scholarly journals Molecular targets of honey bee’s products in cancer prevention and treatment

2019 ◽  
Vol 8 (4) ◽  
pp. 261-268
Author(s):  
Ablassé Rouamba ◽  
Moussa Compaoré ◽  
Martin Kiendrebeogo
Keyword(s):  
Natural Products ◽  
Cancer Prevention ◽  
Molecular Mechanisms ◽  
Sugar Amino Acids ◽  
Genes Expression ◽  
Anti Cancer ◽  
Prevention And Treatment ◽  
Multiple Cell ◽  
Cell Signaling Pathways ◽  
Target Cancer

Chemotherapy and radiotherapy are currently the main treatments for cancer but their toxicities on the surrounding normal cells limit their use in cancer therapy. Moreover, many cancers have developed some resistance to the available anticancer chemicals and put in failure the chemotherapy currently used in the cancer treatment. This failure of the targeted monotherapy resulting from bypass mechanisms has obligated researchers to use agents that interfere with multiple cell-signaling pathways. Recently, researches focused on the use of natural products which can target cancer promoting factors genes expression. Of these natural products, honey has been extensively studied. The pharmacological properties of honey include antioxidant, anti-inflammatory, antibacterial, immunomodulatory, estrogenic and anti-cancer effects. The honey bee’s products are potent sources of nutritional components including sugar, amino-acids, water and minerals. Furthermore honey contains chemopreventive compounds such as flavonoids, phenol acids, tannins, vitamins that may interfere with multiple cell’s pathways and hereby reduce the incidence of many types of cancers. However, the molecular mechanisms of honey bee’s products in cancer prevention and treatment are less known. This review highlights the molecular mechanism of honey bioactive compounds in cancer prevention and treatment.

scholarly journals Honey as a Potential Natural Anticancer Agent: A Review of Its Mechanisms

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Sarfraz Ahmed ◽  
Nor Hayati Othman
Keyword(s):  
Natural Products ◽  
Cancer Prevention ◽  
Therapeutic Agent ◽  
Anticancer Agent ◽  
The Body ◽  
Viable Cells ◽  
Anti Cancer ◽  
Prevention And Treatment ◽  
Necrosis Factor ◽  
Cancer Activity

The main treatment for cancer is by using chemotherapy and radiotherapy which themselves are toxic to other viable cells of the body. Recently, there are many studies focusing on the use of natural products for cancer prevention and treatment. Of these natural products, honey has been extensively researched. The mechanism of the anti-cancer activity of honey as chemopreventive and therapeutic agent has not been completely understood. The possible mechanisms are due to its apoptotic, antiproliferative, antitumor necrosis factor (anti-TNF), antioxidant, anti-inflammatory, estrogenic and immunomodulatory activities. We collate the findings of several studies published in the literature in order to understand the mechanism of its action.

scholarly journals d-Limonene: a bioactive food component from citrus and evidence for a potential role in breast cancer prevention and treatment

2011 ◽  
pp. 31-42
Author(s):  
Jessica A. Miller ◽  
Patricia A. Thompson ◽  
Iman A. Hakim ◽  
H.-H. Sherry Chow ◽  
Cynthia A. Thomson
Keyword(s):  
Breast Cancer ◽  
Cancer Prevention ◽  
Immune Modulation ◽  
Wide Spectrum ◽  
Perillyl Alcohol ◽  
Potent Effect ◽  
Food Component ◽  
Citrus Peel ◽  
Anti Cancer ◽  
Prevention And Treatment

Although limited, observations from cell culture, animal, and epidemiological studies support the presence of anti-cancer properties in citrus peel and the primary bioactive food constituent, d-limonene. Early evidence from animal models suggests that when ingested, d-limonene exhibits a wide spectrum of biologic activity including chemotherapeutic and chemopreventive effects. In some of these early models, an analog of d-limonene, perillyl alcohol, demonstrated a more potent effect than d-limonene itself. Yet, when perillyl alcohol advanced to clinical trials, several trials were ended early due to doselimiting toxicities. Alternatively, oral d-limonene administration in humans is well tolerated even at high doses supporting its investigation as a potential bioactive for cancer prevention. Though the exact mechanisms of action of d-limonene are unclear, immune modulation and antiproliferative effects are commonly reported. Here, we review the pre-clinical evidence for d-limonene’s anticancer mechanisms, bioavailability, and safety, as well as the evidence for anti-cancer effects in humans, focusing on studies relevant to its use in the prevention and treatment of breast cancer.

scholarly journals Anti-Cancer Effects of Green Tea Polyphenols Against Prostate Cancer

Molecules ◽  
2019 ◽  
Vol 24 (1) ◽  
pp. 193 ◽  
Author(s):  
Yasuyoshi Miyata ◽  
Yohei Shida ◽  
Tomoaki Hakariya ◽  
Hideki Sakai
Keyword(s):  
Prostate Cancer ◽  
Green Tea ◽  
Molecular Mechanisms ◽  
Current Knowledge ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
Anti Cancer ◽  
Prevention And Treatment

