scholarly journals Synthesis and Biological Activity of New Antifungal Compounds: A Preliminary Study

2018 ◽  
Vol 6 (5) ◽  
Author(s):  
Jorge A. Cabezas ◽  
José A. Brenes ◽  
Norma Gross ◽  
María L. Arias
Keyword(s):  
Biological Activity ◽  
Antifungal Activity ◽  
Trichophyton Rubrum ◽  
Inhibitory Effect ◽  
Clinical Isolates ◽  
Antifungal Compounds ◽  
Ciclopirox Olamine ◽  
Preliminary Study ◽  
Nail Infection

In the present study, we synthesized three 1,3-enynes from their corresponding aldehydes. They exhibited antifungal activity, which was evaluated against Trichophyton rubrum, the most common dermatophyte responsible for nail infection. The biological activity of these synthetic enynes was compared to terbinafine and ciclopirox olamine, two common antimycotic drugs used to treat nail infections caused by this pathogen. Two of these compounds showed an inhibitory effect similar to terbinafine and cilopirox olamine, when tested against over eleven different T. rubrum strains, including ATCC 28188 strain and ten different clinical isolates, two already classified as multitreated.

scholarly journals Control of Panama disease of banana by intercropping with Chinese chive (Allium tuberosum Rottler): cultivar differences

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Zhenfang Li ◽  
Tong Wang ◽  
Chenling He ◽  
Kelin Cheng ◽  
Rensen Zeng ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Field Experiments ◽  
Disease Incidence ◽  
Inhibitory Effect ◽  
Cultivar Differences ◽  
Antifungal Compounds ◽  
Panama Disease ◽  
Allium Tuberosum ◽  
Leaf Volatiles ◽  
Chinese Chive

Abstract Panama disease (Fusarium wilt disease) caused by Fusarium oxysporum f. sp. cubense race 4 (FOC) severely threatens banana (Musa spp.) production worldwide. Intercropping of banana with Allium plants has shown a potential to reduce Panama disease. In this study, six cultivars of Chinese chive (Allium tuberosum Rottler) were selected to compare their differences in antifungal activity and active compounds. Three cultivars Duokang Fujiu 11, Fujiuhuang 2, and Duokang Sijiqing with higher levels of antifungal compounds were further used for intercropping with banana in the pots and field to compare their effects on growth and disease incidence of banana. The six cultivars showed significant differences in antifungal activity against FOC mycelia growth in both leaf volatiles and aqueous leachates. The aqueous leachates displayed stronger antifungal activity than the volatiles. FJH cultivar showed the best inhibitory effect among all six cultivars. Contents of three main antifungal compounds dipropyl trisulfide (DPT), dimethyl trisulfide (DMT), and 2-methyl-2-pentenal (MP) in volatiles and aqueous leachates varied considerably among cultivars. Pot and field experiments showed that intercropping with three selected Chinese chive cultivars significantly improved banana vegetative growth, increased photosynthetic characteristics and yield but decreased disease incidence of Panama disease. Our results indicate that intercropping with Chinese chive shows potential to reduce banana Panama disease and selection of appropriate cultivars is vital for effective disease control.

scholarly journals Control of Panama disease of banana by intercropping with Chinese chive (Allium tuberosum Rottler): cultivar differences

2020 ◽  
Author(s):  
Zhen-Fang Li ◽  
Tong Wang ◽  
Chenling He ◽  
Kelin Cheng ◽  
Rensen Zeng ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Field Experiments ◽  
Disease Incidence ◽  
Inhibitory Effect ◽  
Cultivar Differences ◽  
Antifungal Compounds ◽  
Panama Disease ◽  
Allium Tuberosum ◽  
Leaf Volatiles ◽  
Chinese Chive

