Faktor – Faktor Yang Mempengaruhi Kejadian Penyakit Demam Berdarah Dengue (DBD) Dan Jenis Serotipe Virus Dengue Di Kabupaten Semarang

Background: Dengue infection continues to present a seriuos public health problem.The cases of Dengue Haemorrhagic Fever (DHF) in Semarang District has increased significantly and cause death. The purpose of this study was to determine the factors that affect the incedence of dengue and dengue virus serotype in Semarang Distric.Method : This is case control study using 54 cases and 54 control are people who live around the case with the caracteristics of age one the same with case and sex of the case.The analysis methods applied were univariate and bivariates with chi-squre and multivariate with logistic regression. Results : Risk factors incidence of dengue in Semarang District were humidity in the room (OR = 5.8; 95% CI = 1.322 to 14.170), the eksistence larvae in the water container (OR = 6.6; 95% CI = 2.386 - 18.277), the habit of using anti-mosquito / repellent (OR = 4.4; 95% CI = 1.076 to 8.875), the habit of hanging clothes (OR = 3.9; 95% CI = 1018 to 9.861). Serotype of dengue virus dominant Den-1.Conclusion : The factors that influence the incidence of DHF are the eksistence larvae the water container, the habit of using anti-mosquito / repellent, the habit of hanging clothes and humidity in the room. Serotype of dengue virus dominant is Den-1. Suggestion necessary environmental management by changing physical environment and the DHF program vector Aedes aegypti intervention. Keywords : Dengue Haemorragic Fever, Serotype of dengue virus

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1405. Clinical and laboratory features of fatal dengue fever in children: a case-control study

Open Forum Infectious Diseases ◽

10.1093/ofid/ofaa439.1587 ◽

2020 ◽

Vol 7 (Supplement_1) ◽

pp. S710-S711

Author(s):

Dolores E Freire ◽

Jeniffer D Olaya ◽

Michael Hawkes

Keyword(s):

Dengue Fever ◽

Case Control Study ◽

Dengue Infection ◽

Healthcare Providers ◽

Case Control ◽

Warning Signs ◽

Total Leukocyte Count ◽

Retrospective Case ◽

Time To Death ◽

Control Study

Abstract Background Dengue fever (DF) is a mosquito-borne illness that causes significant morbidity and mortality in tropical climates. This study compared the clinical features of fatal DF cases to severe non-fatal, and non-severe controls in Ecuador. Methods Retrospective case-control study of children (1 month to 15 years) hospitalized with serologically-confirmed DF in Guayaquil, Ecuador from 2013 to 2017. Cases of severe, fatal (SF) DF were compared to two control groups: (1) severe DF survivors (SS); and (2) patients with dengue with warning signs (DWS), matched 3:1 to cases for age, sex, and admission date. Observational trial profile Results 1051 patients were admitted with suspected DF and 552 were IgM-positive. Patients were classified as SF (n=11), SS (n=30), or DWS (n=511) (Figure1). Among SF cases, median age was 9.6 years (IQR 5.5-11), 7 (64%) were male, and median time to death was 1.5 days (IQR 0.8-4.0). (Table 1) SF cases had a median of 3 (Range 0-5) encounters with healthcare providers prior to presentation, compared to 2 (Range 0-5, p=0.02) for SS and 2 (Range 0-3, p=0.02) for DWS. Physical findings more common in SF cases than controls included: higher weight, tachycardia, tachypnea, delayed capillary refill, and hepatomegaly (p< 0.05 for all comparisons). Neurological manifestations were more prevalent in the SF group: 9/11 (82%) patients compared to 15/30 (50%, p=0.09) in SS and 7/33 (21%, p< 0.01) in DWS. Total leukocyte count (7.8x103/µL versus 4.5x103/µL, p=0.03) and absolute neutrophil count (5.1x103/µL versus 2.1x103/µL, p=0.03) were higher in SF cases than DWS controls. Fewer SF patients received intravenous dextrose than SS controls (27% versus 70%, p=0.03) (Table 2). Admission characteristics of children with dengue fever Management and outcome Conclusion Delayed recognition by healthcare workers, higher weight, vital sign abnormalities, hepatomegaly, neurological symptoms, leukocytosis, neutrophilia, and lack of dextrose in intravenous solutions were associated with mortality in children with DF. These findings have implications for optimizing the diagnosis and management of severe pediatric dengue infection. Disclosures All Authors: No reported disclosures

