scholarly journals Effect of a pre-exercise hydrocortisone dose on short-term physical performance in female patients with primary adrenal failure

2016 ◽  
Vol 174 (1) ◽  
pp. 97-105 ◽  
Author(s):  
Katerina Simunkova ◽  
Nevena Jovanovic ◽  
Espen Rostrup ◽  
Paal Methlie ◽  
Marianne Øksnes ◽  
...  
Keyword(s):  
Physical Activity ◽  
Aerobic Capacity ◽  
Healthy Subjects ◽  
Addison’S Disease ◽  
Exercise Stress ◽  
Addison's Disease ◽  
Short Term ◽  
Maximal Aerobic Capacity ◽  
Post Exercise ◽  
Stress Dose

ObjectiveMany patients with primary adrenal insufficiency (Addison's disease) take extra doses of glucocorticoids during stressful events, but a benefit has not been demonstrated in controlled trials. Here, we investigated the effects of a pre-exercise hydrocortisone dose on cardiorespiratory, hormonal and metabolic parameters in response to short-term strenuous physical activity.DesignThis was a randomized placebo-controlled, cross-over clinical trial.ParticipantsTen women with Addison's disease and 10 age-matched healthy females participated in the study.MeasurementsAll women in the study underwent maximal incremental exercise testing. A stress dose of 10 mg hydrocortisone or placebo was given 1 h prior to exercise on two occasions. Blood samples were drawn before, and 0, 15 and 30 min post exercise. Oxygen uptake, maximal aerobic capacity, endocrine and metabolic responses to physical activity, as well as health status by questionnaires were evaluated.ResultsMaximal aerobic capacity and duration of exercise were significantly lower in patients than in healthy subjects and did not improve with the treatment. After an extra hydrocortisone dose serum cortisol was significantly higher than in the healthy subjects (P<0.001). Post-exercise glucose and adrenaline levels were significantly lower and free fatty acids insignificantly higher in patients irrespective of stress dose. Stress dosing did not alter other metabolic or hormonal parameters or quality of life after the exercise.ConclusionsThe patients did not benefit from an extra dose of hydrocortisone in short strenuous exercise. Stress dosing may not be justified in this setting. Whether stress dosing is beneficial in other types of physical activity will have to be examined further.

scholarly journals A high-sensitivity test in the assessment of adrenocortical insufficiency: 10 microg vs 250 microg cosyntropin dose assessment of adrenocortical insufficiency

1998 ◽  
Vol 159 (2) ◽  
pp. 275-280 ◽  
Author(s):  
JG Gonzalez-Gonzalez ◽  
NE De la Garza-Hernandez ◽  
LG Mancillas-Adame ◽  
J Montes-Villarreal ◽  
JZ Villarreal-Perez
Keyword(s):  
Healthy Subjects ◽  
Low Dose ◽  
Standard Dose ◽  
Addison’S Disease ◽  
High Sensitivity ◽  
Serum Cortisol ◽  
Dose Assessment ◽  
Addison's Disease ◽  
Acth Test ◽  
Adrenocortical Insufficiency

The short cosyntropin (synthetic ACTH) test is recognized as the best screening manoeuvre in the assessment of adrenocortical insufficiency. Recent data, however, suggest that i.v. administration of 250 microg cosyntropin could be a pharmacological rather than a physiological stimulus, losing sensitivity for detecting adrenocortical failure. Our objective was to compare 10 vs 250 microg cosyntropin in order to find differences in serum cortisol peaks in healthy individuals, the adrenocortical response in a variety of hypothalamic-pituitary-adrenal axis disorders and the highest sensitivity and specificity serum cortisol cut-off point values. The subjects were 83 healthy people and 37 patients, the latter having Addison's disease (11), pituitary adenomas (7), Sheehan's syndrome (9) and recent use of glucocorticoid therapy (10). Forty-six healthy subjects and all patients underwent low- and standard-dose cosyntropin testing. In addition, 37 controls underwent the low-dose test. On comparing low- and standard-dose cosyntropin testing in healthy subjects there were no statistical differences in baseline and peaks of serum cortisol. In the group of patients, 2 out of 11 cases of Addison's disease showed normal cortisol criterion values during the standard test but abnormal during the low-dose test. In our group of patients and controls, the statistical analysis displayed a better sensitivity of the low-dose vs standard-dose ACTH test at 30 and 60 min. In conclusion, these results suggest that the use of 10 microg rather than 250 microg cosyntropin i.v. in the assessment of suspicious adrenocortical dysfunction gives better results.