Abstract Panama disease (Fusarium wilt disease) caused by Fusarium oxysporum f. sp. cubense race 4 (FOC) severely threatens banana (Musa spp.) production worldwide. Intercropping of banana with Allium plants has shown a potential to reduce Panama disease. In this study, six cultivars of Chinese chive (Allium tuberosum Rottler) were selected to compare their differences in antifungal activity and active compounds. Three cultivars Duokang Fujiu 11, Fujiuhuang 2, and Duokang Sijiqing with higher levels of antifungal compounds were further used for intercropping with banana in the pots and field to compare their effects on growth and disease incidence of banana. The six cultivars showed significant differences in antifungal activity against FOC mycelia growth in both leaf volatiles and aqueous leachates. The aqueous leachates displayed stronger antifungal activity than the volatiles. FJH cultivar showed the best inhibitory effect among all six cultivars. Contents of three main antifungal compounds dipropyl trisulfide (DPT), dimethyl trisulfide (DMT), and 2-methyl-2-pentenal (MP) in volatiles and aqueous leachates varied considerably among cultivars. Pot and field experiments showed that intercropping with three selected Chinese chive cultivars significantly improved banana vegetative growth, increased photosynthetic characteristics and yield but decreased disease incidence of Panama disease.Our results indicate that intercropping with Chinese chive shows potential to reduce banana Panama disease and selection of appropriate cultivars is vital for effective disease control.

scholarly journals Control of Panama disease of banana by intercropping with Chinese chive (Allium tuberosum Rottler): cultivar differences

2020 ◽  
Author(s):  
Zhen-Fang Li ◽  
Tong Wang ◽  
Chenlin He ◽  
Kelin Cheng ◽  
Rensen Zeng ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Field Experiments ◽  
Disease Incidence ◽  
Inhibitory Effect ◽  
Cultivar Differences ◽  
Antifungal Compounds ◽  
Panama Disease ◽  
Allium Tuberosum ◽  
Leaf Volatiles ◽  
Chinese Chive

Abstract BackgroundPanama disease (Fusarium wilt disease) caused by Fusarium oxysporum f. sp. cubense race 4 (FOC) severely threatens banana (Musa spp.) production worldwide. Intercropping of banana with Allium plants has shown a potential to reduce Panama disease. In this study six cultivars of Chinese chive (Allium tuberosum Rottler) were selected to compare their differences in antifungal activity and active compounds. Three cultivars Duokang Fujiu 11, Fujiuhuang 2, and Duokang Sijiqing with higher levels of antifungal compounds were further used for intercropping with banana in the pots and field to compare their effects on growth and disease incidence of banana.Methods and ResultsThe six cultivars showed significant differences in antifungal activity against FOC mycelia growth in both leaf volatiles and aqueous leachates. The aqueous leachates displayed stronger antifungal activity than the volatiles. FJH cultivar showed the best inhibitory effect among all six cultivars. Contents of three main antifungal compounds dipropyl trisulfide (DPT), dimethyl trisulfide (DMT), and 2-methyl-2-pentenal (MP) in volatiles and aqueous leachates varied considerably among cultivars. Pot and field experiments showed that intercropping with three selected Chinese chive cultivars significantly improved banana vegetative growth, increased photosynthetic characteristics and yield but decreased disease incidence of Panama disease.ConclusionsOur results indicate that intercropping with Chinese chive shows potential to reduce banana Panama disease and selection of appropriate cultivars is vital for effective disease control.

scholarly journals Preliminary study on the inhibitory effect of seaweed Gracilaria verrucosa extract on biofilm formation of Candida albicans cultured from the saliva of a smoker

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 684
Author(s):  
Zaki Mubarak ◽  
Adintya Humaira ◽  
Basri A. Gani ◽  
Zainal A. Muchlisin
Keyword(s):  
Candida Albicans ◽  
Immune System ◽  
Antifungal Activity ◽  
Oral Cavity ◽  
Virulence Factors ◽  
Biofilm Formation ◽  
Inhibitory Effect ◽  
Positive Control ◽  
Multiple Factors ◽  
Preliminary Study

