Prevalence of vitamin D deficiency in apparently healthy children in north India

Background: In the recent years there has been an increased understanding of the role that vitamin D plays in regulation of cell growth, calcium absorption and immunity and its impact on the developing fetus and maternal health is of significant concern. This study aims at evaluating the Vitamin D status in pregnant women and their newborns.Methods: A cross sectional study was done on 100 pregnant females according to inclusion and exclusion criteria. At the time of delivery, maternal blood was collected, and newborn samples were taken from newborn side of umbilical cord and sent for analysis.Results: The prevalence of Vitamin D deficiency has been found to be 85% of pregnant females and 91% of the newborns. Only 5% of pregnant females and 1% of the newborns showed Vitamin D sufficiency. Maternal and newborn vitamin D levels show a positive correlation. Mean maternal and newborn Vitamin D levels were found to be 16.78±7.04 ng/mL and 11.29±5.75 ng/ml.Conclusions: Vitamin D deficiency is highly prevalent among pregnant women in north India. Low maternal vitamin D levels lead to vitamin D deficiency in the newborns also.

Download Full-text

Vitamin D i pokazateli kal'tsiy-fosfornogo obmenau detey, prozhivayushchikh v sredney polose Rossii, v periodmaksimal'noy insolyatsii

Osteoporosis and Bone Diseases ◽

10.14341/osteo201022-6 ◽

2010 ◽

Vol 13 (2) ◽

pp. 2-6 ◽

Cited By ~ 4

Author(s):

A. V. Vitebskaya ◽

G. E. Smirnova ◽

A. V. Il'in

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Central Area ◽

Hypovitaminosis D ◽

Vitamin D Insufficiency ◽

Winter Period ◽

Published Data ◽

Healthy Children ◽

Hydroxyvitamin D ◽

Oncological Diseases

Vitamin D deficiency is associated with rickets in children and osteomalation in adults. Published data support the role of vitamin D insufficiency in development of autoimmune, cardiovascular and oncological diseases. The most precise method to diagnose vitamin D insufficiency is measuring of 25-hydroxyvitamin D (25(OH)-D). We studded the levels of vitamin D and calcium-phosphate turnover parameters during the period of maximal insolation in 140 healthy children and adolescents permanently living in the central area of Russia. Vitamin D insufficiency (25(OH)-D < 20 ng/ml) was detected in 38,6%; in 2,9% of them severe vitamin D deficiency was diagnosed (25(OH)-D < 8 ng/ml). The results correlate with data on hypovitaminosis D prevalence in countries with the same geographical latitude. To clarify the real size of required prophylaxis we need investigation of the same parameters in winter period while minimal insolation.

Download Full-text

Drops Supplementation for Treating Vitamin D Deficiency in Healthy Children and Adolescents: The Important Role of Sun Exposure

International Journal of Pediatrics and Child Health ◽

10.12974/2311-8687.2014.02.01.3 ◽

2014 ◽

Vol 2 (1) ◽

pp. 10-18

Author(s):

Papadopoulou A. ◽

◽

Makris K. ◽

Tsohantari M. ◽

Paulakou M. ◽

...

Keyword(s):

Vitamin D ◽

Children And Adolescents ◽

Vitamin D Deficiency ◽

Sun Exposure ◽

Healthy Children

Download Full-text

Prevalence and significance of vitamin D deficiency and insufficiency among apparently healthy adults

Clinical Biochemistry ◽

10.1016/j.clinbiochem.2010.09.022 ◽

2010 ◽

Vol 43 (18) ◽

pp. 1431-1435 ◽

Cited By ~ 41

Author(s):

Shireen Mansoor ◽

Aysha Habib ◽

Farooq Ghani ◽

Zafar Fatmi ◽

Salma Badruddin ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Healthy Adults ◽

Apparently Healthy

Download Full-text

High prevalence of vitamin D deficiency in type 1 diabetes mellitus and healthy children

Acta Diabetologica ◽

10.1007/s00592-008-0071-6 ◽

2008 ◽

Vol 46 (3) ◽

pp. 183-189 ◽

Cited By ~ 85

Author(s):

Abdulbari Bener ◽

Amer Alsaied ◽

Mariam Al-Ali ◽

Aisha Al-Kubaisi ◽

Basma Basha ◽

...

