scholarly journals Chemical signaling regulates axon regeneration via the GPCR–Gqα pathway in Caenorhabditis elegans

2021 ◽  
pp. JN-RM-0929-21
Author(s):  
Tatsuhiro Shimizu ◽  
Kayoko Sugiura ◽  
Yoshiki Sakai ◽  
Abdul R. Dar ◽  
Rebecca A. Butcher ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Axon Regeneration ◽  
Chemical Signaling

scholarly journals N-Glycosylation of the Discoidin Domain Receptor Is Required for Axon Regeneration in Caenorhabditis elegans

Genetics ◽  
2019 ◽  
Vol 213 (2) ◽  
pp. 491-500 ◽  
Author(s):  
Tatsuhiro Shimizu ◽  
Yuka Kato ◽  
Yoshiki Sakai ◽  
Naoki Hisamoto ◽  
Kunihiro Matsumoto
Keyword(s):  
Caenorhabditis Elegans ◽  
Axon Regeneration ◽  
Discoidin Domain Receptor

scholarly journals Effects of NAD+ in Caenorhabditis elegans Models of Neuronal Damage

Biomolecules ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 993
Author(s):  
Yuri Lee ◽  
Hyeseon Jeong ◽  
Kyung Hwan Park ◽  
Kyung Won Kim
Keyword(s):  
Caenorhabditis Elegans ◽  
Therapeutic Strategy ◽  
Axon Regeneration ◽  
Neuronal Damage ◽  
Biological Processes ◽  
Nematode Caenorhabditis Elegans ◽  
C Elegans ◽  
Neuronal Functions ◽  
Molecular Components

Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor that mediates numerous biological processes in all living cells. Multiple NAD+ biosynthetic enzymes and NAD+-consuming enzymes are involved in neuroprotection and axon regeneration. The nematode Caenorhabditis elegans has served as a model to study the neuronal role of NAD+ because many molecular components regulating NAD+ are highly conserved. This review focuses on recent findings using C. elegans models of neuronal damage pertaining to the neuronal functions of NAD+ and its precursors, including a neuroprotective role against excitotoxicity and axon degeneration as well as an inhibitory role in axon regeneration. The regulation of NAD+ levels could be a promising therapeutic strategy to counter many neurodegenerative diseases, as well as neurotoxin-induced and traumatic neuronal damage.

scholarly journals S6 Kinase Inhibits Intrinsic Axon Regeneration Capacity via AMP Kinase in Caenorhabditis elegans

2014 ◽  
Vol 34 (3) ◽  
pp. 758-763 ◽  
Author(s):  
Thomas Hubert ◽  
Zilu Wu ◽  
Andrew D. Chisholm ◽  
Yishi Jin
Keyword(s):  
Caenorhabditis Elegans ◽  
Axon Regeneration ◽  
Regeneration Capacity ◽  
Amp Kinase ◽  
S6 Kinase

scholarly journals Regulation of Microtubule Dynamics in Axon Regeneration: Insights from C. elegans

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 764 ◽  
Author(s):  
Ngang Heok Tang ◽  
Andrew D. Chisholm
Keyword(s):  
Caenorhabditis Elegans ◽  
Leucine Zipper ◽  
Axon Regeneration ◽  
Axonal Injury ◽  
External Environment ◽  
Nematode Caenorhabditis Elegans ◽  
Intrinsic Factors ◽  
C Elegans ◽  
And Control ◽  
Active Investigation

The capacity of an axon to regenerate is regulated by its external environment and by cell-intrinsic factors. Studies in a variety of organisms suggest that alterations in axonal microtubule (MT) dynamics have potent effects on axon regeneration. We review recent findings on the regulation of MT dynamics during axon regeneration, focusing on the nematode Caenorhabditis elegans. In C. elegans the dual leucine zipper kinase (DLK) promotes axon regeneration, whereas the exchange factor for Arf6 (EFA-6) inhibits axon regeneration. Both DLK and EFA-6 respond to injury and control axon regeneration in part via MT dynamics. How the DLK and EFA-6 pathways are related is a topic of active investigation, as is the mechanism by which EFA-6 responds to axonal injury. We evaluate potential candidates, such as the MT affinity-regulating kinase PAR-1/MARK, in regulation of EFA-6 and axonal MT dynamics in regeneration.

scholarly journals Factors regulating axon regeneration via JNK MAP kinase in Caenorhabditis elegans

2020 ◽  
Vol 167 (5) ◽  
pp. 433-439 ◽  
Author(s):  
Tatsuhiro Shimizu ◽  
Naoki Hisamoto
Keyword(s):  
Caenorhabditis Elegans ◽  
Map Kinase ◽  
Nerve Injury ◽  
Molecular Mechanisms ◽  
Axon Regeneration ◽  
Nematode Caenorhabditis Elegans ◽  
C Elegans ◽  
Excellent Model ◽  
Jnk Cascade

Abstract Axon regeneration following nerve injury is a highly conserved process in animals. The nematode Caenorhabditis elegans is an excellent model for investigating the molecular mechanisms of axon regeneration. Recent studies using C. elegans have shown that the c-Jun N-terminal kinase (JNK) plays the important role in axon regeneration. Furthermore, many factors have been identified that act upstream of the JNK cascade after axotomy. This review introduces these factors and describes their roles during the regulation of axon regeneration.

Attraction to pheromones in Caenorhabditis elegans can be reversed through associative learning

2018 ◽  
Author(s):  
M. Dal Bello ◽  
A. Pérez-Escudero ◽  
F. C. Schroeder ◽  
J. Gore
Keyword(s):  
Caenorhabditis Elegans ◽  
Associative Learning ◽  
Behavioral Plasticity ◽  
Current Knowledge ◽  
Natural Environments ◽  
Chemical Signaling ◽  
Learning Abilities ◽  
C Elegans ◽  
Pheromone Blend

AbstractDespite the ubiquity and importance of chemical signaling, we have only limited insight about the role of learning in the response to pheromones. Here, we demonstrate that responses to pheromones can be reprogrammed through associative learning. In particular, we show that attraction to ascaroside pheromones in the model nematode Caenorhabditis elegans can be reversed by training the animals to associate either a pheromone blend or single synthetic ascarosides with the lack of food. This behavioral plasticity alters worm preference for pheromones following consumption of a food patch, possibly improving foraging in natural environments. By bridging the gap between the current knowledge on the chemical language and the learning abilities of C. elegans, we provide insight on the possible links between learning and chemical signaling in animals.

scholarly journals Caenorhabditis elegans F-box protein promotes axon regeneration by inducing degradation of the Mad transcription factor

2021 ◽  
pp. JN-RM-1024-20
Author(s):  
Tatsuhiro Shimizu ◽  
Strahil Iv. Pastuhov ◽  
Hiroshi Hanafusa ◽  
Yoshiki Sakai ◽  
Yasuko Todoroki ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Caenorhabditis Elegans ◽  
Axon Regeneration ◽  
F Box Protein
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