scholarly journals Elevated hounsfield units and large tumour size on radiological imaging are both suggestive of functionality in incidental adrenal tumours

2014 ◽  
Author(s):  
Dilip Abraham ◽  
Jadwiga Raasz ◽  
Edward Kearney ◽  
Stonny Joseph
Keyword(s):  
Tumour Size ◽  
Radiological Imaging ◽  
Large Tumour ◽  
Hounsfield Units ◽  
Adrenal Tumours ◽  
Large Tumour Size

scholarly journals Primary pure carcinoid tumour of the testis: A case report and review of the literature

2016 ◽  
Vol 88 (3) ◽  
pp. 245 ◽  
Author(s):  
Hideki Takada ◽  
Shoichiro Iwatsuki ◽  
Yasunori Itoh ◽  
Shinya Sato ◽  
Masa Hayase ◽  
...  
Keyword(s):  
Case Report ◽  
Carcinoid Syndrome ◽  
Carcinoid Tumour ◽  
Tumour Size ◽  
Review Of The Literature ◽  
Large Tumour ◽  
Ki 67 ◽  
The Right ◽  
Gross Examination ◽  
Large Tumour Size

Primary testicular carcinoid tumours (TCT) are very rare, and a large tumour size and the presence of carcinoid syndrome predict a malignant course. Histologically, it is difficult to differentiate between benign and malignant TCTs. We report a case of a primary pure TCT with an unusual presentation in a 23- year-old man, who had an asymptomatic, enlarged scrotum on the right side for 7 years. On gross examination, the tumour was 9.6 cm in diameter. The Ki-67 labelling index was 19.8%. High inguinal orchidectomy was performed, and 30 months after surgery the patient remains asymptomatic.

Breast cancer incidence: Decreasing trend in large tumours in women aged 50–74

2016 ◽  
Vol 24 (4) ◽  
pp. 189-194 ◽  
Author(s):  
Florence Molinié ◽  
Solenne Delacour-Billon ◽  
Brigitte Tretarre ◽  
Patricia Delafosse ◽  
Brigitte Seradour ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Incidence Rate ◽  
Cancer Incidence ◽  
Screening Programme ◽  
Tumour Size ◽  
Breast Cancer Mortality ◽  
Breast Cancer Incidence ◽  
Large Tumour ◽  
Large Breast ◽  
Large Tumour Size

Objective A decrease in advanced breast cancer incidence is considered an early indicator of breast cancer mortality reduction in a screening programme. We describe trends in breast cancer incidence according to tumour size and age in three French administrative areas, where an organized screening programme was implemented during the 1990s. Methods Our study included all 28,092 invasive breast cancers diagnosed from 2000 to 2010 in women living in three areas (Hérault, Isère, Loire-Atlantique). Age, year of diagnosis, and size of tumour at diagnosis was provided by the three area cancer registries. Poisson regression models were fitted to estimate changes in incidence over time, after adjustment for age and administrative area. Results From 2000 to 2010, the incidence rate of large (tumour size >20 mm) breast cancer linearly decreased in women aged 50–74 (target age of the screening programme) from 108.4 to 84.1/100,000 (annual percent change = −1.9%, p < 0.001). No change in large breast cancer incidence rate was found in women aged 20–49, or older than 74. Conclusions A decreasing trend in incidence of large tumour size breast cancer in the target age of the screening programme is demonstrated for the first time in France. The overall 20.9% linear decrease over 11 years in these three areas is encouraging and should be closely monitored and extended to other areas of France, where the screening programme was generally implemented only in 2004.

scholarly journals Untreated Giant Ameloblastoma of Jaw - Diagnostic and Management Dilemma

2020 ◽  
Vol 4 (4) ◽  
pp. 313
Author(s):  
Hwang Zhen Shan ◽  
Ahmad Tarmizi Musa ◽  
Nurhayu Abdul Rahman ◽  
Jawaad Ahmed Asif ◽  
Nur Asma Sapiai
Keyword(s):  
Tumour Size ◽  
Radical Resection ◽  
Large Tumour ◽  
Large Size ◽  
Upper Jaw ◽  
Giant Size ◽  
Slow Growing ◽  
Lower Molar ◽  
Molar Region ◽  
Large Tumour Size

