Fabrication of PANI-modified PVDF nanofibrous yarn for pH sensor

Abstract In recent years, with the rise of an intelligent concept, oral and maxillofacial surgery smart dressing had also attracted the interest of researchers, especially for the pH sensor with flexible medium. In this study, polyvinylidene fluoride (PVDF) nanofibrous yarn was fabricated by a conjugate electrospinning process and modified with in situ polymerization of polyaniline (PANI) forming a PANI/PVDF yarn. By a weaving process, these yarns could be weaved into a fabric. It was found that both the PANI/PVDF yarn and the fabric showed a sensitivity to pH, about −48.53 mV per pH for yarn and −38.4 mVper pH for fabric, respectively, in the pH range of 4.0–8.0. These results indicated that the prepared PANI-modified PVDF yarn and fabric might have a potential application in intelligent oral and maxillofacial surgery dressings for monitoring wound healing.

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Antiseptic negative pressure instillation therapy for the treatment of septic wound healing deficits in oral and maxillofacial surgery

Journal of Cranio-Maxillofacial Surgery ◽

10.1016/j.jcms.2018.12.006 ◽

2019 ◽

Vol 47 (3) ◽

pp. 389-393 ◽

Cited By ~ 2

Author(s):

Fabian Matthias Eckstein ◽

Valesca Pinsel ◽

Matthias Christian Wurm ◽

André Wilkerling ◽

Eva-Maria Dietrich ◽

...

Keyword(s):

Wound Healing ◽

Negative Pressure ◽

Maxillofacial Surgery ◽

Oral And Maxillofacial Surgery ◽

Instillation Therapy ◽

Septic Wound

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Printed 2D Proton Sensor for In-Situ Measurement in Glue Lines

Proceedings ◽

10.3390/proceedings2130990 ◽

2018 ◽

Vol 2 (13) ◽

pp. 990 ◽

Cited By ~ 1

Author(s):

Matic Krivec ◽

Thomas Stockinger ◽

Johanna Zikulnig ◽

Friedrich Eibenst ◽

Uwe Müller

Keyword(s):

Cross Talk ◽

Linear Response ◽

Ph Sensor ◽

In Situ Measurements ◽

Cross Linking ◽

Sensitive Material ◽

Signal Change ◽

Ph Range ◽

Pani Layer

A screen printed pH sensor was developed using a PANI layer as a proton sensitive material for the in-situ measurements of matrix cross-linking. The sensor showed a linear response in a broad pH range (3–10) and had an evident cross-talk to Cl− ions. Preliminary in-situ measurements showed a substantial signal change during the cross-linking process.

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A simplified methodology: pH sensing using an in situ fabricated Ir electrode under neutral conditions

Journal of Solid State Electrochemistry ◽

10.1007/s10008-021-05017-6 ◽

2021 ◽

Author(s):

Yuqi Chen ◽

Xiuting Li ◽

Danlei Li ◽

Christopher Batchelor-McAuley ◽

Richard G. Compton

Keyword(s):

Ph Sensor ◽

Iridium Oxide ◽

Ph Sensitive ◽

Ph Sensing ◽

Ph Dependency ◽

Acidic Conditions ◽

Ph Range ◽

Neutral Conditions ◽

Electrochemical Fabrication

AbstractHerein, a simplified fabrication method for the producing of a pH-sensitive iridium electrode is developed. The in situ electrochemical fabrication of an iridium oxide film is optimized and shown to be achievable under neutral conditions rather than the acidic conditions hitherto employed. The formation of a pH sensitive Ir(III/IV) hydrous film is confirmed via XPS. The amperometric pH-sensing properties of this electrochemically generated material were investigated using square wave voltammetry. In the pH range 2–13, the iridium oxide redox signal has a pH dependency of 86.1 ± 1.1 mV per pH unit for midpoint potentials with uncertainties being ± 0.01–0.05 pH. Finally, the newly developed pH sensor was used to measure the pH of a natural water sample with excellent results as compared to a conventional glass pH probe.

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Enhanced Platelet-Rich Plasma (ePRP) Stimulates Wound Healing through Effects on Metabolic Reprogramming in Fibroblasts

International Journal of Molecular Sciences ◽

10.3390/ijms222312623 ◽

2021 ◽

Vol 22 (23) ◽

pp. 12623

Author(s):

Hsin-Pei Weng ◽

Yuan-Yang Cheng ◽

Hsin-Lun Lee ◽

Tai-Yi Hsu ◽

Yu-Tang Chang ◽

...

