Clinical profile and treatment modalities of patients presenting with hyperthyroidism in a tertiary endocrine center in nepal

2019 ◽  
Author(s):  
Ansumali Joshi ◽  
Priyadarshini Yonzon
Keyword(s):  
Clinical Profile ◽  
Treatment Modalities

scholarly journals PC3 - 128 Clinical Profile and Treatment Outcomes of Patients with Primary CNS Lymphoma in a Tertiary Hospital in the Philippines: An Eight-Year Retrospective Review

2016 ◽  
Vol 43 (S4) ◽  
pp. S20-S20
Author(s):  
M.C. Concepcion Sales
Keyword(s):  
Survival Rate ◽  
Combination Chemotherapy ◽  
Single Agent ◽  
Primary Cns Lymphoma ◽  
B Cell Lymphoma ◽  
The Philippines ◽  
Clinical Profile ◽  
Treatment Modalities ◽  
Cns Lymphoma ◽  
Female Ratio

Primary CNS Lymphoma (PCNSL) is an unusual extranodal form of Non-Hodgkin’s lymphoma with a locally aggressive course but a rare tendency to disseminate systemically. It has been documented in that the clinical characteristics and response to treatment among Asians is comparable to the Western population yet no studies done locally are available. Objectives: This study aims to determine the clinico-pathologic profile of patients diagnosed with PCNSL seen at Philippine General Hospital (PGH) from January 2006 to September, 2014 and to evaluate the patients’ response to the following treatment modalities: 1) Combination chemotherapy 2) Chemo-RT 3) Single agent chemotherapy and 4) no specific anti-lymphoma treatment. Methodology: This is a descriptive and retrospective study that included all cases of histologically-proven PCNSL seen at the PGH from January 2006 to September, 2014. The clinical profile, imaging studies and biopsy findings were obtained from the patient records. The survival rates at the end of one and two years of diagnosis were computed. Results and Conclusion. Among patients diagnosed with PCNSL at PGH, there is a higher incidence of PCNSL among males with a male to female ratio of 1.4:1 and have a younger onset with a median age of 50.2 years. Most patients presented with signs of increase ICP and majority had solitary cortical lesions with histopathologic diagnosis of diffuse large B cell lymphoma. Patients who did not undergo any form of treatment had a mean survival of 10 months. Immunocompromised patients had a shorter life-span with a mean survival of 7.5 months. Treatment of combination chemotherapy with HD-MTX and Rituximab had the most favorable outcome followed by HD-MTX only with a 2 year survival rate of 100% and 66% respectively while patients who underwent chemo-RT had a 2 year survival rate of 33% with a high incidence of neurocognitive delay.

Clinical profile and outcome of Henoch Schonlein purpura in a tertiary care hospital in South India

2017 ◽  
Vol 4 (3) ◽  
pp. 822 ◽  
Author(s):  
Shanavas Abbas ◽  
Geetha S. ◽  
Deepthi R.V. ◽  
Jubin Kamar ◽  
Susan Uthup
Keyword(s):  
Clinical Features ◽  
Renal Involvement ◽  
Tertiary Care ◽  
Clinical Profile ◽  
Treatment Modalities ◽  
Joint Involvement ◽  
Care Hospital ◽  
Henoch Schonlein Purpura ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Background: Henoch Schonlein purpura (HSP) is the most common systemic vasculitis in children. It is an immunoglobulin A (IgA) mediated systemic small-vessel vasculitis, with IgA deposition in vessel walls leading to symptoms involving the skin, joints, intestines, and kidneys. The objective of present study was to identify and describe the clinical profile, pattern of joint involvement, histopathological features, treatment modalities and complications of Henoch Schonlein purpura.Methods: 52 children less than 12 years diagnosed to have Henoch Schonlein Purpura according to the European League against Rheumatism criteria were included in the study. All patients were subjected to detailed history taking and thorough examination. The clinical features, investigations, management and complications of the disease were studied. Descriptive statistics was used to analyse the results.Results: The common clinical features were palpable purpura (100%) followed by arthritis (66%) and abdominal pain (50%). Renal manifestations were in the form of hematuria in 12% of the patients. Skin biopsy was done in 25 patients of which 19 had findings suggestive of Henoch Schonlein purpura. Steroids were used in 42% of patients. The severity of illness was associated with lower mean age, arthritis, leg edema and stool occult blood.Conclusions: The clinical features of Henoch Schonlein purpura in the population were different from the previously published studies. Renal involvement was less common. The short-term outcome of the patients were satisfactory. 