scholarly journals Microsatellite Polymorphism of the MHC Class I Chain-Related (MIC-A and MIC-B) Genes Marks the Risk for Autoimmune Addison’s Disease

1999 ◽  
Vol 84 (10) ◽  
pp. 3701-3707 ◽  
Author(s):  
Giovanni Gambelunghe ◽  
Alberto Falorni ◽  
Mehran Ghaderi ◽  
Stefano Laureti ◽  
Cristina Tortoioli ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Absolute Risk ◽  
Central Italy ◽  
Addison’S Disease ◽  
Class I ◽  
Addison's Disease ◽  
Specific Marker ◽  
Hla Dr ◽  
Intron 1 ◽  
Hla Dr3

Abstract The major histocompatibility complex class I chain-related MIC-A and MIC-B genes are located on chromosome 6 between the histocompatibility leucocyte antigen (HLA)-B and the B-associated transcript genes. The presence of 21-hydroxylase autoantibodies is a sensitive and specific marker of autoimmune Addison’s disease. We studied the polymorphism of exon 5 of the MIC-A gene, of intron 1 of the MIC-B gene, and of HLA-DRB1, -DQA1, and -DQB1 genes in 28 autoimmune (21-hydroxylase autoantibody positive) Addison’s disease patients and in 75 healthy subjects from central Italy. The MIC-A5.1 allele was significantly more frequent in Addison’s disease patients (79%) than in healthy subjects (36%) [odds ratio (OR) = 6.52, corrected P (Pc) = 0.0015], whereas MIC-A6 was significantly reduced in affected subjects (15% vs. 56%, OR = 0.13, Pc = 0.002). The A5.1/A5.1 genotype had an OR for autoimmune Addison’s disease as high as 18.0 and an absolute risk of 1 per 1131. In the presence of MIC-A5.1, MICB-CA-25 was significantly increased in Addison’s disease patients (25% vs. 4%, OR = 8.0, P = 0.0039, Pc = 0.047). The MICB-CA-17 allele was absent in Addison’s disease patients, but present in more than 25% healthy individuals (OR = 0.10, P = 0.0025, Pc = 0.03). Among HLA-DR and -DQ haplotypes, only DRB1*03-DQA1*0501-DQB1*0201 (DR3/DQ2) was significantly more frequent in Addison’s disease patients than in healthy subjects, but only in the presence of MIC-A5.1. The frequency of MIC-A5.1 was significantly increased in Addison’s disease patients only in the presence of HLA-DR3-DQ2. Our study demonstrates that susceptibility to autoimmune Addison’s disease is linked to the MIC-A microsatellite allele 5.1 and that both MIC-A5.1 and HLA-DR3/DQ2 are necessary to confer increased genetic risk for Addison’s disease.

Effect of angiotensin II on plasma ACTH in patients with Addison's disease

1985 ◽  
Vol 110 (4) ◽  
pp. 451-455
Author(s):  
Hermann Haller ◽  
Volker Bähr ◽  
Petra Exner ◽  
Wolfgang Oelkers
Keyword(s):  
Angiotensin Ii ◽  
Time Lag ◽  
Addison’S Disease ◽  
Major Effect ◽  
Addison's Disease ◽  
Base Line ◽  
Plasma Acth ◽  
Acth Secretion ◽  
Short Term ◽  
Sodium Deficiency

Abstract. Short-term angiotensin II (All) infusions (3 ng/kg/min) were performed in 5 patients with Addison's disease in order to assess the effect of AII on ACTH secretion. Base line ACTH levels were elevated due to a 9-h time lag between hydrocortisone administration and onset of the study. In 2 separate infusion periods of 30-min duration, All had no unidirectional effect on plasma ACTH. Mean ACTH increased slightly but insignificantly. Mean blood pressure rose by about 10 mmHg. The degree of angiotensinaemia induced is probably similar to the state of moderate to severe sodium deficiency. Short-term changes of All in this order of magnitude have obviously no major effect on ACTH secretion.

