Efficacy of curcuminoids for reducing postoperative pain after laparoscopic gynecologic surgery: A pilot randomized trial

Abstract Background Curcuminoids, which are substances extracted from turmeric, have been proved to have anti-inflammatory and analgesic effects along with a good safety profile. This study aimed to evaluate the clinical efficacy of curcuminoids for reducing postoperative pain in patients who undergo laparoscopic gynecologic surgery. Methods From November 2016 to December 2017, participants were randomly assigned, by blocks of four, to the intervention and control arms of the study. Altogether, 60 patients who were to undergo laparoscopic gynecologic surgery at our institution were enrolled. Intraoperative findings were not significantly different between the two groups. One tablet of curcuminoid extract 250 mg was given to patients in the intervention group four times a day on postoperative days 1–3. Pain was evaluated at 24 and 72 h postoperatively using a 10-point visual analog scale (VAS). Results The median VAS score 24 h after surgery was 3 (1–6) in the intervention group and 4.5 (3–7) in the control group, with the difference reaching statistical significance (p=0.001). The median VAS at 72 h after surgery was 1 (0–2) in the intervention group and 2 (1–5) in the control group (p<0.001). Conclusion Curcuminoids may be an effective supplement to reduce pain severity postoperatively following laparoscopic gynecologic surgery. Trial Registration TCTR20180215001 www.clinicaltrials.in.th

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Impact of ascorbic acid in reducing the incidence of vancomycin associated nephrotoxicity in critically ill patients: A preliminary randomized controlled trial

F1000Research ◽

10.12688/f1000research.55619.1 ◽

2021 ◽

Vol 10 ◽

pp. 929

Author(s):

Nouran Hesham El-Sherazy ◽

Naglaa Samir Bazan ◽

Sara Mahmoud Shaheen ◽

Nagwa A. Sabri

Keyword(s):

Ascorbic Acid ◽

Critically Ill ◽

Critically Ill Patients ◽

Statistical Significance ◽

Intervention Group ◽

Secondary Outcome ◽

Control Group ◽

Control Groups ◽

The Absolute ◽

And Control

Background Antioxidants show nephroprotective effect against vancomycin associated nephrotoxicity (VAN) in animals. This study aimed to assess the ascorbic acid nephro-protective role against VAN clinically. Methods Forty-one critically ill patients were randomly assigned to one of two groups: intervention group (vancomycin IV plus ascorbic acid, n=21) or control group (vancomycin IV only, n=20). Primary outcomes were the incidence of VAN and the absolute change in creatinine parameters, while mortality rate was the secondary outcome. Nephrotoxicity was defined as an increase in serum creatinine (S.cr) by at least 0.5 mg/dL or 50% of baseline for at least two successive measurements. This study is registered at Clinicaltrials.gov (NCT03921099), April 2019. Results Mean absolute S.cr increase was significant when compared between both groups, P-value = 0.036, where S.cr increased by 0.05(0.12) and 0.34(0.55) mg/dL in the intervention and control groups, respectively. Mean absolute Cr.cl decline was significant when compared between both groups, P-value = 0.04, where Cr.cl was decreased by 5.9(17.8) and 22.3(30.4) ml/min in the intervention and control groups, respectively. Incidence of VAN was 1/21(4.7%) versus 5/20(25%) in the intervention and control groups, respectively (RR: 0.19; CI: 0.024–1.49; P-value = 0.093). Mortality was higher in the control group; however, it was not statistically significant, P-value = 0.141. Conclusion Co-administration of ascorbic acid with vancomycin preserved renal function and reduced the absolute risk of VAN by 20.3%, however, the reduction in VAN incidence didn’t reach statistical significance level. Further large multicenter prospective trials are recommended.

