Amelioration of related complications by the combined usage of Gymnadenia orchidis Lindl and pumpkin seed in type 2 diabetic mice

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Subiah Helal Arzoo ◽  
Krishna Chattopadhyay ◽  
Tania Parvin ◽  
Brajadulal Chattopadhyay
Keyword(s):  
Cell Damage ◽  
Nutritional Therapy ◽  
Cellular Damage ◽  
Hypoglycemic Agents ◽  
Diabetic Patients ◽  
Biochemical Tests ◽  
Pumpkin Seed ◽  
Pumpkin Seeds ◽  
Oral Hypoglycemic Drugs

Abstract Background Inflammation, insulin resistance, hyperinsulinemia and cell damage are the major patho-physiological reasons behind type 2 diabetes (T2DM), which is one of the most prevalent non communicable metabolic disorders in the world. Oral hypoglycemic drugs and insulin shots are usually exercised to treat the diabetic patients but it produces many side effects. Thereby paving the way for natural hypoglycemic agents; a Himalayan herb and alternative nutritional therapy; low glycaemic indexed pumpkin seed, are used in combination for a better management of the disease. Objectives To explore the combined efficacy of Gymnadenia orchidis Lindl root Salep and low-glycemic indexed-pumpkin seeds in better management of T2DM and associated complications. Methods Balb/c mice were randomly allocated to six different groups (n=5). Streptozotocin along with high-fat-diet was used to induce T2DM. The experimental animals were supplemented with low-glycemic food or root Salep (200 mg/kg body weight) or combination of both according to their groups for 21 days, post which various biochemical tests were performed. Results T2DM augmented the IL-6, IFN-γ, TNF-α, BAX, Insulin levels, and HOMA-IR with concurrent reduction of IL-4, QUICKI, Bcl-2, estradiol and progesterone levels. FACS revealed augmented cellular damage in T2DM mice. Interestingly, root Salep and pumpkin seeds normalized those parameters in T2DM animals suggesting significant (p<0.001) improvement of immunity of the diseased animals and ameliorated associated complications. Conclusions Root Salep and pumpkin seed display synergism among binomial set of herbal agents which may be safely used for T2DM management.

Vitamin D3 supplementation improves glycemic control in type 2 diabetic patients: Results from an Italian clinical trial

2020 ◽  
pp. 1-10
Author(s):  
Giuseppe Derosa ◽  
Angela D’Angelo ◽  
Chiara Martinotti ◽  
Maria Chiara Valentino ◽  
Sergio Di Matteo ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Metabolic Control ◽  
Vitamin D3 ◽  
Therapy Group ◽  
Hypoglycemic Agents ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Abstract. Background: to evaluate the effects of Vitamin D3 on glyco-metabolic control in type 2 diabetic patients with Vitamin D deficiency. Methods: one hundred and seventeen patients were randomized to placebo and 122 patients to Vitamin D3. We evaluated anthropometric parameters, glyco-metabolic control, and parathormone (PTH) value at baseline, after 3, and 6 months. Results: a significant reduction of fasting, and post-prandial glucose was recorded in Vitamin D3 group after 6 months. A significant HbA1c decrease was observed in Vitamin D3 (from 7.6% or 60 mmol/mol to 7.1% or 54 mmol) at 6 months compared to baseline, and to placebo (p < 0.05 for both). At the end of the study period, we noticed a change in the amount in doses of oral or subcutaneous hypoglycemic agents and insulin, respectively. The use of metformin, acarbose, and pioglitazone was significantly lower (p = 0.037, p = 0.048, and p = 0.042, respectively) than at the beginning of the study in the Vitamin D3 therapy group. The units of Lispro, Aspart, and Glargine insulin were lower in the Vitamin D3 group at the end of the study (p = 0.031, p = 0.037, and p = 0.035, respectively) than in the placebo group. Conclusions: in type 2 diabetic patients with Vitamin D deficiency, the restoration of value in the Vitamin D standard has led not only to an improvement in the glyco-metabolic compensation, but also to a reduced posology of some oral hypoglycemic agents and some types of insulin used.

scholarly journals COMPARATIVE STUDY OF ORAL HYPOGLYCEMIC AGENTS IN TYPE-2 DIABETES OBESE PATIENTS

2018 ◽  
Vol 11 (6) ◽  
pp. 505
Author(s):  
Venkateswarlu Konuru ◽  
Ram Mohan Reedy T
Keyword(s):  
Blood Sugar ◽  
Adverse Drug Reactions ◽  
Glycosylated Hemoglobin ◽  
Dipeptidyl Peptidase ◽  
Hypoglycemic Agents ◽  
Diabetic Patients ◽  
Drug Reactions ◽  
Oral Hypoglycemic Agents ◽  
Peptidase Inhibitors

