scholarly journals Immunostimulatory photochemotherapeutic nanocapsule for enhanced colon cancer treatment

Nanophotonics ◽  
2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Jie Liu ◽  
Fatemeh Movahedi ◽  
Bing Sun ◽  
Luyao Sun ◽  
Bing Zhang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Treatment ◽  
Near Infrared ◽  
Great Promise ◽  
Combination Strategy ◽  
Colon Tumors ◽  
Cancer Cell Death ◽  
Therapeutic Drugs ◽  
Great Progress ◽  
Primary Colon

Abstract Immunotherapy has made great progress in recent years while most cancer patients cannot benefit from it. Photochemotherapy combination strategy holds great promise for developing novel immunotherapy for the patients bearing immunosuppressive tumors such as colon cancer. In this research, a novel core/shell-structured polydopamine (PDA)-based nanoplatform is constructed to load two Food and Drug Administration (FDA)-approved cytotoxic drugs, i.e. immunostimulatory doxorubicin (Dox) and immunomodulatory curcumin (Cur) to achieve immunostimulatory photochemotherapy of primary colon tumors upon 808 nm near infrared (NIR) irradiation (1 W/cm2 for 5 min) and subsequent prevention of rechallenged distant colon tumors. The experimental data have shown that PDA-mediated photothermal therapy (PTT) synergized two therapeutic drugs in inducing colon cancer cell death and very efficiently inhibited the primary tumor growth (by ∼92%) at very low doses of therapeutics (0.25, 5, and 30 mg/kg of Dox, Cur, and PDA, respectively). More significantly, the combined photochemotherapy promoted strong adaptive antitumor immune responses and successfully prevented tumorigenesis in the setting of tumor rechallenge model. Our research has thus demonstrated the promising efficacy of this photochemotherapeutic nanoformulation for colon cancer treatment and provided a way to improve immunostimulatory effects of conventional chemotherapeutic drugs.

The Role of NIR Fluorescence in MDR Cancer Treatment: From Targeted Imaging to Phototherapy

2020 ◽  
Vol 27 (33) ◽  
pp. 5510-5529
Author(s):  
Zengtao Wang ◽  
Qingqing Meng ◽  
Shaoshun Li
Keyword(s):  
Cancer Treatment ◽  
Near Infrared ◽  
Combined Therapy ◽  
Efflux Pumps ◽  
Cross Resistance ◽  
Great Promise ◽  
Drug Efflux ◽  
Nir Dyes ◽  
Nir Imaging ◽  
Drug Efflux Pumps

Background: Multidrug Resistance (MDR) is defined as a cross-resistance of cancer cells to various chemotherapeutics and has been demonstrated to correlate with drug efflux pumps. Visualization of drug efflux pumps is useful to pre-select patients who may be insensitive to chemotherapy, thus preventing patients from unnecessary treatment. Near-Infrared (NIR) imaging is an attractive approach to monitoring MDR due to its low tissue autofluorescence and deep tissue penetration. Molecular NIR imaging of MDR cancers requires stable probes targeting biomarkers with high specificity and affinity. Objective: This article aims to provide a concise review of novel NIR probes and their applications in MDR cancer treatment. Results: Recently, extensive research has been performed to develop novel NIR probes and several strategies display great promise. These strategies include chemical conjugation between NIR dyes and ligands targeting MDR-associated biomarkers, native NIR dyes with inherent targeting ability, activatable NIR probes as well as NIR dyes loaded nanoparticles. Moreover, NIR probes have been widely employed for photothermal and photodynamic therapy in cancer treatment, which combine with other modalities to overcome MDR. With the rapid advancing of nanotechnology, various nanoparticles are incorporated with NIR dyes to provide multifunctional platforms for controlled drug delivery and combined therapy to combat MDR. The construction of these probes for MDR cancers targeted NIR imaging and phototherapy will be discussed. Multimodal nanoscale platform which integrates MDR monitoring and combined therapy will also be encompassed. Conclusion: We believe these NIR probes project a promising approach for diagnosis and therapy of MDR cancers, thus holding great potential to reach clinical settings in cancer treatment.

