scholarly journals Oral liquid levothyroxine treatment at breakfast: a mistake?

2014 ◽  
Vol 170 (1) ◽  
pp. 95-99 ◽  
Author(s):  
Carlo Cappelli ◽  
Ilenia Pirola ◽  
Elena Gandossi ◽  
Annamaria Formenti ◽  
Maurizio Castellano
Keyword(s):  
Thyroid Hormone ◽  
Liquid Form ◽  
Coffee Intake ◽  
Tablet Form ◽  
Significant Difference ◽  
Oral Liquid ◽  
Euthyroid Patient ◽  
Tablet Formulations ◽  
Levothyroxine Treatment

ObjectiveTaking levothyroxine (l-T4) with coffee or with water followed by coffee intake within a few minutes results in poor TSH response in many patients. T4is available in tablet form worldwide, but novel formulations in soft gel capsule or liquid form are now available.DesignWe fortuitously identified a euthyroid patient who wrongly consumed liquidl-T4with coffee at breakfast; after changing the time of consumption to 30 min before breakfast, no change in TSH, free T4(fT4), and free tri-iodothyronine (fT3) concentrations was observed. Once the first patient was identified, additional stable euthyroid patients who consumed liquidl-T4with coffee were identified.MethodsPatients were recruited by searching our ‘thyroid patients’ database. All the patients on liquidl-T4treatment were contacted by phone to ask them whether they tookl-T4at breakfast. We identified 54 patients who were submitted to TSH, fT4, and fT3evaluation, with the indication that the same dosage ofl-T4be consumed 30 min before breakfast. We determined their TSH, fT4, and fT3concentrations after 3 and 6 months again.ResultsNo significant difference in thyroid hormone concentrations was observed in patients when they consumedl-T4at breakfast or when they consumed it 30 min before breakfast for 3 and 6 months (TSH: 2.5±1.1 vs 2.5±1.1 and 2.4±1.1 mIU/l respectively, fT4: 12.4±2.4 vs 12.5±2.4 and 12.3±2.1 pg/ml respectively, and fT3: 3.4±0.6 vs 3.4±0.6 and 3.3±0.5 pg/ml respectively).ConclusionOral liquidl-T4formulations could diminish the problem ofl-T4malabsorption caused by coffee when using traditional tablet formulations.

scholarly journals Blood Micronutrient and Thyroid Hormone Concentrations in the Oldest-Old

2000 ◽  
Vol 85 (6) ◽  
pp. 2260-2265 ◽  
Author(s):  
Giovanni Ravaglia ◽  
Paola Forti ◽  
Fabiola Maioli ◽  
Barbara Nesi ◽  
Loredana Pratelli ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Oldest Old ◽  
Serum Zinc ◽  
Blood Levels ◽  
Elderly Age ◽  
Blood Concentrations ◽  
Significant Difference ◽  
Plasma Retinol ◽  
Age Range

Several micronutrients are involved in thyroid hormone metabolism, but it is unclear whether their marginal deficits may contribute to the alterations in thyroid function observed in extreme aging. The relationships among blood concentrations of thyroid hormones and selenium, zinc, retinol, and α-tocopherol were studied in 44 healthy Northern Italian oldest-old subjects (age range, 90–107 yr), selected by the criteria of the SENIEUR protocol. Control groups included 44 healthy adult (age range, 20–65 yr) and 44 SENIEUR elderly (age range, 65–89 yr) subjects. Oldest-old subjects had higher TSH (P < 0.01) and lower free T3 (FT3)/freeT4 (FT4) ratio, zinc, and selenium serum values (P < 0.001) than adult and elderly control subjects. No significant difference was found for plasma retinol and α-tocopherol values. The associations between micronutrients and thyroid hormones were evaluated by multivariate analysis. In oldest-old subjects, plasma retinol was negatively associated with FT4 (P = 0.019) and TSH serum levels (P = 0.040), whereas serum zinc was positively associated with serum FT3 (P = 0.010) and FT3/FT4 ratio (P = 0.011). In younger subjects, no significant association was found among thyroid variables and micronutrients. In conclusion, blood levels of specific micronutrients are associated with serum iodothyronine levels in extreme aging.