  Objectives: The aim of this study was to evaluate safety and efficacy of oral hypoglycemic agents in obese Type-2 diabetic patients. The objectives are to compare fasting and postprandial blood sugar (PPBS) levels, to compare body mass index (BMI) in all the groups, and to identify glycosylated hemoglobin levels and adverse drug reactions (if present) in all the groups.Method: This is a prospective observational study conducted in care diabetic center over a period of 1 year. All the patients those are receiving only oral hypoglycemic agents continuously over a period of 3 months and BMI ≥30 were enrolled. The patients receiving insulin were excluded. Patients were followed over a period of 3 months and were reviewed on visit basis (every 30 days). All the necessary information was collected into the data collection form that includes demographic details (age, gender, etc.), past medication history, current treatment charts, and their relevant laboratory reports (fasting blood sugar levels [mg/dl], PPBS levels [mg/dl], glycosylated hemoglobin A1c [HbA1c] (%), and BMI [kg/m2]).  Results: A total of 395 patients were recruited into the study and the drugs received by the population were found to be metformin+sulfonylureas (33%), metformin+pioglitazone (26%), and metformin+dipeptidyl peptidase inhibitors (DPI) (23%). A significant reduction in HbA1c was seen in all groups of patients. Adverse drug reactions observed were hypoglycemia, pedal edema, and itching distributed to drugs metformin+DPI, respectively. A significant reduction in BMI was seen in patients receiving DPI and BMI was found to be increased in other groups of patients.Conclusion: Overall, three classes of drugs were found to have similar efficacy. Sulfonylureas were commonly associated with hypoglycemia when compared to other drugs and weight reduction observed in dipeptidyl peptidase inhibitors.

scholarly journals MICROBIOLOGICAL STUDY OF ORAL FLORA IN DIABETIC PATIENTS WITH GINGIVITIS

2018 ◽  
Vol 10 (6) ◽  
pp. 113
Author(s):  
Samira Hsaine ◽  
Fatima Zahrae Fethi ◽  
Reda Charof ◽  
Khadija Ounine
Keyword(s):  
Periodontal Disease ◽  
Culture Media ◽  
Bacterial Species ◽  
Klebsiella Oxytoca ◽  
Diabetic Patients ◽  
Periodontal Pathogens ◽  
Biochemical Tests ◽  
Oral Flora ◽  
Metabolic Dysregulation

Objective: Given the importance of the association between diabetes and periodontal disease, the main objective of the present study was to compare the microbial diversity responsible for gingivitis in patients with and without type 2 diabetes.Methods: Samples were collected from the oral cavity of 134 patients with gingivitis and categorised into 3 groups (68 non-diabetic patients and 66 diabetic patients; 33 with controlled diabetes and 33 with poorly controlled diabetes). Sample culture was carried out on selective culture media. The identification of isolated strains involved a series of biochemical tests including miniature galleries (API 20E and 20 Strep), the traditional biochemical gallery (tubes) and automated bacterial identification (BD Phoenix™).Results: Identification by biochemical methods made it possible to differentiate 14 bacterial species and one yeast. There was greater bacterial diversity in diabetic patients as compared to non-diabetic patients. Periodontal pathogens were isolated from both diabetic and non-diabetic populations; however, certain microbes such as Streptococcus acidominimus, Enterobacter cloacae, Klebsiella oxytoca, and Pseudomonas aeruginosa were present only in diabetics, with a much higher percentage in those with poorly controlled diabetes.Conclusion: Poorly controlled diabetes causes metabolic dysregulation that can increase the severity of periodontal disease.

Correlation Study between H.pylori Bacteria Qnd Biochemical Tests In Type 2 of Iraqi Diabetic Patients

2019 ◽  
Vol 10 (11) ◽  
pp. 4998
Author(s):  
Mohammed Flayyih Tareef ◽  
Abdulrazzaq Neamah Zghair ◽  
Nihad Khalawe Tektook
Keyword(s):  
Correlation Study ◽  
Diabetic Patients ◽  
Biochemical Tests

scholarly journals Prescribing pattern of antidiabetic drugs in tertiary care hospital

2021 ◽  
Vol 10 (3) ◽  
pp. 251
Author(s):  
Anil Kumar P. ◽  
Raj Kumar K.
Keyword(s):  
Diabetes Mellitus ◽  
Lifestyle Modification ◽  
Tertiary Care ◽  
Hypoglycemic Agents ◽  
Fixed Dose ◽  
Multiple Drug ◽  
Diabetic Patients ◽  
Care Hospital ◽  
Prescribing Pattern