Ameloblastoma is a benign locally aggressive odontogenic epithelial neoplasm. It is slow growing tumour and mostly of benign behaviour. The most frequent location is at lower molar region and rarely involve upper jaw or maxillary sinus. Patients are usually asymptomatic until reaching a certain large size. Delayedtreatment is relatively common in our society. Patients mostly seek for treatment when a large tumour size is achieved. Herein we report a case due to its rarity, giant size, imaging challenge and management, which involves radical resection and free flap reconstruction.International Journal of Human and Health Sciences Vol. 04 No. 04 October’20 Page : 313-318

Risk factors for the local recurrence of giant cell tumours of the sacrum treated with nerve-sparing surgery

2020 ◽  
Vol 102-B (10) ◽  
pp. 1392-1398
Author(s):  
Yongzhao Zhao ◽  
Xiaodong Tang ◽  
Taiqiang Yan ◽  
Tao Ji ◽  
Rongli Yang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Local Recurrence ◽  
Cox Regression ◽  
Tumour Size ◽  
Univariate Analysis ◽  
Nerve Sparing ◽  
Large Tumour ◽  
Cox Regression Analysis ◽  
Independent Risk Factors ◽  
Large Tumour Size

Aims There is a lack of evidence about the risk factors for local recurrence of a giant cell tumour (GCT) of the sacrum treated with nerve-sparing surgery, probably because of the rarity of the disease. This study aimed to answer two questions: first, what is the rate of local recurrence of sacral GCT treated with nerve-sparing surgery and second, what are the risk factors for its local recurrence? Methods A total of 114 patients with a sacral GCT who underwent nerve-sparing surgery at our hospital between July 2005 and August 2017 were reviewed. The rate of local recurrence was determined, and Kaplan-Meier survival analysis carried out to evaluate the mean recurrence-free survival. Possible risks factors including demographics, tumour characteristics, adjuvant therapy, operation, and laboratory indices were analyzed using univariate analysis. Variables with p < 0.100 in the univariate analysis were further considered in a multivariate Cox regression analysis to identify the risk factors. Results The rate of local recurrence of sacral GCT treated with nerve-sparing surgery was 28.95% (33/114). Multivariate Cox regression analysis showed that large tumour size (> 8.80 cm) (hazard ratio (HR) 3.16; 95% confidence interval (CI) 1.27 to 7.87; p = 0.014), high neutrophil-to-lymphocyte ratio (NLR) (> 2.09) (HR 3.13; 95% CI 1.28 to 7.62; p = 0.012), involvement of a sacroiliac joint (HR 3.09; 95% CI 1.06 to 9.04; p = 0.039), and massive intraoperative blood loss (> 1,550 ml) (HR 2.47; 95% CI 1.14 to 5.36; p = 0.022) were independent risk factors for local recurrence. Conclusion Patients with a sacral GCT who undergo nerve-sparing surgery have a local recurrence rate of 29%. Large tumour size, high NLR, involvement of a sacroiliac joint, and massive intraoperative blood loss are independent risk factors. Cite this article: Bone Joint J 2020;102-B(10):1392–1398.

scholarly journals Clinical characteristics and tumour size evolution in patients with bilateral adrenal tumours

2016 ◽  
Author(s):  
Simona Galoiu ◽  
Raluca Pena ◽  
Raluca Trifanescu ◽  
Dan Alexandru Niculescu ◽  
Anda Dumitrascu ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Tumour Size ◽  
Adrenal Tumours ◽  
Size Evolution

scholarly journals Prognostic Value of Tumour Size in Colon Cancer – Smaller is Better?

