Green Tea Extract Protects against Early Alcohol-Induced Liver Injury in Rats

2002 ◽  
Vol 383 (3-4) ◽  
pp. 663-670 ◽  
Author(s):  
G.E. Arteel ◽  
T. Uesugi ◽  
L.N. Bevan ◽  
E. Gäbele ◽  
M.D. Wheeler ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Injury ◽  
Green Tea ◽  
Epigallocatechin Gallate ◽  
Average Concentration ◽  
Green Tea Extract ◽  
Protein Levels ◽  
Polyphenolic Extract ◽  
Male Wistar Rats ◽  
Tea Extract

Abstract Oxidants have been shown to be involved in alcoholinduced liver injury. This study was designed to test the hypothesis that the antioxidant polyphenolic extract of green tea, comprised predominantly of epigallocatechin gallate, protects against early alcoholinduced liver injury in rats. Male Wistar rats were fed highfat liquid diets with or without ethanol (10 14 g kg 1 day 1) and green tea (300 mg kg 1 day 1) continuously for 4 weeks using an intragastric enteral feeding protocol. Mean body weight gains (~4 g/day) were not significantly different between treatment groups, and green tea extract did not the affect average concentration or the cycling of urine ethanol concentrations (0 550 mg dl 1 day 1). After 4 weeks, serum ALT levels were increased significantly about 4-fold over control values (35±3 IU/l) by enteral ethanol (114±18); inclusion of green tea extract in the diet significantly blunted this increase (65±10). Enteral ethanol also caused severe fatty accumulation, mild inflammation, and necrosis in the liver. While not affecting fat accumulation or inflammation, green tea extract significantly blunted increases in necrosis caused by ethanol. Furthermore, ethanol significantly increased the accumulation of protein adducts of 4-hydroxynonenal, a product of lipid peroxidation and an index of oxidative stress; green tea extract blocked this effect almost completely. TNFa protein levels were increased in liver by alcohol; this phenomenon was also blunted by green tea extract. These results indicate that simple dietary antioxidants, such as those found in green tea, prevent early alcoholinduced liver injury, most likely by preventing oxidative stress.

Green tea extract and its major component epigallocatechin gallate inhibits hepatitis B virus in vitro

2008 ◽  
Vol 78 (3) ◽  
pp. 242-249 ◽  
Author(s):  
Jun Xu ◽  
Jue Wang ◽  
Fei Deng ◽  
Zhihong Hu ◽  
Hualin Wang
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Green Tea ◽  
Epigallocatechin Gallate ◽  
Green Tea Extract ◽  
B Virus ◽  
Tea Extract

Potential role of green tea extract and epigallocatechin gallate in preventing bisphenol A-induced metabolic disorders in rats: Biochemical and molecular evidence

Phytomedicine ◽  
2021 ◽  
pp. 153754
Author(s):  
Mahdieh Sadat Mohsenzadeh ◽  
Bibi Marjan Razavi ◽  
Mohsen Imenshahidi ◽  
Seyed Abbas Tabatabaee Yazdi ◽  
Seyed Ahmad Mohajeri ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Green Tea ◽  
Metabolic Disorders ◽  
Potential Role ◽  
Epigallocatechin Gallate ◽  
Green Tea Extract ◽  
Molecular Evidence ◽  
Tea Extract

scholarly journals Efektivitas Ekstrak Teh Hijau (Camellia sinensis L.) terhadap Penurunan Kadar Glukosa Darah Puasa Tikus Wistar (Rattus norvegicus) yang diInduksi Aloksan

2020 ◽  
Vol 15 (1) ◽  
pp. 86-97
Author(s):  
Hafshah . ◽  
Kristina Simanjuntak
Keyword(s):  
Green Tea ◽  
Fasting Blood Glucose ◽  
White Male ◽  
Green Tea Extract ◽  
Male Rats ◽  
Test Results ◽  
Male Wistar Rats ◽  
Bonferroni Test ◽  
Tea Extract ◽  
Post Hoc

