scholarly journals Bioactive Phenolic Compounds from Aerial Parts of Plinia glomerata

2007 ◽  
Vol 62 (3-4) ◽  
pp. 196-200 ◽  
Author(s):  
Claúdia Serafin ◽  
Viviane Nart ◽  
Angela Malheiros ◽  
Márcia Maria de Souza ◽  
Luiz Fischer ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Chemical Composition ◽  
Phenolic Compounds ◽  
Spectroscopic Data ◽  
P Values ◽  
Analgesic Drugs ◽  
Antinociceptive Action ◽  
Chromatographic Techniques ◽  
Aerial Parts

Abstract The present work describes the antinociceptive properties and chemical composition of the aerial parts of Plinia glomerata (Myrtaceae). Both of the extracts evaluated, acetonic and methanolic, showed potent antinociceptive action, when analyzed against acetic acid-induced abdominal constrictions in mice, with calculated ID50 (mg/kg, i. p.) values of 24.8 and 3.3, respectively. Through usual chromatographic techniques with an acetonic extract, the following compounds were obtained: 3,4,3′-trimethoxy flavellagic acid (1), 3,4,3′-trimethoxy flavellagic acid 4′-O-glucoside (3) and quercitrin (4), which were identified based on spectroscopic data. Compounds 1 (ID50 = 3.9 mg/kg, i. p., or 10.8 μmol/kg) and 3 (ID50 = 1.3 mg/kg or 2.5 μmol/kg) were notably more active than some well-known analgesic drugs used here for comparison.

Bioactivity of Flavonoids Isolated from Lychnophora markgravii against Leishmania amazonensis Amastigotes

2009 ◽  
Vol 64 (7-8) ◽  
pp. 509-512 ◽  
Author(s):  
Marcos José Salvador ◽  
Fabiana Terezinha Sartori ◽  
Ana Claudia B. C. Sacilotto ◽  
Elizabeth M. F. Pral ◽  
Silvia Celina Alfieri ◽  
...  
Keyword(s):  
Methyl Ether ◽  
Spectroscopic Data ◽  
Leishmania Amazonensis ◽  
Active Compounds ◽  
Esi Ms ◽  
Chemical Structures ◽  
Chromatographic Techniques ◽  
Aerial Parts ◽  
Leishmania Amastigotes

The bioactivity of the flavonoids pinostrobin (1), pinocembrin (2), tectochrysin (3), galangin 3-methyl ether (4), and tiliroside (5) isolated from Lychnophora markgravii aerial parts was investigated in vitro against amastigote stages of Leishmania amazonensis. The compounds were isolated by several chromatographic techniques and their chemical structures were established by ESI-MS and NMR spectroscopic data. The flavonoids 1 and 3 were the most active compounds; they markedly reduced the viability of Leishmania amastigotes.

scholarly journals Phytochemical composition and pharmacological assessment of callus and parent plant of Asteriscus graveolens (Forssk.) Less. from Algerian Sahara

2020 ◽  
Vol 19 (9) ◽  
pp. 1895-1901
Author(s):  
Fairouz Belhadi ◽  
Saida Ouafi ◽  
Nadia Bouguedoura
Keyword(s):  
Acetic Acid ◽  
Phenolic Compounds ◽  
Acute Toxicity ◽  
Hplc Analysis ◽  
Callus Cultures ◽  
Phytochemical Analysis ◽  
Oral Toxicity ◽  
Phytochemical Composition ◽  
Aerial Parts ◽  
Anti Inflammatory

Purpose: To determine the phytochemical composition, acute toxicity, as well as analgesic and antiinflammatory properties of extracts of the aerial parts and callus cultures of Asteriscus graveolens.Methods: Different standard chemical tests were used for the screening of bioactive compounds in aqueous extracts of aerial parts of Asteriscus graveolens (PAE) and callus (CAE). High-performance liquid chromatography (HPLC) analysis was performed to identify the constituents of the glycosidic extract (GE). Acute oral toxicity test was carried out to ascertain the safety of the plant material. The analgesic and anti-inflammatory properties of the extracts were determined using acetic acid-induced writhing test and carrageenan-induced edema test, respectively.Results: Phytochemical analysis showed some differences in composition between the aerial parts and callus cultures. Results from HPLC analysis revealed the presence of 12 phenolic compounds in the GE of adult plants. In addition to being orally safe (no mortality), all extracts showed significant inhibition of acetic acid-induced chemical pain: PAE and GE produced 63 and 68 % reductions in pain, respectively, relative to 60.26 % pain reduction by aspirin. All extracts exerted potent anti-inflammatory effects, with PAE producing the highest effect (73 %) at a dose of 100 mg/mL.Conclusion: Asteriscus graveolens extracts possess potent pharmacological properties due to the presence of some phenolic compounds, especially flavonoids. These findings provide a scientific basis for the traditional uses of Asteriscus graveolens, and indicate that it is a potential source of antiinflammatory agents. Keywords: Acute toxicity, Anti-nociceptive, Anti-inflammatory, Aqueous extract, Callus, Flavonoids