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Cryotherapy Reduced Postoperative Pain in Gynecologic Surgery: A Randomized Controlled Trial

Pain Research and Treatment ◽

10.1155/2019/2405159 ◽

2019 ◽

Vol 2019 ◽

pp. 1-6 ◽

Cited By ~ 2

Author(s):

Apisada Chumkam ◽

Densak Pongrojpaw ◽

Athita Chanthasenanont ◽

Junya Pattaraarchachai ◽

Kornkarn Bhamarapravatana ◽

...

Keyword(s):

Postoperative Pain ◽

Statistical Difference ◽

Controlled Trial ◽

Exploratory Laparotomy ◽

Gynecologic Surgery ◽

Control Group ◽

Study Group ◽

Control Groups ◽

Vas Score ◽

And Control

Objective. To examine the effectiveness of cryotherapy for reducing postoperative pain in patients who underwent exploratory laparotomy for gynecologic surgery. Materials and Methods. Patients who had indication for an exploratory laparotomy gynecologic procedure were selected by attending physicians to undergo abdominal surgery via low transverse skin incision. The participants were randomized into study and control groups with simple random sampling methods. Cold packs were applied at two hours after operation for 6 hours. The visual analog scale (VAS) score was recorded at two, 6, and 12 hours after operation. Result. One hundred cases were recruited and then divided into study and control groups equally. The mean age of both groups was 43 years. There was no difference in demographics data of both groups. Half of the participants in both groups underwent hysterectomies. At two hours after surgery, both groups had similar VAS scores. The study group had a lower VAS score at 6 and 12 hours after surgery than the control group with statistical difference. Morphine consumption within 24 hours after surgery in both the study and control groups was 2.8±3.4 and 3.0±4.4 mg, respectively, with no statistical difference. However the registration time of the first morphine requirement in the study group was statistically more prolonged than that of the control group. The lengths of hospital stay in both groups were similar. There was no complication reported in this study. Conclusion. Cryotherapy can reduce postoperative pain. In this presented study the patients who underwent gynecologic surgery had improved pain relief and prolonged time for the first dose of the analgesic drug.

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Effect of Sphenopalatine Ganglion Block With Bupivacaine on Postoperative Pain in Patients Undergoing Endoscopic Sinus Surgery

Allergy & Rhinology ◽

10.1177/2152656718821282 ◽

2019 ◽

Vol 10 ◽

pp. 215265671882128 ◽

Cited By ~ 5

Author(s):

Ahmad Rezaeian ◽

Seyed Mostafa Hashemi ◽

Zeinab Sadat Dokhanchi

Keyword(s):

Postoperative Pain ◽

Endoscopic Sinus Surgery ◽

Intervention Group ◽

Sinus Surgery ◽

Control Group ◽

Sphenopalatine Ganglion ◽

Ganglion Block ◽

Rescue Analgesia ◽

Sphenopalatine Ganglion Block ◽

And Control

Background Postoperative pain is one of the most complications in endoscopic sinus surgery. We aimed to evaluate the effect of the sphenopalatine ganglion block (SPGB) with bupivacaine on postoperative pain in patients undergoing endoscopic sinus surgery. Methods and Materials: In this clinical trial, 40 patients who indicated functional endoscopic sinus surgery were selected and then divided into 2 parallel groups as intervention and control. The intervention group was received 1.5 mL of bupivacaine 0.5% (injected to sphenopalatine ganglion) and while control was injected 1.5 mL of normal saline at the same injection site. Also, the visual analogue scale (VAS) was recorded immediately after anesthesia, along with 6, 12, 24, 48 h, 7 days, and 21 days after the operation for all patients. Results Immediately after anesthesia, as well as 6, 12, and 24 h after the operation, VAS in the intervention group was significantly lower than in the control group ( P < .05, for all). However, there were no significant differences between the 2 groups regarding VAS 48 h as well as 7 and 21 days after surgery ( P > .05, for both). Also, the rescue analgesia in the intervention group was significantly lower than in the control group ( P = .01). Conclusion SPGB with bupivacaine 0.5% (1.5 mL) was a simple, effective, safe, and noninvasive method for the management of postoperative pain in the patients undergoing endoscopic sinus surgery.

