scholarly journals Predictors of hepatocellular carcinoma in patients with liver cirrhosis

2015 ◽  
Vol 61 (1) ◽  
pp. 47-50
Author(s):  
Crina Pop ◽  
B. Kozma ◽  
Silvia Drasovean ◽  
Daniela Dobru ◽  
Alina Boeriu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
Abdominal Ultrasound ◽  
Study Data ◽  
Statistical Association ◽  
Viral Etiology ◽  
Female Ratio ◽  
Male Female Ratio ◽  
Important Health ◽  
A Prospective Study

Abstract Background and aim: Hepatocellular carcinoma (HCC) is one of the most important health problem, with an increasing incidence worldwide. The aim of the present study was to determine the factors that predict HCC occurrence in a group of patients with liver cirrhosis developed on various etiologies. Material and Methods: A total of 282 consecutive patients with liver cirrhosis seen between January 1, 2013 and July 31, 2014 were enrolled in a prospective study. Data from patient’s history, physical exams, laboratory tests and abdominal ultrasound were collected. Results: 282 patients were included in the study with a median age of 59.6 and a male/female ratio of 1.38/1; 12.41% (35) were diagnosed with HCC. Alcohol consumption was documented in 19 cases (54.28%), without statistical association (p=0.621), and 7 (20%) were smokers (p=0.403). According to etiological factors of liver cirrhosis: 7 (20%) had background B virus infection, 15 (42.85%) HCV infection and 11 (31.42%) cases incriminated other causes of cirrhosis (alcohol). Chi2 test identified a statistically significant association between the occurrence of HCC and viral etiology of cirrhosis (p = 0.001, r = 18,830). No statistical association was found between Child Pugh scoring of cirrhosis and HCC (p=0.774) and a statistically significant association but inversely proportional was identified between neoplasia and obesity (p=0.008, r= -0.157). Conclusion: In conclusion the viral etiology of liver cirrhosis is found to be an important risk factor for HCC, and liver cancer was inversely associated with nutritional status.

Clinical Manifestations of Cholelithiasis in Quito, Ecuador. A Cohort Study

2021 ◽  
pp. 12
Author(s):  
◽  
◽  
Keyword(s):  
Epigastric Pain ◽  
Medical Center ◽  
Clinical Manifestations ◽  
Abdominal Ultrasound ◽  
Common Symptom ◽  
Low Back ◽  
Female Ratio ◽  
Male Female Ratio ◽  
The Right ◽  
A Prospective Study

Introduction: A prospective study was carried out, with the aim of establishing the clinical manifestations of cholelithiasis in the population of Quito, Ecuador. Methods: During the period from January 2012 to October 2017, 534 patients were referred from different outpatient clinics of the Ecuadorian Institute of Social Security to the Batan Medical Center with the diagnosis of cholelithiasis after a clinical assessment and abdominal ultrasound, to be treated surgically. Results: Sixty-nine percent of patients were female with a male-female ratio of 1:2.21. Mean age was 44.9 years. Pain was the most common symptom in our study: 95.7%. Among these patients, pain was located in the epigastrium in 49.8%, in the right hypochondrium in 45.1% and only 0.8% had low back pain. Pain ranged from moderate and even severe. The remaining 4.3% of patients had dyspepsia or were asymptomatic. Conclusions: This finding highlights the fact that epigastric pain must be always considered as a clinical manifestation on cholelithiasis.

scholarly journals Factors associated with hepatocellular carcinoma occurrence after HCV eradication in patients without cirrhosis or with compensated cirrhosis

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243473
Author(s):  
Kazumichi Abe ◽  
Hiroto Wakabayashi ◽  
Haruo Nakayama ◽  
Tomohiro Suzuki ◽  
Masahito Kuroda ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Multivariate Analysis ◽  
Survival Rates ◽  
Virologic Response ◽  
Female Ratio ◽  
Factors Affecting ◽  
Direct Acting Antiviral ◽  
Compensated Cirrhosis ◽  
Male Female Ratio ◽  
Direct Acting

