scholarly journals GC-MS analysis of mango stem bark extracts (Mangifera indica L.), Haden variety. Possible contribution of volatile compounds to its health effects

2021 ◽  
Vol 19 (1) ◽  
pp. 27-38
Author(s):  
Alberto J. Núñez Sellés ◽  
Juan Agüero Agüero ◽  
Lauro Nuevas Paz
Keyword(s):  
Volatile Compounds ◽  
Mangifera Indica ◽  
Pharmaceutical Formulations ◽  
Stem Bark ◽  
Volatile Components ◽  
Analgesic Effects ◽  
Preparative Column Liquid Chromatography ◽  
Bioactive Ingredients ◽  
Anti Inflammatory ◽  
First Time

Abstract Mango stem bark extracts (MSBE) have been used as bioactive ingredients for nutraceutical, cosmeceutical, and pharmaceutical formulations due to their antioxidant, anti-inflammatory, and analgesic effects. We performed the MSBE preparative column liquid chromatography, which led to the resolution and identification by GC-MS of 64 volatile compounds: 7 hydrocarbons, 3 alcohols, 1 ether, 3 aldehydes/ketones, 7 phenols, 20 terpenoids (hydrocarbons and oxygenated derivatives), 9 steroids, 4 nitrogen compounds, and 1 sulphur compound. Major components were β-elemene, α-guaiene, aromadendrene, hinesol, 1-octadecene, β-eudesmol, methyl linoleate, juniper camphor, hinesol, 9-methyl (3β,5α)-androstan-3-ol, γ-sitosterol, β-chamigrene, 2,5-dihydroxymethyl-phenetylalcohol, N-phenyl-2-naphtaleneamine, and several phenolic compounds. The analysis of MSBE, Haden variety, by GC-MS is reported for the first time, which gives an approach to understand the possible synergistic effect of volatile compounds on its antioxidant, analgesic, and anti-inflammatory effects. The identification of relevant bioactive volatile components from MSBE extracts, mainly terpenes from the eudesmane family, will contribute to correlate its chemical composition to previous determined pharmacological effects.

scholarly journals The anti-inflammatory activity of standard aqueous stem bark extract of Mangifera indica L. as evident in inhibition of Group IA sPLA2

2016 ◽  
Vol 88 (1) ◽  
pp. 197-209 ◽  
Author(s):  
BHADRAPURA LAKKAPPA DHANANJAYA ◽  
SUDHARSHAN SHIVALINGAIAH
Keyword(s):  
Mangifera Indica ◽  
Direct Interaction ◽  
Pharmaceutical Formulations ◽  
Stem Bark ◽  
Inflammatory Activity ◽  
Bark Extract ◽  
Binding Studies ◽  
Edema Formation ◽  
Stem Bark Extract ◽  
Anti Inflammatory

ABSTRACT The standard aqueous stem bark extract is consumed as herbal drink and used in the pharmaceutical formulations to treat patients suffering from various disease conditions in Cuba. This study was carried out to evaluate the modulatory effect of standard aqueous bark extract of M. indica on Group IA sPLA2. M. indica extract, dose dependently inhibited the GIA sPLA2 (NN-XIa-PLA2) activity with an IC50 value 8.1 µg/ml. M. indica extract effectively inhibited the indirect hemolytic activity up to 98% at ~40 µg/ml concentration and at various concentrations (0-50 µg/ml), it dose dependently inhibited the edema formation. When examined as a function of increased substrate and calcium concentration, there was no relieve of inhibitory effect on the GIA sPLA2. Furthermore, the inhibition was irreversible as evidenced from binding studies. It is observed that the aqueous extract ofM. indica effectively inhibits sPLA2 and it is associated inflammatory activities, which substantiate their anti-inflammatory properties. The mode of inhibition could be due to direct interaction of components present in the extract, with sPLA2 enzyme. Further studies on understanding the principal constituents, responsible for the anti-inflammatory activity would be interesting to develop this into potent anti-inflammatory agent.

scholarly journals Investigation of the Anti-Inflammatory and Analgesic Activities of Ethanol Extract of Stem Bark of SonapathaOroxylum indicum In Vivo

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
K. Lalrinzuali ◽  
M. Vabeiryureilai ◽  
Ganesh Chandra Jagetia
Keyword(s):  
Inflammatory Diseases ◽  
Ethanol Extract ◽  
Stem Bark ◽  
The Body ◽  
Protective Measure ◽  
Analgesic Effects ◽  
Oroxylum Indicum ◽  
Anti Inflammatory ◽  
Analgesic Activities

