scholarly journals Parenteral nutrition effects of Omega-3 fatty acids on C-reactive protein, high-density lipoprotein, lymphocyte characteristics and the treatment of critically ill patients

2020 ◽  
Vol 66 (3) ◽  
pp. 52
Author(s):  
Chunhua Ni ◽  
Jianxun Cao ◽  
Dechuan Li ◽  
Wei Wu ◽  
Lei Cao ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Parenteral Nutrition ◽  
High Density Lipoprotein ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Density Lipoprotein ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Intravenous Lipid Emulsions to Deliver Bioactive Omega-3 Fatty Acids for Improved Patient Outcomes

Marine Drugs ◽  
2019 ◽  
Vol 17 (5) ◽  
pp. 274 ◽  
Author(s):  
Philip C. Calder
Keyword(s):  
Fatty Acids ◽  
Parenteral Nutrition ◽  
Fish Oil ◽  
Hospital Stay ◽  
Critically Ill ◽  
Adult Patients ◽  
Lipid Emulsions ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Meta Analyses

Lipids used in intravenous nutrition support (i.e., parenteral nutrition) provide energy, building blocks, and essential fatty acids. These lipids are included as emulsions since they need to be soluble in an aqueous environment. Fish oil is a source of bioactive omega-3 fatty acids (eicosapentaenoic acid and docosahexaenoic acid). Lipid emulsions, including fish oil, have been used for parenteral nutrition for adult patients post-surgery (mainly gastrointestinal). This has been associated with alterations in biomarkers of inflammation and immune defense, and in some studies, a reduction in length of intensive care unit and hospital stay. These benefits, along with a reduction in infections, are emphasized through recent meta-analyses. Perioperative administration of fish oil may be superior to postoperative administration, but this requires further exploration. Parenteral fish oil has been used in critically ill adult patients. Here, the influence on inflammatory processes, immune function, and clinical endpoints is less clear. However, some studies found reduced inflammation, improved gas exchange, and shorter length of hospital stay in critically ill patients if they received fish oil. Meta-analyses do not present a consistent picture but are limited by the small number and size of studies. More and better trials are needed in patient groups in which parenteral nutrition is used and where fish oil, as a source of bioactive omega-3 fatty acids, may offer benefits.

scholarly journals Does omega-3 fatty acids supplementation affect C-Reactive protein and Nitric oxide in pediatric patients undergoing hemodialysis?

2016 ◽  
Vol 5 (5) ◽  
Author(s):  
Areej Mohamed Ateya ◽  
Dr. Nagwa Ali Sabri ◽  
Dr. Ihab El Hakim ◽  
Dr. Sara M Shaheen
Keyword(s):  
Nitric Oxide ◽  
Fatty Acids ◽  
Endothelial Dysfunction ◽  
Pediatric Patients ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
C Reactive Protein ◽  
Once Daily ◽  
Reactive Protein ◽  
Traditional Risk Factors

<italic>Background:</italic>Chronic kidney disease (CKD) is a worldwide public health problem in the pediatric population. Patients with CKD die of cardiovascular causes rather than from renal disease. There are several traditional and non-traditional risk factors for cardiovascular disease (CVD) in these patients. Endothelial dysfunction is one of the non-traditional risk factors for CVD. Many studies have shown the ability of omega-3 fatty acids to improve the endothelial function and reduce the cardiovascular events in the general population. Thus, the aim of this study was to evaluate the effect of omega-3 fatty acids supplementation on markers of endothelial dysfunction in children with CKD on regular hemodialysis (HD). <italic>Methods and procedures:</italic> This double-blinded randomized placebo-controlled trial included 49 pediatric patients on maintenance HD. Group 1 (n=25) received 1 g omega-3 capsule once daily and group 2 (n=24) received 1 g matched placebo capsule once daily. Both groups were treated for four months. Blood samples were taken from patients of both groups at baseline and after 4 months of supplementation. Serum samples were examined for C-reactive protein (CRP) and nitric oxide (NO) levels as markers of endothelial dysfunction. <italic>Results:</italic> Our results showed that CRP was reduced insignificantly in omega-3 group. NO levels showed no significant differences between groups at the end of the study. <italic>Conclusion:</italic> The administration of 1 g omega-3 capsule once daily for 4 months had no beneficial effects neither on CRP nor NO but should evaluate more.