Decreased physical activity, reduced QoL and presence of debilitating fatigue in patients with Addison's disease

2016 ◽  
Vol 85 (3) ◽  
pp. 354-360 ◽  
Author(s):  
Eline S. van der Valk ◽  
Lisanne C.C.J. Smans ◽  
Hedwig Hofstetter ◽  
Janine H. Stubbe ◽  
Marieke de Vries ◽  
...  
Keyword(s):  
Physical Activity ◽  
Addison’S Disease ◽  
Addison's Disease

Comparison of structured and unstructured physical activity training on predicted VO2max and heart rate variability in adolescents – a randomized control trial

2017 ◽  
Vol 28 (3) ◽  
Author(s):  
Vivek Kumar Sharma ◽  
Senthil Kumar Subramanian ◽  
Krishnakumar Radhakrishnan ◽  
Rajathi Rajendran ◽  
Balasubramanian Sulur Ravindran ◽  
...  
Keyword(s):  
Physical Activity ◽  
Blood Pressure ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Body Fat ◽  
Aerobic Capacity ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Maximal Aerobic Capacity ◽  
And Gender

AbstractBackground:Physical inactivity contributes to many health issues. The WHO-recommended physical activity for adolescents encompasses aerobic, resistance, and bone strengthening exercises aimed at achieving health-related physical fitness. Heart rate variability (HRV) and maximal aerobic capacity (VO2max) are considered as noninvasive measures of cardiovascular health. The objective of this study is to compare the effect of structured and unstructured physical training on maximal aerobic capacity and HRV among adolescents.Methods:We designed a single blinded, parallel, randomized active-controlled trial (Registration No. CTRI/2013/08/003897) to compare the physiological effects of 6 months of globally recommended structured physical activity (SPA), with that of unstructured physical activity (USPA) in healthy school-going adolescents. We recruited 439 healthy student volunteers (boys: 250, girls: 189) in the age group of 12–17 years. Randomization across the groups was done using age and gender stratified randomization method, and the participants were divided into two groups: SPA (n=219, boys: 117, girls: 102) and USPA (n=220, boys: 119, girls: 101). Depending on their training status and gender the participants in both SPA and USPA groups were further subdivided into the following four sub-groups: SPA athlete boys (n=22) and girls (n=17), SPA nonathlete boys (n=95) and girls (n=85), USPA athlete boys (n=23) and girls (n=17), and USPA nonathlete boys (n=96) and girls (n=84).Results:We recorded HRV, body fat%, and VO2 max using Rockport Walk Fitness test before and after the intervention. Maximum aerobic capacity and heart rate variability increased significantly while heart rate, systolic blood pressure, diastolic blood pressure, and body fat percentage decreased significantly after both SPA and USPA intervention. However, the improvement was more in SPA as compared to USPA.Conclusions:SPA is more beneficial for improving cardiorespiratory fitness, HRV, and reducing body fat percentage in terms of magnitude than USPA in adolescent individuals irrespective of their gender and sports activities.

scholarly journals Physical activity and maximal aerobic capacity in breast cancer survivors: Why this is important

2014 ◽  
Vol 71 (1) ◽  
pp. 66-72
Author(s):  
Zorica Brdareski ◽  
Aleksandar Djurovic ◽  
Snezana Susnjar ◽  
Mirjana Zivotic-Vanovic ◽  
Andjelka Ristic ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Cancer Survivors ◽  
Aerobic Capacity ◽  
Breast Cancer Survivors ◽  
Maximal Aerobic Capacity

nema

scholarly journals Effects of Low-Intensity Resistance Exercise with Slow Movement and Tonic Force Generation on Short-Term Glycemic Variability in Healthy Subjects: A Randomized Controlled Study

