Nanoparticle-functionalized microcapsules for in vitro delivery and sensing

Nanophotonics ◽  
2012 ◽  
Vol 1 (2) ◽  
pp. 171-180 ◽  
Author(s):  
Susana Carregal-Romero ◽  
Markus Ochs ◽  
Wolfgang J. Parak
Keyword(s):  
Quantum Dots ◽  
Magnetic Nanoparticles ◽  
Optical Excitation ◽  
Building Blocks ◽  
Inorganic Nanoparticles ◽  
Hybrid Particles ◽  
Practical Applications ◽  
Field Gradients ◽  
Magnetic Field Gradients

AbstractInorganic nanoparticles such as magnetic nanoparticles, fluorescent quantum dots, and plasmonic nanoparticles can be used as building blocks for designing multifunctional systems based on polymeric capsules. The properties of the inorganic nanoparticles hereby are harnessed to provide additional functionality to the polymer capsules. Biological applications towards in vitro sensing and delivery are discussed. Examples will be given in which magnetic nanoparticles are used to direct capsules with magnetic field gradients, colloidal quantum dots are used to identify capsules via the formation of optical barcodes, and gold nanoparticles are used as light-controlled heat-sources for opening capsules and releasing macromolecules from their cavity upon optical excitation. This demonstrates that combination of inorganic nanoparticles and organic/polymeric molecules as carrier matrices allow for tailoring multifunctional hybrid particles for practical applications.

scholarly journals Effects of magnetic field gradients on the aggregation dynamics of colloidal magnetic nanoparticles

Soft Matter ◽  
2015 ◽  
Vol 11 (38) ◽  
pp. 7606-7616 ◽  
Author(s):  
D. Heinrich ◽  
A. R. Goñi ◽  
T. M. Osán ◽  
L. M. C. Cerioni ◽  
A. Smessaert ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Molecular Dynamics ◽  
Magnetic Nanoparticles ◽  
Molecular Dynamics Simulations ◽  
Theoretical Models ◽  
Experimental Results ◽  
Field Gradients ◽  
Magnetic Field Gradients ◽  
Dynamics Simulations

We combined theoretical models, experimental results and molecular dynamics simulations to explain the aggregation dynamics of ferrofluids in the presence of magnetic field gradients.

scholarly journals Going Hands-Free: MagnetoSuture™ for Untethered Guided Needle Penetration of Human Tissue Ex Vivo

Robotics ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 129
Author(s):  
Lamar O. Mair ◽  
Sagar Chowdhury ◽  
Xiaolong Liu ◽  
Onder Erin ◽  
Oleg Udalov ◽  
...  
Keyword(s):  
Surgical Procedures ◽  
Ex Vivo ◽  
Robotic Surgical Procedures ◽  
Needle Penetration ◽  
Field Gradients ◽  
Surgical Tool ◽  
Surgical Suture ◽  
Magnetic Field Gradients ◽  
Proof Of Principle

The application of force in surgical settings is typically accomplished via physical tethers to the surgical tool. While physical tethers are common and critical, some internal surgical procedures may benefit from a tetherless operation of needles, possibly reducing the number of ports in the patient or the amount of tissue damage caused by tools used to manipulate needles. Magnetic field gradients can dynamically apply kinetic forces to magnetizable objects free of such tethers, possibly enabling ultra-minimally invasive robotic surgical procedures. We demonstrate the untethered manipulation of a suture needle in vitro, exemplified by steering through narrow holes, as well as needle penetration through excised rat and human tissues. We present proof of principle manipulations for the fully untethered control of a minimally modified, standard stainless steel surgical suture needle.

Confinement of magnetic nanoparticles inside multisegmented nanotubes by means of magnetic field gradients

2012 ◽  
Vol 111 (1) ◽  
pp. 013916 ◽  
Author(s):  
R. F. Neumann ◽  
M. Bahiana ◽  
S. Allende ◽  
J. Escrig ◽  
D. Altbir
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Field Gradients ◽  
Magnetic Field Gradients

scholarly journals Magnetically induced enzymatic cascades – advancing towards multi-fuel direct/mediated bioelectrocatalysis

2019 ◽  
Vol 1 (5) ◽  
pp. 1686-1692 ◽  
Author(s):  
Katharina Herkendell ◽  
Andreas Stemmer ◽  
Ran Tel-Vered
Keyword(s):  
Magnetic Field ◽  
Power Generation ◽  
Magnetic Nanoparticles ◽  
Modified Electrodes ◽  
Field Gradients ◽  
Functionalized Magnetic Nanoparticles ◽  
Enzymatic Cascades ◽  
Magnetic Field Gradients ◽  
Mediated Bioelectrocatalysis

Enzyme-functionalized magnetic nanoparticles are channeled by magnetic field gradients onto modified electrodes to activate enzymatic cascades for multi-substrate power generation.

scholarly journals Recent advances in drug release monitoring

Nanophotonics ◽  
2019 ◽  
Vol 8 (3) ◽  
pp. 391-413 ◽  
Author(s):  
Fenfen Zheng ◽  
Weiwei Xiong ◽  
Shasha Sun ◽  
Penghui Zhang ◽  
Jun Jie Zhu
Keyword(s):  
Drug Release ◽  
Polymeric Nanoparticles ◽  
Imaging Techniques ◽  
Building Blocks ◽  
Inorganic Nanoparticles ◽  
Inappropriate Drug ◽  
Monitoring Drug ◽  
Multi Mode