Keyword(s):

Diabetes Mellitus ◽

Vitamin D ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Vitamin D Deficiency ◽

Healthy Children ◽

High Prevalence

Download Full-text

Low Level of Vitamin D is Correlated with High C-Reactive Protein (CRP) and Disease Activity in Indonesian Juvenile Idiopathic Arthritis (JIA) Patients

The Indonesian Biomedical Journal ◽

10.18585/inabj.v12i2.1143 ◽

2020 ◽

Vol 12 (2) ◽

pp. 149-56

Author(s):

Desy Wulandari ◽

Wisnu Barlianto ◽

Tita Luthfia Sari

Keyword(s):

Vitamin D ◽

Juvenile Idiopathic Arthritis ◽

Serum Level ◽

Disease Activity ◽

Vitamin D Deficiency ◽

Control Group ◽

Healthy Children ◽

C Reactive Protein ◽

Low Level ◽

Reactive Protein

BACKGROUND: Vitamin D plays essential role in the regulation of inflammation, such as in pathogenesis of Juvenile Idiopathic Arthritis (JIA). Vitamin D deficiency has been reported among JIA patients, but there were conflicting results regarding the correlation with disease activity. This study aimed to assess vitamin D serum level and its correlation with C-Reactive Protein (CRP) and disease activity in JIA patients.METHODS: Children who were diagnosed with JIA according to International League of Associations for Rheumatology (ILAR) criterias were enrolled as JIA group subjects, while age and sex-matched healthy children were enrolled as the control group subjects. Vitamin D and CRP serum level were measured. Disease activity of JIA patients was calculated by Juvenile Arthritis Disease ActivityScore-27 (JADAS-27).RESULTS: Vitamin D serum level was lower in the JIA group compared to the healthy control group (p=0.000). Among 26 JIA patients, 61.5% were deficient, 30.8% were insufficient, and 7.7% had normal vitamin D. No significant different in CRP level between vitamin D group (p=0.441), but there was significant different in JADAS-27 (p=0.001). The mean of CRP and JADAS-27 were found highest in vitamin D deficiency group. Vitamin D serum level was negatively correlate with CRP (p=0.021, r=-0.452) and JADAS-27 (p=0.001 r=-0.595).CONCLUSION: Low level of vitamin D in JIA patients was inversely related to higher CRP and disease activity,suggesting that vitamin D supplementation could be havepotential role in JIA treatment.KEYWORDS: vitamin D, CRP, disease activity,JADAS-27, JIA

Download Full-text

Modulating effect of vitamin D status on serum anti-adenovirus 36 antibody amount in children with obesity: National Food and Nutrition Surveillance

10.21203/rs.2.16332/v2 ◽

2020 ◽

Author(s):

Bahareh Nikooyeh ◽

Bruce Hollis ◽

Tirang Reza Neyestani

Keyword(s):

Vitamin D ◽

Normal Weight ◽

Overweight And Obesity ◽

Surveillance Program ◽

Healthy Children ◽

Vitamin D Status ◽

Food And Nutrition ◽

Unit Increase ◽

Adenovirus 36 ◽

Apparently Healthy

Abstract Background. The association of ADV-36 infection and obesity has been reported in children. The objective of this study was to examine the hypothesis that the association between ADV-36 infection and adiposity may be mediated by sub-optimal vitamin D status of the host. Methods. Ninety one apparently healthy children in different weight categories (normal weight: 33, overweight: 33, obesity: 25) aged 5-18 years were randomly selected from the registered population at National Food and Nutrition Surveillance Program (NFNS). The groups were matched based on age and sex. Anthropometric, biochemical and serological assessments were performed. Results. The amount of anti-ADV36-Ab increased whereas circulating concentrations of 25(OH)D decreased across BMI categories with higher amounts in children with normal weight than in children with overweight and obesity (31.0±16.4, 22.5±10.5 and 21.9±9.8 nmol/L, respectively, p=0.004). Logistic regression analysis revealed that for each unit increment of anti-ADV36-Ab, the chance of increase in weight was 8.5 times (OR: 8.5, p=0.029). Interestingly, when 25(OH)D was introduced into the model, anti-ADV36-Ab was no longer the predictor of weight increment and the chance of increase in weight reduced 5% for each unit increase in 25(OH)D concentration (OR: 0.95, p=0.012). Conclusion. It is suggested that ADV36-induced lipogenesis may be mediated by vitamin D deficiency in children with obesity.

Download Full-text