scholarly journals Polycyclic Polyprenylated Acylphloroglucinol Derivatives from Hypericum acmosepalum

Molecules ◽  
2018 ◽  
Vol 24 (1) ◽  
pp. 50 ◽  
Author(s):  
Jiao Wang ◽  
Mengjiao Shi ◽  
Jiajia Wang ◽  
Jin Li ◽  
Tengfei Ji
Keyword(s):  
Organic Chemistry ◽  
Hot Spots ◽  
Spectroscopic Data ◽  
Chemical Constituents ◽  
Neuroprotective Effect ◽  
Pharmacological Activities ◽  
Chromatographic Techniques ◽  
Aerial Parts ◽  
Phloroglucinol Derivatives ◽  
Novel Structures

Hypericum acmosepalum belongs to the Hypericum genus of the Guttiferae family. The characteristic components in Hypericum are mainly a series of polycyclic polyprenylated acylphloroglucinols (PPAPs), flavonoids, and xanthones. Among them, the PPAPs have received much attention due to their novel structures and diverse pharmacological activities and have become hot spots in organic chemistry and medicinal chemistry. However, there are few reports about the chemical constituents of Hypericum acmosepalum at present, especially the PPAPs. This research is dedicated to the study of the air-dried aerial parts of Hypericum acmosepalum, which were extracted with 95% EtOH under reflux, then suspended and successively partitioned with petroleum ether and ethyl acetate. Five PPAP derivatives were obtained using various chromatographic techniques, and their structures were determined by NMR spectroscopic data, including two new phloroglucinol derivatives, hyperacmosin A (1) and hyperacmosin B (2). Those compounds were evaluated for their neuroprotective effect using two models.

scholarly journals Diurnal variation of the chemical composition and its repercussion on the biological activity polyphenolics of Salvia officinalis aerial parts

2019 ◽  
pp. 7-21
Author(s):  
Safa Rguez ◽  
amel Msaada ◽  
Majdi Hammami ◽  
Mejda Daami Remadi ◽  
Ikbel Chayeb ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Phenolic Compounds ◽  
Diurnal Variation ◽  
Biological Activities ◽  
Salvia Officinalis ◽  
Total Polyphenols ◽  
Methanolic Extracts ◽  
Aerial Parts ◽  
Total Antioxidant

This study reported the diurnal variation of the chemical composition and biological activities of phenolic compounds of Salvia officinalis cultivated in Tunisia. The HPLC determination of different phenolic compounds showed that the amounts of total polyphenols reach its maximum at 7 am. Estimation of the antioxidant activity of different methanolic extracts of Salvia officinalis showed that the extract of 5 pm had the most effective antiradical power against DPPH and the best iron reducing capacity. The strongest total antioxidant capacity was recorded for extracts of 12 and 5 pm. The methanol extracts of sage also have a capacity to reduce the appetence of Spodoptera littoralis larvae. This activity did not vary with the harvesting time.

scholarly journals Chemical Profile of Essential Oils and Headspace Volatiles of Chaerophyllum hirsutum from Serbia

2017 ◽  
Vol 12 (9) ◽  
pp. 1934578X1701200 ◽  
Author(s):  
Goran M. Petrović ◽  
Jelena G. Stamenković ◽  
Gordana S. Stojanović ◽  
Violeta D. Mitić ◽  
Bojan K Zlatković
Keyword(s):  
Chemical Composition ◽  
Phenolic Compounds ◽  
Essential Oils ◽  
Chemical Profile ◽  
Headspace Volatiles ◽  
Dominant Class ◽  
Aerial Parts ◽  
Main Class ◽  
Main Component ◽  
Root Essential Oil