scholarly journals Comparisons of Thyroid Hormone, Intelligence, Attention, and Quality of Life in Children with Obstructive Sleep Apnea Hypopnea Syndrome before and after Endoscopic Adenoidectomy

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Hui-Wei Feng ◽  
Tao Jiang ◽  
Hong-Ping Zhang ◽  
Zhe Wang ◽  
Hai-Ling Zhang ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Thyroid Hormone ◽  
Intelligence Quotient ◽  
Obstructive Sleep ◽  
Significant Difference ◽  
Before And After ◽  
Hypopnea Syndrome

Objective. The aim of this study was to compare the differences in thyroid hormone, intelligence, attention, and quality of life (QoL) of children with obstructive sleep apnea hypopnea syndrome (OSAHS) before and after endoscopic adenoidectomy.Method. A total of 35 OSAHS children (21 males and 14 females with a mean age of6.81±1.08years) were included in this study for analyzing the levels of thyroid hormone, intelligence, attention, and QoL. There were 22 children underwent endoscopic adenoidectomy with bilateral tonsillectomy (BT), while the other 13 children who underwent endoscopic adenoidectomy without bilateral tonsillectomy without BT.Results. Our results revealed no significant difference in serum free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH) levels in OSAHS children before and after endoscopic adenoidectomy (allP>0.05). However, there were significant differences in full-scale intelligence quotient (FIQ) (92.45±5.88versus106.23±7.39,P<0.001), verbal intelligence quotient (VIQ) (94.17±15.01versus103.91±9.74,P=0.006), and performance intelligence quotient (PIQ) (94.12±11.04versus104.31±10.05,P=0.001), attention (98.48±8.74versus106.87±8.58,P<0.001), and total OSA-18 scores (87.62±17.15versus46.61±10.15,P<0.001) between before and after endoscopic adenoidectomy in OSAHS children.Conclusion. Our findings provided evidence that the intelligence, attention, and QoL of OSAHS children may be significantly improved after endoscopic adenoidectomy.

Characterization of Chitosan Obtained from Snail Shell (Achatina fulica) and its Excipient Potentials in Metronidazole Tablet Formulation

2021 ◽  
Vol 20 (1) ◽  
pp. 31-39
Author(s):  
Oluyemisi Adebowale Bamiro ◽  
Aishat Oyinkansola Salisu ◽  
Ese Mary Iyere ◽  
Olatundun Atoyegbe ◽  
Olutayo Ademola Adeleye ◽  
...  
Keyword(s):  
Tablet Formulation ◽  
Achatina Fulica ◽  
Flow Properties ◽  
Crushing Strength ◽  
Snail Shell ◽  
Significant Difference ◽  
Swelling Capacity ◽  
Tablet Formulations ◽  
Scanning Electron

The aim of the work was to characterize chitosan extracted from snail shell and evaluate its use as a disintegrant and binder in metronidazole tablet formulation in comparison with standard chitosan (SC). The mechanical properties were assessed using crushing strength and friability, while the release properties were assessed using disintegration and dissolution times. The extracted chitosan (EC) was crystalline in nature and the scanning electron microscopy (SEM) showed polygonal particles with rough surface. The moisture and swelling capacity was 1.80% and 15.00%, respectively. The densities and flow properties were significantly (p<0.05) higher than those of the SC. As a binder, the crushing strength of formulations containing EC was higher than SC, but both formulation failed friability test. There was significant difference between the disintegration times of the metronidazole formulations containing EC and SC as a disintegrant. The result showed that EC is more effective as a binder in tablet formulations. Dhaka Univ. J. Pharm. Sci. 20(1): 31-39, 2021 (June)

scholarly journals Criteria for paediatric oral liquid form

2021 ◽  
Vol 5 (1) ◽  
pp. 018-019
Author(s):  
Gavrus Daniela ◽  
Busquets Ferran Bossacoma ◽  
Català Josep Maria ◽  
Genestar Joan Lluis Vinent ◽  
Flaque Miquel Villaronga
Keyword(s):  
Liquid Form ◽  
Oral Liquid

scholarly journals Peculiarities of Carbohydrate Exchange in Patients with Generalized Periodontitis of Young Age Persons

