Vitamin D status and association to bone health in 781 healthy 8-11 years old Danish school children: preliminary results from the Opus school meal study

AbstractSufficient summer/autumn vitamin D status appears important to mitigate winter nadirs at northern latitudes. We conducted a cross-sectional study to evaluate autumn vitamin D status and its determinants in 782 Danish 8–11-year-old children (55°N) using baseline data from the Optimal well-being, development and health for Danish children through a healthy New Nordic Diet (OPUS) School Meal Study, a large randomised controlled trial. Blood samples and demographic and behavioural data, including 7-d dietary recordings, objectively measured physical activity, and time spent outdoors during school hours, were collected during September–November. Mean serum 25-hydroxyvitamin D (25(OH)D) was 60·8 (sd 18·7) nmol/l. Serum 25(OH)D levels ≤50 nmol/l were found in 28·4 % of the children and 2·4 % had concentrations <25 nmol/l. Upon multivariate adjustment, increasing age (per year) (β −2·9; 95 % CI −5·1, −0·7 nmol/l), female sex (β −3·3; 95 % CI −5·9, −0·7 nmol/l), sampling in October (β −5·2; 95 % CI −10·1, −0·4 nmol/l) and November (β −13·3; 95 % CI −17·7, −9·1), and non-white ethnicity (β −5·7; 95 % CI −11·1, −0·3 nmol/l) were negatively associated with 25(OH)D (all P<0·05). Likewise, immigrant/descendant background was negatively associated with 25(OH)D, particularly in females (β −16·3; 95 % CI −21·9, −10·7) (P<0·001) (Pinteraction=0·003). Moderate-to-vigorous physical activity (MVPA) (min/d) (β 0·06; 95 % CI 0·01, 0·12), outdoor walking during school hours (min/week) (β 0·4; 95 % CI 0·1, 0·6) and intake of vitamin D-containing supplements ≥3 d/week (β 8·7; 95 % CI 6·4, 11·0) were positively associated with 25(OH)D (all P<0·05). The high proportion of children with vitamin D status below the recommended sufficiency level of 50 nmol/l raises concern as levels expectedly drop further during winter months. Frequent intake of vitamin D supplements was strongly associated with status. MVPA and outdoor activity during school hours should be investigated further in interventions to improve autumn vitamin D status in children at northern latitudes.

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Vitamin D status and bone health in survivors of childhood lymphoblastic leukemia

Bone Abstracts ◽

10.1530/boneabs.2.p97 ◽

2013 ◽

Author(s):

M Schundeln Michael ◽

K Hauffa Pia ◽

C Goretzki Sara ◽

Lahner Harald ◽

Marschke Laura ◽

...

Keyword(s):

Vitamin D ◽

Bone Health ◽

Lymphoblastic Leukemia ◽

Vitamin D Status

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Faculty Opinions recommendation of The vitamin D status in ankylosing spondylitis in relation to intestinal inflammation, disease activity, and bone health: a cross-sectional study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726390630.793550517 ◽

2018 ◽

Author(s):

Paul Emery ◽

Leticia Garcia-Montoya

Keyword(s):

Vitamin D ◽

Ankylosing Spondylitis ◽

Disease Activity ◽

Bone Health ◽

Intestinal Inflammation ◽

Cross Sectional Study ◽

Vitamin D Status ◽

Sectional Study ◽

Cross Sectional

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Vitamin D Status of Elite Athletes in Singapore and Its Associations With Muscle Function and Bone Health

Journal of Science in Sport and Exercise ◽

10.1007/s42978-020-00093-y ◽

2021 ◽

Author(s):

Liyan Huang ◽

Danny Lum ◽

Mohammad Haiyum ◽

Kirsty A. Fairbairn

Keyword(s):

Vitamin D ◽

Bone Health ◽

Muscle Function ◽

Elite Athletes ◽

Vitamin D Status

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Effects of cholecalciferol supplementation and optimized calcium intakes on vitamin D status, muscle strength and bone health: A one-year pilot randomized controlled trial in adults with severe burns

Burns ◽

10.1016/j.burns.2014.07.005 ◽

2015 ◽

Vol 41 (2) ◽

pp. 317-325 ◽

Cited By ~ 27

Author(s):

Anne-Françoise Rousseau ◽

Marguerite Foidart-Desalle ◽

Didier Ledoux ◽

Christophe Remy ◽

Jean-Louis Croisier ◽

...

Keyword(s):

Vitamin D ◽

Randomized Controlled Trial ◽

Bone Health ◽

Controlled Trial ◽

Vitamin D Status ◽

Randomized Controlled ◽

Severe Burns ◽

Cholecalciferol Supplementation ◽

One Year ◽

Pilot Randomized Controlled Trial

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Vitamin D Status among Thai School Children and the Association with 1,25-Dihydroxyvitamin D and Parathyroid Hormone Levels

PLoS ONE ◽

10.1371/journal.pone.0104825 ◽

2014 ◽

Vol 9 (8) ◽

pp. e104825 ◽

Cited By ~ 5

Author(s):

Lisa A. Houghton ◽

Andrew R. Gray ◽

Michelle J. Harper ◽

Pattanee Winichagoon ◽

Tippawan Pongcharoen ◽

...

