Vitamin D i pokazateli kal'tsiy-fosfornogo obmenau detey, prozhivayushchikh v sredney polose Rossii, v periodmaksimal'noy insolyatsii

Vitamin D deficiency is associated with rickets in children and osteomalation in adults. Published data support the role of vitamin D insufficiency in development of autoimmune, cardiovascular and oncological diseases. The most precise method to diagnose vitamin D insufficiency is measuring of 25-hydroxyvitamin D (25(OH)-D). We studded the levels of vitamin D and calcium-phosphate turnover parameters during the period of maximal insolation in 140 healthy children and adolescents permanently living in the central area of Russia. Vitamin D insufficiency (25(OH)-D < 20 ng/ml) was detected in 38,6%; in 2,9% of them severe vitamin D deficiency was diagnosed (25(OH)-D < 8 ng/ml). The results correlate with data on hypovitaminosis D prevalence in countries with the same geographical latitude. To clarify the real size of required prophylaxis we need investigation of the same parameters in winter period while minimal insolation.

Download Full-text

HYPOVITAMINOSIS D

The Professional Medical Journal ◽

10.29309/tpmj/2015.22.12.797 ◽

2015 ◽

Vol 22 (12) ◽

pp. 1535-1540

Author(s):

Ghazala Ahmad ◽

Nadeem Hashmat ◽

Naureen Kanwal Satti

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Clinical Signs ◽

Signs And Symptoms ◽

Hypovitaminosis D ◽

Healthy Children ◽

Hydroxyvitamin D ◽

Pediatric Clinic ◽

Calcium Phosphorus ◽

Clinical Signs And Symptoms

Objectives: To determine the frequency of vitamin D deficiency in children under12 years of age in the absence of significant clinical signs and symptoms in an ambulatory caresettings. Study Design: Descriptive study. Settings and duration: This study was conductedin Pediatric Out Patient Department of KAUH from June 2013 to June 2014. Materials andmethods: Patients attending the pediatric clinic in KAUH Riyadh, KSA, from June2013 to June2014, in which 287 healthy children under 12 years were enrolled. Serum calcium, phosphorus,alkaline phosphatase and 25-hydroxyvitamin D [25(OH) D] were measured .X ray wrists weretaken for radiological evidence of rickets. 25(OH) D levels <50 ng/mL and <25 ng/mL weredefined as insufficiency and severe vitamin D deficiency, respectively. Results: A high prevalenceof vitamin D deficiency is observed in healthy children even in absence of clinical signs andsymptoms. The problem should be highlighted and there is a need to create awareness amongpeople about the etiology of vitamin D deficiency and its prevention.There is a strong need forlong term planning including populationscreening, dietary supplementation with vitamin D andfood fortification.

Download Full-text

Very high rates of vitamin D insufficiency in women of child-bearing age living in Beijing and Hong Kong

British Journal Of Nutrition ◽

10.1017/s0007114507844382 ◽

2008 ◽

Vol 99 (6) ◽

pp. 1330-1334 ◽

Cited By ~ 43

Author(s):

Jean Woo ◽

Christopher W. K. Lam ◽

Jason Leung ◽

Winny Y. Lau ◽

Edith Lau ◽

...

Keyword(s):

Vitamin D ◽

Hong Kong ◽

Pregnant Women ◽

Vitamin D Deficiency ◽

Vitamin D Insufficiency ◽

Dietary Intakes ◽

Hydroxyvitamin D ◽

The North ◽

25 Hydroxyvitamin D ◽

The Relationship

We aimed to describe the vitamin D status of young women living in two Chinese cities in the spring – Beijing in the north (latitude 39° north) and Hong Kong (latitude 22° north) in the south. We also examined the relationship between serum 25-hydroxyvitamin D and parathyroid hormone (PTH) concentrations to determine a threshold for serum 25-hydroxyvitamin D above which there is no further suppression of PTH. Finally, we examined whether dietary Ca intake influences this relationship. Non-pregnant women aged 18–40 years (n 441) were recruited between February and June. Fasting blood was collected and dietary intakes were assessed using 5 d food records. Mean serum 25-hydroxyvitamin D concentration was lower in Beijing than Hong Kong women (29 v. 34 nmol/l; P < 0·001). Vitamin D deficiency ( ≤ 25 nmol/l) was indicated in 40 % of Beijing and 18 % of Hong Kong women, and over 90 % of women in both cities were insufficient ( ≤ 50 nmol/l). Mean Ca and vitamin D intakes were 478 mg/d and 2·0 μg/d, respectively. The relationship between 25-hydroxyvitamin D concentration and PTH was linear throughout the range with a slope of − 0·36 (different from 0; P < 0·001; R 0·26), with no apparent threshold. There was no influence of Ca intake on the relationship between 25-hydroxyvitamin D and PTH concentration. Vitamin D deficiency is common and insufficiency is very common in non-pregnant women in Hong Kong and Beijing during spring. Serum 25-hydroxyvitamin D was inversely associated with PTH with no apparent threshold. Strategies such as vitamin D fortification or supplementation may be required.