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Discriminating Tonate Virus from Dengue Virus Infection: A Matched Case–Control Study in French Guiana, 2003–2016

American Journal of Tropical Medicine and Hygiene ◽

10.4269/ajtmh.19-0156 ◽

2020 ◽

Vol 102 (1) ◽

pp. 195-201

Author(s):

Rémi Mutricy ◽

Félix Djossou ◽

Séverine Matheus ◽

Enguerrane Lorenzi-Martinez ◽

Franck De Laval ◽

...

Keyword(s):

Virus Infection ◽

Dengue Virus ◽

French Guiana ◽

Case Control Study ◽

Case Control ◽

Dengue Virus Infection ◽

Matched Case ◽

Matched Case Control Study ◽

Control Study

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Perinatal analyses of Zika- and dengue virus-specific neutralizing antibodies: A microcephaly case-control study in an area of high dengue endemicity in Brazil

PLoS Neglected Tropical Diseases ◽

10.1371/journal.pntd.0007246 ◽

2019 ◽

Vol 13 (3) ◽

pp. e0007246 ◽

Cited By ~ 12

Author(s):

Priscila M. S. Castanha ◽

Wayner V. Souza ◽

Cynthia Braga ◽

Thalia Velho Barreto de Araújo ◽

Ricardo A. A. Ximenes ◽

...

Keyword(s):

Dengue Virus ◽

Neutralizing Antibodies ◽

Case Control Study ◽

Case Control ◽

Control Study

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Large outbreak of verocytotoxin-producingEscherichia coliO157 infection in visitors to a petting farm in South East England, 2009

Epidemiology and Infection ◽

10.1017/s0950268811002111 ◽

2011 ◽

Vol 140 (8) ◽

pp. 1400-1413 ◽

Cited By ~ 38

Author(s):

C. IHEKWEAZU ◽

K. CARROLL ◽

B. ADAK ◽

G. SMITH ◽

G. C. PRITCHARD ◽

...

Keyword(s):

Physical Environment ◽

Case Control Study ◽

Case Control ◽

Farm Animals ◽

Causative Organism ◽

Management Procedures ◽

Large Outbreak ◽

South East England ◽

Farm Livestock ◽

Control Study

SUMMARYIn the summer of 2009, an outbreak of verocytotoxigenicEscherichia coliO157 (VTEC O157) was identified in visitors to a large petting farm in South East England. The peak attack rate was 6/1000 visitors, and highest in those aged <2 years (16/1000). We conducted a case-control study with associated microbiological investigations, on human, animal and environmental samples. We identified 93 cases; 65 primary, 13 secondary and 15 asymptomatic. Cases were more likely to have visited a specific barn, stayed for prolonged periods and be infrequent farm visitors. The causative organism was identified as VTEC O157 PT21/28 with the same VNTR profile as that isolated in faecal specimens from farm animals and the physical environment, mostly in the same barn. Contact with farm livestock, especially ruminants, should be urgently reviewed at the earliest suspicion of a farm-related VTEC O157 outbreak and appropriate risk management procedures implemented without delay.

