scholarly journals Effects of Sevelamer Hydrochloride on Uremic Toxins Serum Indoxyl Sulfate and P-Cresyl Sulfate in Hemodialysis Patients

2017 ◽  
Vol 9 (9) ◽  
pp. 765-770 ◽  
Author(s):  
Cheng-Jui Lin ◽  
Chi-Feng Pan ◽  
Chih-Kuang Chuang ◽  
Hsuan-Liang Liu ◽  
Sung-Fa Huang ◽  
...  
Keyword(s):  
Hemodialysis Patients ◽  
Uremic Toxins ◽  
Indoxyl Sulfate ◽  
Sevelamer Hydrochloride

scholarly journals The relationship of indoxyl sulfate and p-cresyl sulfate with target cardiovascular proteins in hemodialysis patients

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ping-Hsun Wu ◽  
Yi-Ting Lin ◽  
Yi-Wen Chiu ◽  
Gabriel Baldanzi ◽  
Jiun-Chi Huang ◽  
...  
Keyword(s):  
Hemodialysis Patients ◽  
Complement Component ◽  
Uremic Toxins ◽  
Indoxyl Sulfate ◽  
Free Form ◽  
Negatively Associated ◽  
Coronary Syndrome ◽  
Increased Risk ◽  
Related Proteins ◽  
The Relationship

AbstractProtein-bound uremic toxins (Indoxyl sulfate [IS] and p-cresyl sulfate [PCS]) are both associated with cardiovascular (CV) and all-cause mortality in subjects with chronic kidney disease (CKD). Possible mechanisms have not been elucidated. In hemodialysis patients, we investigated the relationship between the free form of IS and PCS and 181 CV-related proteins. First, IS or PCS concentrations were checked, and high levels were associated with an increased risk of acute coronary syndrome (ACS) in 333 stable HD patients. CV proteins were further quantified by a proximity extension assay. We examined associations between the free form protein-bound uremic toxins and the quantified proteins with correction for multiple testing in the discovery process. In the second step, the independent association was evaluated by multivariable-adjusted models. We rank the CV proteins related to protein-bound uremic toxins by bootstrapped confidence intervals and ascending p-value. Six proteins (signaling lymphocytic activation molecule family member 5, complement component C1q receptor, C–C motif chemokine 15 [CCL15], bleomycin hydrolase, perlecan, and cluster of differentiation 166 antigen) were negatively associated with IS. Fibroblast growth factor 23 [FGF23] was the only CV protein positively associated with IS. Three proteins (complement component C1q receptor, CCL15, and interleukin-1 receptor-like 2) were negatively associated with PCS. Similar findings were obtained after adjusting for classical CV risk factors. However, only higher levels of FGF23 was related to increased risk of ACS. In conclusion, IS and PCS were associated with several CV-related proteins involved in endothelial barrier function, complement system, cell adhesion, phosphate homeostasis, and inflammation. Multiplex proteomics seems to be a promising way to discover novel pathophysiology of the uremic toxin.

Pilot Study of Probiotic Supplementation on Uremic Toxicity and Inflammatory Cytokines in Chronic Kidney Patients

2020 ◽  
Vol 16 (4) ◽  
pp. 470-480
Author(s):  
Cristina T. Roth-Stefanski ◽  
Carla Dolenga ◽  
Lia S. Nakao ◽  
Roberto Pecoits-Filho ◽  
Thyago P. de Moraes ◽  
...  
Keyword(s):  
Pilot Study ◽  
Inflammatory Cytokines ◽  
Lactobacillus Acidophilus ◽  
Serum Levels ◽  
Uremic Toxins ◽  
Indoxyl Sulfate ◽  
Bacterial Metabolism ◽  
Probiotic Supplementation ◽  
Primary Endpoints ◽  
Inflammatory Profile

Background: Bacterial metabolism contributes to the generation of uremic toxins in patients with chronic kidney disease (CKD). It has been investigated the use of probiotics in the reduction of uremic toxins intestinal production. Objective: The aim of this pilot study was to evaluate the effect of probiotic supplementation on reducing the production of uremic toxins and the inflammatory profile of CKD patients. Methods: We performed a randomized, blind, placebo-controlled, crossover study on patients with CKD stages 3 and 4. The intervention was a probiotic formulation composed of Lactobacillus acidophilus strains given orally three times a day for 3 months. Changes in uremic toxins (p-Cresylsulfate and Indoxyl Sulfate) and serum inflammatory cytokines were the primary endpoints. Results: Of the 44 patients randomized, 25 completed the study (mean age 51 ± 9.34, 64% female, mean eGFR 36 ± 14.26 mL/min/1.73m², mean BMI 28.5 ± 5.75 kg/m²). At 3 months, there were no significant changes in any of the studied biomarkers including p-cresylsulfate (p = 0.57), Indoxyl sulfate (p = 0.08) and interleukin-6 (p = 0.55). Conclusion: Lactobacillus acidophilus strains given as probiotic were not able to reduce serum levels of uremic toxins and biomarkers of inflammation in CKD patients in stage 3 and 4.