Background: Candida albicans is an opportunistic fungus that infects the oral cavity. Increases in colony numbers of C. albicans can be caused by multiple factors, such as smoking, a weakened immune system, taking antibiotics and with immune-compromised individuals. Smoking can increase the virulence factor of C. albicans and make it stronger. One of the virulence factors of C. albicans is the biofilm it forms. The C. albicans biofilm makes it more tolerant to extracts of the seaweed Gracilaria verrucosa, which has antifungal activity. The objective of the study was to examine the ability of the G. verrucosa extracts to inhibit the formation of biofilm by C. albicans obtained from the saliva of smoker. Methods: A total of six concentrations of G. verrucosa (6.25, 12.5, 25, 50, 75 and 100%) were tested in this study. The positive control was fluconazole 0.31 µg/ml C. albicans was taken from the saliva of one smoker in Faculty of Dentistry, Syiah Kuala University. The total amount of biofilm was assessed using an ELISA reader. The data were subjected to Kruskal-Wallis test at a significance limit of p<0.05. Results: The seaweed extract has three bio-active compounds: steroids, terpenoid, and tannins. The results showed that the inhibitory activity of seaweed on C. albicans biofilm formation increases as its concentration increases. The highest effectiveness was recorded at a seaweed concentration of 100% at 48 h of exposure. Conclusions: The optimal inhibition of the C. albicans biofilm formation was recorded at the concentration of 100% G. verrucosa after 48 hours of exposure.

scholarly journals Evaluation of the antifungal activity of marine actinomycetes isolates against the phytopathogenic fungi Colletotrichum siamense KA: A preliminary study for new antifungal compound discovery

Pharmacia ◽  
2021 ◽  
Vol 68 (4) ◽  
pp. 837-843
Author(s):  
Qonita Gina Fadhilah ◽  
Iman Santoso ◽  
Andi Eko Maryanto ◽  
Sarini Abdullah ◽  
Yasman Yasman
Keyword(s):  
Antifungal Activity ◽  
Mangrove Ecosystem ◽  
Phytopathogenic Fungi ◽  
Antagonistic Activity ◽  
Antifungal Compound ◽  
Antifungal Compounds ◽  
Marine Actinomycetes ◽  
Colletotrichum Siamense ◽  
Preliminary Study ◽  
Different Strains

Marine actinomycetes are being explored to discover potential actinomycetes that produce antifungal compounds. In a previous study, marine actinomycetes isolates from the mangrove ecosystem were found to inhibit growth of the phytopathogenic fungi Colletotrichum siamense KA. In this study, the three of these isolates with the highest antagonistic activity—SM11, SM14, and SM15—were evaluated for their antifungal activity using antibiosis assay. The fermentation was performed in SCB:PDB medium (1:1) for 6, 9, and 12 days. The results showed that SM14 was the strongest potential isolate; it inhibited the growth of C. siamense KA on average up to 64.90% for 12 days on PDA filtrate medium. Molecular identification showed SM14 was closely related to Streptomyces sanyensis, but had differences in morphological and biochemical characteristics compared to SM11 or SM15. This indicated that the three isolates were different strains and may challenge further research on identifying and analyzing their antifungal compounds.

scholarly journals Control of Panama disease of banana by intercropping with Chinese chive (Allium tuberosum Rottler): cultivar differences

2020 ◽  
Author(s):  
Zhen-Fang Li ◽  
Tong Wang ◽  
Chenlin He ◽  
Kelin Cheng ◽  
Rensen Zeng ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Field Experiments ◽  
Disease Incidence ◽  
Inhibitory Effect ◽  
Cultivar Differences ◽  
Antifungal Compounds ◽  
Panama Disease ◽  
Allium Tuberosum ◽  
Leaf Volatiles ◽  
Chinese Chive