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The Effect of Vitamin B6 on Reducing the Number and the Size of Breast Cysts and the Amount of Recurrence after Aspiration in Women

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2019/v31i630348 ◽

2019 ◽

pp. 1-7

Author(s):

Setareh Soltany ◽

Hamid Reza Hemmati ◽

Jafar Alavy Toussy ◽

Parisa Alavi Toosi

Keyword(s):

Vitamin B6 ◽

Intervention Group ◽

Control Group ◽

Control Groups ◽

Double Blind ◽

Breast Cyst ◽

The Difference ◽

Palpable Breast ◽

Breast Lumps ◽

And Control

Introduction: Palpable breast lumps are one of the most prevalent breast problems in women who visit a doctor. Most of these lumps are benign, and many of these benign lumps, have cystic nature. One of the suggested treatments for breast cyst is vitamin B6 intake. So, this study aimed to determine the effect of vitamin B6 on reducing the number and the size of breast cysts and reducing the amount of recurrence after aspiration. Materials and Methods: This study is a double-blind randomized clinical trial. Patients simply divided into two groups randomly, intervention group (receiving 150 mg vitamin B6 twice a day for two months) and control group (placebo). After data collection, the database produced, and information came in by SPSS-22 software. Descriptive results extracted in the form of tables and graphs. In all cases was used α=0.05. Results: At the end of the study, 65 patients (34 people in the intervention group, and 31 people in the control group) studied. At the end of the survey in the non-palpable cysts, was observed a significant decrease in the number and the size of breast cysts in each group receiving vitamin B6 or placebo. Still, the difference was not significant in comparing the two groups. 19 patients (2.29%) had palpable cysts that aspiration performed in all cases. After the study period, no recurrence of cysts observed in any of the intervention and control groups. Conclusion: The study showed that vitamin B6 had no effect on reducing the size and the number of non-palpable breast cysts and prevent recurrence of palpable cysts after aspiration.

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Have the same pathogenicity of Ureaplasma Parvum and Ureaplasma Urealyticum in non-specific cervicitis? -based on digital droplet PCR assay

10.21203/rs.3.rs-284649/v1 ◽

2021 ◽

Author(s):

Yanfang Huang ◽

Xiaoqin Xu ◽

Panpan Lv ◽

Zhen Zhao

Keyword(s):

Ureaplasma Urealyticum ◽

Statistical Significance ◽

Control Group ◽

Pcr Assay ◽

Ureaplasma Parvum ◽

Digital Droplet Pcr ◽

Droplet Pcr ◽

The Difference ◽

And Control ◽

Ureaplasma Spp

Abstract Background: Ureaplasma spp. are association with a various of infectious diseases in female, but it still limited evidence for the pathogenicity in nonspecific cervicitis. The aim of this study was to develop and evaluate a digital droplet PCR (ddPCR) assay for quantified the load of Ureaplasma spp in cervical swabs. Methods: A total of 293 non-specific cervicitis (NSC) patients and 211 asymptomatic female fulfilled the inclusion criteria. Cervical swabs were identified by qPCR and further absolutely quantified by ddPCR. Results: The prevalence of U.parvum were 51.9% (152/293) and 46.9% (99/211); while U.urealyticum were 8.2% (24/293) and 8.1% (17/211) in the NSC and Control group, respectively. In addition, the average Ct value and median copy number per microliter of U.parvum were 31.33 (n=152) and 599 (n=48) in the NSC group and 33.68 (n=99) and 17.4 (n=33) in control group, respectively, suggest that the load of U.parvum of NSC group were significantly higher than the asymptomatic individual (P<0.001). But, the median load number of U.urealyticum were 1.26 (n=22) and 5.35 (n=14) copies per microliter two groups, the difference was no statistical significance (P>0.05). Conclusions: our study suggests that often carrying U.parvum at a high load but not U.urealyticum may have an important implications on the development and progression of cervicitis among female.