scholarly journals Combinatorial Therapeutic Approaches with Nanomaterial-Based Photodynamic Cancer Therapy

Pharmaceutics ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 120
Author(s):  
Yang Hao ◽  
Chih Kit Chung ◽  
Zhenfeng Yu ◽  
Ruben V. Huis in ‘t Veld ◽  
Ferry A. Ossendorp ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Treatment Options ◽  
Great Promise ◽  
Cancer Therapies ◽  
Multiple Cancer ◽  
Primary Tumors ◽  
Minimal Invasiveness ◽  
Combination Strategies ◽  
Therapeutic Drugs ◽  
Local Cell

Photodynamic therapy (PDT), in which a light source is used in combination with a photosensitizer to induce local cell death, has shown great promise in therapeutically targeting primary tumors with negligible toxicity and minimal invasiveness. However, numerous studies have shown that noninvasive PDT alone is not sufficient to completely ablate tumors in deep tissues, due to its inherent shortcomings. Therefore, depending on the characteristics and type of tumor, PDT can be combined with surgery, radiotherapy, immunomodulators, chemotherapy, and/or targeted therapy, preferably in a patient-tailored manner. Nanoparticles are attractive delivery vehicles that can overcome the shortcomings of traditional photosensitizers, as well as enable the codelivery of multiple therapeutic drugs in a spatiotemporally controlled manner. Nanotechnology-based combination strategies have provided inspiration to improve the anticancer effects of PDT. Here, we briefly introduce the mechanism of PDT and summarize the photosensitizers that have been tested preclinically for various cancer types and clinically approved for cancer treatment. Moreover, we discuss the current challenges facing the combination of PDT and multiple cancer treatment options, and we highlight the opportunities of nanoparticle-based PDT in cancer therapies.

scholarly journals Therapeutic Ultrasound-Enhanced Immune Checkpoint Inhibitor Therapy

2021 ◽  
Vol 9 ◽  
Author(s):  
Jinyun Yuan ◽  
Dezhuang Ye ◽  
Si Chen ◽  
Hong Chen
Keyword(s):  
Immune Responses ◽  
Cancer Treatment ◽  
Immune Checkpoint ◽  
Focused Ultrasound ◽  
Checkpoint Inhibitors ◽  
Complete Response ◽  
High Intensity Focused Ultrasound ◽  
Great Promise ◽  
Combination Strategy ◽  
Antitumor Effects

Immune checkpoint inhibitors (ICIs) are designed to reinvigorate antitumor immune responses by interrupting inhibitory signaling pathways and promote the immune-mediated elimination of malignant cells. Although ICI therapy has transformed the landscape of cancer treatment, only a subset of patients achieve a complete response. Focused ultrasound (FUS) is a noninvasive, nonionizing, deep penetrating focal therapy that has great potential to improve the efficacy of ICIs in solid tumors. Five FUS modalities have been incorporated with ICIs to explore their antitumor effects in preclinical studies, namely, high-intensity focused ultrasound (HIFU) thermal ablation, HIFU hyperthermia, HIFU mechanical ablation, ultrasound-targeted microbubble destruction (UTMD), and sonodynamic therapy (SDT). The enhancement of the antitumor immune responses by these FUS modalities demonstrates the great promise of FUS as a transformative cancer treatment modality to improve ICI therapy. Here, this review summarizes these emerging applications of FUS modalities in combination with ICIs. It discusses each FUS modality, the experimental protocol for each combination strategy, the induced immune effects, and therapeutic outcomes.

131I-labeled gold nanoframeworks for radiotherapy-combined second near-infrared photothermal therapy of cancer

2021 ◽  
Author(s):  
Danling Cheng ◽  
Jiali Gong ◽  
Peng Wang ◽  
Jingyi Zhu ◽  
Ningyue Yu ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Heat Generation ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Great Promise ◽  
Anticancer Efficacy

Photothermal therapy (PTT) has shown a great promise for cancer treatment via light-triggered heat generation, while the anticancer efficacy of sole PTT is often limited. In this study, we report...