scholarly journals Effect of omega 3 fatty acids on C-reactive protein and interleukin-6 in patients with advanced nonsmall cell lung cancer

Medicine ◽  
2018 ◽  
Vol 97 (37) ◽  
pp. e11971 ◽  
Author(s):  
Yan Lu ◽  
Ren-gang Chen ◽  
San-zou Wei ◽  
Han-guo Hu ◽  
Fei Sun ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Fatty Acids ◽  
Cell Lung Cancer ◽  
Interleukin 6 ◽  
Nonsmall Cell Lung Cancer ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
C Reactive Protein ◽  
Reactive Protein

Lower high-density lipoprotein cholesterol and increased omega-6 polyunsaturated fatty acids in first-degree relatives of bipolar patients

2004 ◽  
Vol 34 (1) ◽  
pp. 103-112 ◽  
Author(s):  
S. SOBCZAK ◽  
A. HONIG ◽  
A. CHRISTOPHE ◽  
M. MAES ◽  
R. W. C. HELSDINGEN ◽  
...  
Keyword(s):  
Fatty Acids ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
First Degree Relatives ◽  
Omega 6

Background. Lower serum high-density lipoprotein cholesterol and increased ratio of omega-6/omega-3 fatty acids have been reported in unipolar and bipolar depressed patients. Changes in cholesterol and fatty acids have been suggested to affect membrane viscosity and consequently serotonergic neurotransmitter expression.The goal of this study was to investigate whether lower baseline cholesterol and increased omega-6 and lower omega-3 fatty acids are present in healthy first-degree relatives of bipolar patients compared with controls and whether these changes were associated with neuroendocrine responses to an i.v. tryptophan challenge or mood.Method. Baseline cholesterol, fatty acids and mood were determined in healthy first-degree relatives of patients with bipolar disorders (N=30) and healthy matched controls (N=15) (parallel-group design). Prolactin and cortisol were measured following tryptophan infusion.Results. First-degree relatives showed significantly lower plasma high-density lipoprotein cholesterol and increased total omega-6 fatty acids in phospholipids. Lower total omega-3 and higher total omega-6 fatty acids in phospholipids were positively correlated with peak prolactin response to tryptophan. Lower total omega-3 fatty acids in phospholipids and cholesteryl esters were associated with lower mood.Conclusions. Abnormalities of lower plasma high-density lipoprotein cholesterol and increased total omega-6 fatty acids in phospholipids in these subjects are in agreement with findings in bipolar and major depressed patients. Changes in fatty acids show an association with central serotonergic parameters. It is suggested that these abnormalities in cholesterol and fatty acids may constitute a trait marker for bipolar disorders.

Fish or Chips?

Physiology ◽  
2003 ◽  
Vol 18 (2) ◽  
pp. 50-54
Author(s):  
Axel R. Heller ◽  
Hermann J. Theilen ◽  
Thea Koch
Keyword(s):  
Fatty Acids ◽  
Fish Oil ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Extracellular Space ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
High Turnover ◽  
Omega 6 ◽  
Long Chain

Cell membranes are not simply barriers separating intracellular from extracellular space. Rather, they represent a dynamic high-turnover system that adapts to current demands. During inflammation, prostaglandins and leukotrienes are formed from membrane-derived phospholipids. Encouraging improvements in critically ill patients were observed after nutritional replacement of long-chain omega-6 fatty acids with long-chain omega-3-fatty acids, contained in fish oil.

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