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Development and Application of One Separation-Free Safety Tube on the Disposable Infusion Needle

Computational and Mathematical Methods in Medicine ◽

10.1155/2020/6896517 ◽

2020 ◽

Vol 2020 ◽

pp. 1-4

Author(s):

Weifen Lu ◽

Qianli Pan ◽

Yinxin Zhou ◽

Wenyu Chen ◽

Hongyan Zhang ◽

...

Keyword(s):

Exposure Time ◽

Statistical Significance ◽

Intervention Group ◽

Operation Time ◽

Control Group ◽

Needle Stick ◽

Significant Difference ◽

New Type ◽

Needle Stick Injuries ◽

The Difference

Objective. To develop a new type infusion set and apply it to the clinic, as well as explore its effectiveness in the prevention from needle stick injuries. Methods. A total of 200 inpatients who were in need of intravenous infusion with a disposable infusion needle were included and randomly divided into two groups: intervention group and control group. Disposable infusion needles with a separation-free safety tube were used in the intervention group, whereas conventional ones were used in the control group. Then, effects of the two types of infusion sets were observed and compared. Results. As for the operation time for infusion, it was (82.19±1.80) seconds in the intervention group and (83.02±1.83) seconds in the control group, with the difference statistically significant (P<0.05). Besides, the exposure time of the needles after infusion in the intervention group was (3.36±0.17) seconds while (18.85±1.18) seconds in the control group; the difference between which was statistically significant (P<0.05). In terms of the time for needle disposal, (18.60±0.84) seconds was required in the intervention group, while for the control group, it took (18.85±1.18) seconds, and the difference between two groups was of statistical significance as well (P<0.05). Nevertheless, there was no statistically significant difference in the accidental slip rate of the needles as that turned out 0% in both groups (P>0.05). It was worth noting that the block rate of the disposed needles in the intervention group was 100%. Conclusion. The separation-free safety tube on the disposable infusion needle could instantly block the sharp needle after infusion, which reduces the needle exposure time and lowers the risk of needle stick injuries. In the meantime, the safety tube is convenient to use, and its application can shorten the time for infusion and needle disposal, consequently improving the working efficiency of nurses. As the new type safety tube has above advantages and would not raise the risk of needle slippage, it is worthy of clinical promotion.

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Burnout and distress in Australian physician trainees: Evaluation of a wellbeing workshop

Australasian Psychiatry ◽

10.1177/1039856219833793 ◽

2019 ◽

Vol 27 (3) ◽

pp. 255-261 ◽

Cited By ~ 2

Author(s):

Carmen Axisa ◽

Louise Nash ◽

Patrick Kelly ◽

Simon Willcock

Keyword(s):

Alcohol Use ◽

Statistical Significance ◽

Intervention Group ◽

Control Group ◽

Depression Anxiety Stress Scale ◽

Screening Criteria ◽

Quality Of Life Scale ◽

Life Scale ◽

Workshop Intervention ◽

And Control

Objective: To evaluate the effectiveness of a workshop intervention to promote wellbeing for Australian physician trainees using a randomized-controlled design. Methods: Participants were randomly assigned into intervention and control groups. The intervention group attended a half-day workshop. Outcome measures included depression anxiety stress scale, professional quality of life scale and alcohol use disorders identification test. Demographic and work/life factors were measured. Measurements were recorded at baseline, 3 and 6 months, and the workshop was evaluated by participants. Results: High rates of burnout (76%) and secondary traumatic stress (91%) were detected among study participants and around half met screening criteria for depression (52%), anxiety (46%) and stress (50%) at baseline. Workshop evaluations showed that participants agreed that the training was relevant to their needs (96%) and met their expectations (92%). There was a small reduction in alcohol use, depression and burnout in the intervention group compared with the control group at 6 months, but these changes did not reach statistical significance. Conclusion: High rates of psychological morbidity detected in the study suggest that physician trainees are a vulnerable group who may benefit from initiatives that promote wellbeing and changes in the workplace to reduce distress.