Prostate cancer is the most common cancer among men. Green tea consumption is reported to play an important role in the prevention of carcinogenesis in many types of malignancies, including prostate cancer; however, epidemiological studies show conflicting results regarding these anti-cancer effects. In recent years, in addition to prevention, many investigators have shown the efficacy and safety of green tea polyphenols and combination therapies with green tea extracts and anti-cancer agents in in vivo and in vitro studies. Furthermore, numerous studies have revealed the molecular mechanisms of the anti-cancer effects of green tea extracts. We believe that improved understanding of the detailed pathological roles at the molecular level is important to evaluate the prevention and treatment of prostate cancer. Therefore, in this review, we present current knowledge regarding the anti-cancer effects of green tea extracts in the prevention and treatment of prostate cancer, with a particular focus on the molecular mechanisms of action, such as influencing tumor growth, apoptosis, androgen receptor signaling, cell cycle, and various malignant behaviors. Finally, the future direction for the use of green tea extracts as treatment strategies in patients with prostate cancer is introduced.

Polymethoxyflavones: Chemistry and Molecular Mechanisms for Cancer Prevention and Treatment

2019 ◽  
Vol 5 (2) ◽  
pp. 98-113 ◽  
Author(s):  
Yen-Chen Tung ◽  
Ya-Chun Chou ◽  
Wei-Lun Hung ◽  
An-Chin Cheng ◽  
Roch-Chui Yu ◽  
...  
Keyword(s):  
Cancer Prevention ◽  
Molecular Mechanisms ◽  
Prevention And Treatment

scholarly journals Molecular Mechanisms Linking Exercise to Cancer Prevention and Treatment

2018 ◽  
Vol 27 (1) ◽  
pp. 10-21 ◽  
Author(s):  
Pernille Hojman ◽  
Julie Gehl ◽  
Jesper F. Christensen ◽  
Bente K. Pedersen
Keyword(s):  
Cancer Prevention ◽  
Molecular Mechanisms ◽  
Prevention And Treatment

scholarly journals Natural products targeting the p53 tumor suppressor-A novel approach for future cancer therapy- A review

2021 ◽  
Vol 1 (2) ◽  
pp. 167-176
Author(s):  
Ali Esmail Al-Snafi
Keyword(s):  
Natural Products ◽  
Cancer Therapy ◽  
Tumor Suppressor ◽  
Medicinal Plants ◽  
Cancer Prevention ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Novel Approach ◽  
Prevention And Treatment ◽  
Expression And Activity

Mutations of p53, a tumor suppressor gene, are known to be involved in multiplication and metastasis of tumors. A number of natural products targeted the p53-MDM2 pathway. This review is an attempt to highlight the medicinal plants that can modulate the expression and activity ofp53tumor suppression, for cancer prevention and treatment.

scholarly journals ACNPD: The Database for Elucidating the Relationships Between Natural Products, Compounds, Molecular Mechanisms, and Cancer Types

2021 ◽  
Vol 12 ◽  
Author(s):  
Xiaojie Tan ◽  
Jiahui Fu ◽  
Zhaoxin Yuan ◽  
Lingjuan Zhu ◽  
Leilei Fu
Keyword(s):  
Natural Products ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Signaling Pathways ◽  
Molecular Mechanisms ◽  
Cancer Drugs ◽  
Internal Factors ◽  
Online Resource ◽  
Anti Cancer ◽  
Cancer Types

Objectives: Cancer is well-known as a collection of diseases of uncontrolled proliferation of cells caused by mutated genes which are generated by external or internal factors. As the mechanisms of cancer have been constantly revealed, including cell cycle, proliferation, apoptosis and so on, a series of new emerging anti-cancer drugs acting on each stage have also been developed. It is worth noting that natural products are one of the important sources for the development of anti-cancer drugs. To the best of our knowledge, there is not any database summarizing the relationships between natural products, compounds, molecular mechanisms, and cancer types.Materials and methods: Based upon published literatures and other sources, we have constructed an anti-cancer natural product database (ACNPD) (http://www.acnpd-fu.com/). The database currently contains 521 compounds, which specifically refer to natural compounds derived from traditional Chinese medicine plants (derivatives are not considered herein). And, it includes 1,593 molecular mechanisms/signaling pathways, covering 10 common cancer types, such as breast cancer, lung cancer and cervical cancer.Results: Integrating existing data sources, we have obtained a large amount of information on natural anti-cancer products, including herbal sources, regulatory targets and signaling pathways. ACNPD is a valuable online resource that illustrates the complex pharmacological relationship between natural products and human cancers.Conclusion: In summary, ACNPD is crucial for better understanding of the relationships between traditional Chinese medicine (TCM) and cancer, which is not only conducive to expand the influence of TCM, but help to find more new anti-cancer drugs in the future.

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