Keyword(s):

Wound Healing ◽

Growth Factors ◽

Energy Metabolism ◽

Metabolic Regulation ◽

Platelet Rich Plasma ◽

Maxillofacial Surgery ◽

Dermal Fibroblasts ◽

Metabolic Reprogramming ◽

Metabolic Effects ◽

Oral And Maxillofacial Surgery

As a source of growth factors for expediting wound healing and tissue regeneration, plasma-rich plasma (PRP) has been extensively applied in diverse fields including orthopaedics, ophthalmology, oral and maxillofacial surgery, dentistry, and gynaecology. However, the function of PRP in metabolic regulations remains enigmatic. A standardized method was devised herein to enrich growth factors and to lyophilize it as enhanced PRP (ePRP) powder, which could become ubiquitously available without mechanical centrifugation in clinical practice. To identify metabolic reprogramming in human dermal fibroblasts under ePRP treatment, putative metabolic targets were identified by transcriptome profiling and validated for their metabolic effects and mechanism. ePRP does not only promote wound healing but re-aligns energy metabolism by shifting to glycolysis through stimulation of glycolytic enzyme activity in fibroblasts. On the contrary, oxygen consumption rates and several mitochondrial respiration activities were attenuated in ePRP-treated fibroblasts. Furthermore, ePRP treatment drives the mitochondrial resetting by hindering the mitochondrial biogenesis-related genes and results in a dampened mitochondrial mass. Antioxidant production was further increased by ePRP treatment to prevent reactive oxygen species formation. Besides, ePRP also halts the senescence progression of fibroblasts by activating SIRT1 expression. Importantly, the glycolytic inhibitor 2-DG can completely reverse the ePRP-enhanced wound healing capacity, whereas the mitochondrial inhibitor oligomycin cannot. This is the first study to utilize PRP for comprehensively investigating its effects on the metabolic reprogramming of fibroblasts. These findings indicate that PRP’s primary metabolic regulation is to promote metabolic reprogramming toward glycolytic energy metabolism in fibroblasts, preserving redox equilibrium and allowing anabolic pathways necessary for the healing and anti-ageing process.

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Influence of Trans-operative Complications on Socket Healing Following Dental Extractions

The Journal of Contemporary Dental Practice ◽

10.5005/jcdp-8-1-52 ◽

2007 ◽

Vol 8 (1) ◽

pp. 52-59 ◽

Cited By ~ 10

Author(s):

Wasiu Lanre Adeyemo ◽

Akinola Ladipo Ladeinde ◽

Mobolanle Olugbemiga Oguniewe

Keyword(s):

Wound Healing ◽

Alveolar Bone ◽

Bone Fractures ◽

Maxillofacial Surgery ◽

University Teaching ◽

Oral And Maxillofacial Surgery ◽

Extraction Site ◽

Operative Complications ◽

Socket Healing ◽

Healing Assessment

Abstract Aim Extraction healing complications have been attributed to several factors. The influence of trans-operative complications on an extraction site wound healing was the focus of this investigation. Methods and Materials This prospective study was conducted at the Oral Surgery Clinic of the Department of Oral and Maxillofacial Surgery of the Lagos University Teaching Hospital (LUTH) in Nigeria . Subjects selected were those referred for one or two adjacent extractions and who satisfied the inclusion criteria for the study. The relevant pre-operative information recorded for each patient were age and sex of patient, indications for extraction, time taken to extract the tooth, tooth/teeth removed, and any trans-operative complications. Extractions were performed with dental forceps, elevators, or both under local anaesthesia. Patients were blindly evaluated on the third and seventh post-operative day for socket healing assessment without reference to preoperative information on the patients. Results Seventy-three (24.25%) of 301 teeth considered for socket healing assessment had various transoperative complications due to accidental crown, root, or alveolar bone fractures. Of the 73 extractions with trans-operative complications during extraction, 18 developed a socket healing complication, while 17 of the 228 extractions without trans-operative complications developed socket healing complications (p = .000). The mean (SD) time taken to extract teeth developing healing complications was also found to be significantly longer than those without healing complications (p < .01). Conclusions The study demonstrated the combination of tooth/bone fragments in the socket and increased time of extraction due to trans-operative complications and accidents predispose to the development of extraction site wound healing disturbance. Citation Adeyemo WL, Ladeinde AL, Ogunlewe MO. Influence of Trans-operative Complications on Socket Healing Following Dental Extractions. J Contemp Dent Pract 2007 January;(8)1:052-059.

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The Effect of Black Cumin (Nigella sativa sp.) Gel Extract in Wound Healing Process Post Tooth Extraction

Journal of Biomimetics Biomaterials and Biomedical Engineering ◽

10.4028/www.scientific.net/jbbbe.48.41 ◽

2020 ◽

Vol 48 ◽

pp. 41-46

Author(s):

Rahmi Syaflida Dalimunte ◽

Olivia Avriyanti Hanafiah ◽

Hendry Rusdy

Keyword(s):

