scholarly journals An Interesting Case of Blood Group Switch after Breast Cancer Therapy

2020 ◽  
Vol 3 ◽  
pp. e9
Author(s):  
Meher Ayyazuddin ◽  
◽  
Qudsia Umaira Khan ◽  
Keyword(s):  
Blood Group ◽  
Antigen Expression ◽  
Blood Groups ◽  
Interesting Case ◽  
Chemotherapy Treatment ◽  
Local Irradiation ◽  
Breast Cancer Therapy ◽  
Remission Status ◽  
Time Period ◽  
Specific Antigens

Blood groups are determined by specific antigens attached to red blood cells that are either carbohydrate or protein in nature. Changes in gene expression encoding for various blood types are rare, with the ABO blood group antigen most commonly altered. We report a female patient whose blood group changed from A, Rh positive to A, Rh negative, over the period of 10 years (1999-2009). During this time period, she was diagnosed with breast carcinoma and a lumpectomy was performed, followed by chemotherapy (with anthracycline and docetaxel) along with local irradiation. There has been no remission after recovery. It was noticed that the patient’s blood group had changed. A possible reason may be Rh mosaicism and a mutation in the Rh gene, resulting in the alteration of Rh antigen expression. The reason causing this mutation is unclear. However, in some cases changes in blood groups are related to patients’ chemotherapy treatment and their remission status.

scholarly journals Predictive modeling of complex ABO glycan phenotypes by lectin microarrays

2020 ◽  
Vol 4 (16) ◽  
pp. 3960-3970
Author(s):  
Waseem Q. Anani ◽  
Heather E. Ashwood ◽  
Anna Schmidt ◽  
Robert T. Burns ◽  
Gregory A. Denomme ◽  
...  
Keyword(s):  
Blood Group ◽  
Solid Organ Transplantation ◽  
Antigen Expression ◽  
Blood Groups ◽  
Abo Blood Group ◽  
Solid Organ ◽  
Abo Blood Groups ◽  
Membrane Glycoproteins ◽  
Lectin Microarray ◽  
Lectin Array

Abstract Serological classification of individuals as A, B, O, or AB is a mainstay of blood banking. ABO blood groups or ABH antigens, in addition to other surface glycans, act as unique red blood cell (RBC) signatures and direct immune responses. ABO subgroups present as weakened, mixed field, or unexpected reactivity with serological reagents, but specific designations remain complex. Lectins detect glycan motifs with some recognizing ABH antigens. We evaluated a 45-probe lectin microarray to rapidly analyze ABO blood groups and associated unique glycan signatures within complex biological samples on RBC surface glycoproteins. RBC membrane glycoproteins were prepared from donor RBCs, n = 20 for each blood group. ABO blood group was distinguishable by lectin array, including variations in ABH antigen expression not observed with serology. Principal component analysis highlighted broad ABO blood group clusters with unexpected high and low antigen expression and variations were confirmed with ABH antibody immunoblotting. Using a subset of lectins provided an accurate method to predict an ABO serological phenotype. Lectin microarray highlighted the importance of ABO localization on glycoproteins and glycolipids and pointed to increased glycocalyx complexity associated with the expression of A and B antigens including high mannose and branched polylactosamine. Thus, lectins identified subtle surface ABO blood group glycoprotein density variations not detected by routine serological methods. Transfusion services observe alterations in ABH expression during malignancy, and ABO incompatible solid organ transplantation is not without risk of rejection. The presented methods may identify subtle but clinically significant ABO blood group differences for transfusion and transplantation.

Interrelations of Thrombo-Embolic Diseases and Blood-Group Distribution

1963 ◽  
Vol 09 (02) ◽  
pp. 472-474 ◽  
Author(s):  
W Dick ◽  
W Schneider ◽  
K Brockmüller ◽  
W Mayer
Keyword(s):  
Normal Distribution ◽  
Blood Group ◽  
Blood Groups ◽  
The Other ◽  
Other Hand ◽  
Group Distribution

SummaryA comparison between the repartition of the blood groups in 461 patients suffering from thromboembolic disorders and the normal distribution has shown a statistically ascertained predominance of the group A1. On the other hand the blood groups 0 and A2 are distinctly less frequent than in the normal distribution.

scholarly journals Associations between smoking and blood-group, and the risk of dyslipidaemia amongst French women

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
C. J. MacDonald ◽  
A. L. Madika ◽  
G. Severi ◽  
A. Fournier ◽  
M. C. Boutron-Ruault
Keyword(s):  
Blood Group ◽  
Smoking Status ◽  
Effect Modification ◽  
Blood Groups ◽  
Cross Sectional ◽  
Increased Risk ◽  
Cardio Vascular Disease ◽  
Never Smokers ◽  
Cardio Vascular ◽  
Incident Cases

