The Kidney Beans (Phaseolus vulgaris) Pods Extract Affects the Central and Peripheral Serotonergic Systems in Rats With High-Calorie Diet-Induced Obesity

The influence of kidney beans pods extract on obesity development was investigated. It was found that administration of P. vulgaris pods extract led to decrease of body weight and body mass index of the animals which were on high-calorie diet. Found changes could be result of decrease of food intake by rats treated with extract in compare with rats in high-calorie diet group.

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The evaluation of lipid peroxidation and oxidative modification of proteins in blood serum under obesity development and the consumption of aqueous kidney beans Phaseolus vulgaris pods extract

Current Issues in Pharmacy and Medical Sciences ◽

10.2478/cipms-2020-0008 ◽

2020 ◽

Vol 33 (1) ◽

pp. 38-44

Author(s):

Alona Yurchenko ◽

Daryna Krenytska ◽

Olexii Savchuk ◽

Tetiana Halenova ◽

Natalia Raksha ◽

...

Keyword(s):

Lipid Peroxidation ◽

Oxidative Modification ◽

Resistance Development ◽

Oxidative Modification Of Proteins ◽

Kidney Beans ◽

Calorie Diet ◽

Diet Control ◽

High Calorie Diet ◽

High Calorie

AbstractOur interest has focused on the investigation of the anti-obese potential of kidney beans (P. vulgaris) pods extract. In the course of the study, obesity development in rats was induced with high-calorie diet. Control and obese rats then have consumed with aqueous kidney beans (P. vulgaris) pods extract during 6 weeks (200 mg/kg). Results show that the long-term consumption of P. vulgaris pods extract can lead to the reduction of hyperglycemia and insulin resistance development. Furthermore, we saw a normalization of lipid peroxidation parameters and oxidative modification of protein due to the consumption of the kidney beans (P. vulgaris) pods extract. Our experimental data demonstrate the ability of the kidney beans (P. vulgaris) pod extracts to mitigate obesity development but the details of this mechanism remains to be not fully understood.

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Relationship between sympathetic activity and diet-induced obesity in two rat strains

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.1983.245.3.r364 ◽

1983 ◽

Vol 245 (3) ◽

pp. R364-R371 ◽

Cited By ~ 10

Author(s):

B. E. Levin ◽

J. Triscari ◽

A. C. Sullivan

Keyword(s):

Sympathetic Activity ◽

Caloric Intake ◽

Sprague Dawley ◽

Rat Strains ◽

Sympathetic Function ◽

Diet Induced Obesity ◽

Sprague Dawley Rats ◽

Calorie Diet ◽

High Calorie Diet ◽

High Calorie

Chronic diet-induced obesity developed in 50-60% of male Sprague-Dawley rats fed a relatively high-calorie diet for 90 days. The remaining rats decreased their caloric intake and resisted the development of obesity. All male Fischer F-344 rats fed this diet for 85 days became obese but to only half the degree of the obese Sprague-Dawley rats. The development of chronic obesity in both rat strains was associated with decreased norepinephrine (NE) levels in hearts and aortas and decreased NE turnover in aortas compared with chow-fed controls. However, 40-50% of the Sprague-Dawley rats did not become obese on this diet, yet showed similar findings suggesting an effect of dietary composition on sympathetic function. The more profoundly obese Sprague-Dawley rats additionally showed decreased or absent NE turnover in their hearts and pancreases. Since sympathetic function in both strains of rats with diet-induced obesity was either depressed or normal, it appears unlikely that the initial enhancement of sympathetic activity seen during short-term overfeeding plays an important continuing role in combating more chronic states of obesity in the rat.