Inflammation is all a pervasive phenomenon, which is elicited by the body in response to obnoxious stimuli as a protective measure. However, sustained inflammation leads to several diseases including cancer. Therefore it is necessary to neutralize inflammation. Sonapatha (Oroxylum indicum), a medicinal plant, is traditionally used as a medicine in Ayurveda and other folk systems of medicine. It is commonly used to treat inflammatory diseases including rheumatoid arthritis and asthma. Despite this fact its anti-inflammatory and analgesic effects are not evaluated scientifically. Therefore, the anti-inflammatory and analgesic activities of Sonapatha (Oroxylum indicum) were studied in Swiss albino mice by different methods. The hot plate, acetic acid, and tail immersion tests were used to evaluate the analgesic activity whereas xylene-induced ear edema and formalin induced paw edema tests were used to study the anti-inflammatory activity of Sonapatha. The administration of mice with 250 and 300 mg/kg b.wt. ofO. indicumreduced pain and inflammation indicating that Sonapatha possesses analgesic and anti-inflammatory activities. The maximum analgesic and anti-inflammatory activities were observed in mice receiving 300 mg/kg b.wt. ofO. indicumethanol extract.Our study indicates thatO. indicumpossesses both anti-inflammatory and analgesic activities and it may be useful as an anti-inflammatory agent in the inflammation related disorders.

scholarly journals Cytotoxic and Anti-Inflammatory Activities of Dihydroisocoumarin and Xanthone Derivatives from Garcinia picrorhiza

Molecules ◽  
2021 ◽  
Vol 26 (21) ◽  
pp. 6626
Author(s):  
Edwin R. Sukandar ◽  
Sutin Kaennakam ◽  
Pia Raab ◽  
Xuehong Nöst ◽  
Kitiya Rassamee ◽  
...  
Keyword(s):  
2D Nmr ◽  
Stem Bark ◽  
No Production ◽  
Hep G2 ◽  
Pharmacological Studies ◽  
Ic50 Values ◽  
Hela S3 ◽  
Anti Inflammatory ◽  
First Time ◽  
Mcf 7

Garcinia picrorhiza, a woody plant native to Sulawesi and Maluku Islands, Indonesia, has been traditionally used as a wound healing ointment. In our continuous search for bioactive compounds from this plant, 15 phenolic compounds were isolated from its stem bark, including a previously undescribed dihydroisocoumarin, 2′-hydroxyannulatomarin, and two undescribed furanoxanthones, gerontoxanthone C hydrate and 3′-hydroxycalothorexanthone. The structures of the new metabolites were elucidated on the basis of spectroscopic analysis, including 1D and 2D NMR and HRESIMS. Gerontoxanthone C hydrate possessed cytotoxicity against four cancer cells (KB, HeLa S3, MCF-7, and Hep G2) with IC50 values ranging from 5.6 to 7.5 µM. Investigation on the anti-inflammatory activities showed that 3′-hydroxycalothorexanthone inhibited NO production in RAW 264.7 and BV-2 cell lines with IC50 values of 16.4 and 13.8 µM, respectively, whereas only (−)-annulatomarin possessed inhibition activity on COX-2 enzyme over 10% at 20 µM. This work describes the presence of 3,4-dihydroisocoumarin structures with a phenyl ring substituent at C-3, which are reported the first time in genus Garcinia. These findings also suggest the potential of furanxanthone derivatives as cytotoxic and anti-inflammatory agents for further pharmacological studies.

scholarly journals Volatiles of the Inflorescences of the Madeiran Orchids, Goodyera macrophylla Lowe and Gennaria diphylla (Link) Parl. and Their Role in Pollination

2007 ◽  
Vol 2 (4) ◽  
pp. 1934578X0700200
Author(s):  
Francisco M. Fernandes ◽  
A. Cristina Figueiredo ◽  
José G. Barroso ◽  
Luís G. Pedro ◽  
Christopher C. Wilcock ◽  
...  
Keyword(s):  
Volatile Compounds ◽  
Floral Scent ◽  
Volatile Components ◽  
Rare Endemic ◽  
First Time ◽  
Headspace Sorption ◽  
Type Apparatus

Goodyera macrophylla, considered a rare endemic, and Gennaria diphylla are two native terrestrial Orchidaceae species that can be found mainly in Madeiran Laurisilva. The volatile compounds contributing to the floral scent of these two Madeiran orchids were analysed and compared for the first time. The volatiles, isolated by distillation-extraction in a Likens-Nickerson-type apparatus, and those extracted by headspace sorption, were analysed by GC and GC-MS. The main volatile components isolated by distillation-extraction were γ-terpinene (13%) and n-nonanal (11%) in G. macrophylla and n-octacosane (19%) and n-heptacosane (13%) in G. diphylla. The main volatile components isolated by headspace sorption were p-cymene (21%), α-pinene (15%) and linalool (14%) in G. macrophylla and cis-arbusculone (28%) and lilac alcohol (26%) in G. diphylla. The importance of the volatiles in the pollination of these orchids is discussed.