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A community based case-control study to determine the risk factors of dengue fever in Bangladesh

10.1101/2021.08.24.21262563 ◽

2021 ◽

Author(s):

Md. Sahidur Rahman ◽

Fatema Mehejabin ◽

Rumana Rashid

Keyword(s):

Risk Factors ◽

Dengue Fever ◽

Potential Risk ◽

Case Control Study ◽

Dengue Infection ◽

Significant Risk ◽

Case Control ◽

College Hospital ◽

Tropical Country ◽

Control Study

In a tropical country like Bangladesh where the climatic condition favors the growth of Aedes mosquito vectors, the success of dengue prevention depends largely on the proper identification and controlling of the socio-demographic and lifestyle-related risk factors. A case-control study including 150 cases and 150 controls were conducted aimed to explore the potential risk and protective factors and their association with dengue virus infection in the Chattogram district of Bangladesh. Cases were confirmed for dengue patients admitted in Chattogram medical college hospital and Bangladesh institute of tropical and infectious diseases during August and September 2019. Whereas, controls were non-dengue patients admitted in other departments of the same hospitals through gender age and location matching. The questionnaire data were collected through telephone-based interviews which included information regarding general demography, daily life activities, housing with its surroundings status. Chi-square and binary logistic regression were performed for identifying potential risk factors and their association with the occurrences of dengue fever. The study found that travel history to the high incidence area, the place of staying most of the time, living in 21 to 40 years old houses, and the temporary residence of the city were statistically significant risk factors for getting the dengue infection. On contrary, Quality of indoor daylight, ventilation, bus stand/garage, stagnant water, and any construction site around 250 meters of the house did not show significant association with dengue fever.

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Faculty Opinions recommendation of Perinatal analyses of Zika- and dengue virus-specific neutralizing antibodies: A microcephaly case-control study in an area of high dengue endemicity in Brazil.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.735305002.793581259 ◽

2020 ◽

Author(s):

Tian Wang

Keyword(s):

Dengue Virus ◽

Neutralizing Antibodies ◽

Case Control Study ◽

Case Control ◽

Control Study

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Vitamin D Deficiency in Dengue Hemorrhagic Fever and Dengue Shock Syndrome among Sri Lankan Children: A Case-Control Study

Journal of Tropical Medicine ◽

10.1155/2021/4173303 ◽

2021 ◽

Vol 2021 ◽

pp. 1-5

Author(s):

Sharmila Dissanayake ◽

Sureshi Tennekoon ◽

Sharmila Gaffoor ◽

Guwani Liyanage

Keyword(s):

Vitamin D ◽

Logistic Regression ◽

Case Control Study ◽

Dengue Infection ◽

Dengue Shock Syndrome ◽

Hemorrhagic Fever ◽

Case Control ◽

Healthy Controls ◽

Multivariate Logistic Regression ◽

Control Study

Introduction. Dengue fever is a vector-borne disease associated with a significant public health impact. The clinical picture ranges from undifferentiated fever to more severe forms such as dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Compared to healthy controls, we explored the likelihood of having vitamin D deficiency (VDD) among children with severe dengue infection. Methods. This case-control study compared hospitalized children (2 months to 12 years) with DHF and DSS with radiologically confirmed plasma leak with age-matched healthy controls. The association of 25-hydroxy vitamin D [25(OH)D] level, age, sex, and socioeconomic status with DHF/DSS was assessed using univariate and multivariate logistic regression. Results. Forty children with DHF/DSS were compared with 52 healthy controls. Mean (SD) age was 8.8 (2.9) years and 7.9 (3.7) years among cases and controls, respectively. Most (n = 28, 70%) had DHF. In multivariate logistic regression, the likelihood of having VDD [25(OH)D < 20 ng/mL] was 3.6 times higher in cases compared to controls (Odds Ratio (OR): 3.65, 95% Confidence Interval (CI): 1.461, 9.102, p = 0.006 ). When serum 25(OH)D was used as a continuous independent variable, the strength of the association between DHF/DSS and serum 25(OH)D was weak but statistically significant; the likelihood of having DHF/DSS is 0.94 times less with 1 ng/mL increase in serum 25(OH)D (OR: 0.940, 95% CI: 0.887, 0.995, p = 0.03 ). Conclusion. The present study suggests that the likelihood of having VDD among children with DHF/DSS is higher than that in their healthy counterparts. Thus, further studies are critical in confirming whether vitamin D repletion is beneficial in preventing severe forms of dengue in the quest to reduce the morbidity and mortality associated with dengue infection.

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