Uremic toxins levels from the gut microbiota seem not to be altered by physical exercise in hemodialysis patients

2021 ◽  
Author(s):  
Jessyca Sousa de Brito ◽  
Drielly Vargas ◽  
Greicielle Santos da Silva ◽  
Sandra Marinho ◽  
Natália Alvarenga Borges ◽  
...  
Keyword(s):  
Physical Exercise ◽  
Gut Microbiota ◽  
Hemodialysis Patients ◽  
Uremic Toxins

Could resistant starch supplementation improve inflammatory and oxidative stress biomarkers and uremic toxins levels in hemodialysis patients? A pilot randomized controlled trial

2018 ◽  
Vol 9 (12) ◽  
pp. 6508-6516 ◽  
Author(s):  
Marta Esgalhado ◽  
Julie A. Kemp ◽  
Renata Azevedo ◽  
Bruna R. Paiva ◽  
Milena B. Stockler-Pinto ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Resistant Starch ◽  
Controlled Trial ◽  
Hemodialysis Patients ◽  
Uremic Toxins ◽  
Oxidative Stress Biomarkers ◽  
Randomized Controlled ◽  
Stress Biomarkers ◽  
And Oxidative Stress ◽  
Pilot Randomized Controlled Trial

Prebiotic-resistant starch supplementation may be a good strategy to reduce inflammation, oxidative stress and uremic toxins in CKD patients.

scholarly journals SP705EFFECT OF LACTOBACILLUS RHAMNOSUS ON SERUM UREMIC TOXINS IN HEMODIALYSIS PATIENTS

2017 ◽  
Vol 32 (suppl_3) ◽  
pp. iii375-iii375
Author(s):  
Fatemeh Poor-Reza Gholi ◽  
Nooshin Dalili ◽  
Farzad Eidi ◽  
Alireza Ostadrahimi
Keyword(s):  
Lactobacillus Rhamnosus ◽  
Hemodialysis Patients ◽  
Uremic Toxins

Chronic Acid–Base Perturbations in Hemodialysis Patients Treated with Sevelamer Hydrochloride: A Two-year Follow-up Study

2007 ◽  
Vol 31 (12) ◽  
pp. 892-895 ◽  
Author(s):  
Demetrios V. Vlahakos ◽  
Kalliopi Retsa ◽  
Sofia Kalogeropoulou ◽  
Spiros Katsoudas ◽  
Dimitra Bacharaki ◽  
...  
Keyword(s):  
Hemodialysis Patients ◽  
Acid Base ◽  
Follow Up Study ◽  
Sevelamer Hydrochloride

Impact of sevelamer hydrochloride on serum magnesium concentrations in hemodialysis patients

2016 ◽  
Vol 29 (4) ◽  
pp. 184-190 ◽  
Author(s):  
Ryota Ikee ◽  
Takayuki Toyoyama ◽  
Toko Endo ◽  
Masataka Tsunoda ◽  
Nobuo Hashimoto
Keyword(s):  
Serum Magnesium ◽  
Hemodialysis Patients ◽  
Sevelamer Hydrochloride

scholarly journals Syndecan-1 and Free Indoxyl Sulfate Levels Are Associated with miR-126 in Chronic Kidney Disease

2021 ◽  
Vol 22 (19) ◽  
pp. 10549
Author(s):  
Ophélie Fourdinier ◽  
Griet Glorieux ◽  
Benjamin Brigant ◽  
Momar Diouf ◽  
Anneleen Pletinck ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Endothelial Dysfunction ◽  
Kidney Disease ◽  
Internal Control ◽  
Univariate Analysis ◽  
Uremic Toxins ◽  
Indoxyl Sulfate ◽  
Endothelial Glycocalyx ◽  
Correlated Parameters

Chronic kidney disease (CKD) is a major cause of death worldwide and is associated with a high risk for cardiovascular and all-cause mortality. In CKD, endothelial dysfunction occurs and uremic toxins accumulate in the blood. miR-126 is a regulator of endothelial dysfunction and its blood level is decreased in CKD patients. In order to obtain a better understanding of the physiopathology of the disease, we correlated the levels of miR-126 with several markers of endothelial dysfunction, as well as the representative uremic toxins, in a large cohort of CKD patients at all stages of the disease. Using a univariate analysis, we found a correlation between eGFR and most markers of endothelial dysfunction markers evaluated in this study. An association of miR-126 with all the evaluated uremic toxins was also found, while uremic toxins were not associated with the internal control, specifically cel-miR-39. The correlation between the expression of endothelial dysfunction biomarker Syndecan-1, free indoxyl sulfate, and total p-cresyl glucuronide on one side, and miR-126 on the other side was confirmed using multivariate analysis. As CKD is associated with reduced endothelial glycocalyx (eGC), our results justify further evaluation of the role of correlated parameters in the pathophysiology of CKD.

Effect of reducing calcium load using sevelamer hydrochloride on bone metabolic markers in hemodialysis patients with low parathyroid hormone levels

2009 ◽  
Vol 42 (10) ◽  
pp. 769-776
Author(s):  
Toru Inoue ◽  
Katsuyuki Nagatoya ◽  
Maki Kagitani ◽  
Haruhiko Ueda ◽  
Yoji Katsuoka ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Hemodialysis Patients ◽  
Bone Metabolic Markers ◽  
Metabolic Markers ◽  
Hormone Levels ◽  
Sevelamer Hydrochloride ◽  
Calcium Load
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