scholarly journals Pesticide Exposure and Stunting among Children in Agricultural Areas

2019 ◽  
Vol 10 (1) ◽  
pp. 17-29 ◽  
Author(s):  
Apoina Kartin ◽  
Hertanto W Subagio ◽  
Suharyo Hadisaputro ◽  
Martha I Kartasurya ◽  
Suhartono Suhartono ◽  
...  
Keyword(s):  
Pesticide Exposure ◽  
Perinatal Period ◽  
Thyroid Stimulating Hormone ◽  
Growth Disorders ◽  
Level Energy ◽  
Nutrient Adequacy ◽  
Significant Difference ◽  
History Of ◽  
High Level ◽  
Agricultural Areas

Background: The prevalence of growth disorders among school-aged children in Indonesia is high (30.7%). Pesticides have been massively used in Indonesian agricultural areas. Objective: To determine if exposure to pesticides is associated with stunting among children in agricultural areas. Methods: This case-control study included 160 children (48 cases and 112 controls) aged 8–12 years. Exposure to pesticides was measured based on the history of the exposure since perinatal period, infancy, and childhood of the participants. Stunting was determined as a height for age z-score (HAZ) < -2 SD. Other variables measured were levels of thyroid stimulating hormone (TSH), insulin-like growth factor-1 (IGF-1), hemoglobin, zinc, albumin, nutrient adequacy level (energy and protein), and history of infection, low-birth weight (LBW), and mother's height. Results: There were no significant difference between the cases and controls in terms of in the baseline characteristics, except for the median IGF-1 level; it was significantly (p<0.001) lower in the cases (66.73 ng/mL) than the controls (112.57 ng/mL). High level of pesticide exposure (p=0.029) and low IGF-1 levels (p<0.001) were significantly associated with stunting. After adjusting for confounding variables, these variables were found to be independent risk factors for stunting in children (aOR 3.90, 95% CI 1.15 to 13.26; and aOR 8.35, 95% CI 3.65 to 19.14, respectively). Conclusion: Pesticide exposure could be a risk factor for the occurrence of growth disorders in children living in agricultural areas. Necessary actions should be taken to protect children living in agricultural areas from exposure to pesticides.

Experiments on egg discrimination in two North American corvids: further evidence for retention of egg ejection

2004 ◽  
Vol 82 (9) ◽  
pp. 1399-1407 ◽  
Author(s):  
Todd J Underwood ◽  
Spencer G Sealy ◽  
Celia M McLaren
Keyword(s):  
Brood Parasitism ◽  
Alternative Hypothesis ◽  
Egg Discrimination ◽  
Corvus Brachyrhynchos ◽  
Detection Model ◽  
Egg Ejection ◽  
Significant Difference ◽  
History Of ◽  
Pica Nuttalli ◽  
High Level

In the absence of brood parasitism in North America, black-billed magpies, Pica hudsonia (Sabine, 1822), and yellow-billed magpies, Pica nuttalli (Audubon, 1837), may have retained egg-discrimination behaviour that evolved in Eurasian magpies, Pica pica (L., 1758), in response to parasitism by Old World cuckoos. We further examined this hypothesis by testing the egg-discrimination abilities of black-billed magpies and the American crow, Corvus brachyrhynchos Brehm, 1822, which has no history of brood parasitism. In addition, we tested an alternative hypothesis that black-billed magpies evolved or retained egg discrimination to counter conspecific parasitism by testing their ability to eject foreign conspecific eggs and by using a signal detection model to estimate the level of conspecific parasitism required for ejection to be favoured. Black-billed magpies ejected all non-mimetic eggs and 62% of mimetic eggs. Significantly more mimetic eggs were ejected during the incubation stage than during the laying stage. Magpies ejected significantly more non-mimetic eggs than mimetic eggs overall, but there was no difference in ejection frequency during incubation. American crows ejected 21% of non-mimetic eggs and 8% of mimetic eggs. There was no significant difference in ejection frequency of the two egg types. Black-billed magpies ejected 11% of conspecific eggs and a relatively high level of conspecific parasitism (22%–49%) would be required to select for conspecific ejection, which provides little support for conspecific parasitism as a current selection pressure for maintaining egg discrimination. Thus, black-billed magpies appear to have retained egg rejection in the absence of parasitism through speciation from Eurasian magpies.

scholarly journals Evaluation of factor VIII value in normal women and whom encountered recurrent pregnancy loss: is there any significant difference?

