Basic Chromium(III) Carboxylates: Reactions of Chromium(III) Chloride with Some Carboxylic Acids

1979 ◽  
Vol 34 (10) ◽  
pp. 1369-1372 ◽  
Author(s):  
Ramesh Kapoor
Keyword(s):  
Acetic Anhydride ◽  
General Formula ◽  
Carboxylic Acids ◽  
Magnetic Measurements ◽  
Molar Conductance ◽  
Strong Affinity ◽  
Elemental Analyses

Abstract Anhydrous chromium(III) chloride reacts with pure carboxylic acids (RCOOH where R = CH3, C2H5, n-C3H7, CH2Cl, CHCl2 and CCl3) to give basic trinuclear chromium(III) carboxylates of the general formula [Cr3O(OOCR)6]+Cl-. The reaction of CrCl3 with acetic anhydride, however, gives a partially substituted product, CrCl(OOCCH3)2.The formation of basic carboxylates has been attributed to the strong affinity of Cr3+ ions for water that they can abstract it even from pure carboxylic acids. Their addition compounds with ammonia have also been prepared. The compounds have been characterized by their elemental analyses, IR, molar conductance and magnetic measurements.

scholarly journals Synthesis, Characterization and Antiproliferative Activity of the Co(II), Ni(II), Cu(II), Pd(II) and Pt(II) Complexes of 2-(4-Thiazolyl)Benzimidazole (Thiabendazole)

2001 ◽  
Vol 8 (4) ◽  
pp. 189-194 ◽  
Author(s):  
Marek Z. Wisniewski ◽  
Tadeusz Glowiak ◽  
Adam Opolski ◽  
Joanna Wietrzyk
Keyword(s):  
Breast Cancer ◽  
General Formula ◽  
Magnetic Measurements ◽  
Human Cancer ◽  
Urinary Bladder Carcinoma ◽  
X Ray ◽  
Human Cancer Cell Lines ◽  
Elemental Analyses ◽  
Mcf 7

Complexes of 2-(4-thiazolyi)benzimidazole (thiabendazole, THBD) with Co(II), Ni(II), Cu(ll) of general formula ML2(NO3)2 H2O and complexes of Pd(II) and Pt(II) of general formula ML2Cl2 H2O have been obtained and characterized by elemental analyses, IR and far IR spectroscopy and magnetic measurements. The X-ray crystal structure of the copper(II) complex has been determined. The in vitro cell proliferation inhibitory activity of these compounds was examined against human cancer cell lines A 549 (lung carcinoma), HCV-29 T (urinary bladder carcinoma), MCF-7 (breast cancer), T47D (breast cancer), MES-SA (uterine carcinoma) and HL-60 (promyelocytic leukemia). Pt-THBD has been found to exhibit an antileukemic activity of the HL-60 line cells matching that of an arbitrary criterion.

scholarly journals Penta-Coordinated Complexes of Bis(2,4-pentanedionato) Copper(II) with Some Oxygen Donor Organic Solvents

1981 ◽  
Vol 36 (1) ◽  
pp. 42-44 ◽  
Author(s):  
B. P. Baranwal ◽  
G. K. Parashar ◽  
R. C. Mehrotra
Keyword(s):  
Molecular Weight ◽  
General Formula ◽  
Organic Solvents ◽  
Electronic Spectra ◽  
Magnetic Measurements ◽  
Oxygen Donor ◽  
Elemental Analyses ◽  
Form Addition

Bis(2,4-pentanedionato) Copper(II) reacts with some oxygen donor organic solvents to form addition complexes with general formula, Cu(2,4-pentanedionato)2. L (where L = MeOH, EtOH, PriOH, ButOH, THF, MeCOMe, MeCOEt and MeCOPrn). The complexes were recrystallized and characterized by the elemental analyses, infrared and electronic spectra, molecular weight and magnetic measurements.

Boron Spirochelates Derived from Some Hydroxamic Acids and Carboxylic Acids

1990 ◽  
Vol 45 (8) ◽  
pp. 1123-1127 ◽  
Author(s):  
M. K. Das ◽  
S. Chakraborty
Keyword(s):  
Carboxylic Acid ◽  
Boric Acid ◽  
General Formula ◽  
Carboxylic Acids ◽  
Hydroxamic Acid ◽  
Hydroxamic Acids ◽  
Uv Spectra ◽  
Elemental Analyses

A number of boron spirochelates of the general formula B[R′CON(R)O]Y have been synthesized by the single-pot reaction of boric acid, a hydroxamic acid R′CON(R)OH and a carboxylic acid H2Y. The spirochelates have been characterized by elemental analyses, by IR, NMR (1H and 11B) and UV spectra and conductance measurements. They are non-electrolytes.