AbstractDyslipidaemia is a major risk factor for cardio-vascular disease, as it promotes atherosclerosis. While cross-sectional studies have identified higher serum cholesterol amongst individuals with the A blood group, there is less evidence from prospective studies whether this translates into a higher risk of dyslipidaemia that requires treatment, nor if this genetic factor interacts with smoking status. This study aimed to prospectively determine potential associations between smoking, ABO blood groups, and risk of incident dyslipidaemia requiring treatment, and to assess associations over strata of blood ABO group. We assessed associations between blood ABO group, smoking and dyslipidaemia in 74,206 women participating in the E3N cohort. We included women who did not have cardiovascular disease at baseline. Logistic regression was used to determine associations between ABO group, smoking and prevalent dyslipidaemia at baseline. Cox proportional hazard models were then used to determine if blood ABO group and smoking were associated with the risk of incident dyslipidaemia, amongst women free of dyslipidaemia at baseline. At baseline 28,281 women with prevalent dyslipidaemia were identified. Compared to the O-blood group, the non-O blood group was associated higher odds of with prevalent dyslipidaemia (ORnon-O = 1.09 [1.06: 1.13]). Amongst the women free of dyslipidaemia at baseline, 6041 incident cases of treated dyslipidaemia were identified during 454,951 person-years of follow-up. The non-O blood groups were associated with an increased risk of dyslipidaemia when compared to the O-group (HRnon-O = 1.16 [1.11: 1.22]), specifically the A blood-group (HRA = 1.18 [1.12: 1.25]). Current smokers were associated with an increased risk of incident dyslipidaemia (HR smokers = 1.27 [1.16: 1.37]), compared to never-smokers. No evidence for effect modification between smoking and ABO blood group was observed (p-effect modification = 0.45), although the highest risk was observed among AB blood group women who smoked (HR = 1.76 [1.22: 2.55]). In conclusion, the non-O blood groups, specifically the A group were associated with an increased risk of dyslipidaemia. Current smokers were associated with a 30% increased risk of dyslipidaemia. These results could aid in personalised approaches to the prevention of cardiovascular risk-factors.

scholarly journals ABO and P1 Blood Group Antigen Expression andstxGenotype and Outcome of ChildhoodEscherichia coliO157:H7 Infections

2002 ◽  
Vol 185 (2) ◽  
pp. 214-219 ◽  
Author(s):  
Srdjan Jelacic ◽  
Cheryl L. Wobbe ◽  
Daniel R. Boster ◽  
Marcia A. Ciol ◽  
Sandra L. Watkins ◽  
...  
Keyword(s):  
Blood Group ◽  
Antigen Expression ◽  
Blood Group Antigen

ABO histo-blood group antigen expression on the graft endothelium long term after ABO-compatible, non-identical heart transplantation.

2006 ◽  
Vol 13 (2) ◽  
pp. 166-170 ◽  
Author(s):  
Simon C. Koestner ◽  
Andreas Kappeler ◽  
Thomas Schaffner ◽  
Thierry P. Carrel ◽  
Paul J. Mohacsi
Keyword(s):  
Heart Transplantation ◽  
Blood Group ◽  
Antigen Expression ◽  
Blood Group Antigen

Modulation of ABH histo-blood group antigen expression in normal and myasthenic human thymus

Apmis ◽  
2006 ◽  
Vol 114 (10) ◽  
pp. 669-674
Author(s):  
VICTORIA S. SARAFIAN ◽  
TSVETANA T. MARINOVA
Keyword(s):  
Blood Group ◽  
Antigen Expression ◽  
Blood Group Antigen ◽  
Human Thymus

An Insight into the General Trend of Blood Group Dissemination among Local Population of Muzaffarabad

2020 ◽  
pp. 39-43
Author(s):  
OJS Admin
Keyword(s):  
Blood Group ◽  
Disease Susceptibility ◽  
General Trend ◽  
Local Population ◽  
Blood Groups ◽  
Blood Group System ◽  
Group System ◽  
Insight Into

Blood groups ABO and Rhesus, constituting the most principal blood group system, are of key signicance for clinical and transfusion practices and are moreover, thought to be associated with disease susceptibility.

scholarly journals Correlation of ABO Blood Groups and Rh Factor with The Severity of Generalized Chronic Periodontitis: Across Sectional Study in Riyadh, Saudi Arabia

2019 ◽  
Vol 7 (4) ◽  
pp. 617-622 ◽  
Author(s):  
Diana Mostafa ◽  
Essam I. Elkhatat ◽  
Pradeep Koppolu ◽  
Muna Mahgoub ◽  
Esam Dhaifullah ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Blood Group ◽  
Chronic Periodontitis ◽  
Periodontal Diseases ◽  
Blood Groups ◽  
Blood Group Antigens ◽  
Abo Blood Groups ◽  
Sectional Study ◽  
Cross Sectional ◽  
Group I

BACKGROUND: The development of periodontal diseases depends on the presence of causative microorganisms, host immunity and risk factors. Although variability present among the types of periodontal diseases, all are represented to a shared interaction between host and bacteria. ABO blood groups are the most investigated erythrocyte antigen system. However, limited investigations have been conducted to explore the alliance between ABO blood groups and periodontal diseases. AIM: Our purpose was to explore any possible association between the severity of chronic periodontitis with ABO blood groups and Rh factor. METHODS: A cross-sectional study was carried out on 205 patients out of 1126 generalised chronic periodontitis patients (GCP) who were referred to Al-Farabi Colleges, Riyadh, Saudi Arabia. They were categorized into; group I (mild), group II (moderate) and group III (sever). RESULTS: The patients with blood group O were at a greater risk to develop GCP irrespective of its severity, followed by those with blood group A, B, and AB. The dispensation of the Rh factor in all groups exhibited a significantly greater distribution of Rh positive. CONCLUSION: Genetic factors such as ABO blood group antigens may act as a risk influencer that affects the progression and severity of the chronic periodontitis.

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