47 (9) ◽  
pp. 4026 ◽  
Author(s):  
Asan Kochkorov ◽  
Konstantin Gugleta ◽  
Claudia Zawinka ◽  
Robert Katamay ◽  
Josef Flammer ◽  
...  
Keyword(s):  
Retinal Vessel ◽  
Vessel Diameter ◽  
Short Term ◽  
Retinal Vessel Diameter ◽  
History Of ◽  
Cold Extremities

What’s Next?

2009 ◽  
Vol 217 (2) ◽  
pp. 95-102 ◽  
Author(s):  
Theo Herrmann
Keyword(s):  
Historical Development ◽  
Psychological Research ◽  
History Of Psychology ◽  
Complex Pattern ◽  
Short Term ◽  
Historical Changes ◽  
The Future ◽  
History Of

One cannot predict the future of the sciences or that of psychology. The question “What’s next?” gives reason to think about which principles to which psychology has developed. In analyzing the historical development of psychology, one should differentiate between basic psychological research, psychological technology, and the structure of institutions. Historical changes of psychology occur slowly and continuously. These continuous changes are obviously a foil for short-term changes that we can refer to as discontinuities. The complex pattern of continuities and discontinuities is based on very different conditions. External and internal causes of the changes in the history of psychology are discussed.

scholarly journals Temporal Variation of Chlorophyll-a Concentrations in Highly Dynamic Waters from Unattended Sensors and Remote Sensing Observations

Sensors ◽  
2018 ◽  
Vol 18 (8) ◽  
pp. 2699 ◽  
Author(s):  
Jian Li ◽  
Liqiao Tian ◽  
Qingjun Song ◽  
Zhaohua Sun ◽  
Hongjing Yu ◽  
...  
Keyword(s):  
Remote Sensing ◽  
Water Quality ◽  
Chlorophyll Fluorescence ◽  
Chlorophyll A ◽  
Temporal Variations ◽  
Lake Area ◽  
Short Term ◽  
Chl A ◽  
Spatio Temporal

Monitoring of water quality changes in highly dynamic inland lakes is frequently impeded by insufficient spatial and temporal coverage, for both field surveys and remote sensing methods. To track short-term variations of chlorophyll fluorescence and chlorophyll-a concentrations in Poyang Lake, the largest freshwater lake in China, high-frequency, in-situ, measurements were collected from two fixed stations. The K-mean clustering method was also applied to identify clusters with similar spatio-temporal variations, using remote sensing Chl-a data products from the MERIS satellite, taken from 2003 to 2012. Four lake area classes were obtained with distinct spatio-temporal patterns, two of which were selected for in situ measurement. Distinct daily periodic variations were observed, with peaks at approximately 3:00 PM and troughs at night or early morning. Short-term variations of chlorophyll fluorescence and Chl-a levels were revealed, with a maximum intra-diurnal ratio of 5.1 and inter-diurnal ratio of 7.4, respectively. Using geostatistical analysis, the temporal range of chlorophyll fluorescence and corresponding Chl-a variations was determined to be 9.6 h, which indicates that there is a temporal discrepancy between Chl-a variations and the sampling frequency of current satellite missions. An analysis of the optimal sampling strategies demonstrated that the influence of the sampling time on the mean Chl-a concentrations observed was higher than 25%, and the uncertainty of any single Terra/MODIS or Aqua/MODIS observation was approximately 15%. Therefore, sampling twice a day is essential to resolve Chl-a variations with a bias level of 10% or less. The results highlight short-term variations of critical water quality parameters in freshwater, and they help identify specific design requirements for geostationary earth observation missions, so that they can better address the challenges of monitoring complex coastal and inland environments around the world.

Community Care in Camberwell

1984 ◽  
Vol 145 (2) ◽  
pp. 178-186 ◽  
Author(s):  
Elizabeth Sturt
Keyword(s):  
Patient Care ◽  
Residential Care ◽  
Day Care ◽  
Community Care ◽  
Important Determinant ◽  
First Year ◽  
Short Term ◽  
Term Care ◽  
Residential Services ◽  
History Of

SummaryA census was taken of all patients in psychiatric hostels and homes, psychiatric day care, and short-term in-patient care who also had at least one year's history of contact with services. During the following two years, 61% of the patients stayed continuously in day or residential care, while 17% were discharged from care within the first year and made no further use of day or residential services. Two main patterns of contact were evident–repeated short-term in-patient care or longer-term care in services outside hospital. Their most important determinant was whether a viable marriage still existed for the patient.

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