Syntheses and Cytotoxicity Screening of some Novel 1,2,4-Triazine Derivatives against Liver Carcinoma Cell Lines

2020 ◽  
Vol 17 ◽  
Author(s):  
W. Abd El-Fattah
Keyword(s):  
Acetic Anhydride ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Aromatic Aldehydes ◽  
Liver Carcinoma ◽  
Anticancer Activities ◽  
Carcinoma Cell Lines ◽  
Elemental Analyses ◽  
Triazine Derivatives ◽  
C Nmr

: In this work, 1,2,4-triazine derivatives were synthesized and evaluated for anticancer activities. Series of 1,2,4-triazine derivatives (4a, b) were prepared via the reaction of N-benzoyl glycine (1) with aromatic aldehydes in presence of fused sodium acetate and acetic anhydride to give 1,3-oxazolinone derivatives (2a, b), followed by condensation with 1-(ethoxycarbonyl) hydrazine (3) in glacial acetic acid. Compounds (4a, b) then reacted with acetic anhydride, ethyl chloroacetate and 2,4-dinitrophenyl hydrazine yielded the corresponding to N-acetyl derivatives (5a, b), N-(ethoxycarbonyl) methyl derivative (6) and 1,2-disubstituted hydrazine (7), respectively. The structures of the 1,2,4-triazine derivatives were confirmed by IR, 1H, 13C NMR, MS and elemental analyses. Anticancer activity of some 1,2,4-triazine derivatives (4-7) have been investigated. The results revealed that compounds 4a (IC50= 2.7μM), 5a (IC50= 1.5μM), and 5b (IC50= 3.9μM) show promising inhibitory growth efficacy compared to a standard antitumor drug (IC50= 4.6μM). These three compounds can be considered as potential agents against human hepatocellular carcinoma cell lines (HepG-2).

scholarly journals Template synthesis and characterization of biologically active transition metal complexes comprising 14-membered tetraazamacrocyclic ligand

2010 ◽  
Vol 75 (2) ◽  
pp. 217-228 ◽  
Author(s):  
Dharmpal Singh ◽  
Krishan Kumar ◽  
Ramesh Kumar ◽  
Jitender Singh
Keyword(s):  
Magnetic Measurements ◽  
Macrocyclic Ligand ◽  
Salmonella Typhi ◽  
Molar Conductance ◽  
Biologically Active ◽  
Distorted Octahedral Geometry ◽  
Bacterial Strains ◽  
In Vitro Antibacterial Activity ◽  
Active Transition

A novel series of complexes of the type [M(C28H24N4)X2], where M = Co(II), Ni(II), Cu(II), Zn(II) and Cd(II), X = Cl-, NO3 -, CH3COO- and (C28H24N4) corresponds to the tetradentate macrocyclic ligand, were synthesized by template condensation of 1,8-diaminonaphthalene and diacetyl in the presence of divalent metal salts in methanolic medium. The complexes were characterized by elemental analyses, conductance and magnetic measurements, as well as by UV/Vis, NMR, IR and MS spectroscopy. The low values of the molar conductance indicate non-electrolyte type of complexes. Based on these spectral data, a distorted octahedral geometry may be proposed for all of these complexes. All the synthesized macrocyclic complexes were tested for in vitro antibacterial activity against some pathogenic bacterial strains, viz Bacillus cereus, Salmonella typhi, Escherichia coli and Staphylococcus aureus. The MIC values shown by the complexes against these bacterial strains were compared with the MIC shown by the standard antibiotics linezolid and cefaclor.

scholarly journals Syntheses and characterisation of chloro(h3-allyl) dicarbonylmolybdenum(II) complexes of chiral and achiral ditertiaryphosphines

2012 ◽  
Vol 10 (1) ◽  
pp. 165-171
Author(s):  
Joe Jesu Raj ◽  
Devendra Pathak ◽  
Pramesh Kapoor
Keyword(s):  
General Formula ◽  
Force Constant ◽  
Spectroscopic Techniques ◽  
Multinuclear Nmr ◽  
Precursor Complex ◽  
Elemental Analyses ◽  
Secular Equations

