Facile one-pot syntheses of new C-28 esters of oleanolic acid and studies on their antiproliferative effect on T cells
2018 ◽
Vol 73
(11-12)
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pp. 417-421
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Abstract Structure-activity relationship studies on oleanolic acid (1) have resulted in facile syntheses of its new C-28 esters 2–7 by way of one-pot reaction of 1 with a variety of alkylating agents. Oleanolic acid and its new esters were studied for their in vitro antiproliferative effect on healthy human peripheral blood mononuclear cell isolated phytohemagglutinin activated T cells. Results showed that compounds 1, 3, and 5 exhibited significant inhibitory activity on T-cell proliferation. Compound 5 was found to be the most potent, with an IC50 value of 4.249 μg/mL, among all tested compounds, and its activity could be attributed to the presence of bromine atom in the molecule.
1979 ◽
Vol 76
(12)
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pp. 6627-6631
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2013 ◽
Vol 20
(2)
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pp. 156-164
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