Keyword(s):

Vitamin D ◽

Parathyroid Hormone ◽

School Children ◽

Vitamin D Status ◽

Hormone Levels ◽

Dihydroxyvitamin D ◽

1,25 Dihydroxyvitamin D

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Cross-sectional study reveals a high prevalence of vitamin D deficiency among healthy school children in central Kerala, India

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20190745 ◽

2019 ◽

Vol 6 (2) ◽

pp. 867

Author(s):

Ayyappan Anitha ◽

Suresh A. Poovathinal ◽

Vijitha Viswambharan ◽

Ismail Thanseem ◽

Mahesh M. Vasu ◽

...

Keyword(s):

Vitamin D ◽

School Children ◽

Skin Color ◽

Economic Status ◽

Cross Sectional Study ◽

Vitamin D Status ◽

Sectional Study ◽

Cross Sectional ◽

Vitamin D Levels ◽

High Prevalence

Background: Authors examined serum vitamin D status among the healthy school children belonging to the south Indian state of Kerala.Methods: A cross-sectional study, participants were recruited through medical camps organized in Thrissur and Palakkad districts of central Kerala during the months of March and April 2017. A 174 healthy school children (98 males and 76 females) aged 5-13 years were recruited for the study. The children were found to be healthy on the basis of physical examination by a Paediatrician. None of the children had any symptoms of skeletal deformities. All the children were drug-naive. Data on height, weight, skin color, food habits, physical activities and socio-economic status were recorded. A 2ml of peripheral blood samples were collected from the participants. Total vitamin D in the serum was estimated by chemiluminescence immunoassay (CLIA).Results: VDD was observed in 60.92% and insufficiency in 30.46% of the participants. Only 8.62% of the participants had normal vitamin D levels. The mean vitamin D level was 19.93 ng/ml. Males had significantly higher vitamin D levels compared to females. Factors such as age, height, weight, diet, skin color and socio-economic status did not influence vitamin D levels.Conclusions: This is the first study of vitamin D status among the school-age children of Kerala. This paper adds further evidence to the reports indicating high prevalence of subclinical VDD among children across India and calls for action.

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Differences in vitamin D status and calcium metabolism in Saudi Arabian boys and girls aged 6 to 18 years: effects of age, gender, extent of veiling and physical activity with concomitant implications for bone health

Public Health Nutrition ◽

10.1017/s1368980011003612 ◽

2012 ◽

Vol 15 (10) ◽

pp. 1845-1853 ◽

Cited By ~ 16

Author(s):

Maryam A Al-Ghamdi ◽

Susan A Lanham-New ◽

Jalal A Kahn

Keyword(s):

Physical Activity ◽

Vitamin D ◽

Saudi Arabia ◽

Parathyroid Hormone ◽

Bone Health ◽

Age Groups ◽

Hypovitaminosis D ◽

Vitamin D Status ◽

Kingdom Of Saudi Arabia ◽

Cross Sectional

AbstractObjectiveFew data exist looking at vitamin D status and bone health in school-aged boys and girls from Saudi Arabia. The present study aimed to determine the extent of poor vitamin D status in school boys and girls aged 6–18 years and to examine if there was any difference in status with age, physical activity and veiling and concomitant effects on bone.DesignCross-sectional study.SettingJeddah, Kingdom of Saudi Arabia.SubjectsA total of 150 boys (7–16 years) and 150 girls (6–18 years) from local schools were divided into age categories: 6–9 years (elementary school); 10–12 years (secondary school); 13–14 years (middle years); 15–18 years (high school).ResultsVitamin D status was significantly lower in girls than boys in all age groups (P < 0·01), with the 15–18-year-old girls having the lowest level (22·0 (sd 9·4) nmol/l) in comparison to the 15–18-year-old boys (39·3 (sd 14·0) nmol/l) and the 6–9-year-old girls (41·2 (sd 9·3) nmol/l). Parathyroid hormone status was highest in the 15–18-year-old girls in comparison to boys of the same age. A total of 64 % of 15–18-year-old girls had 25-hydroxyvitamin D (25OHD) status <25 nmol/l in comparison to 31 % in the 13–14 years age category, 26 % in the 10–12 years category and 2·5 % in the 6–9 years category. No boys had 25OHD status <25 nmol/l. Fully veiled girls had lower 25OHD status than partly veiled or unveiled girls (P < 0·05). Low 25OHD and high parathyroid hormone was associated with lower bone mass in the 6–9 years and 13–14 years age groups (P < 0·05).ConclusionsThese data suggest significant hypovitaminosis D in older adolescent females, which is a cause for concern given that there is currently no public health policy for vitamin D in the Kingdom of Saudi Arabia.

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