2020 ◽  
Vol 9 (3) ◽  
pp. 1034
Author(s):  
Douaa Al Rez ◽  
Hasan Naser Eldine ◽  
Marwan Alhalabi
Keyword(s):  
Factor Viii ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Fetal Loss ◽  
Control Group ◽  
Increased Risk ◽  
Significant Difference ◽  
History Of ◽  
Normal Women ◽  
High Level

Background: Recurrent pregnancy loss (RPL) is a serious problem on the women, it defined as two or more consecutive pregnancy losses before the fetus has reached birth. The aim of this study is to evaluate the association between the elevation in the factor VIII and RPL. Because women who have thrombophilia have increased risk of fetal loss in most studies.Methods: A total 72 women were recruited in this case control study. They divided into two groups: the RPL group included 41 women with a history of recurrent pregnancy loss and the control group included 31 healthy women, who had at least one successful pregnancy and none of them had a history of fetal loss or complicated pregnancy.Results: A majority of the patients of this study didn't have a high level of factor VIII, 9 of 41 (22%) patients of RPL group in comparison with 21 of 32 (65,6%) of control group, that suffer from the increase rate of FVIII, this means that factor VIII doesn't effect on RPL.Conclusions: The present study showed that the serum elevation in the factor VIII is not significantly associated with RPL.

Evaluation of Serum Ferritin and Anti-Thyroid Peroxidase Antibody Status in Newly Diagnosed Subclinical Cases of Hypothyroidism

2020 ◽  
Vol 20 ◽  
Author(s):  
Rajlaxmi Tiwari ◽  
Gautom Kumar Saharia ◽  
Manaswini Mangaraj
Keyword(s):  
Serum Ferritin ◽  
Multinomial Logistic Regression ◽  
Thyroid Stimulating Hormone ◽  
Thyroid Peroxidase ◽  
Newly Diagnosed ◽  
Free T4 ◽  
Ferritin Concentration ◽  
Serum Ferritin Concentration ◽  
Significant Difference ◽  
High Level

Background:: Serum ferritin concentrations are altered in hypothyroidism, but there is no available literature regarding the status of serum ferritin in anti-thyroid peroxidase (anti-TPO) positive hypothyroidism. The objectives: of our study were to evaluate the titer of anti-TPO and serum ferritin in newly diagnosed hypothyroid patients and to find out any difference of serum ferritin concentration between antibody-positive and antibody-negative patients. Methods:: A total of 143 subjects above the age of 18 years were recruited, and serum Thyroid Stimulating Hormone (TSH), free T3, free T4, anti-TPO, and ferritin were assayed by chemiluminescence method. According to their serum analysis findings, three groups were made as Group 1 of 49 subjects with hypothyroidism and anti-TPO positive, Group 2 of 47 subjects with hypothyroidism and anti-TPO negative, and Group 3 of 47 euthyroid and anti-TPO negative controls. Results: : Kruskal Wallis H test was applied, and the difference in concentration of TSH, FT3, FT4, Ferritin, anti-TPO amongst the three groups was found to be significant. The relationship between anti-TPO levels and serum ferritin concentration was further studied by multinomial logistic regression. We have found that there is a significant difference between the concentrations of ferritin; hence, it is highly likely that those with a high level of anti-TPO antibody shall have a higher concentration of serum ferritin. Conclusion:: ferritin concentrations were decreased in anti-TPO negative hypothyroidism, but in case of anti-TPO positive hypothyroidism the ferritin concentrations are raised. Hence, hypothyroidism should not always be considered as an iron deficiency state.

scholarly journals ANALISIS FAKTOR RESIKO PAPARAN PESTISIDA PADA KEHAMILAN DENGAN KEJADIAN BERAT BADAN LAHIR RENDAH (BBLR) DI KOTA PADANGSIDIMPUAN TAHUN 2019