2021 ◽  
Vol 11 (4) ◽  
pp. 1536
Author(s):  
Takuro Shoji ◽  
Hidetaka Hamasaki ◽  
Akiko Kawaguchi ◽  
Yoko Waragai ◽  
Hidekatsu Yanai
Keyword(s):  
Physical Activity ◽  
Glycemic Control ◽  
Resistance Exercise ◽  
Healthy Subjects ◽  
Glycemic Variability ◽  
Force Generation ◽  
Controlled Study ◽  
Control Group ◽  
Short Term ◽  
Low Intensity

Resistance exercise improves daily glycemic control. Low-intensity resistance exercise with slow movements and tonic force generation (LST) is a resistance exercise protocol that can increase skeletal muscle mass and strength without considerable physical burden; however, its effect on glycemic variability is unknown. The aim of this study was to investigate the effect of LST on short-term glycemic variability, expressed as the M-value, in healthy individuals. We recruited 20 healthy subjects (mean age: 27.9 ± 3.9 years) with normal glucose tolerance, and subjects were randomly assigned to the control (n = 10) or LST (n = 10) groups. Subjects in the LST group performed the resistance exercise with 40–50% of the one-repetition maximum for 40 min. All subjects wore a subcutaneous continuous glucose monitoring system and a triaxial accelerometer, and their daily glycemic variability and physical activity were measured. One hour after the intervention, in the LST group, the variability of blood glucose levels was significantly decreased compared to the control group (M-values in the LST group: pre 3.5 ± 6.2, post 2.7 ± 2.7, p = 0.575; M-values in the control group: pre 0.4 ± 0.7, post 2.7 ± 2.0, p = 0.017). However, there were no differences in total physical activity and daily glycemic control between groups. The findings of this study suggest that LST improves short-term glycemic variability in healthy subjects.

The physical activity level and aerobic capacity estimation (VO2max) among the administrative staff of the Pars Special Economic Energy Zone (Assaluyeh, Iran) with different BMIs

2019 ◽  
Vol 38 (3) ◽  
Author(s):  
Mohammad Rafatifard ◽  
Seyed Saeed Mazloomy Mahmoodabad ◽  
Hossein Fallahzadeh
Keyword(s):  
Physical Activity ◽  
Aerobic Capacity ◽  
Oil And Gas ◽  
Oil And Gas Industry ◽  
Overweight And Obesity ◽  
Activity Level ◽  
Administrative Staff ◽  
Maximal Aerobic Capacity ◽  
Energy Zone ◽  
Significant Difference

AbstractBackgroundThe purpose of this study was to examine the level of physical activity (PA) and maximal aerobic capacity (VO2max) among office workers of the Pars Special Economic Energy Zone in Iran with different body mass indexes (BMIs).Materials and methodsThis research was descriptive, and a correlation of variables was applied as its execution method. Administrative staff of two centers were randomly selected from 20 to 30 administrative centers of the Pars Special Economic Energy Zone, Assaluyeh, Iran, and included 294 male employees who were willing to participate in this research and who met the inclusion criteria (being in the age range of 20–60 years, lacking specific diseases, and who had enough physical fitness to do PA) who were purposefully selected.ResultsThe age-adjusted means for the PA score (7.93 ± 1.12) and VO2max(48.66 ± 6.95) mL/min/kg were calculated. After adjusting for other variables, significant difference was found between BMI and age (β = 0.20; p = 0.005), BMI and VO2max(β = 0.302; p = 0.001), as well as BMI and the total PA score (β = −0.304; p = 0.045).ConclusionsThe results of this study showed low levels of PA (work, exercise and leisure) and respiratory capacity in the administrative staff of the oil and gas industry, which is associated with overweight and obesity.

Sign in / Sign up

Export Citation Format

Share Document