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Efecto de una intervención estructurada de enfermería en disminución del hábito tabáquico en mujeres fumadoras

Enfermería Global ◽

10.6018/eglobal.18.1.315761 ◽

2018 ◽

Vol 18 (1) ◽

pp. 281-303

Author(s):

Patricia Cid Henriquez ◽

Olivia Sanhueza Alvarado ◽

José Manuel Merino ◽

Katia Sáez Carrillo

Keyword(s):

Quality Of Life ◽

Intervention Group ◽

Control Group ◽

Calidad De Vida ◽

Structured Intervention ◽

The Difference ◽

Las Mujeres ◽

And Control ◽

Los Grupos

Introducción: El consumo del tabaco está asociado al incremento de la morbilidad y la mortalidad femenina. Este hábito implica además un deterioro en la calidad de vida relacionada con salud. El propósito de esta investigación fue determinar el efecto de una intervención estructurada que motivara a las mujeres a disminuir el consumo diario de cigarrillos y mejorar su calidad de vida. Método: Diseño experimental con preprueba-postprueba y grupo de control con asignación de los grupos al azar. De 120 personas se homologaron los dos grupos con cinco caracteristicas, se homologó nuevamente la muestra porque respondieron la entrevista en domicilio sólo 64 personas. El grupo intervención estuvo constituido por 10 mujeres entre 18 y 65 años de la región del Bio- Bío, y el grupo control por 20 mujeres. Se aplicó un cuestionario semiestructurado de características sociodemográficas, de test, cuestionarios y escalas que midieron las variables asociadas al consumo, y las orientaciones subjetivas y conductuales, previo consentimiento informado. La intervención estructurada estuvo conformada por: métodos activos de aprendizaje, consejería con énfasis en el fortalecimiento de la percepción de autoeficacia. Resultados: La diferencia de medias en el tiempo y la diferencia de medias entre los grupos (grupo tratamiento y grupo control) es de casi 5 cigarrillos (4,8), esta interacción (tiempo-grupo) resulta a un nivel de significación menor al uno por diez mil.Conclusiones: Esta intervención requiere de reforzamiento periódico hasta lograr la deshabituación tabáquica e incidir en la calidad de vida relacionada con salud de las mujeres con hábito tabáquico. Introduction: Tobacco consumption is associated with an increase in female morbidity and mortality. This habit also implies deterioration in the quality of life related to health. The purpose of this research was to determine the effect of a structured intervention that motivated women to reduce their daily consumption of cigarettes and improve their quality of life.Method: Experimental design with pre-test-post-test and control group with allocation of the groups at random. Out of 120 people, the two groups were approved with five characteristics. The sample was homologated again because the home interview was answered by only 64 people. The intervention group consisted of 10 women between 18 and 65 years old from the Bio-Bio region, and the control group by 20 women. A semi-structured questionnaire with sociodemographic characteristics, test, questionnaires and scales that measured the variables associated with consumption, and subjective and behavioral guidelines, with prior informed consent, was applied. The structured intervention consisted of: active learning methods, counseling with emphasis on strengthening the perception of self-efficacy. Results: The difference of means in time and the difference of means between the groups (treatment group and control group) is of almost 5 cigarettes (4,8). This interaction (time-group) results has a level of significance less than one in ten thousand. Conclusions: This intervention requires periodic reinforcement to achieve smoking cessation and affect the quality of life related to health of women with smoking.

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Effect of Foot Reflexology on Postoperative Pain in Patients Undergoing Tibia Plating Surgery: A Randomized Clinical Trial

Complementary Medicine Journal ◽

10.32598/cmja.10.3.1019.1 ◽

2020 ◽

Vol 10 (3) ◽

pp. 258-269

Author(s):

Fatemeh Imani ◽

◽

Ebrahim Nasiri ◽

Houshang Akbari ◽

Mohammad Reza Safdari ◽

...