Download Full-text

Assessment of Relationship Between Serum Vitamin D Levels and Metabolic Syndrome Components in Hemodialysis Patients

Galician Medical Journal ◽

10.21802/gmj.2021.1.3 ◽

2021 ◽

Vol 28 (1) ◽

pp. E202113

Author(s):

Sevil Karahan Yılmaz ◽

Cuma Mertoğlu ◽

Aylin Ayaz

Keyword(s):

Metabolic Syndrome ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Serum Vitamin ◽

Vitamin D Insufficiency ◽

Hemodialysis Patients ◽

Hydroxyvitamin D ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

25 Oh Vitamin D

Aim: This study is aimed to evaluate the relationship between serum vitamin D levels and metabolic syndrome in hemodialysis patients. Materials and Methods: This study was conducted with participation of 80 patients undergoing hemodialysis for more than 6 months three times a week, aged > 18 years. Their height, dry weight, waist circumference were measured. Biochemical parameters such as serum 25-hydroxyvitamin D, lipid profile, and fasting blood glucose were analyzed. Metabolic syndrome was defined using the National Cholesterol Education Program Adult Treatment Panel III criteria. Severe vitamin D deficiency, 25 (OH) vitamin D < 5 ng/ml; mild vitamin D deficiency, 25 (OH) vitamin D 5-15 ng/ml; vitamin D insufficiency, 25 (OH) vitamin D 16-30 ng/ml, and vitamin D sufficiency, 25 (OH) vitamin D > 30 ng/ml were categorized. Statistical analysis of the data was performed with the use of SPSS version 21.0. Results: 48.4% of hemodialysis patients were identified to have metabolic syndrome. According to the serum levels of vitamin D; 35.0% of patients had severe vitamin D deficiency, 37.4% of patients had mild vitamin D deficiency, 18.8% of patients had vitamin D insufficiency and 8.8% of patients had vitamin D sufficiency (> 30 ng/ml). Vitamin D insufficiency was significantly associated with metabolic syndrome and central obesity. Conclusions: Deficiency/insufficiency is observed in serum 25-hydroxyvitamin D levels in hemodialysis patients. Vitamin D insufficiency is associated with metabolic syndrome.

Download Full-text

Prevalence of Vitamin D Deficiency Among Patients After Kidney Transplantation in Latvia

Proceedings of the Latvian Academy of Sciences Section B Natural Exact and Applied Sciences ◽

10.2478/prolas-2013-0007 ◽

2013 ◽

Vol 67 (1) ◽

pp. 35-41

Author(s):

Ināra Ādamsone ◽

Inese Folkmane ◽

Diāna Amerika ◽

Rafails Rozentāls

Keyword(s):

Vitamin D ◽

Kidney Transplantation ◽

Vitamin D Deficiency ◽

Graft Function ◽

Inverse Correlation ◽

Hypovitaminosis D ◽

Vitamin D Insufficiency ◽

Kidney Graft ◽

Immunosuppressive Medications ◽

Total Alkaline

Nutritional Vitamin D deficiency is an increasingly recognised condition in chronic kidney disease patients and in patients after kidney transplantation. The main goal of the present study was to estimate the prevalence of hypovitaminosis D in the cohort of kidney grafted patients in Latvia and to determine the relationships between vitamin D level and kidney graft function, time since transplantation, gender, use of particular immunosuppressive medications, and some biochemical parameters. We measured the 25(OH)D serum level in 165 patients. Mean age of patients was 49.7 years (range: 11-80). Median time after transplantation was 6.5 years (range 0.8-16.4 years). Mean 25(OH)D level for all cohort was 22.71 ± 7.06 ng/mL; only 30/165 (18%) of patients were vitamin D sufficient. 71/165 (43%) patients showed insufficient 25(OH)D level, 62/165 (38%) patients were mildly vitamin D deficient, and 2/165 (1%) were severely vitamin D deficient. Serum creatinine level was negatively correlated with 25(OH)D (r = -0.21; P < 0.01). We also observed an inverse correlation between iPTH and 25(OH) D (r = -0.35, P < 0.0001) and between total alkaline phosphatase and 25(OH) D (r = -0.20, P < 0.01). This study confirmed the almost universal prevalence of vitamin D insufficiency among kidney graft recipients and emphasized importance of regular evaluation and proper supplementation of Vitamin D in this population.