2018 ◽  
Vol 25 (2) ◽  
Author(s):  
Halyna Kimak ◽  
Halyna Melnychuk ◽  
Hanna Ersteniuk
Keyword(s):  
Lactic Acid ◽  
Lactate Dehydrogenase ◽  
Carbohydrate Metabolism ◽  
Young Patients ◽  
Young Age ◽  
Lactate Dehydrogenase Activity ◽  
Significant Difference ◽  
Oral Liquid ◽  
Lactate Levels ◽  
Healthy Persons

There were studied 92 somatically healthy persons of young age (18-25 years old), with generalized periodontitis (GP) of initial-I degree of development, among them: 30 patients with chronic generalized periodontitis (CGP), who were included into group І; and 32 patients with exacerbation of the chronic generalized periodontitis (ECGP) – into group II; and 30 healthy patients. The carbohydrate metabolism indexes were studied, namely: the content of glucose, pyruvate (pyruvic acid) and lactate (lactic acid) and lactate dehydrogenase activity (LDG) in the oral liquid.We have determined that in the presence of CGP of the initial-I degree of development, and especially in its exacerbation, there is a significant increase of indicators of carbohydrate metabolism. In young patients with CGP indicators of glucose, pyruvate, lactate and LDG activity in the oral liquid increased by 2.0, 1.34, 1.58 and 1.37 (p<0.001, p<0.01) times respectively, and in case of ECGP they grew even more: by 2.71, 1.98, 1.76 and 2.07 (p<0.001) times, respectively.Among all the indicators, that characterize the carbohydrate metabolism, in addition to the level of pyruvate, in case of different course of GP a significant difference was revealed: in patients with ECGP compared with the data in CGP, glucose and lactate levels and LDG activity in the oral liquid were significantly higher - at 35.75% (p<0.05), 34.29% (p<0.01) and 36.59% (p<0.001) respectively.Detected violations of carbohydrate metabolism indeces in the oral liquid indicate the involvement of these processes in the pathogenesis of GP and the necessity of their correction. 

Comparative effects of prednisolone and thyroid hormone on bile secretion in the dog

1961 ◽  
Vol 201 (3) ◽  
pp. 577-581 ◽  
Author(s):  
Joseph H. Gans ◽  
Kenneth McEntee
Keyword(s):  
Bile Acid ◽  
Thyroid Hormone ◽  
Acid Content ◽  
Enterohepatic Circulation ◽  
Early Period ◽  
Hepatic Function ◽  
Bile Secretion ◽  
Control Group ◽  
Biliary Cholesterol ◽  
Significant Difference

The enterohepatic circulation of euthyroid dogs contained 1.25 ± 0.24 g bile acids/10 kg body wt. The bile acid content of the enterohepatic circulation of hyperthyroid dogs given thyroid hormones for 3 weeks was 0.72 ± 0.21g/10kg body wt., a significant difference from the control group ( P( t) < .01). No significant differences in biliary cholesterol output were recorded. Bile secretory changes in the hyperthyroid state were unrelated to food intake or changes in body weight. No evidence was found to indicate an early period of enhanced bile acid or biliary cholesterol secretion accompanying thyroid hormone administration. The administration of prednisolone trimethylacetate to euthyroid dogs resulted in a significant ( P( t) < .01) increase in total bile volume recovered. The enterohepatic bile acid content of the prednisolone-treated dog was 1.84 ± .48 g/10 kg body wt., the difference from the control group being of marginal significance ( P( t) < .05 > .02). Two hepatic function tests, the secretory response to sodium dehydrocholate administration and the rate of disappearance of bromsulfonphthalein from plasma, did not indicate any gross derangement in hepatic function in the hyperthyroid or prednisolone-treated dogs.