2021 ◽  
Author(s):  
Siyi Lu ◽  
Bingyan Wang ◽  
Zhenzhen Liu ◽  
Fei Li ◽  
Yongqu Lu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Prognostic Value ◽  
Tumour Size ◽  
Disease Free Survival ◽  
Tumour Microenvironment ◽  
Clinicopathological Characteristics ◽  
Free Survival ◽  
Small Tumour ◽  
Mismatch Repair Status ◽  
Large Tumour Size

Abstract Background: The prognostic value of tumour size in colon cancer remains controversial. This study aimed to reveal the correlation between tumour size and prognosis of colon cancer.Methods: A total of 498 patients with colon cancer were included in this study. The correlation of tumour size with prognosis, mismatch repair status and other clinicopathological characteristics as well as tumour microenvironment was analysed.Results: For stage IIA microsatellite stable (MSS) colon cancer, tumours sized <3.5 cm and ≥5 cm were associated with a poorer disease free survival (DFS) compared with tumours sized between 3.5 and 5 cm (p=0.002). Small tumour size (HR=5.098, p=0.001) and large tumour size (HR=2.749, p=0.029) were found to be independent prognostic factors for stage IIA MSS colon cancer. Moreover, high expression of transgelin (TAGLN), a marker of cancer-associated fibroblasts (CAFs), was found to be an independent prognostic factor for poorer DFS (HR=9.651, p=0.009), which was also associated with smaller tumour size (p=0.027).Conclusion: Small (<3.5 cm) and large (≥5 cm) tumour sizes are associated with decreased DFS in stage IIA MSS colon cancer. Enrichment of TAGLN+ CAFs is associated with decreased DFS and small tumour size.

Long-term socio-economic impact of vestibular schwannoma for patients under observation and after surgery

2003 ◽  
Vol 117 (12) ◽  
pp. 955-964 ◽  
Author(s):  
Tina Tos ◽  
Per Caye-Thomasen ◽  
Sven-Eric Stangerup ◽  
Mirko Tos ◽  
Jens Thomsen
Keyword(s):  
Vestibular Schwannoma ◽  
Tumour Size ◽  
Well Being ◽  
Daily Activities ◽  
Large Tumour ◽  
Small Tumour ◽  
Social Ability ◽  
Vocational Status ◽  
Socio Economic Impact

This study describes and compares the long-term socio-economic impact for patients diagnosed with a vestibular schwannoma and either operated on or observed.A consecutive sample of patients diagnosed with vestibular schwannoma in Denmark and either operated on (748 patients) or observed by the wait-and-re-scan policy (272 patients) during the period 1976-2000 were studied retrospectively. The consequences of operation/diagnosis (andobservation) on vocational status, ability to handle daily chores and some psycho-social aspects were studied by means of a prospective postal questionnaire. Ninety-six per cent of the operated and 83 per cent of the observed patients answered the questionnaire. Overall, 34 per cent of operated patients resumed their daily activities within one to two months, and 76 per cent within four to six months. Patients operated on for a large tumour resumed their daily activities later than patients with a small tumour. Regardless of tumour size, employment was unchanged for the majority of observed and operated patients. The vocational consequences were significantly worse for operated patients with a large tumour, than for observed patients. However, no difference existed between the observed group and operated patients with a tumour below 20 mm in size. A change in vocational status was most frequent for assisting spouses, unskilled manual workers and the self-employed. The majority of both observed and operated patients experienced no change in their ability to handle daily chores. The changed ability of operated patients was worse than that of observed patients. Among various changes in their psycho-social well-being, decrease in social ability was the most frequent complaint in both groups, followed by increased fatigue, decreased concentration, increased irritability, depression and headache, decreased intellect and libido. Regardless of tumour size, the change in social ability, concentration and fatigue was worse for operatedpatients. Concerning headache, patients operated on for a large tumour were better off than observed patients and patients operated on fora small tumour. There was no difference between the operated and observed groups concerning irritability, intellect and libido.Deterioration of vocational status, ability to handle daily chores and several aspects of psycho-social well-being are reported both by patients operated on and observed for vestibular schwannoma. However, the negative changes were more frequent among the operated patients, although the differences were surprisingly modest, especially when comparing observed patients with patients operated on for a small tumour.

scholarly journals Predictors of post-thymectomy long-term neurological remission in thymomatous myasthenia gravis: an analysis from a multi-institutional database