scholarly journals Triterpenoids from Phyllanthus acidus (L.) Skeels

2019 ◽  
Vol 2 (2) ◽  
pp. 71-75 ◽  
Author(s):  
Huy Thuc Duong ◽  
Hung Huu Nguyen ◽  
Tuyet Thi Anh Nguyen ◽  
Hao Xuan Bui
Keyword(s):  
Plant Species ◽  
Spectroscopic Analysis ◽  
Folk Medicine ◽  
Ethanol Extract ◽  
Stem Bark ◽  
Nmr Data ◽  
Phyllanthus Acidus ◽  
Anti Inflammatory ◽  
First Time

The genus Phyllanthus (Phyllanthaceae) includes more than 900 plant species found in tropical and subtropical regions. Many of these species are widely used in folk medicine. The leaves, roots, and stem bark of Phyllanthus acidus (L.) Skeels have been used in Vietnamese folk medicine as an antibacterial, antiviral, analgesic, anti-inflammatory, neuroprotective, hepatoprotective, antifibrotic. From the ethanol extract of the roots of Phyllanthus acidus (L.) Skeels growing in Binh Thuan province, six compounds phyllanthol (1), glochidone (2), lupeol (3), glochidonol (4), 􀀱-lupene (5), and spruceanol (6) were isolated. Their structures were established by extensive spectroscopic analysis as well as comparison with NMR data in the literatures. This is the first time that compounds 4-6 were found in Phyllanthus acidus (L.) Skeels.

Anti-inflammatory and analgesic effects of Careya arborea stem bark in experimental animal models

2006 ◽  
Vol 9 (1) ◽  
Author(s):  
R Sambathkumar ◽  
T Sivakumar ◽  
R Shanmuga Sundaram ◽  
P Sivakumar ◽  
R Nethaji ◽  
...  
Keyword(s):  
Animal Models ◽  
Experimental Animal ◽  
Stem Bark ◽  
Experimental Animal Models ◽  
Analgesic Effects ◽  
Anti Inflammatory

scholarly journals Volatile Compounds Content, Physicochemical Parameters, and Antioxidant Activity of Beers with Addition of Mango Fruit (Mangifera Indica)

Molecules ◽  
2020 ◽  
Vol 25 (13) ◽  
pp. 3033 ◽  
Author(s):  
Alan Gasiński ◽  
Joanna Kawa-Rygielska ◽  
Antoni Szumny ◽  
Anna Czubaszek ◽  
Justyna Gąsior ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Volatile Compounds ◽  
Physicochemical Parameters ◽  
Mangifera Indica ◽  
Volatile Components ◽  
Polyphenol Content ◽  
Volatile Composition ◽  
Mango Fruit ◽  
Trained Panel ◽  
Mango Pulp

This study was performed to determine the possibility of using mango fruit (Mangifera indica) in brewing technology. The aim of using the SPME-HS-GC-MS technique was to assess what changes occurred in the volatile composition of mango beers brewed in this study. Mango fruit was added to the beer in five different forms to ascertain what kind of preparation should be used to improve beer aroma. Analysis of the volatile components in mango beer showed that beer without mango addition was characterized by the lowest content of volatile compounds (1787.84 µg/100 mL). The addition of mango fruit increased the concentration of compounds, such as α-pinene, β-myrcene, terpinolene, α-terpineol, cis-β-ocimene, caryophyllene, and humulene, in beer. Beer prepared with mango pulp addition was characterized by the highest concentration of volatile components from mango beers (2112.15 µg/100 mL). Furthermore, beers with mango addition were characterized by a higher polyphenol content (up to 44% higher than control beer) and antioxidant activity than control beer and were evaluated by a trained panel as having a better taste and aroma than beer without fruit addition.

Evaluation of anti-inflammatory and analgesic activities and the phytochemical study of Astragalus arbusculinus gum in animal models

2015 ◽  
Vol 26 (4) ◽  
Author(s):  
Asie Shojaii ◽  
Manijeh Motevalian ◽  
Nazanin Rahnama
Keyword(s):  
Aqueous Extract ◽  
Wistar Rats ◽  
Inflammatory Diseases ◽  
Phytochemical Study ◽  
Analgesic Effects ◽  
Male Wistar Rats ◽  
Anti Inflammatory ◽  
Analgesic Activities ◽  
First Time ◽  
Different Doses

AbstractThe importance of inflammatory diseases and side effects of conventional drugs necessitate the finding of new anti-inflammatory agents from natural sources. In this study, for the first time, the anti-inflammatory and analgesic effects of the aqueous extract ofThirty-five male Wistar rats were divided into five groups and pretreated with different doses ofThe extract ofThe aqueous extract of

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