AbstractA series of the complexes of the general formula [ClMo(CO)2(η 3-C3H5)(P-P)], [where (P-P) = (m-CH3C6H4)2P(CH2)2PPh2 (m-t-dppe); cis-Ph2PCH=CHPPh2 (cis-diphos); Ph2PCH2CH2AsPh2 (arsaphos); Ph2P(CH2)4PPh2 (dppb); (±)-1,2-C6H4(PMePh)2 (rac-diphos); (2R,3R)Ph2PC*H(Me)C*H(Me)PPh2 (+)-chiraphos; (R,R)-Me2C(O)2{C*HCH2PPh2}2 (-)-diop] were synthesised by the reaction of the precursor complex [ClMo(CO)2(η 3-C3H5)(CH3CN)2] with the corresponding ditertiary phosphine in acetone. The complexes were isolated as yellow to orange air-stable solids and characterised by elemental analyses, FTIR and multinuclear NMR [1H, 31P{1H}] spectroscopic techniques. The carbonyl force constant values were calculated by Cotton and Kraihanzel approximate secular equations using ν C≡O stretching frequencies observed in the FTIR and these were found to be 14.30–14.59 mdyne 0-A−1 and 0.23–0.70 mdyne Å−1 for K1 and Ki respectively. Spectroscopic evidences have confirmed cis-octahedral structures for the synthesized complexes.

scholarly journals Synthesis characterization of Cr(III), Fe(III), Co(II), Ni(II), Cu(II) and Zn(II) complexes of 2,12-dimethyl-3-13-di-n-propyl-l,4,ll,14-tetraazacycloeicosa-1,13,l1,13-tetraene

2002 ◽  
Vol 67 (12) ◽  
pp. 825-832 ◽  
Author(s):  
Raghu Prasad ◽  
Mala Mathur
Keyword(s):  
Metal Ions ◽  
Metal Complexes ◽  
Electronic Spectra ◽  
Magnetic Measurements ◽  
Elemental Analyses

Metal complexes of a 20-membered tetraazamacrocycle 2,12-dimethyl-3,13-di-n-propyl 1,4,11,14-tetraazacycloeicosa-1,3,11,13-tetraene(L) of the type [MLX2]X(M=Cr(III), Fe(III); X=NO3)[CoLNO3]NO3, [NiL(NO3)2], [CuL]Cl2 and [ZnLCl2]have been prepared by 2+2 cyclocondensation of 2,3-hexanedione with 1,6-diaminohexane in the presence of metal ions as templates. These complexes were characterized by elemental analyses, conductances, IR and electronic spectra and magnetic measurements.

scholarly journals Synthesis, characterization, x-ray diffraction studies and biological activities of iron(III) and cobalt(II) complexes with alanine

2018 ◽  
Vol 6 (2) ◽  
pp. 132
Author(s):  
Shuaibu Musa ◽  
S O. Idris ◽  
A D. Onu
Keyword(s):  
Amino Acid ◽  
Biological Activities ◽  
Human Life ◽  
Molar Conductance ◽  
Biological Molecules ◽  
X Ray Diffraction ◽  
Monoclinic Crystal ◽  
X Ray ◽  
Metal Ligands ◽  
Elemental Analyses

The resulted complexes produced between Fe (III) and Co (II) with biological molecules like amino acids play an important role in human life. They can be used as bioactive compounds as well as in industries. Fe (III) and Co (II) complexes are synthesized with Alanine amino acid. The complexes were characterized by X-ray diffraction, magnetic suscetivility, elemental analysis (AAS), molar conductance, melting point, infrared and uv-visible spectrophotometry analyses. The elemental analyses were used to determine the chelation ratio, 1:3(metal: ligands) for iron (III) Alanine and 1:2 ratio for cobalt (II) Alanine. The molar conductivity of the complexes show that the complexes are not electrolytic in nature. The x-ray data suggest monoclinic crystal system for all the complexes with the exception of Co-alanine, which is hexagonal. The magnetic susceptivility and electronic spectra suggest the complexes are high spin with octahedral geometry.The complexes show enhance activity in comparable to the amino acid.  

scholarly journals New Complexes of Pr(III), Sm(III), Gd(lll), Gd(III), La(III) 1-(2-Benzthyazolyl)-3-methyl-4-azo-(4-nitrophenyl)-Pyrazolyn-5-one

1998 ◽  
Vol 6 (6) ◽  
pp. 53-62
Author(s):  
Anca Emandi ◽  
Mariana Balasoiu ◽  
Tudor Rosu
Keyword(s):  
Molecular Weight ◽  
Molar Conductance ◽  
Lanthanide Ions ◽  
X Ray ◽  
Visible Spectra ◽  
Elemental Analyses ◽  
Trivalent Lanthanide

1-(2-Benzthyazolyl)-3-methyl-4-azo-(4-nitrophenyl)-Pyrazolyn-5-one (HL) possesses a chelating behavior. Its chelates with a number of trivalent lanthanide ions Pr(III), Sm(III),Gd(III), Ho(III), La(III) of the type Na3[Ln(L)2(OH)4] have been isolated and characterized on the basis of their elemental analyses, IR and visible spectra, magnetic and molar conductance studies, thermal and X-ray analysis and molecular weight determinations. All chelates have a monomeric octa-coordinated stn1cture and square antiprismatic (C2) symmetry.

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