The sufferers of Diabetes Mellitus (DM) in Indonesia is the highest with fourth number in the world, with a mortality rate of 1.2 million in 2012. Because of it, DM research using antihyperglycemic green tea is needed. This study aims to determine the effectiveness of green tea extracts on decreasing fasting blood glucose (KGDP) levels in alloxan-induced white male Wistar rats. Samples were 30 male rats, aged 8-12 weeks, weight ± 200 grams. Rats were grouped into 6 groups with the first group (K1) as a control, the second group (K2) induced alloxan, the third group (K3) induced alloxan with glibenclamide, the fourth group (K4), the fifth group (K5), and the sixth group (K6) induced alloxan with green tea extract as the treatment with dose of green tea extract, 200 mg/kg, 400 mg/kg, and 800 mg/kg. The first, FBG level examination is done 3 days after induction of alloxan using a glucometer. Giving green tea extract was given for 16 days orally, then FBG level re-examined from the tail of rats. One Way ANOVA Test Results, there is the effectiveness of green tea extract on reducing FBG level (p = 0,000). The post hoc Bonferroni test showed that giving 800 mg/kg of green tea extract was the best dose in reducing KGDP close to normal (p = 0,000).

scholarly journals Green Tea Extract Ameliorates Learning and Memory Deficits in Ischemic Rats via Its Active Component Polyphenol Epigallocatechin-3-gallate by Modulation of Oxidative Stress and Neuroinflammation

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Kuo-Jen Wu ◽  
Ming-Tsuen Hsieh ◽  
Chi-Rei Wu ◽  
W. Gibson Wood ◽  
Yuh-Fung Chen
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Learning And Memory ◽  
Green Tea ◽  
Memory Impairment ◽  
Memory Deficits ◽  
Green Tea Extract ◽  
Morris Water Maze Test ◽  
Learning And Memory Deficits ◽  
Tea Extract

Ischemic stroke results in brain damage and behavioral deficits including memory impairment. Protective effects of green tea extract (GTex) and its major functional polyphenol (−)-epigallocatechin gallate (EGCG) on memory were examined in cerebral ischemic rats. GTex and EGCG were administered 1 hr before middle cerebral artery ligation in rats. GTex, EGCG, and pentoxifylline (PTX) significantly improved ishemic-induced memory impairment in a Morris water maze test. Malondialdehyde (MDA) levels, glutathione (GSH), and superoxide dismutase (SOD) activity in the cerebral cortex and hippocampus were increased by long-term treatment with GTex and EGCG. Both compounds were also associated with reduced cerebral infraction breakdown of MDA and GSH in the hippocampus. Inin vitroexperiments, EGCG had anti-inflammatory effects in BV-2 microglia cells. EGCG inhibited lipopolysaccharide- (LPS-) induced nitric oxide production and reduced cyclooxygenase-2 and inducible nitric oxide synthase expression in BV-2 cells. GTex and its active polyphenol EGCG improved learning and memory deficits in a cerebral ischemia animal model and such protection may be due to the reduction of oxidative stress and neuroinflammation.

Green tea extract and its major polyphenol (−)-epigallocatechin gallate improve muscle function in a mouse model for Duchenne muscular dystrophy

2006 ◽  
Vol 290 (2) ◽  
pp. C616-C625 ◽  
Author(s):  
Olivier M. Dorchies ◽  
Stéphanie Wagner ◽  
Ophélie Vuadens ◽  
Katri Waldhauser ◽  
Timo M. Buetler ◽  
...  
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Mouse Model ◽  
Green Tea ◽  
Epigallocatechin Gallate ◽  
Green Tea Extract ◽  
Triceps Surae ◽  
Muscle Quality ◽  
Muscle Adaptation ◽  
Tea Extract

Duchenne muscular dystrophy is a frequent muscular disorder caused by mutations in the gene encoding dystrophin, a cytoskeletal protein that contributes to the stabilization of muscle fiber membrane during muscle activity. Affected individuals show progressive muscle wasting that generally causes death by age 30. In this study, the dystrophic mdx 5Cv mouse model was used to investigate the effects of green tea extract, its major component (−)-epigallocatechin gallate, and pentoxifylline on dystrophic muscle quality and function. Three-week-old mdx 5Cv mice were fed for either 1 or 5 wk a control chow or a chow containing the test substances. Histological examination showed a delay in necrosis of the extensor digitorum longus muscle in treated mice. Mechanical properties of triceps suræ muscles were recorded while the mice were under deep anesthesia. Phasic and tetanic tensions of treated mice were increased, reaching values close to those of normal mice. The phasic-to-tetanic tension ratio was corrected. Finally, muscles from treated mice exhibited 30–50% more residual force in a fatigue assay. These results demonstrate that diet supplementation of dystrophic mdx 5Cv mice with green tea extract or (−)-epigallocatechin gallate protected muscle against the first massive wave of necrosis and stimulated muscle adaptation toward a stronger and more resistant phenotype.

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