Download Full-text

Vitamin D in Therapeutics: Past, Present and Future

MVP Journal of Medical Sciences ◽

10.18311/mvpjms/2016/v3/i2/6390 ◽

2016 ◽

Vol 3 (2) ◽

pp. 128

Author(s):

Jeetendra Singh ◽

Sameer B. Dharrao ◽

Tushar Baheti

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Human Body ◽

Indian Population ◽

Vitamin D Insufficiency ◽

Direct Sunlight ◽

Hydroxyvitamin D ◽

Patients At Risk ◽

25 Hydroxyvitamin D ◽

In The Beginning

In the beginning of 20th century vitamin D was classified as a vitamin but later considered as a prohormone ("conditional" vitamin) which influences the expression of more than 200 genes in the human body. Worldwide vitamin D insufficiency affects about 50% of the population and in India about 80% of population has vitamin D level less than normal. In India sunshine is abundant but still Indians are deprived of this sunshine vitamin. Minimal exposure to direct sunlight, staying indoors, use of sunscreen lotions, pollution, clothing, dietary and cooking habits are most important factors for vitamin D deficiency in the Indian population. Serum 25 hydroxyvitamin D level is the initial diagnostic test in patients at risk for deficiency. Treatment with either vitamin D2 or vitamin D3 is recommended for patients having deficiency, keeping hypervitaminosis in mind.

Download Full-text

Vitamin D deficiency and insufficiency in pregnant women: a longitudinal study

British Journal Of Nutrition ◽

10.1017/s0007114509297236 ◽

2009 ◽

Vol 102 (6) ◽

pp. 876-881 ◽

Cited By ~ 152

Author(s):

Valerie A. Holmes ◽

Maria S. Barnes ◽

H. Denis Alexander ◽

Peter McFaul ◽

Julie M. W. Wallace

Keyword(s):

Vitamin D ◽

Longitudinal Study ◽

Pregnant Women ◽

Hypovitaminosis D ◽

Vitamin D Insufficiency ◽

Vitamin D Supplementation ◽

Vitamin D Status ◽

Maternal Vitamin ◽

Hydroxyvitamin D ◽

Supplement Use

Maternal vitamin D insufficiency is associated with childhood rickets and longer-term problems including schizophrenia and type 1 diabetes. Whilst maternal vitamin D insufficiency is common in mothers with highly pigmented skin, little is known about vitamin D status of Caucasian pregnant women. The aim was to investigate vitamin D status in healthy Caucasian pregnant women and a group of age-matched non-pregnant controls living at 54–55°N. In a longitudinal study, plasma 25-hydroxyvitamin D (25(OH)D) was assessed in ninety-nine pregnant women at 12, 20 and 35 weeks of gestation, and in thirty-eight non-pregnant women sampled concurrently. Plasma 25(OH)D concentrations were lower in pregnant women compared to non-pregnant women (P < 0·0001). Of the pregnant women, 35, 44 and 16 % were classified as vitamin D deficient (25(OH)D < 25 nmol/l), and 96, 96 and 75 % were classified as vitamin D insufficient (25(OH)D < 50 nmol/l) at 12, 20 and 35 weeks gestation, respectively. Vitamin D status was higher in pregnant women who reported taking multivitamin supplements at 12 (P < 0·0001), 20 (P = 0·001) and 35 (P = 0·001) weeks gestation than in non-supplement users. Vitamin D insufficiency is evident in pregnant women living at 54–55°N. Women reporting use of vitamin D-containing supplements had higher vitamin D status, however, vitamin D insufficiency was still evident even in the face of supplement use. Given the potential consequences of hypovitaminosis D on health outcomes, vitamin D supplementation, perhaps at higher doses than currently available, is needed to improve maternal vitamin D nutriture.