The present study aimed to investigate the incidence of hepatocellular carcinoma (HCC) and factors related to HCC occurrence after direct-acting antiviral (DAA) treatment in the Fukushima Liver Academic Group (FLAG). We conducted a multicenter retrospective cohort study of 1068 patients without cirrhosis (NC) or with compensated liver cirrhosis (LC) who achieved a sustained virologic response (SVR). First, we compared the cumulative HCC incidence and survival rates in NC (n = 880) and LC (n = 188) patients without a history of HCC treatment. Second, we performed multivariate analysis of factors related to HCC occurrence after DAA treatment. Overall, the average age was 65 years, and the male/female ratio was 511/557. Thirty-nine (4%) patients developed HCC. The cumulative 4-year HCC incidence and survival rates were 3.0% and 99.8% in NC patients and 11.5% and 98.5% in LC patients, respectively. The independent factors affecting HCC occurrence identified by multivariate analysis were the serum albumin (ALB) level before SVR for NC patients and the ALBI score, platelet count, and diabetes before SVR for LC patients. The factors related to HCC occurrence differed between NC and LC patients. Careful surveillance of post-SVR patients with these risk factors is needed.

scholarly journals Is There a Place for Elastography in the Diagnosis of Hepatocellular Carcinoma?

2021 ◽  
Vol 10 (8) ◽  
pp. 1710
Author(s):  
Ana-Maria Ghiuchici ◽  
Ioan Sporea ◽  
Mirela Dănilă ◽  
Roxana Șirli ◽  
Tudor Moga ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
Shear Wave Elastography ◽  
Abdominal Ultrasound ◽  
Liver Parenchyma ◽  
Final Diagnosis ◽  
Focal Liver Lesions ◽  
Additional Information ◽  
Contrast Enhanced Ct ◽  
Contrast Enhanced

Background and Aims: Elastography can provide information regarding tissue stiffness (TS). This study aimed to analyze the elastographic features of hepatocellular carcinoma (HCC) and the factors that influence intratumoral elastographic variability in patients with liver cirrhosis. Methods: This prospective study included 115 patients with liver cirrhosis and hepatocellular carcinoma evaluated between June 2016–November 2019. A total of 88 HCC nodules visualized in conventional abdominal ultrasound (US) met the inclusion criteria and underwent elastographic evaluation. Elastographic measurements (EM) were performed in HCC and liver parenchyma using VTQ (Virtual Touch Quantification), a point shear wave elastography (pSWE) technique. In all patients, we performed contrast-enhanced ultrasound (CEUS), and the final diagnosis of HCC was established by contrast-enhanced-CT or contrast-enhanced-MRI. Results: The mean VTQ values in HCCs were 2.16 ± 0.75 m/s. TS was significantly lower in HCCs than in the surrounding liver parenchyma 2.16 ± 0.75 m/s vs. 2.78 ± 0.92 (p < 0.001). We did not find significant differences between the first five and the last five EM, and the intra-observer reproducibility was excellent ICC: 0.902 (95% CI: 0.87–0.950). However, the tumor size, heterogeneity, and depth correlated with higher intralesional stiffness variability (p < 0.001). Conclusions: VTQ brings additional information for HCC characterization. Intra-observer reproducibility for both HCC and liver parenchyma was excellent. Knowing the stiffness of HCC’s might endorse an algorithm-based approach towards focal liver lesions (FLLs) in liver cirrhosis.

scholarly journals Complications of Total Thyroidectomy in 50 Cases in The Department of Endocrine Surgery in BSMMU

2019 ◽  
Vol 17 (1) ◽  
pp. 25-29
Author(s):  
Md Alamgir Hossain Sikder ◽  
AEM Mahfuzur Rahman ◽  
Abul Khair ◽  
Md Jahangir Alam ◽  
Mohammed Rafiqul Lslam
Keyword(s):  
Total Thyroidectomy ◽  
Multinodular Goiter ◽  
Endocrine Surgery ◽  
Published Data ◽  
Female Ratio ◽  
Male Female Ratio ◽  
A Prospective Study ◽  
Surgery Department