The present study reports the chemical composition on the headspace volatiles and essential oils obtained from fresh roots, shoots and inflorescences of Chaerophyllum hirsutum. In headspace samples, the most dominant class was monoterpene hydrocarbons, but the main compounds were different. The root had β-phellandrene as the major compound. Sabinene was the main component in the shoots volatiles, while the inflorescence was dominated by endo-fenchyl acetate. The composition of the essential oils of the aerial parts and the oil obtained from root was found to be quite different. The root essential oil showed the presence of phenolic compounds (13.2%), while in the oils from the aerial parts these compounds were present in very small amounts (0.1% in the shoots and 0.2% in the inflorescences oil). In total, 70 compounds were identified in the oil isolated from the root, with γ-terpinene (15.8%) as the major compound of the oil. In the oils isolated from the shoots and the inflorescences, for which 55 and 69 compounds were identified, respectively, the main class was represented by oxygenated sesquiterpenes with acorenone B as the main component, representing 57.0% of the shoots and 44.6% of the inflorescences.

scholarly journals PHYTOCHEMICAL STUDY OF ZYGOPHYLLUM ALBUM EXTRACT

2020 ◽  
Vol 4 (5) ◽  
pp. 1-10
Author(s):  
Belmimoun A ◽  
Meddah B ◽  
Side Larbi K ◽  
Sonnet P.
Keyword(s):  
Chemical Composition ◽  
Phenolic Compounds ◽  
Functional Food ◽  
Methanolic Extract ◽  
Folk Medicine ◽  
Extraction Methods ◽  
Phytochemical Study ◽  
Aerial Parts ◽  
Health Products ◽  
Promising Source

The aerial parts of Zygophyllum album L. are used in folk medicine as an anti-diabetic agent and as a drug active against several pathologies. In this work we present the chemical composition of Algerian phenolic extracts obtained by different solvents and extraction methods The phytochemical study was based on a colometer method, Phenolic compound content and LC/ESI-MS analyses The methanolic extract of zygophyllum album was at least the best extract studied for its quantitative and qualitative richness in phenolic compounds All Z.album extracts and specially the methanolic one are a promising source of health products for functional food or nutraceutical industries.

scholarly journals Chemical analysis of some Ocimum basilicum medicinal teas

2021 ◽  
Vol 14 (3) ◽  
pp. 145-148
Author(s):  
Daniela BENEDEC ◽  
◽  
Diana ROZSA (RUS) ◽  
Daniela HANGANU ◽  
Ilioara ONIGA ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Phenolic Compounds ◽  
Caffeic Acid ◽  
Ocimum Basilicum ◽  
Caffeic Acid Derivatives ◽  
Aromatic Character ◽  
Aerial Parts ◽  
Three Samples ◽  
Therapeutic Properties ◽  
Layer Chromatography

Objectives. Ocimum basilicum is one of the widespread medicinal plants, widely used due to its multiple therapeutic properties (antimicrobial, antiviral, hypoglycemic, antispasmodic, anti-inflammatory, carminative, stomachic, antioxidant, analgesic, etc.), as well as its specific aromatic character. The aim of this study was to comparatively investigate the chemical composition (flavonoids, caffeic acid derivatives, tannins, essential oil) of the aerial parts of some Romanian medicinal teas of Ocimum basilicum. Materials and methods. The content of flavonoids, phenolic acids and tannins in three samples of O. basilicum tea were determined spectrophotometrically. Identification of important phenolic compounds (rutin, isoquercitrin chlorogenic acid and caffeic acid) was performed by thin layer chromatography (TLC). The essential oils were obtained by hydrodistillation method. Outcomes and conclusions. Following the quantitative determinations performed, it can be seen that the basil samples are rich in active principles, and their use for the treatment of some diseases can be justified.

Microwave Pretreatment of Vegetable Materials to Increase the Extraction Yield of Natural Products

2018 ◽  
Vol 69 (8) ◽  
pp. 1976-1979
Author(s):  
Ioana Asofiei ◽  
Ioan Calinescu ◽  
Adina Ionuta Gavrila ◽  
Daniel Ighigeanu ◽  
Diana Martin
Keyword(s):  
Natural Products ◽  
Chemical Composition ◽  
Phenolic Compounds ◽  
Total Phenolic Content ◽  
Phenolic Content ◽  
Extraction Yield ◽  
Total Phenolic ◽  
Microwave Pretreatment ◽  
Pretreatment Time ◽  
Conventional Extraction

It was designed and built a laboratory experimental installation (LEI) for the microwave pretreatment of vegetable materials. To study the influence of microwave pretreatment on the total phenolic content (TPC), a conventional extraction of polyphenols from treated and untreated fresh sea buckthorn leaves was performed. For short extraction times, the amount of phenolic compounds was higher for the extracts obtained from treated leaves, but a long pretreatment time (28 s) led to a decrease in TPC. The qualitative analysis showed that the chemical composition is not affected by the microwave pretreatment.