Abstract Panama disease (Fusarium wilt disease) caused by Fusarium oxysporum f. sp. cubense race 4 (FOC) severely threatens banana (Musa spp.) production worldwide. Intercropping of banana with Allium plants has shown a potential to reduce Panama disease. In this study, six cultivars of Chinese chive ( Allium tuberosum Rottler) were selected to compare their differences in antifungal activity and active compounds. Three cultivars Duokang Fujiu 11, Fujiuhuang 2, and Duokang Sijiqing with higher levels of antifungal compounds were further used for intercropping with banana in the pots and field to compare their effects on growth and disease incidence of banana. The six cultivars showed significant differences in antifungal activity against FOC mycelia growth in both leaf volatiles and aqueous leachates. The aqueous leachates displayed stronger antifungal activity than the volatiles. FJH cultivar showed the best inhibitory effect among all six cultivars. Contents of three main antifungal compounds dipropyl trisulfide (DPT), dimethyl trisulfide (DMT), and 2-methyl-2-pentenal (MP) in volatiles and aqueous leachates varied considerably among cultivars. Pot and field experiments showed that intercropping with three selected Chinese chive cultivars significantly improved banana vegetative growth, increased photosynthetic characteristics and yield but decreased disease incidence of Panama disease. Our results indicate that intercropping with Chinese chive shows potential to reduce banana Panama disease and selection of appropriate cultivars is vital for effective disease control.

scholarly journals In Vitro Antifungal Activity of Novel Triazole Efinaconazole and Five Comparators against Dermatophyte Isolates

2018 ◽  
Vol 62 (5) ◽  
Author(s):  
Ali Rezaei-Matehkolaei ◽  
Sadegh Khodavaisy ◽  
Mohamad Mahdi Alshahni ◽  
Takashi Tamura ◽  
Kazuo Satoh ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Trichophyton Rubrum ◽  
Geometric Mean ◽  
Clinical Isolates ◽  
The Novel ◽  
Large Collection ◽  
Content Type ◽  
Trichophyton Interdigitale ◽  
In Vitro Antifungal Activity

ABSTRACT The objective of this study was to assess the in vitro activity of the novel triazole antifungal drug, efinaconazole, and five comparators (luliconazole, lanoconazole, terbinafine, itraconazole, and fluconazole) against a large collection of Trichophyton interdigitale and Trichophyton rubrum clinical isolates. The geometric mean MICs were the lowest for luliconazole (0.0005 μg/ml), followed by lanoconazole (0.002 μg/ml), efinaconazole (0.007 μg/ml), terbinafine (0.011 μg/ml), itraconazole (0.095 μg/ml), and fluconazole (12.77 μg/ml). It appears that efinaconazole, lanoconazole, and luliconazole are promising candidates for the treatment of dermatophytosis due to T. interdigitale and T. rubrum .

scholarly journals Control of Panama disease of banana by intercropping with Chinese chive (Allium tuberosum Rottler): cultivar differences

2020 ◽  
Author(s):  
Zhen-Fang Li ◽  
Tong Wang ◽  
Chenling He ◽  
Kelin Cheng ◽  
Rensen Zeng ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Field Experiments ◽  
Disease Incidence ◽  
Inhibitory Effect ◽  
Cultivar Differences ◽  
Antifungal Compounds ◽  
Panama Disease ◽  
Allium Tuberosum ◽  
Leaf Volatiles ◽  
Chinese Chive

Abstract Panama disease (Fusarium wilt disease) caused by Fusarium oxysporum f. sp. cubense race 4 (FOC) severely threatens banana (Musa spp.) production worldwide. Intercropping of banana with Allium plants has shown a potential to reduce Panama disease. In this study, six cultivars of Chinese chive ( Allium tuberosum Rottler) were selected to compare their differences in antifungal activity and active compounds. Three cultivars Duokang Fujiu 11, Fujiuhuang 2, and Duokang Sijiqing with higher levels of antifungal compounds were further used for intercropping with banana in the pots and field to compare their effects on growth and disease incidence of banana. The six cultivars showed significant differences in antifungal activity against FOC mycelia growth in both leaf volatiles and aqueous leachates. The aqueous leachates displayed stronger antifungal activity than the volatiles. FJH cultivar showed the best inhibitory effect among all six cultivars. Contents of three main antifungal compounds dipropyl trisulfide (DPT), dimethyl trisulfide (DMT), and 2-methyl-2-pentenal (MP) in volatiles and aqueous leachates varied considerably among cultivars. Pot and field experiments showed that intercropping with three selected Chinese chive cultivars significantly improved banana vegetative growth, increased photosynthetic characteristics and yield but decreased disease incidence of Panama disease. Our results indicate that intercropping with Chinese chive shows potential to reduce banana Panama disease and selection of appropriate cultivars is vital for effective disease control.

