scholarly journals Gender dimorphism in body composition abnormalities in acromegaly: males are more affected than females

2008 ◽  
Vol 159 (6) ◽  
pp. 773-779 ◽  
Author(s):  
N Sucunza ◽  
M J Barahona ◽  
E Resmini ◽  
J M Fernández-Real ◽  
J Farrerons ◽  
...  

BackgroundAcromegaly changes body composition (BC), but long-term gender differences have not been reported.ObjectiveTo evaluate BC in active and controlled acromegalic patients.Design and methodsClinical and biochemical variables and BC (by dual-energy X-ray absorptiometry) were evaluated in 60 acromegalic patients (19 active, 41 controlled) and 105 controls, matched for age and gender.ResultsAcromegalic males (n=24) had more total mass (89±13 vs 76.5±15.3 kg, P<0.001), lean body mass (LBM; 64.6±8.7 vs 56.4±5.8 kg, P<0.001), and bone mineral content (BMC; 2.9±0.5 vs 2.6±0.3 kg, P<0.05) than controls (n=33). Controlled male patients (n=14) had more total mass (89±14.7 vs 76.5±15.3 kg, P<0.05) and a trend to have more LBM (61.8±9.4 vs 56.4±5.8 kg, P=0.065) than controls. Only in active disease was a decrease in fat mass (FM) observed, compared with controlled patients and controls (males: 19.5±5.3 vs 27±6.2 and 25.9±4%, P<0.001; females: 30.3±6.7 vs 37.1±5.8 and 36.5±6.6%, P<0.01). In females, no further differences were observed. No differences in BMC were found between eugonadal and hypogonadal acromegalic patients, but in hypogonadal females, acromegaly appeared to prevent the BMC loss seen in hypogonadal postmenopausal controls. GH and IGF1 levels were negatively correlated with FM (males, P<0.05; females, P<0.001), but in the regression analysis GH was a predictor of FM only in women.ConclusionsControl of acromegaly reverts decreased FM in both genders; only in males more total mass and a trend for more LBM persist. The anabolic effect of GH on bone reverted in cured males, but persisted in females and appeared to override the bone loss of menopause.

2003 ◽  
Vol 95 (5) ◽  
pp. 2039-2046 ◽  
Author(s):  
P. J. Gately ◽  
D. Radley ◽  
C. B. Cooke ◽  
S. Carroll ◽  
B. Oldroyd ◽  
...  

The objective of the present study was to investigate the accuracy of percent body fat (%fat) estimates from dual-energy X-ray absorptiometry, air-displacement plethysmography (ADP), and total body water (TBW) against a criterion four-compartment (4C) model in overweight and obese children. A volunteer sample of 30 children (18 male and 12 female), age of (mean ± SD) 14.10 ± 1.83 yr, body mass index of 31.6 ± 5.5 kg/m, and %fat (4C model) of 41.2 ± 8.2%, was assessed. Body density measurements were converted to %fat estimates by using the general equation of Siri (ADPSiri) (Siri WE. Techniques for Measuring Body Composition. 1961) and the age- and gender-specific constants of Lohman (ADPLoh) (Lohman TG. Exercise and Sport Sciences Reviews. 1986). TBW measurements were converted to %fat estimates by assuming that water accounts for 73% of fat-free mass (TBW73) and by utilizing the age- and gender-specific water contents of Lohman (TBWLoh). All estimates of %fat were highly correlated with those of the 4C model ( r ≥ 0.95, P < 0.001; SE ≤ 2.14). For %fat, the total error and mean difference ± 95% limits of agreement compared with the 4C model were 2.50, 1.8 ± 3.5 (ADPSiri); 1.82, -0.04 ± 3.6 (ADPLoh); 2.86, -2.0 ± 4.1 (TBW73); 1.90, -0.3 ± 3.8 (TBWLoh); and 2.74, 1.9 ± 4.0 DXA (dual-energy X-ray absorptiometry), respectively. In conclusion, in overweight and obese children, ADPLoh and TBWLoh were the most accurate methods of measuring %fat compared with a 4C model. However, all methods under consideration produced similar limits of agreement.


2015 ◽  
Vol 781 ◽  
pp. 3-6
Author(s):  
Sophonwit Somchai ◽  
Jirun Potinakkha ◽  
Nararat Ruangchaijatupon ◽  
V. Prasertchareonsuk ◽  
M. Leeprakobboon ◽  
...  

This paper shows the feasibility analysis of the 4th generation (4G) telecommunication system on 800-900 MHz spectrum. It applies the Long-Term Evolution (LTE) wireless communication and makes a feasibility design of cell site placement. An academic community is selected as a studied site because the high usage of advanced communication technologies. Due to the variety of population density, age, and gender, Khon Kaen University is chosen. This paper also suggests the model for cell site installation and cell site positions in Khon Kaen University area.