Objective: To determine the complications of the patients undergoing total thyroidectomy. Method: A prospective study was held at Department of Endocrine Surgery in BSMMU from January 2006 to December 2006 Method: Fifty patients with multinodular goiter and carcinoma thyroid of both sexes were selected from admitted patient of endocrine surgery department. All patients were evaluated preoperatively and total thyroidectomy was done and post operative was followed up. Out of 50 patients 35 patients were female and 15 patients male, male - female ratio 1 :2.3. 40 patients were carcinoma thyroid, 10 patients were multinodular goiter. The overall incidence of postoperative complication in this series was 4. out of 50 patients 1 patient developed haematoma. 1 patient developed wound infection and 1 patient developed transient tetany on 2nd postoperative day which was improved later on. 1 patient developed a thyroid nodule 6th month after total thyroidectomy for carcinoma thyroid. In long term from total thyroidectomy 40 patients were followed up, 10 patients did not attend an subsequent follow up. Out of 40 patients 36 patients were out of complication. Conclusion: The results are comparable with the current published data and demonstrate that total thyroidectomy can performed with minimum complication rate. Journal of Surgical Sciences (2013) Vol. 17 (1) : 25-29

scholarly journals Male/female ratio of patients with hepatocellular carcinoma.

1991 ◽  
Vol 39 (5) ◽  
pp. 1060-1062
Author(s):  
Tetsuo MORIMOTO ◽  
Fujio MURAKAMI ◽  
Yasuhiko MIYOSHI ◽  
Ikuo MITANI ◽  
Hiroaki KAWANO ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Female Ratio ◽  
Male Female Ratio

Hepatocellular Carcinoma in Liver Cirrhosis: A Prospective Study

1993 ◽  
Vol 28 (6) ◽  
pp. 540-544 ◽  
Author(s):  
D. Imberti ◽  
F. Fornari ◽  
G. Sbolli ◽  
E. Buscarini ◽  
L. Squassante ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
Prospective Study ◽  
A Prospective Study

scholarly journals Clinical Utility of Alpha Fetoprotein and HCCR-1, Alone or in Combination, in Patients with Chronic Hepatitis, Liver Cirrhosis and Hepatocellular Carcinoma

2011 ◽  
Vol 30 (6) ◽  
pp. 307-315 ◽  
Author(s):  
Peng Jirun ◽  
Guoxin Zhang ◽  
Hyun Kee Kim ◽  
Seon-Ah Ha ◽  
Jin Zhongtian ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
Chronic Hepatitis ◽  
Normal Subjects ◽  
Alpha Fetoprotein ◽  
Combined Use ◽  
Significant Difference ◽  
Serum Alpha Fetoprotein ◽  
Immunohistochemical Studies ◽  
A Prospective Study

Serum alpha fetoprotein (AFP) is the most widely used tumor marker in detecting patients with hepatocellular carcinoma (HCC). However, it has been indicated that HCCR-1 (human cervical cancer oncogene 1) might be supplementary to AFP in the detection. We conducted a prospective study in 120 normal and 524 liver disease patients to evaluate the significance of simultaneous measurement of 2 tumor markers (AFP and HCCR-1) in the diagnosis of HCC through the cohort study in Korea and China. We also performed immunohistochemical studies using 25 normal subjects (N), 32 liver cirrhosis (LC) and 116 HCC tissues. The sensitivities of AFP (20 ng/mL) and HCCR-1 (10 ng/mL) in HCC were 55.8% (164/294) and 44.2% (130/294), respectively. When AFP was combined with HCCR-1, sensitivities increased to 4.2% (N), 12.7% (chronic hepatitis; CH), 50.0% (LC), and 77.2% (HCC), respectively. Although there was no significant difference in the diagnostic rate for HCC between AFP and HCCR-1, many cases for AFP-negative HCC were positive for HCCR-1 and vice versa. Moreover, the combined use of AFP and HCCR-1 improved the diagnostic rate to 70.8% in small HCC (< 2 cm) and 81.6% in large HCC (≥ 2 cm), respectively. AFP and HCCR-1 are independent markers. Our result suggests that the HCCR-1 could be an useful biomarker for HCC while the diagnostic rate could be significantly improved in the combined use of HCCR-1 and AFP.