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Effect of two hypercaloric diets on the hormonal and metabolic profile of the adrenal gland

Hormone Molecular Biology and Clinical Investigation ◽

10.1515/hmbci-2021-0007 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Mokrani Zoulikha ◽

Zerrouki Nacira ◽

Gernigon-Spichalowicz Therese ◽

Soltani Yacine

Keyword(s):

Adipose Tissue ◽

Adrenal Gland ◽

Metabolic Profile ◽

Visceral Obesity ◽

Male Adult ◽

Diet Induced Obesity ◽

Calorie Diet ◽

Visceral Adipose ◽

High Calorie Diet ◽

High Calorie

Abstract Objectives Who disrupts who? It is not clear what the interaction is between a high calorie diet (HCD) and adrenal axis activation in obesity. The goal was to assess the effect of two hypercaloric diets commercialized in Algeria on the hormonal and metabolic profile of the adrenal gland in rabbits. Methods Two classes of local male adult rabbits (n=16) and a finishing diet (FD) as a control for 15 weeks. Results It has been shown that HCD-received animals have developed visceral obesity, dyslipidemia and insulin resistance IR by dramatically increasing body weight, visceral fat tissue and adrenal weight, combined with elevated plasma levels of ACTH, cortisol, leptin and insulin. The HCD diet increased the levels of cortisol in the visceral adipose tissue (VAT), in peri-adrenal adipose tissue (PAAT), and decreased cortisol levels in the liver. HCD also causes the process of inflammatory fibrosis associated with the migration and spread of chromaffin cells in the adrenal gland. Conclusions This study gives new insights into how diet-induced obesity studied on local rabbits affects the biology of the adrenal gland. The correlation of these changes with paracrine connections between the chromaffin cell and glomerulosa indicates potential therapeutic methods for obese-related steroid hormone dysfunction.

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The effects of melatonin administration in determined times of day on the kidney in rats with high-calorie diet-induced obesity

Bulletin of Taras Shevchenko National University of Kyiv Series Problems of Physiological Functions Regulation ◽

10.17721/1728_2624.2019.26.35-41 ◽

2019 ◽

Vol 26 (1) ◽

pp. 35-41

Author(s):

O. Kalmukova ◽

T. Kushmyruk ◽

M. Dzerzhynsky

Keyword(s):

Functional State ◽

Antioxidant Properties ◽

The Body ◽

Correction Function ◽

Diet Induced Obesity ◽

Melatonin Administration ◽

Kidney Morphology ◽

Calorie Diet ◽

High Calorie Diet ◽

High Calorie

Kidneys, like the cardiovascular system, are one of the main target organs, the most vulnerable to obesity, because the first take on the metabolism correction function at an increasing excess of fat tissue in the body. Kidney affection under obesity is a multifactorial thing that is caused by a number of processes, including inflammation, oxidative stress, lipid metabolism disorders, renin-angiotensin-aldosterone system activation, insulin resistance and other factors. An optimal candidate for reducing the harmful effects of kidneys obesity should be a compound that simultaneously exhibits anti-inflammatory and antioxidant properties, controls the circadian rhythm, and also affects on the adipokines secretion. The molecule that meets these conditions is melatonin.The aim of our study was to determine morpho-functional state (morphology characteristic of kidney glomeruli and tubules; morphometric parameters: area and density of glomeruli) of kidney in rats with high-calorie (high fat) diet-induced obesity after melatonin administration in determined time of the day. Melatonin was administered daily by gavage for 7 weeks in dose 30 mg/kg 1 h before lights-off (ZT11) rats with high-calorie diet (HCD). Rats with HCD had huge changes in kidney morphology, which manifested in presence of numerous mesangial cells outside glomeruli and lipid droplets in tubules epithelial cells, while area and density of glomeruli in cm2 decrease. In general kidney with above mentioned characteristic from HCD rats lose their ability to conduct strongly renal function. After melatonin used in rats with HCD arise leveling of pathological changes, which associated with consumption of HCD. Namely, in rats with development obesity melatonin administrations led to increase area and density in comparison to HCD group, moreover glomeruli density reach control values. This is suggest that melatonin have protecting effect against glomerular degeneration. In conclusions, melatonin influence on kidney morpho-functional state in rats with HCD and turn back pathological its changes, moreover evening administration can use for obesity therapy via its strong action on conservation glomerular morphology.

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