Increased Plasma Levels of Free Tissue Factor Pathway Inhibitor in Patients with Graves’ Disease

1998 ◽  
Vol 79 (05) ◽  
pp. 919-923 ◽  
Author(s):  
Eriko Morishita ◽  
Takuma Hashimoto ◽  
Hidesaku Asakura ◽  
Masanori Saito ◽  
Masahide Yamazaki ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Tissue Factor ◽  
Tissue Factor Pathway Inhibitor ◽  
Plasma Concentrations ◽  
Free Form ◽  
Control Group ◽  
Graves Disease ◽  
Thyroid State ◽  
Significant Difference ◽  
Tissue Factor Pathway

SummaryTissue factor pathway inhibitor (TFPI) is present in a free-form and in lipoprotein-associated forms in plasma. In this study, the plasma concentrations of total TFPI (tTFPI) and free-form TFPI (fTFPI) were measured in 25 patients with Graves’ disease and 25 age-matched healthy subjects, and the relationship between thyroid state and plasma TFPI was examined. Plasma concentrations (median) of tTFPI and fTFPI in Graves’ patients who were hyperthyroid were significantly increased compared with Graves’patients who were euthyroid (152 ng/ml versus 124 ng/ml, p <0.01 and 41.3 ng/ml versus 20.2 ng/ml, p <0.0001, respectively), and control subjects (152 ng/ml versus 96 ng/ml, p <0.0001 and 41.3 ng/ml versus 18.7 ng/ml, p <0.0001, respectively). There was no significant difference in plasma fTFPI concentrations between the euthyroid group and the control group. Plasma fTFPI concentrations correlated closely with thyroid hormone (T3) levels in the patients (r = 0.559, p <0.005). Serial measurement of individual patients revealed that plasma concentrations of fTFPI and tTFPI were significantly decreased, reaching normal control values upon attainment of euthyroidism. In conclusion, the close correlation between plasma fTFPI and serum thyroid hormone levels suggests that thyroid hormones might influence the synthesis or metabolism of TFPI on the surface of endothelial cells in patients with Graves’ disease. This is the first report concerning high concentrations of plasma fTFPI in patients with hyperthyroidism.

ABNORMAL REGULATION OF THYROID FUNCTION IN PATIENTS WITH CHRONIC CHAGA'S DISEASE

1966 ◽  
Vol 53 (1) ◽  
pp. 162-176 ◽  
Author(s):  
D. A. Lomonaco ◽  
H. L. Oliveira ◽  
J. Kieffer ◽  
R. R. Pieroni
Keyword(s):  
Thyroid Hormone ◽  
Chagas Disease ◽  
Thyroid Function ◽  
Thyroid Dysfunction ◽  
Functional Study ◽  
Control Groups ◽  
Chronic Form ◽  
Significant Difference ◽  
The Difference ◽  
Chronic Chagas Disease

ABSTRACT The problem of thyroid dysfunction in Chagas' disease is discussed on the basis of the functional study of three series of patients with the chronic form of the disease. There was no significant association between Chagas' disease and goiter. No significant difference was found between the average plasma PBI in the groups of patients and that of the control groups. However, the values in the Chagas groups showed a much wider dispersion than those of the non Chagas controls; the difference between the corresponding variances was statistically significant. A loss of efficiency of the mechanisms concerned with the homeostasis of circulating thyroid hormone seems to occur in chronic Chagas' disease. This is interpreted as a possible result of the nervous lesion characteristic of the disease, which might involve neuronal links of homeostatic circuits responsible for the release of TSH.

Thyroid Hormone Resistance and Pituitary Enlargement After Thyroid Ablation in a Woman on Levothyroxine Treatment

Thyroid ◽  
2008 ◽  
Vol 18 (10) ◽  
pp. 1119-1123 ◽  
Author(s):  
Monica Marazuela ◽  
Lia Nattero ◽  
Dolores Moure ◽  
Iluminada García-Polo ◽  
Nicte Figueroa-Vega ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Hormone Resistance ◽  
Thyroid Hormone Resistance ◽  
Thyroid Ablation ◽  
Pituitary Enlargement ◽  
Levothyroxine Treatment
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