Wound Healing ◽

Treatment Group ◽

Tooth Extraction ◽

Nigella Sativa ◽

Healing Process ◽

Maxillofacial Surgery ◽

Control Group ◽

Wound Healing Process ◽

Oral And Maxillofacial Surgery ◽

Black Cumin

Objective: This study aims to investigate the effects of black cumin extract (Nigella sativa) on the process of wound healing in tooth extraction sockets. Material and Methods: This study involved 24 patients from the Department of Oral and Maxillofacial Surgery grouped into the control and treatment groups. After extracting the first or second molar left or right in adult patients, the black cumin extractwas applied to the socket in the treatment group as soon as possible while it was not applied in the control group. The sockets were divided into 1,2,3 groups, which were treated as black cumin extracts of 10%, 12%, and 14% respectively. On day 1,3,7, patients were recalled and sockets size were calculated to analyze wound healing. Results: Black cumin was found to be able to make the wound healing faster in the treatment group when compared to the control group. Although the effect was not immediately apparent on the second day, on the seventh day the group treated with black cumin extract had a smaller sizing average compared to the control group. The concentration of 12% black cumin extract was found to have the best effect on wound healing. Significance of findings: Black cumin extract can make wound healing in tooth extraction sockets in patients.

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A Double Blind Study on the Efficacy of Local Application of Hemocoagulase Solution in Wound Healing

The Journal of Contemporary Dental Practice ◽

10.5005/jp-journals-10024-1334 ◽

2013 ◽

Vol 14 (3) ◽

pp. 394-400 ◽

Cited By ~ 2

Author(s):

Sachin Aslam ◽

PG Francis ◽

BHS Rao ◽

M Ummar ◽

JK Issac ◽

...

Keyword(s):

Wound Healing ◽

Epithelial Cells ◽

Maxillofacial Surgery ◽

Blind Study ◽

Local Application ◽

Dental Extraction ◽

Hemostatic Agent ◽

Oral And Maxillofacial Surgery ◽

Double Blind Study ◽

Double Blind

ABSTRACT Aim The present double blind study has been designed to evaluate the efficacy of local application of hemocoagulase solution as compared to a placebo in wound healing following dental extraction. Materials and methods A total of 20 patients who required dental extraction for orthodontic intervention were included. The hemocoagulase solution and a placebo were locally applied to the extraction sockets and the efficacy of the solution in terms of bleeding control, anti-inflammatory responses, its antiseptic properties and efficacy in wound healing were evaluated. Results The mean time required to achieve hemostasis was found to be 1.37 minutes in side A (test) and 2.33 minutes in side B (control) indicating that side A achieved faster hemostasis when compared to side B. At the 6th hour postoperatively, bleeding was not evident on either sides, and the amount of pain in side A was found to be less compared to side B. The number of RBCs, polymorphs, chronic inflammatory cells were not different in both the groups, whereas at 3rd postoperative day epithelial cells were greater in side A (test) compared to side B (control). Biopsy reports on the 12th postoperative day indicated that the number of fibroblasts, epithelial cells, collagen count was found to be greater in side A (test) compared to side B (control). Conclusion The topical hemocoagulase solution may be advocated in the field of oral and maxillofacial surgery, as a hemostatic agent and promoter of wound healing. However, further studies, with large number of cases and different clinical situations should be considered to authenticate the efficacy of this hemocoagulase solution in the practice of oral and maxillofacial surgery. Clinical significance Wound healing plays an important role in the success of any surgical procedure, such as extractions, and the hemocoagulase system may act as a hemostatic agent and a promoter of wound healing. How to cite this article Aslam S, Francis PG, Rao BHS, Ummar M, Issac JK, Nair RB. A Double Blind Study on the Efficacy of Local Application of Hemocoagulase Solution in Wound Healing. J Contemp Dent Pract 2013;14(3):394-400.

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A Review on the Application of Silver Nanoparticles in Oral and Maxillofacial Surgery

European Journal of Dentistry ◽

10.1055/s-0041-1731589 ◽

2021 ◽

Author(s):

Diane Isabel Selvido ◽

Bishwa Prakash Bhattarai ◽

Apiwat Riddhabhaya ◽

Kadkao Vongsawan ◽

Siripen Arunpraphan ◽

...

Keyword(s):

Wound Healing ◽

Silver Nanoparticles ◽

Tissue Regeneration ◽

Maxillofacial Surgery ◽

Oral And Maxillofacial Surgery ◽

Clinical Settings ◽

Antibacterial Resistance ◽

Dental Setting ◽

Implant Dentistry ◽

Healing Bone

AbstractSilver nanoparticles (AgNPs) have been taken advantage of in dentistry because of their good antibacterial resistance and self-sustaining potential. However, in oral and maxillofacial surgery and implantology, there is a lesser amount of evidence. The few pieces of evidence need to be accentuated for possible amplification of its use in the dental setting. AgNPs in oral and maxillofacial surgery can be used in wound healing, bone healing, extractions, guided tissue regeneration, apical surgeries, oral cancer, and dental implants. This review aims to feature the utilization and application of AgNPs in oral and maxillofacial surgery and implant dentistry, emphasizing its need for potential future development in clinical settings.

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