scholarly journals Profile of congenital digital anomalies in children seen in two tertiary health facilities in Southern Nigeria

2020 ◽  
Vol 7 (4) ◽  
pp. 966
Author(s):  
Okoro Philemon Ekemenye ◽  
Otene Cletus Ikechukwu
Keyword(s):  
Surgical Care ◽  
Health Facilities ◽  
Female Ratio ◽  
Limb Anomalies ◽  
Southern Nigeria ◽  
Male Female Ratio ◽  
Congenital Limb ◽  
The Common ◽  
A Prospective Study ◽  
And Training

Background: Anomalies of the digits are among the common congenital limb anomalies seen worldwide. Whereas the majority of these digital malformations are relatively minor and require simple treatment, some of them are complex and often associated with other anomalies and systemic disorders. Reports on the occurrence of these anomalies and their treatment are scanty in our region. The study sought to evaluate the burden of these digital anomalies among paediatric patients seen in our centres and outcome of treatment.Methods: Study was carried out as a prospective study in two tertiary health facilities in Southern Nigeria between June 2014 and May 2019. Data obtained and analyzed were the patients’ gender, age, family history, type of digital anomaly, the limb/s involved, other limb anomalies, systemic disorders, treatment given, outcome, and duration of follow up.Results: A total of 113 children with anomalies of the fingers and or toes were seen during the study period, but 104 were analyzed. They comprised, 63 (60.6%) were males and 41 (39.4%) females giving a male female ratio of 1.5:1. Polydactyly was by far the commonest digital anomaly and the upper limbs were mostly affected. Associated anomalies contributed significantly to morbidity and mortality in those cases.Conclusions: Digital anomalies are fairly common surgical problems in our region. Though majority of cases are mild and are easily treated, the more complex ones still pose a challenge to treatment in our practice. There is need for more interest and training among surgeons in our region to improve the surgical care and outcome of treatment of these digital anomalies in our region.

scholarly journals A prospective study of clinico-radiological assesment and management of obstructive jaundice in Mmimsr, Mullana

2021 ◽  
Author(s):  
Karaninder Singh Wilku ◽  
Himank Gandhi
Keyword(s):  
Early Diagnosis ◽  
Obstructive Jaundice ◽  
Prospective Study ◽  
Abdominal Ultrasound ◽  
Vital Role ◽  
Diagnosis And Treatment ◽  
Female Ratio ◽  
Cbd Stones ◽  
Benign Pathology ◽  
A Prospective Study

Background: Obstructive jaundice poses diagnostic and therapeutic challenges. This study was undertaken to highlight the clinical and radiological assessment of obstructive jaundice in our setting and to approach for early diagnosis and treatment before irreversible tissue insult sets in.Methods: Present study was prospective study conducted at Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana, Ambala. Data were collected on prescribed proforma and analyzed stastically.Results: A total of 50 patients were studied. It is more common in productive adult with the mean age of 51.04±12.40 years. The male to female ratio was 1:1.08. Majority of the patients were having benign pathology (62%) and choledocholithiasis was the commonest benign cause. Abdominal ultrasound was the diagnostic imaging done in all patients and revealed dilated CBD (>1 cm) in 78% cases, dilated IHBR in 96%of cases and multiple CBD stones in 78.3% of cases. CT was reserved for suspected malignant and MRCP was planned in stone or benign causes. 70% patients were selected for ERCP and 62% of patients underwent definitive open procedure viz choledocholithotomy (40%), hepaticojejunostomy (12%).Conclusions: Obstructive jaundice in our study was more prevalent in females and the cause is mostly CBD stones. The result suggests that early diagnosis and treatment plays vital role in the prognosis of patients with obstructive jaundice.  

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