2019 ◽  
Vol 57 (5) ◽  
pp. 867-873 ◽  
Author(s):  
Kwon Joong Na ◽  
Kwanyong Hyun ◽  
Chang Hyun Kang ◽  
Samina Park ◽  
Hyun Joo Lee ◽  
...  
Keyword(s):  
Myasthenia Gravis ◽  
Cox Regression ◽  
Tumour Size ◽  
Immunosuppressive Treatment ◽  
Cumulative Probability ◽  
Large Tumour ◽  
Cox Regression Analysis ◽  
Neurological Outcomes ◽  
Surgical Methods

Abstract OBJECTIVES Thymectomy is the treatment of choice for thymomatous myasthenia gravis (MG) for both oncological and neurological aspects. However, only a few studies comprising small numbers of patients have investigated post-thymectomy neurological outcomes. We examined post-thymectomy long-term neurological outcomes and predictors of thymomatous MG using a multi-institutional database. METHODS In total, 193 patients (47.3 ± 12.0 years; male:female = 90:103) with surgically resected thymomatous MG between 2000 and 2013 were included. Complete stable remission (CSR) and composite neurological remission (CNR), defined as the achievement of CSR and pharmacological remission after thymectomy, were evaluated. Predictors for CSR and CNR were examined by Cox regression analysis. RESULTS The median duration between MG and thymectomy was 3.1 months. In addition, 161 patients (83.4%) had symptoms less than Myasthenia Gravis Foundation of America clinical classification III. All patients underwent an extended thymectomy; there were no perioperative deaths. The 10-year cumulative probability of CSR and CNR was 36.9% and 69.1%, respectively. Mild preoperative symptoms were a significant predictor for CSR (P = 0.040), and a large tumour was a predictor for CNR (P &lt; 0.001). Patients with a large tumour were associated with early MG onset and no steroid treatment. Surgical methods, thymoma stage and histological subtypes were not associated with long-term neurological remission. CONCLUSIONS Large tumour size and preoperative mild symptoms were predictors for long-term neurological outcome in thymomatous MG. Considering that patients with early onset of MG and no immunosuppressive treatment tend to have large tumours, early surgical intervention for patients with thymomatous MG having mild symptoms might be beneficial for controlling neurological outcomes.

The optimal imaging of adrenal tumours: a comparison of different methods

2007 ◽  
Vol 14 (3) ◽  
pp. 587-599 ◽  
Author(s):  
Ioannis Ilias ◽  
Anju Sahdev ◽  
Rodney H Reznek ◽  
Ashley B Grossman ◽  
Karel Pacak
Keyword(s):  
Tumour Size ◽  
Nuclear Medicine Imaging ◽  
Adrenal Tumours ◽  
Unenhanced Ct ◽  
Contrast Enhanced ◽  
Adrenal Imaging ◽  
Magnetic Resonance Imaging Mri ◽  
Hormonal Evaluation ◽  
Weighted Sequences ◽  
Ct And Mri

Computed tomography (CT; unenhanced, followed by contrast-enhanced examinations) is the cornerstone of imaging of adrenal tumours. Attenuation values of <10 Hounsfield units on an unenhanced CT are practically diagnostic for adenomas. When lesions cannot be characterised adequately with CT, magnetic resonance imaging (MRI) evaluation (with T1- and T2-weighted sequences and chemical shift and fat-suppression refinements) is sought. Functional nuclear medicine imaging is useful for adrenal lesions that are not adequately characterised with CT and MRI. Scintigraphy with [131I]-6-iodomethyl norcholesterol (a labelled cholesterol analogue) can differentiate adrenal cortical adenomas from carcinomas. Phaeochromocytomas appear as areas of abnormal and/or increased uptake of [123I]- and [131I]-meta-iodobenzylguanidine (a labelled noradrenaline analogue). The specific and useful roles of adrenal imaging include the characterisation of tumours, assessment of true tumour size, differentiation of adenomas from carcinomas and metastases, and differentiation of hyperfunctioning from non-functioning lesions. Adrenal imaging complements and assists the clinical and hormonal evaluation of adrenal tumours.

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