scholarly journals Antifungal Activity of Capridine β as a Consequence of Its Biotransformation into Metabolite Affecting Yeast Topoisomerase II Activity

Pathogens ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 189
Author(s):  
Iwona Gabriel ◽  
Kamila Rząd ◽  
Ewa Paluszkiewicz ◽  
Katarzyna Kozłowska-Tylingo
Keyword(s):  
Antifungal Activity ◽  
Fungal Pathogens ◽  
Topoisomerase Ii ◽  
Fungal Infections ◽  
Inhibitory Effect ◽  
Antifungal Compounds ◽  
Metabolite Formation ◽  
Frequent Use ◽  
Fungal Dna ◽  
Inhibitory Potential

In the last few years, increasing importance is attached to problems caused by fungal pathogens. Current methods of preventing fungal infections remain unsatisfactory. There are several antifungal compounds which are highly effective in some cases, however, they have limitations in usage: Nephrotoxicity and other adverse effects. In addition, the frequent use of available fungistatic drugs promotes drug resistance. Therefore, there is an urgent need for the development of a novel antifungal drug with a different mechanism of action, blocking of the fungal DNA topoisomerases activity appear to be a promising idea. According to previous studies on the m-AMSA moderate inhibitory effect on fungal topoisomerase II, we have decided to study Capridine β (also acridine derivative) antifungal activity, as well as its inhibitory potential on yeast topoisomerase II (yTOPOII). Results indicated that Capridine β antifungal activity depends on the kind of strains analyzed (MICs range 0.5–64 μg mL−1) and is related to its biotransformation in the cells. An investigation of metabolite formation, identified as Capridine β reduction product (IE1) by the fungus Candida albicans was performed. IE1 exhibited no activity against fungal cells due to an inability to enter the cells. Although no antifungal activity was observed, in contrast to Capridine β, biotransformation metabolite totally inhibited the yTOPOII-mediated relaxation at concentrations lower than detected for m-AMSA. The closely related Capridine β only slightly diminished the catalytic activity of yTOPOII.

Complexes of Cu (II) with a-Ketoglutaric Acid and 1- (o-tolyl) Biguanide Synthesis, characterization and biological Activity

2019 ◽  
Vol 70 (10) ◽  
pp. 3603-3610
Author(s):  
Madalina Mihalache ◽  
Cornelia Guran ◽  
Aurelia Meghea ◽  
Vasile Bercu ◽  
Ludmila Motelica ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Biological Activity ◽  
Candida Albicans ◽  
Antifungal Activity ◽  
Copper Complexes ◽  
Substrate Adhesion ◽  
Inert Substrate

The three copper complexes having a-ketoglutaric acid (H2A) and 1- (o-tolyl) biguanide (TB) ligands have been synthesized and characterized. The proposed formulas for these complexes are: [Cu(TB)(HA)]Cl (C1), [Cu(TB)(HA)CH3COO]�H2O (C2) and [Cu(TB)(HA)](NO3) (C3) where HA represents deprotonated H2A. The complexes obtained were tested for antibacterial activity against Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 27853, antifungal activity on Candida albicans ATCC 10231 and antitumor activity on HeLa tumor cells. Due to the antitumor, antifungal, antimicrobial activity and inhibition of inert substrate adhesion, complexes synthesized could be used for potential therapeutic applications.

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