Colon Cancer Treatment in Rural North and South Carolina

1999 ◽  
Vol 23 (5) ◽  
pp. 428-434 ◽  
Author(s):  
Sarah E. Tropman ◽  
Theresa Hatzell ◽  
Electra Paskett ◽  
Thomas Ricketts ◽  
M. robert Cooper ◽  
...  
Keyword(s):  
Colon Cancer ◽  
South Carolina ◽  
Cancer Treatment ◽  
North And South

scholarly journals Application of Nanoparticles and Nanomaterials in Thermal Ablation Therapy of Cancer

Nanomaterials ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. 1195 ◽  
Author(s):  
Zhannat Ashikbayeva ◽  
Daniele Tosi ◽  
Damir Balmassov ◽  
Emiliano Schena ◽  
Paola Saccomandi ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Thermal Ablation ◽  
Conventional Heating ◽  
Great Promise ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Ablation Therapy ◽  
Treatment Techniques ◽  
Thermal Ablation Therapy ◽  
Heating Capacity ◽  
Tumor Region

Cancer is one of the major health issues with increasing incidence worldwide. In spite of the existing conventional cancer treatment techniques, the cases of cancer diagnosis and death rates are rising year by year. Thus, new approaches are required to advance the traditional ways of cancer therapy. Currently, nanomedicine, employing nanoparticles and nanocomposites, offers great promise and new opportunities to increase the efficacy of cancer treatment in combination with thermal therapy. Nanomaterials can generate and specifically enhance the heating capacity at the tumor region due to optical and magnetic properties. The mentioned unique properties of nanomaterials allow inducing the heat and destroying the cancerous cells. This paper provides an overview of the utilization of nanoparticles and nanomaterials such as magnetic iron oxide nanoparticles, nanorods, nanoshells, nanocomposites, carbon nanotubes, and other nanoparticles in the thermal ablation of tumors, demonstrating their advantages over the conventional heating methods.

Eradication of minimal residual disease in the perioperative period in primary colon cancer

2015 ◽  
Vol 4 (4) ◽  
pp. 157-166 ◽  
Author(s):  
Paul H Sugarbaker ◽  
Paolo Sammartino ◽  
Antonios-Apostolos Tentes
Keyword(s):  
Colon Cancer ◽  
Minimal Residual Disease ◽  
Residual Disease ◽  
Perioperative Period ◽  
Primary Colon Cancer ◽  
Primary Colon ◽  
Minimal Residual

scholarly journals Colorectal Metastasis from Ovarian Neoplasm Mimicking Primary Colon Cancer

2021 ◽  
pp. 41-46
Author(s):  
Anum Aqsa ◽  
Sami Droubi ◽  
Shivantha Amarnath ◽  
Fady Haddad ◽  
Liliane Deeb
Keyword(s):  
Colon Cancer ◽  
Previous History ◽  
Ovarian Neoplasm ◽  
Direct Visualization ◽  
Female Status ◽  
Internal Malignancy ◽  
Primary Colon Cancer ◽  
Primary Colon ◽  
History Of ◽  
Secondary Metastasis

Metastasis to the colon from another primary internal malignancy is an untypical and a seldom reported entity. Direct visualization during colonoscopy is considered the gold standard of diagnosis. Pathologic diagnosis with immunohistochemical staining is essential to differentiate primary colorectal malignancy from secondary metastasis to the colon. We, hereby, present a case of a 53-year-old female status-post resection of left-sided papillary serous ovarian neoplasm who presented 2 years later with a single rectosigmoid intraluminal ulcerative mass imitating a primary colon cancer. Biopsies of the mass were consistent with metastasis from her primary ovarian carcinoma. We believe this case is unique because of the rarity of ovarian cancer metastasizing to the colon intraluminally rather than through direct locoregional invasion. Furthermore, it highlights the importance of considering secondary metastasis in patients with previous history of another primary internal malignancy.

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