2020 ◽  
Vol 3 (1) ◽  
pp. 39-47
Author(s):  
Fithri Handayani Lubis
Keyword(s):  
Risk Factors ◽  
Pregnant Women ◽  
Pesticide Exposure ◽  
Bivariate Analysis ◽  
Control Group ◽  
Case Group ◽  
Chi Square ◽  
History Of ◽  
Agricultural Areas ◽  
And Storage

Low birth weight (LBW) is one of the main causes of infant mortality. The problem that arises is whether there is a relationship between risk factors for pesticide exposure during pregnancy and the incidence of LBW in agricultural areas. The purpose of this study was to determine the risk factors for pesticide exposure associated with LBW incidence. This research is a case control study. Subjects were divided into two groups: a case group of 25 farmers with a history of giving birth to LBW and a control group who were neighbors of case subjects without a history of giving birth to LBW, a total of 25 farmers. This research data collection using interviews and observations. Data analysis used univariate and bivariate analysis (chi square and fisher as alternatives). Research results: risk factors for exposure to pesticides that have been shown to be associated with the incidence of LBW in Padangsidimpuan, include: occupation of pregnant women related to pesticides (OR = 6,769) completeness of personal protective equipment (PPE) while doing activities in the fields (OR = 18,857) and storage pesticides (OR = 12,667). The recommended advice is to avoid work that is directly related to pesticides during pregnancy, if you have to participate in agricultural activities, pregnant women should use complete PPE.

scholarly journals The Effect of Levothyroxine Discontinuation Timing on Postoperative Hypothyroidism after Hemithyroidectomy for Papillary Thyroid Microcarcinoma

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Tae Kwun Ha ◽  
Dong Wook Kim ◽  
Ha Kyoung Park ◽  
Jin Wook Baek ◽  
Yoo Jin Lee ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Gland ◽  
Thyroid Stimulating Hormone ◽  
Papillary Thyroid Microcarcinoma ◽  
Papillary Thyroid ◽  
Thyroid Microcarcinoma ◽  
Significant Difference ◽  
History Of ◽  
Serological Data

Objective. No previous studies regarding the appropriate timing of thyroid hormone discontinuation after hemithyroidectomy have been published. This study aimed to identify the appropriate timing for levothyroxine discontinuation after hemithyroidectomy among patients with papillary thyroid microcarcinoma (PTMC).Methods. This study retrospectively evaluated 304 patients who underwent ≥1 attempt to discontinue levothyroxine after hemithyroidectomy for treating PTMC between January 2008 and December 2013. Fifty-three patients were excluded because of preoperative hypothyroidism or hyperthyroidism, a history of thyroid hormone or antithyroid therapy, no available serological data, or a postoperative follow-up of <24 months. We evaluated the associations of successful levothyroxine discontinuation with patient age, sex, preoperative serological data, underlying thyroid gland histopathology, anteroposterior diameter of the residual thyroid gland, number of discontinuation attempts, and initial discontinuation timing.Results. Among the 251 included patients, 125 patients (49.8%) achieved successful levothyroxine discontinuation during the follow-up period after hemithyroidectomy. There was a significant difference in the outcomes for patients who underwent an initial discontinuation attempt at ≤3 months and ≥4 months after hemithyroidectomy (p< 0.001). There were significant differences in the discontinuation outcomes according to underlying thyroid histopathology (p= 0.001), preoperative thyroid-stimulating hormone levels (p< 0.001), and number of discontinuation attempts (p< 0.001).Conclusions. Among patients with PTMC, the initial levothyroxine discontinuation attempt is recommended at ≥4 months after hemithyroidectomy.

scholarly journals Riwayat paparan pestisida dan kekurangan asupan zat gizi sebagai faktor risiko kejadian anemia pada ibu hamil di daerah pertanian