Background: The aim of the current study was to investigate the prescribing pattern of anti-diabetic drugs in diabetic patients attending tertiary care teaching hospital in Kurnool.Methods: A prospective, cross-sectional, observational survey was carried out in 100 patients of diabetes mellitus attending diabetes outpatient/medicine outpatient departments, to assess their prescribing pattern of anti-diabetic drugs.Results: Average number of anti-diabetic drugs per prescription was 1.4. Metformin (biguanide) was the commonest prescribed individual drug among oral hypoglycemic agents. Fixed dose combination of biguanide and sulfonylurea was prescribed commonly. Monotherapy dominated over polytherapy and there was a higher percentage of use of insulin in type 2 diabetics.Conclusions: OHAs still dominate the prescribing pattern, but there was a shifting trend toward the use of insulin preparations in the management of type 2 diabetes mellitus. Intensification of current drug treatment as well as planning multiple drug interventions with lifestyle modification is necessary.

scholarly journals A qualitative study on non-adherence to oral hypoglycemic agents in type 2 diabetics

2017 ◽  
Vol 4 (4) ◽  
pp. 1099
Author(s):  
Sourav Agarwala ◽  
Md. Asif Ansari ◽  
Uttam Kumar Paul ◽  
Arup Bandyopadhyay
Keyword(s):  
Diabetes Mellitus ◽  
Qualitative Study ◽  
Low Income ◽  
Alternative Treatment ◽  
Hypoglycemic Agents ◽  
Diabetic Patients ◽  
Audio Recording ◽  
Economic Issues ◽  
North Bengal

Background: Non-adherence to oral hypoglycaemic agents is both a global and ubiquitous problem during treatment of type 2 diabetes mellitus. This leads to unwanted persistence and aggregation of hyperglycemia as well as many of the complications of diabetes mellitus and even to early death. However, there have been quite a few studies on this issue but different studies have shown different reasons of non-adherence because of this confusion and also because no studies have been done in Bihar and North Bengal, the present authors decided to go for a qualitative study on this issue.Methods: This study was conducted in the medicine OPD of two medical colleges one in Bihar and another in north Bengal. The study method was one of the qualitative descriptive nature in which open interviews are conducted on non-compliant diabetic patients. Audio recording was taken in each case after taking written permission from the patients as well as from the institutional ethical committee. A transcript in English was made manually of each audio recording and then transcript analysis was done using categories and codes.Results: The results showed existence for four broad categories, viz, adverse effect, economic issues, availability and alternative treatment. Each category was divided into several codes like - adverse effects into weakness, hypoglycemia, organ damage, vertigo and fear; economic issues into high cost, low income, lifelong high expenditure and family crisis; availability into total non-availability, local non-availability, travel expenses and problems to buy from distance and brand non-availability; lastly alternative treatment included Ayurveda, Homeopathy and jori-buti. The last two categories, viz, non-availability and alternative therapy are very much unique in our study.Conclusions: It can be concluded that non-adherence is very much a problem in our places as it is in other places, nationally and globally. But it is slightly different here. We must find out solutions for this problem and start interventions immediately.

scholarly journals Association of Antidiabetic Treatment with the Type of Obesity in Type 2 Diabetic Patients

Esculapio ◽  
2021 ◽  
Vol 16 (4 (oct 2020 - dec 2020)) ◽  
Author(s):  
Jawariea Ali ◽  
Sheikh Sajjad Ali ◽  
Muhammad Imran ◽  
Tuba Tariq ◽  
Umair Mahmood ◽  
...  
Keyword(s):  
Abdominal Obesity ◽  
Analytical Study ◽  
P Value ◽  
Diabetic Patients ◽  
Key Words Diabetes ◽  
Type 2 Diabetic Patients ◽  
Antidiabetic Treatment ◽  
Oral Hypoglycemic Drugs ◽  
Type 2 Diabetic

Objective: To find association between antidiabetic treatment and the type of obesity in type 2 diabetic patients. Methods: The study was conducted in National Institute of Diabetes & Endocrinology (NIDE), Karachi, over a period of 6 months, ie. from January to June, 2018. It was an observational analytical study, for which 59 patients were selected via non-probability sampling, as per inclusion and exclusion criteria. Data was collected through detailed history, examination. A database was developed and analyzed on SPSS 17. A p- value <0.05 was taken as statistically significant. Results: Fifty nine patients fulfilling the inclusion criteria were included in this study. While 30 (50.8%) had generalized obesity, 29 (49.2%) were not having generalized obesity. Further it was observed that 35 (59.3%) had abdominal obesity, while 24 (40.7%) were not having abdominal obesity. A total of 39 (66.1%) were on insulin, while 20 (43.9%) were not on insulin. Finally, 41 (69.5%) were on oral hypoglycemic drugs, while 18 (30.5%) were not on oral hypoglycemic drugs. P-values were not significant for the study parameters. Conclusion: There is no association between antidiabetic treatment and type of obesity in type 2 diabetic patients. Key Words: Diabetes, obesity, body mass index, insulin, oral hypoglycemic drugs How to Cite: Ali J, Ali S.S, Imran S, Tariq T, Mahmood U, Iqbal J. Association of antidiabetic treatment with the type of obesity in type 2 diabetic patients. Esculapio.2020;16(04):97-100.

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