AbstractMonitoring drug releasein vitroandin vivois of paramount importance to accurately locate diseased tissues, avoid inappropriate drug dosage, and improve therapeutic efficiency. In this regard, it is promising to develop strategies for real-time monitoring of drug release inside targeted cells or even in living bodies. Thus far, many multi-functional drug delivery systems constructed by a variety of building blocks, such as organic molecules, polymeric nanoparticles, micelles, and inorganic nanoparticles, have been developed for drug release monitoring. Especially, with the advancements in imaging modalities relating to nanomaterials, there has been an increasing focus on the use of non-invasive imaging techniques for monitoring drug release and drug efficacy in recent years. In this review, we introduce the application of fluorescence imaging, magnetic resonance imaging (MRI), surface-enhanced Raman scattering (SERS), and multi-mode imaging in monitoring drug release, involving a variety of nanomaterials such as organic or inorganic nanoparticles as imaging agents; their design principles are also elaborated. Among these, a special emphasis is placed on fluorescence-based drug release monitoring strategies, followed by a brief overview of MRI, SERS, and multi-mode imaging-based strategies. In the end, the challenges and prospects of drug release monitoring are also discussed.

Sub-100 nm Confinement of Magnetic Nanoparticles Using Localized Magnetic Field Gradients

2003 ◽  
Vol 125 (42) ◽  
pp. 12704-12705 ◽  
Author(s):  
Adam R. Urbach ◽  
J. Christopher Love ◽  
Mara G. Prentiss ◽  
George M. Whitesides
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Field Gradients ◽  
Magnetic Field Gradients ◽  
Localized Magnetic Field

scholarly journals Coherent transfer of quantum information in a silicon double quantum dot using resonant SWAP gates

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
A. J. Sigillito ◽  
M. J. Gullans ◽  
L. F. Edge ◽  
M. Borselli ◽  
J. R. Petta
Keyword(s):  
Quantum Dots ◽  
Quantum Dot ◽  
Double Quantum ◽  
High Fidelity ◽  
Silicon Quantum Dots ◽  
Field Gradients ◽  
Double Quantum Dot ◽  
Swap Gate ◽  
Magnetic Field Gradients ◽  
Qubit Operation

AbstractSpin-based quantum processors in silicon quantum dots offer high-fidelity single and two-qubit operation. Recently multi-qubit devices have been realized; however, many-qubit demonstrations remain elusive, partly due to the limited qubit-to-qubit connectivity. These problems can be overcome by using SWAP gates, which are challenging to implement in devices having large magnetic field gradients. Here we use a primitive SWAP gate to transfer spin eigenstates in 100 ns with a fidelity of $${\bar{F}}_{{\rm{SWAP}}}^{{\rm{(p)}}}=98 \%$$F¯SWAP(p)=98%. By swapping eigenstates we are able to demonstrate a technique for reading out and initializing the state of a double quantum dot without shuttling charges through the quantum dot. We then show that the SWAP gate can transfer arbitrary two-qubit product states in 300 ns with a fidelity of $${\bar{F}}_{{\rm{SWAP}}}^{{\rm{(c)}}}=84 \%$$F¯SWAP(c)=84%. This work sets the stage for many-qubit experiments in silicon quantum dots.

Development of Modified Viscoelastic Solution with Magnetic Nanoparticles – Potential Method for Targeted Treatment of Chondral Injuries

2013 ◽  
Vol 583 ◽  
pp. 145-149 ◽  
Author(s):  
Rodica Marinescu ◽  
Dan Laptoiu ◽  
Iulian Antoniac ◽  
Cristian Petcu
Keyword(s):  
Magnetic Nanoparticles ◽  
Cartilage Lesion ◽  
Potential Method ◽  
Layer By Layer ◽  
Ftir Analysis ◽  
Field Gradients ◽  
Layer Method ◽  
Iron Salts ◽  
Magnetic Field Gradients ◽  
Active Substances

Intra-articular treatments offer the advantage of achieving high active substance concentrations at the site of cartilage lesion. One problem with these drugs is that of low remanence. A method to prolong the survival time of substance inside the joint may improve the cartilage repair and patient symptoms. Targeted therapy aims to optimize the delivery of these drugs set in a solution of magnetic nanoparticles, by injection into the knee joint, in order to increase the residence time of active substances through the application of high magnetic field gradients in the joint area by using extracorporeal magnets. Synthesized magnetic nanoparticles, which were covered by layer-by-layer method in consecutive layers of protection, are stable and retain their character and magnetic-polymer composites features required to be used for their intended purpose. FTIR analysis demonstrated the presence of iron salts in the synthesized ferrofluid, and of the characteristic groups of polymer coating which demonstrated that the technique of embedding in polymer layers by layer-by-layer method is viable.

scholarly journals All-optical charging and charge transport in quantum dots

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Jacob Hastrup ◽  
Lorenzo Leandro ◽  
Nika Akopian
Keyword(s):  
Quantum Dots ◽  
Charge Transport ◽  
Building Blocks ◽  
Photonic Devices ◽  
Optically Active ◽  
Band Alignment ◽  
Multiple Quantum ◽  
Practical Applications ◽  
All Optical ◽  
Quantum Technology

Abstract Optically active quantum dots are one of the promising candidates for fundamental building blocks in quantum technology. Many practical applications would comprise of multiple coupled quantum dots, each of which must be individually chargeable. However, the most advanced demonstrations are limited to devices with only a single dot, and individual charging has neither been demonstrated nor proposed for an array of optically active quantum dots. Here we propose and numerically demonstrate a method for controlled charging of multiple quantum dots and charge transport between the dots. We show that our method can be implemented in realistic structures with fidelities greater than 99.9%. The scheme is based on all-optical resonant manipulation of charges in an array of quantum dots formed by a type-II band alignment, such as crystal-phase quantum dots in nanowires. Our work opens new practical avenues for realizations of advanced quantum photonic devices, for instance, solid-state quantum registers with a photonic interface.

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