2019 ◽  
Vol 7 (2) ◽  
pp. 69-75 ◽  
Author(s):  
Sulistyawati Sulistyawati ◽  
Ani Margawati ◽  
Ali Rosidi ◽  
Suhartono Suhartono
Keyword(s):  
Risk Factor ◽  
Vitamin C ◽  
Pregnant Women ◽  
Nutrient Intake ◽  
Pesticide Exposure ◽  
Agricultural Area ◽  
Chi Square ◽  
Nutrient Adequacy ◽  
History Of ◽  
Exposure History

Background: Anemia in pregnant women in Brebes Regency, Central Java in 2016 was still high at 60.7%. Brebes Regency is an area of onion farming with a high intensity of pesticide use. Objectives: This study aimed to prove the history of pesticide exposure and lack of nutrient intake (iron and vitamin C) was risk factor for the incidence of anemia in pregnant women in agricultural area. Methods: Case control study with 41 cases (anemia) and 41 controls (non-anemia) as study subjects. The subjects were selected using purposive sampling method. Pesticide exposure history included the involvement of pregnant women in agricultural activities, frequency of exposure and length of exposure was measured by interview using structured questionnaire. Anemia data were obtained by measuring hemoglobin levels. Other independent variables measured were nutritional intake (protein, iron, and vitamin C) using semi-quantitative food frequency questionnaire (SQ-FFQ) method to determine the level of nutrient adequacy in pregnant women. Data were analyzed using chi-square test and logistic regression.Result: Hemoglobin levels in the case ranged from 7.2 g/dl to 10.9 g/dl. The results of multivariate logistic regression showed that pesticide exposure history (OR= 4.9, 95% CI:1.75-13.67), level of iron adequacy (OR = 2.9, 95% CI:1.06– 8.29) and level of vitamin C adequacy (OR = 3.4, 95% CI:1.10– 10.28) as risk factors for the incidence of anemia in pregnant women in agricultural area.Conclusion: The history of pesticide exposure and lack of nutrient intake (iron and vitamin C) was risk factor for the incidence of anemia in pregnant women in agricultural area.

Effect of prolonged intermittent thyrotropin-releasing hormone administration to fetal and neonatal rats

1979 ◽  
Vol 57 (1) ◽  
pp. 31-34 ◽  
Author(s):  
P. Walker ◽  
J. H. Dussault
Keyword(s):  
Repeated Administration ◽  
Perinatal Period ◽  
Thyroid Stimulating Hormone ◽  
Thyrotropin Releasing Hormone ◽  
Neonatal Rats ◽  
Adult Rats ◽  
Subcutaneous Injections ◽  
Releasing Hormone ◽  
Significant Difference ◽  
The Mean

Fetal and neonatal rats received daily subcutaneous injections of 10 μg thyrotropin-releasing hormone (TRH) until 7 or 14 days postnatally. At 70 days the pups were challenged with 1 μg TRH intravenously via an indwelling jugular cannula. Basal serum thyroxine, triiodothyronine, and thyroid-stimulating hormone (TSH) concentrations did not differ among the three groups. The mean TSH responses as determined by the mean peak TSH concentration and the total TSH response as determined by planimetry were not significantly different, and there was no significant difference in pituitary TSH content following the TRH challenge among the three groups. This study suggests that the integrity of the hypothalamo–pituitary axis in adult rats cannot be affected by the repeated administration of pharmacologic doses of TRH during the perinatal period.

scholarly journals Thyroid function in pregnant females carrying thyroid peroxidase antibodies

2003 ◽  
Vol 49 (5) ◽  
pp. 23-29
Author(s):  
V. V. Fadeyev ◽  
S. V. Lesnikova ◽  
G. A. Melnichenko
Keyword(s):  
Odds Ratio ◽  
Thyroid Stimulating Hormone ◽  
Control Group ◽  
Thyroid Peroxidase ◽  
Second Trimester ◽  
Early Gestation ◽  
Pregnant Females ◽  
Thyroid Peroxidase Antibodies ◽  
History Of ◽  
High Level