Download Full-text

Significant Independent Predictors of Vitamin D Deficiency in Inpatients and Outpatients of a Nephrology Unit

International Journal of Endocrinology ◽

10.1155/2013/237869 ◽

2013 ◽

Vol 2013 ◽

pp. 1-5 ◽

Cited By ~ 3

Author(s):

Recep Bentli ◽

Hulya Taskapan ◽

Halil Toktaş ◽

Ozkan Ulutas ◽

Adnan Ozkahraman ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Female Gender ◽

Vitamin D Insufficiency ◽

Vitamin D Supplementation ◽

Documentary Evidence ◽

Hydroxyvitamin D ◽

Nitrogen Levels ◽

25 Hydroxyvitamin D ◽

Higher Doses

Aims. Kidney disease was found to be a major risk factor for vitamin D deficiency in a population study of patients hospitalized. The aims of the study were to describe the prevalence of vitamin D deficiency inpatients and outpatients in a nephrology department during fall and to evaluate effect of assessing serum 25-hydroxyvitamin D (25(OH)D) levels and previous supplementation of cholecalciferol on vitamin D status.Methods. We studied 280 subjects in total, between October and January. The subjects were recruited from the following two groups: (a) inpatients and (b) outpatients in nephrology unit. We examined previous documentary evidence of vitamin D supplementation of the patients.Results. The prevalence of vitamin D deficiency among these 280 patients was 62,1% (174 patients). Fifty-three patients (18.9%) had severe vitamin D deficiency, 121 patients (43.2%) moderate vitamin D deficiency, and 66 patients (23.6%) vitamin D insufficiency. In logistic regression analysis female gender, not having vitamin D supplementation history, low serum albumin, and low blood urea nitrogen levels were significant independent predictors of vitamin D deficiency while no association of vitamin D deficiency with diabetes mellitus, serum creatinine, eGFR, and being hospitalized was found.Conclusion. Vitamin D deficiency, seems to be an important problem in both inpatients and outpatients of nephrology. Monitoring serum 25(OH)D concentrations regularly and replacement of vitamin D are important. Women in Turkey are at more risk of deficiency and may therefore need to consume higher doses of vitamin D.

Download Full-text

Vitamin D status is related to severity at onset of diabetes and worse glycemic control

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2020-0149 ◽

2020 ◽

Vol 33 (10) ◽

pp. 1265-1271

Author(s):

Raquel Segovia-Ortí ◽

Antonia Barceló Bennassar ◽

Diego de Sotto-Esteban ◽

Pilar Sanchís Cortés

Keyword(s):

Vitamin D ◽

Glycemic Control ◽

Glycosylated Hemoglobin ◽

Winter Season ◽

Hypovitaminosis D ◽

Vitamin D Insufficiency ◽

Baseline Serum ◽

Hydroxyvitamin D ◽

Bivariate Correlation ◽

25 Hydroxyvitamin D

AbstractObjectivesOur aim is to evaluate whether 25-hydroxyvitamin D at onset of type 1 diabetes mellitus (T1DM) would influence analytical variables of worse prognosis of the disease at the beginning and after one year of development.MethodsA retrospective study of pediatric patients (0–14 years) diagnosed with T1DM with initial measurements of 25-hydroxyvitamin D was performed at Son Espases Hospital, between March 2012 and April 2019 (n=67).ResultsVitamin D insufficiency was related to age, glycosylated hemoglobin, and creatinine. An improvement in glycosylated hemoglobin was found in subjects whose baseline serum 25(OH)D was >30 ng/mL. Bivariate correlation analysis adjusted by age showed a significantly positive correlation of vitamin D with pH (r=0.279), bicarbonate (r=0.338), and free levothyroxine (r=0.293). Independent variables associated with vitamin D insufficiency were age (odds ratio [OR]=1.2) and winter season (OR=10.52).ConclusionHypovitaminosis D is related to biochemical variables showing greater severity and higher glycosylated hemoglobin at diagnosis: higher creatinine, lower free levothyroxine, pH, and bicarbonate. Unsupplemented patients with baseline deficiency showed persistently worse glycemic control vs. those with baseline repletion.

Download Full-text

High prevalence of vitamin D deficiency among normotensive and hypertensive pregnant women in Ghana

BMC Pregnancy and Childbirth ◽

10.1186/s12884-021-03802-9 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Linda Ahenkorah Fondjo ◽

Worlanyo Tashie ◽

William K. B. A. Owiredu ◽

Enoch Appiah Adu-Gyamfi ◽

Laila Seidu

Keyword(s):