Keyword(s):

Clinical Trial ◽

Postoperative Pain ◽

Randomized Clinical Trial ◽

Repeated Measures ◽

Intervention Group ◽

Control Group ◽

Control Groups ◽

Chi Square ◽

Chi Square Test ◽

And Control

Objective: One of the major problems of patients after orthopedic surgeries is acute pain. The present study aims to evaluate the effect of foot reflexology massage on postoperative pain in patients undergoing plating surgery for tibia fracture. Methods: This study is a randomized clinical trial conducted on 96 patients who were candidates for tibia plating surgery referred to Imam Ali Hospital in Bojnourd, Iran, randomly divided into intervention and control groups. Foot reflexology massage in the intervention group was performed on patients’ healthy feet for 10 minutes, one hour before surgery. In the control group, the foot sole was touched for one minute without any pressure. Pain intensity was measured using the standard Visual Analog Scale before and immediately after the intervention and 2, 4, 6, 12 and 24 hours after surgery. Data were analyzed using chi-square test, t-test, repeated measures ANOVA, Mann-Whitney U and Friedman tests. Results: The baseline pain scores in the intervention and control groups were reported 8.1±0.9 and 8.4±0.9, respectively. After the intervention, the pain score in these groups was reduced to 6.9±1.1 and 8.1±1.0, respectively (P<0.001). At other times, up to 24 hours after surgery, the pain reduction was higher in the intervention group (P<0.05). Conclusion: Foot reflexology massage reduces postoperative pain of patients undergoing tibia plating surgery. Therefore, this method can be used to reduce pain and anxiety in orthopedic surgery patients.

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Impact of Clinical Pharmacist Mediated Discharge Counseling and SMS Reminders Service on Medication Adherence in Chronic Disorders

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i59b34402 ◽

2021 ◽

pp. 446-453

Author(s):

Y. Samhitha Reddy ◽

K. Somashekar Reddy

Keyword(s):

Medication Adherence ◽

Clinical Pharmacist ◽

Statistical Significance ◽

Intervention Group ◽

Pill Count ◽

Control Group ◽

Sms Reminders ◽

Chronic Disorders ◽

And Control

Aims: This study aimed to assess the effect of discharge counseling with SMS reminders on medication adherence in chronic disorders. Study Design: Prospective randomized open-label trial Place and Duration of Study: The study was conducted at the dispensing department of a secondary care referral charity hospital located in a small village. The study was conducted for a period of six months from October 2018 to April 2019. Methodology: Upon consent, a total of 364 patients were enrolled in this study and randomized into two groups viz., intervention group (n=182) and control group (n=182) respectively, with and without discharge counseling and SMS reminder on medication usage by the clinical pharmacist. The level of medication adherence was measured using a pill count and visual analog scale (VAS) methods at two follow-up visits includes baseline and final follow-up visit (gap of two months). A two-sample Wilcoxon rank‑sum (Mann–Whitney) was used to compare the statistical mean difference of medication adherence levels between two groups at each follow‑up visit. Results: The mean age of intervention and control groups were 57.1±8.55 and 58.5±8.53; most of the subjects were >60 years of age and were typically suffering from hypertension (30.2%) and diabetes (34.8%). Initially, at baseline, the values of medication adherence level (pill-count method) were closer in both intervention (82.4±7.3) and control group (81.35±6.4), whereas at follow up visits, the levels of the intervention group (93.2±6.0, 95.6±2.25) were significantly increased (p<0.0001) as compared to the control group (81.2±8.5, 80.6±8.1). Conclusion: Thus, the statistical significance infers that the clinical pharmacist-mediated discharge counseling with SMS reminders would increase medication adherence levels in chronic disorders.

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