То define risk factors for gestational hypothyroxinemia in females carrying thyroid peroxidase antibodies (TPO Ab) during preg­nancy, a study was performed, which included 73 females at dif­ferent periods of pregnancy in accordance with the following cri­teria: the lack of impaired dysfunction of the thyroid gland (TG) on primary examination; elevated TPO Ab levels (more than 100 mEU/l; no history of TG pathology. The control group comprised 128 pregnant females without TG pathology. Evaluation of TG function in females with TPO Ab who received and did not the physiological doses of iodine revealed that the function did not differ by the end of pregnancy. The odds ratio for hypothyrox­inemia in pregnant females with more than 100 mEU/l of TPO Ab was 3.14. In a subgroup of females with TPO Ab and the en­larged TG in the second trimester, the level of fT4 was signifi­cantly lower and that of thyroid-stimulating hormone (TSH) was significantly higher than those in the control group. Logistic re­gression analysis indicated that a relatively high level of TSH in early gestation was most significant in females with TPO Ab. It is concluded that it is expedient to consider whether preventive levothyroxine therapy is performed in females who carry TPO Ab with the enlarged TG and with TSH level that is relatively high (more than 2 mMe/l) for early pregnancy.

Factor V Leiden Is Associated with Repeated and Recurrent Unexplained Fetal Losses

1997 ◽  
Vol 77 (05) ◽  
pp. 0822-0824 ◽  
Author(s):  
Elvira Grandone ◽  
Maurizio Margaglione ◽  
Donatella Colaizzo ◽  
Marina d'Addedda ◽  
Giuseppe Cappucci ◽  
...  
Keyword(s):  
Protein C ◽  
Strong Association ◽  
Activated Protein C ◽  
Fetal Loss ◽  
Factor V Leiden ◽  
Factor V ◽  
Significant Difference ◽  
History Of ◽  
Fv Leiden ◽  
Caucasian Women

SummaryActivated protein C resistance (APCR) is responsible for most cases of familial thrombosis. The factor V missense mutation Arg506>Gln (FV Leiden) has been recognized as the commonest cause of this condition. Recently, it has been suggested that APCR is associated with second trimester fetal loss. We investigated the distribution of FV Leiden in a sample (n = 43) of Caucasian women with a history of two or more unexplained fetal losses. A group (n = 118) of parous women with uneventful pregnancies from the same ethnical background served as control. We found the mutation in 7 cases (16.28%) and 5 controls (4.24%; p = 0.011). A statistically significant difference between women with only early fetal loss vs those with late events (p = 0.04) was observed. Our data demonstrate a strong association between FV Leiden and fetal loss. Furthermore, they indicate that late events are more common in these patients.

PCR-RFLP Detection od PAI-2 Gene Variants: Prevelence in Ethnic Groups and Disease Relationship in patients Undergoing corony Angiography

1997 ◽  
Vol 77 (05) ◽  
pp. 0955-0958 ◽  
Author(s):  
Carole A Foy ◽  
Peter J Grant
Keyword(s):  
Gene Variants ◽  
Genotype Distribution ◽  
Pima Indians ◽  
Significant Difference ◽  
Pcr Rflp ◽  
History Of ◽  
Caucasian Patients ◽  
Clinical Conditions ◽  
Rflp Assay ◽  
Coronary Atheroma

SummaryPAI-2 is a fibrinolytic inhibitor produced predominantly by monocytes. Most PAI-2 is intracellular making study in clinical conditions difficult. Abnormalities in production may be associated with inflammation and fibrinolysis at sites of tissue damage such as the atherosclerotic plaque.PAI-2 gene variants have been described: variant A consists of Asn120, Asn404 and Ser413 and variant B consists of Asp120, Lys404 and Cys413. We designed a PCR-RFLP assay using primers spanning the region containing Asn/Lys404 and Ser/Cys413. Variant B contains an Mwol restriction site. We analysed 302 Pima Indians and 286 healthy Caucasian volunteers. To investigate relationships between genotype and vascular disease we analysed 333 Caucasian patients undergoing coronary angiography.Gene variant B was more common in the Pimas than in Caucasians (p <0.0001). There was no significant difference in genotype distribution between the volunteers and patients. In the patients there was no association between genotype and either a history of MI or extent of coronary atheroma.

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