Vitamin D ◽

Birth Weight ◽

Low Birth Weight ◽

Pregnant Women ◽

Vitamin D Deficiency ◽

Hypovitaminosis D ◽

Sub Saharan Africa ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

In Pregnancy

Abstract Background Hypovitaminosis D in pregnancy is associated with adverse health outcomes in mothers, newborns and infants. This study assessed the levels of 25-hydroxyvitamin D [25(OH)D] in normotensive pregnancies and in preeclampsia, evaluated the association between vitamin D deficiency and preeclampsia risk; and determined the foeto-maternal outcome in preeclamptic women with vitamin D deficiency. Methods This case-control study was conducted among pregnant women who visited the Comboni Hospital, in Ghana from January 2017 to May 2018 for antenatal care. A total of 180 pregnant women comprising 88 preeclamptic women (PE) and 92 healthy normotensive pregnant women (NP) were recruited. Socio-demographic, clinical and obstetric data were obtained using validated questionnaires. Blood pressure and anthropometrics were measured, and blood samples were collected for the estimation of 25- hydroxyvitamin D [25(OH)D] using enzyme-linked immunosorbent assay technique. Lipids (total cholesterol, triglycerides, HDL-cholesterol and LDL-cholesterol) were also estimated. Results A total of 81.7% of the study participants had vitamin D deficiency. Of these, 88.6% of the women with PE had vitamin D deficiency compared to 75.0% in the NP. Vitamin D levels were significantly reduced in the PE women compared to the normotensive pregnant women (p = 0.001). A higher proportion of the preeclamptic women who were vitamin D deficient had preterm delivery (p < 0:0001) and delivered low birth weight infants (p < 0:0001), and infants with IUGR (p < 0:0001) compared to the control group (p < 0:0001). Pregnant women with PE presented with significant dyslipidemia, evidenced by significantly elevated TC (p = 0.008), LDL (p < 0.0001), triglycerides (p = 0.017) and a significantly reduced HDL (p = 0.001) as compared to NP. In the preeclamptic women, serum 25(OH) D showed an inverse, but not significant association with TC (β = − 0.043, p = 0.722, TG (β = − 0.144, p = 0.210) and LDL (β = − 0.076, p = 0.524) and a positive, but not significant association with HDL (β = 0.171, p = 0.156). Conclusion The prevalence of vitamin D deficiency is high in both normotensive pregnancies and pregnancies complicated by preeclampsia but amplified in preeclampsia. Higher proportion of pregnant women with hypovitaminosis D had preterm babies and delivered low birth weight neonates. Additional studies are needed to explore the potential benefits and optimal dosing of vitamin D use in pregnancy, especially in sub-Saharan Africa.

Download Full-text

Vitamin D and PTH: data from a cross-sectional study in an equatorial population

Endocrine Connections ◽

10.1530/ec-20-0206 ◽

2020 ◽

Vol 9 (7) ◽

pp. 667-675

Author(s):

Natércia Neves Marques de Queiroz ◽

Franciane Trindade Cunha de Melo ◽

Fabrício de Souza Resende ◽

Luísa Corrêa Janaú ◽

Norberto Jorge Kzan de Souza Neto ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Hypovitaminosis D ◽

Serum Levels ◽

Cross Sectional Study ◽

Vitamin D Insufficiency ◽

Institute Of Medicine ◽

Sectional Study ◽

Cross Sectional ◽

Endocrine Society

Objective: Investigate the prevalence of vitamin D deficiency in an equatorial population through a large-sample study. Methods: Cross-sectional study with 30,224 healthy individuals from the North Region, in Brazil (Amazônia – state of Pará), who had 25-hydroxy-vitamin D (25(OH)D) and intact parathyroid hormone (PTH) serum levels measured by immunoassay method. Those with history of acute or chronic diseases were excluded. Abnormal levels of calcium, creatinine, glycemia and albumin were also exclusion criteria. Results: 25(OH)D levels were 29.1 ± 8.2 ng/mL and values <12.7 ng/mL were equal to < −2 s.d. below average. Hypovitaminosis D was present in 10% of subjects according to the Institute of Medicine (values <20 ng/mL) and in 59%, in consonance with Endocrine Society (values 20–30 ng/mL as insufficiency and <20 ng/mL as deficiency) criteria. Individuals were divided according to four age brackets: children, adolescents, adults and elderly, and their 25(OH)D levels were: 33 ± 9; 28.5 ± 7.4; 28.3 ± 7.7; 29.3 ± 8.5 ng/mL, respectively. All groups differed in 25(OH)D, except adolescents vs adults. Regression model showed BMI, sex, living zone (urban or rural) and age as independent variables to 25(OH)D levels. Comparing subjects with vitamin D deficiency (<20 ng/mL) to those with vitamin D insufficiency (20–30 ng/mL), a difference between PTH levels in these two groups was observed (95.9 ± 24.7 pg/mL vs 44.2 ± 64.5 pg/mL; P < 0.01). Additionally, the most accurate predictive vitamin D level for subclinical hyperparathyroidism in ROC curve was 26 ng/mL. Conclusion: Our equatorial population showed low prevalence of vitamin D hypovitaminosis ranging with age bracket. The insufficient category by Endocrine Society was corroborated by our PTH data.

Download Full-text