scholarly journals Cohort profile: the ESC-EORP Chronic Ischaemic Cardiovascular Disease Long Term (CICD LT) registry

2019 ◽  
Author(s):  
Michel Komajda ◽  
Francesco Cosentino ◽  
Roberto Ferrari ◽  
Cécile Laroche ◽  
Aldo Maggioni ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Coronary Revascularization ◽  
Stable Coronary Artery Disease ◽  
Research Programme ◽  
Clinical Profile ◽  
Treatment Modalities ◽  
Common Disease ◽  
Coronary Syndrome ◽  
European Society Of Cardiology

Abstract Aims The European Society of Cardiology (ESC) EURObservational Research Programme (EORP) Chronic Ischaemic Cardiovascular Disease Long Term (CICD LT) registry aims to study the clinical profile, treatment modalities, and outcomes of patients diagnosed with CICD in a contemporary environment in order to assess whether these patients at high cardiovascular (CV) risk are treated according to ESC guidelines on prevention or on stable coronary disease and to determine mid- and long-term outcomes and their determinants in this population. Methods and results Nine thousand one hundred and seventy-four patients over 18 years with documented CICD defined by a history acute coronary syndrome with/without ST elevation, previous coronary revascularization, or stable coronary artery disease were enrolled between 1 May 2015 and 31 July 2018. Individual patient data on clinical profile, biology, and treatment modalities were collected across 154 centres from 20 ESC countries. Two years of follow-up is scheduled in order to determine the following clinical outcomes: all-cause and CV death, all-cause and CV hospitalizations, changes in medications, and quality of life using the EuroQol5D-5L score. Conclusion The CICD LT is an international registry of care and outcomes of patients hospitalized with CICD which will provide insights into the contemporary profile and management of patients with this common disease.

scholarly journals Clinical profile, diagnostic, treatment modalities and outcomes of pulmonary embolism- a retrospective tertiary centre study

2020 ◽  
Vol 72 ◽  
pp. S49
Author(s):  
Suresh Kumar Paidi ◽  
M. Krishna chaitanya ◽  
Krishna Kumar Mohanan Nair ◽  
Bijulal Sasidharan ◽  
Sanjay Ganapathi ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Clinical Profile ◽  
Treatment Modalities ◽  
Centre Study ◽  
Tertiary Centre

scholarly journals A study on clinical profile and management of lump in breast at tertiary rural hospital, Wardha, Maharashtra, India

2017 ◽  
Vol 4 (3) ◽  
pp. 998
Author(s):  
S. R. Chandak ◽  
Md. Omar Tabrez
Keyword(s):  
Risk Factors ◽  
Breast Disease ◽  
Clinical Profile ◽  
Treatment Modalities ◽  
Rural India ◽  
Breast Diseases ◽  
Breast Lump ◽  
Radiological Features ◽  
Age Variation ◽  
Breast Lumps

Background: Breast lumps diseases are one of the most common diseases in India which include congenital, traumatic, inflammatory, hormonal mastopathy, benign and malignant neoplastic conditions. Around 200,000 cases of breast diseases are diagnosed annually. In India, as there is no study of breast disease conducted separately in rural India hence studies are required to evaluate the incidence and prevalence of breast lump diseases so that interventions can be done to educate and guide people about the risk factors, importance of screening and management strategies.Methods: We have conducted our study on 50 cases of lump in breast with the objective to know their incidence, clinical, pathological and radiological features of various breast swellings and different investigative approach different treatment modalities and their outcome presenting in rural India.Results: The present study of lump in the breast was based on 50 cases admitted in AVBRH, Wardha, Maharashtra, India. During this period maximum patient were of benign breast lump as compared to malignant. All patients were females with age variation from 15 years to 55 years. Majority of patients had lumps varying from 2 months to more than 12 months.Conclusions: Most of the patients from benign lump were managed with excision of lump and all patient of malignant lump underwent mastectomy.

scholarly journals Epidemiological & Clinical Profile of Patients Presented with Mandible Fracture in a Tertiary Care Hospital

2018 ◽  
Vol 36 (3) ◽  
pp. 107-111
Author(s):  
Farjana Sultana ◽  
Md Rezaul Karim ◽  
Ismat Ara Haider
Keyword(s):  
The Body ◽  
Coronoid Process ◽  
Clinical Profile ◽  
Treatment Modalities ◽  
Care Hospital ◽  
Anatomic Site ◽  
Large Variability ◽  
Mandible Fracture ◽  
Fracture Management ◽  
Mandible Fractures