Chemical Composition, Antibacterial, Insecticidal and Anti-Oxidant Activities of Three Acantholimon Species (A. atropatanum, A. gilliatii and A. tragacanthium)

2020 ◽  
Vol 10 (3) ◽  
pp. 272-278
Author(s):  
Ardalan Pasdaran ◽  
Satyajit D. Sarker ◽  
Lutfun Nahar ◽  
Azadeh Hamedi
Keyword(s):  
Antibacterial Activity ◽  
Chemical Composition ◽  
Essential Oil ◽  
Essential Oils ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Main Compound ◽  
Aerial Parts ◽  
Anti Oxidant ◽  
Gas Chromatography Mass Spectroscopy

Background: The essential oil from the Acantholimon genus have been an integral part of the traditional food additive in Middle East. Most of the plants in Acantholimon genus have not been studied scientifically. The aim of this study is to investigate the chemical composition, antibacterial, insecticidal and anti-oxidant activities of three Acantholimon species including Acantholimon atropatanum, A. gilliatii and A. tragacanthium. Method: The essential oils of the aerial parts were extracted by hydrodistillation. Chemical constitutions were identified by gas chromatography- mass spectroscopy technique, also their toxicities were assessed against the two important grain products pests, Oryzeaphilus mercator and Tribolium castaneum. Antibacterial activity was assessed against the three foodborne bacteria that include Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus based on the disc diffusion assay. Free-radical-scavenging property was identified based on 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity. Results: 2-hexahydrofarnesyl acetone was the main compound in A. gilliatii and A. tragacanthium, whilst farnesyl acetone, heptacosane and germacrene D were the principal components of A. atropatanum essential oil. These oils exhibited 40-90% mortality of O. mercator and/or T. castaneum at a dose of 12 μl/l air after 48h of exposure, and exhibited significant free-radicalscavenging property (RC50 = 3.7 × 10-3 - 8.3 × 10-3 mg/ml). The oils of A. tragacanthium and A. gilliatii showed a weaker antibacterial activity compared to A. atropatanum. Conclusion: A. atropatanum, A. gilliatii and A. tragacanthium essential oils had significant insecticidal and anti-oxidant properties. They also showed week to moderate antibacterial activity against P. aeruginosa and S. aureus.

scholarly journals By-Products of Camu-Camu [Myrciaria dubia (Kunth) McVaugh] as Promising Sources of Bioactive High Added-Value Food Ingredients: Functionalization of Yogurts

Molecules ◽  
2019 ◽  
Vol 25 (1) ◽  
pp. 70 ◽  
Author(s):  
Natália Conceição ◽  
Bianca R. Albuquerque ◽  
Carla Pereira ◽  
Rúbia C. G. Corrêa ◽  
Camila B. Lopes ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Phenolic Compounds ◽  
Food System ◽  
Food Additives ◽  
Added Value ◽  
Phenolic Profile ◽  
Food Ingredients ◽  
Myrciaria Dubia ◽  
By Products ◽  
Fruit Part

Camu-camu (Myrciaria dubia (Kunth) McVaugh) is a fruit economically relevant to the Amazon region, mostly consumed in the form of processed pulp. Our aim was to perform an unprecedented comparative study on the chemical composition and bioactivities of the camu-camu pulp and industrial bio-residues (peel and seed), and then the most promising fruit part was further explored as a functionalized ingredient in yogurt. A total of twenty-three phenolic compounds were identified, with myricetin-O-pentoside and cyanindin-3-O-glucoside being the main compounds in peels, followed by p-coumaroyl hexoside in the pulp, and ellagic acid in the seeds. The peel displayed the richest phenolic profile among samples, as well as the most significant antibacterial (MICs = 0.625–10 mg/mL) and anti-proliferative (GI50 = 180 µg/mL against HeLa cells) activities. For this reason, it was selected to be introduced in a food system (yogurt). Taken together, our results suggest the possibility of using the camu-camu peel as a source of food additives.

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