2008 ◽  
Vol 3 (2) ◽  
pp. 165-195 ◽  
Author(s):  
UNTO HÄKKINEN ◽  
PEKKA MARTIKAINEN ◽  
ANJA NORO ◽  
ELINA NIHTILÄ ◽  
MIKKO PELTOLA

AbstractThis study revisits the debate on the ‘red herring’, i.e. the claim that population aging will not have a significant impact on health care expenditure (HCE), using a Finnish data set. We decompose HCE into several components and include both survivors and deceased individuals into the analyses. We also compare the predictions of health expenditure based on a model that takes into account the proximity to death with the predictions of a naïve model, which includes only age and gender and their interactions. We extend our analysis to include income as an explanatory variable. According to our results, total expenditure on health care and care of elderly people increases with age but the relationship is not as clear as is usually assumed when a naïve model is used in health expenditure projections. Among individuals not in long-term care, we found a clear positive relationship between expenditure and age only for health centre and psychiatric inpatient care. In somatic care and prescribed drugs, the expenditure clearly decreased with age among deceased individuals. Our results emphasize that even in the future, health care expenditure might be driven more by changes in the propensity to move into long-term care and medical technology than age and gender alone, as often claimed in public discussion. We do not find any strong positive associations between income and expenditure for most non-LTC categories of health care utilization. Income was positively related to expenditure on prescribed medicines, in which cost-sharing between the state and the individual is relatively high. Overall, our results indicate that the future expenditure is more likely to be determined by health policy actions than inevitable trends in the demographic composition of the population.


Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Changwei Li ◽  
Ruiyuan Zhang ◽  
Luqi Shen ◽  
Sangzhu Laba

Background: Tibet has a disproportionately higher prevalence of hypertension, compared to other regions of China. This may be related to long-term exposure to the high altitude. The aim of our study is to evaluate associations of altitudes with prevalence of hypertension among residents aged 15 years and older in Tibet, China. Method: A total of 11,407 Tibet residents in the 5 th National Health Services Survey (NHSS) in 2013-2015 were included in this study. Physician diagnosed hypertension was determined based on self-report. County level altitude was identified and assigned to all residents in a county. Association between altitude and hypertension prevalence was assessed by two logistic regression models: model 1 adjusted for age and gender, and model 2 additionally adjusted for marital status, education, smoking, drinking, exercise, distance to a medical institute, area of residency, and body mass index (BMI). Non-linear relationship between altitude and prevalence of hypertension was explored by restricted cubic spline analyses. Sensitivity analysis were performed by restricting residents in rural and/or nomadic areas. Result: The prevalence of self-reported hypertension is 15.7%, the medication adherence rate is 14%, and the control rate is 10.3%. Compared to residents without physician diagnosed hypertension, those with hypertension were closer to a hospital, older, having lower education level, and less likely to be a smoker or live in an urban area. Altitude showed a U shape relationship with the prevalence of hypertension with a turning point at around 3,800 meters. For residents living more than 3,800 meters above sea level, a 1,000 meters increase in altitude was associated with 2.05 (95% confidence interval: 1.62-2.61) times higher odds of having physician diagnosed hypertension, after adjusting for age and gender. When further controlling for all covariates, the OR dropped to 1.87 (1.46-2.41) but still significant. For residents living below the altitude of 3,800 meters, 1000 meters’ increase was associated 0.55 (95% CI: 0.33-0.92) less likelihood of having physician diagnosed hypertension. Conclusion: The burden of self-reported hypertension was high among Tibet residents. Altitude was in a U-shaped association with the prevalence of hypertension with a turning point at around 3,800 meters.


2005 ◽  
Vol 20 (3) ◽  
pp. 351-384 ◽  
Author(s):  
NIGEL GOOSE

This article examines the relative incidence of poverty among the elderly in nineteenth-century Hertfordshire with special reference to gender. Both national and local sources are employed to highlight the particular difficulties experienced by the elderly, male poor under the New Poor Law, and the short and long term problems they faced as a result of seasonal unemployment and an overstocked labour market. For elderly women, the extent to which their poverty was relieved by employment in cottage industry, almshouse accommodation, the continuing receipt of out-relief and a higher incidence of family support are examined to provide an assessment of the manner in which poverty was gendered in the nineteenth century.


1994 ◽  
Vol 35 (2) ◽  
pp. 282-282 ◽  
Author(s):  
A Lapillonne ◽  
B L Salle ◽  
P Braillon ◽  
M Chambon

Author(s):  
Cem Kagar ◽  
Teslime Kagar

In this report, we investigated the impact of after-school STEM clubs on children’s attitudes to STEM-related subjects. 236 children aged 8-12 took part in this study. For the purpose of this study, a quantitative research method was adopted where a survey prior to the STEM activities and at the end of 30 weeks of the after-school club have been used to make sense of children’s perspectives on STEM-related subjects. The study also explored whether the age and gender of the children would influence their attitudes towards these subjects.Keywords: STEM, Engineering, Cross-curricular, Computer Science, Primary education


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