Mandible is the second most commonly fractured bone after nasal bone, though it is the largest and strongest facial bone. Fractures of the mandible can involve only one site or can often involve multiple anatomic sites. It account for 36% to 59% of all maxillofacial fracture. The large variability in reported prevalence is due to a variety of contributing factors such as gender, age, environment, and socio-economic status of patient, as well as the mechanism of the injury. The most favorable site of fracture (in descending order) in mandible is the body, angle, condylar region, symphysis, and coronoid process. The descriptive type of cross sectional retrospective study was undertaken to determine the epidemiological & clinical profile of patients presented with fractures of mandible and their different methods of treatment modalities. Four hundred and thirty five patients with mandible fractures were treated during the year 2014-2015. A review of patient’s record was conducted. Data regarding age, gender, cause of fracture, anatomic site and treatment modalities were reviewed. There was higher prevalence in male (3.9:1), with occurrence peak between 21-30 years. The principal causes of fracture in this study were RTA (Road Traffic Accidents) representing 54.02% followed by physical assault 17.24%, Fall, Sports injury, Blow by heavy objects, Tube well injury & others which includes Tire blast injury, Gunshot injury, Iatrogenic cause, Pathological fracture, Boat handle injury, Penetrating injury by metal etc. The most injured sites were in parasymphysis (26.31%) followed by angle of mandible 17.89% then symphysis, condyle, body of mandible, dentoalveolar, ramus, coronoid process of mandible. Most patients (70.11%) of mandible fractures were treated by closed reduction (arch bar, arch bars with intermaxillary fixation IMF, eyelet wiring & lateral compression plate) & 21.83% of patients were treated with open reduction (miniplates fixation. 3D plate fixation) .Only 8.05% patients were managed by conservative approach. This study reflects patterns of mandible fracture within the community and discuss various methods of mandible fracture management in the department of Maxillofacial casualty in Dhaka Dental college hospital. It is hoped that information presented here will be useful to the government agencies and health care professionals involved in planning future programs of prevention & treatment of mandible fracture.J Bangladesh Coll Phys Surg 2018; 36(3): 107-111

scholarly journals Clinical profile and outcomes of acute kidney injury patients in an intensive care unit in India

2020 ◽  
Vol 7 (4) ◽  
pp. 245
Author(s):  
Vivek S. Narayan Pillai ◽  
C. Joe Varghese ◽  
Christopher C. Pais ◽  
Vijay Gopal Rai ◽  
Mahabala Chakrapani
Keyword(s):  
Intensive Care Unit ◽  
Acute Kidney Injury ◽  
Intensive Care ◽  
Mortality Rate ◽  
Care Center ◽  
Tertiary Care ◽  
Kidney Injury ◽  
Clinical Profile ◽  
Treatment Modalities ◽  
Presenting Symptoms

<p class="abstract"><strong>Background:</strong> The limited epidemiological and outcome data of acute kidney injury (AKI) is available in developing countries. The current single-center study determined the clinical profile of AKI by attempting to identify the presenting symptoms, etiologies, treatment modalities, and disease prognosis in patients admitted in intensive care unit at a tertiary care center in Mangalore, India.</p><p class="abstract"><strong>Methods:</strong> This retrospective study enrolled 70 AKI patients between October 2001 and October 2003, admitted at Wenlock district hospital, Mangalore, KMC hospital Attawar, Mangalore and KMC hospital, Jyothi circle, Mangalore, having a serum creatinine level greater than 1.4 mg/dl and blood urea greater than 53 mg/dl.</p><p class="abstract"><strong>Results:</strong> Amongst the enrolled patients, 45.7% of patients were 40-60 years old and 49 were males with no significant (p=0.412) gender difference. The most common presenting symptom was diminished micturition present in 47.1% of patients and the most common etiology of AKI was sepsis found in 27.1% of patients with the highest (17.1%) mortality. Amongst the patients who underwent conservative treatment (n=52) the mortality rate was 42.8%, while in those who underwent hemodialysis (n=18) the mortality rate was 4.2%. The overall survival rate in the study was 52.9%.</p><p class="abstract"><strong>Conclusions: </strong>The epidemiological data obtained in this study is similar to the previous studies in India with hemodialysis appearing to have better disease outcomes compared to conservative therapy.</p>

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