scholarly journals Incident atrial fibrillation in patients with differentiated thyroid cancer: a meta-analysis

2021 ◽  
Vol 28 (5) ◽  
pp. 325-335
Author(s):  
Georgios Kostopoulos ◽  
Ioannis Doundoulakis ◽  
Christina Antza ◽  
Emmanouil Bouras ◽  
Krishnarajah Nirantharakumar ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Thyroid Cancer ◽  
Incidence Rate ◽  
Differentiated Thyroid Cancer ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Prediction Interval ◽  
Meta Analysis ◽  
Grey Literature ◽  
Healthy Controls

Differentiated thyroid cancer (DTC) represents the most common form of thyroid neoplasms and is becoming increasingly prevalent. Evidence suggests a possible relationship between DTC diagnosis and subsequent atrial fibrillation (AF). If confirmed, this may present an alarming health risk (AF) in an otherwise condition with a relatively good prognosis (DTC). The aim of this systematic review and meta-analysis is to provide for the first time a pooled estimate of AF incidence in DTC patients in comparison to healthy controls. A detailed search in electronic databases, clinical trial registries and grey literature was performed to identify studies reporting the incidence of AF in DTC patients. Newcastle–Ottawa quality assessment scale was used to assess study quality. We used a random effects (RE) generalized linear mixed model (GLMM) in pooling of individual studies and also calculated a prediction interval for the estimate of a new study. Six observational studies met the eligibility criteria, which included totally 187,754 patients with DTC and 199,770 healthy controls. The median follow-up period was 4.3 to 18.8 years; the incidence rate of AF was 4.86 (95% CI, 3.29 to 7.17, I2 = 96%) cases per 1000 person-years, while the incidence rate ratio was 1.54 (95% CI, 1.44 to 1.65, I2 = 0%, 95% PI, 1.33 to 1.78).This is the first meta-analysis to confirm that patients with DTC are at a high risk for developing AF, which may be attributed to a state of iatrogenic hyperthyroidism due to long-term thyrotropin suppression therapy.

scholarly journals Injuries in Elite Men’s Rugby Union: An Updated (2012–2020) Meta-Analysis of 11,620 Match and Training Injuries

2021 ◽  
Author(s):  
Sean Williams ◽  
Charli Robertson ◽  
Lindsay Starling ◽  
Carly McKay ◽  
Stephen West ◽  
...  
Keyword(s):  
Incidence Rate ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Meta Analysis ◽  
Team Sports ◽  
Rugby Union ◽  
Injury Incidence ◽  
Injury Data ◽  
Analytic Review ◽  
Elite Level

Abstract Background The most recent meta-analytic review of injuries in elite senior men’s Rugby Union was published in 2013. The demands of the game at the elite level are continually changing alongside law amendments and developments in player preparation. As such, an updated meta-analysis of injury data in this setting is necessary. Objective To meta-analyse time-loss injury data in elite senior men’s Rugby Union between 2012 and 2020. Methods Electronic databases were searched using the keywords ‘rugby’ and ‘inj*’. Nineteen studies met the inclusion criteria. Injury incidence rate data were modelled using a mixed-effects Poisson regression model. Days missed data were modelled using a general linear mixed model. Results The included data encompassed a total of 8819 match injuries and 2801 training injuries. The overall incidence rate of injuries in matches was 91 per 1000 h (95% confidence interval (CI) 77–106). The estimated mean days missed per match injury was 27 days (95% CI 23–32). The overall incidence rate of match concussions was 12 per 1000 h (95% CI 9–15). The overall incidence rate of training injuries was 2.8 per 1000 h (95% CI 1.9–4.0). Playing level was not a significant effect modifier for any outcome. Conclusions The injury incidence rate and mean days missed per injury in the present meta-analysis were higher, but statistically equivalent to, the 2013 meta-analysis (81 per 1000 h and 20 days, respectively). The injury incidence rate for match injuries in elite senior men’s Rugby Union is high in comparison to most team sports, though the training injury incidence rate compares favourably. The tackle event and concussion injuries should continue to be the focus of future preventative efforts.

scholarly journals Ablation rate after radioactive iodine therapy in patients with differentiated thyroid cancer at intermediate or high risk of recurrence: a systematic review and a meta-analysis

2021 ◽  
Author(s):  
Michele Klain ◽  
Carmela Nappi ◽  
Emilia Zampella ◽  
Valeria Cantoni ◽  
Roberta Green ◽  
...  
Keyword(s):  
Systematic Review ◽  
Thyroid Cancer ◽  
High Risk ◽  
Differentiated Thyroid Cancer ◽  
Meta Analysis ◽  
Ablation Rate ◽  
Intermediate Risk ◽  
Risk Of Recurrence ◽  
Successful Ablation ◽  
Risk Patients

Abstract Purpose We performed a systematic review and a meta-analysis to investigate the successful ablation rate after radioiodine (RAI) administration in patients with differentiated thyroid cancer (DTC) at intermediate-high risk of recurrence. Methods A comprehensive literature search of the PubMed, Scopus, and Web of Science databases was conducted according to the PRISMA statement. Results The final analysis included 9 studies accounting for 3103 patients at intermediate-high risk of recurrence. In these patients, the successful ablation rates ranged from 51 to 94% with a 71% pooled successful ablation and were higher in intermediate (72%) than in high (52%)-risk patients. Despite the rigorous inclusion standards, a significant heterogeneity among the evaluated studies was observed. Higher administered RAI activities are associated with a lower successful ablation rate in the whole population and in the subgroup of high-risk patients. Furthermore, pooled recurrence rate in intermediate-risk patients achieving successful ablation was only 2% during the subsequent 6.4-year follow-up while the pooled recurrence rate was 14% in patients who did not achieve a successful ablation. Conclusion In a large sample of 3103 patients at intermediate-high risk of persistent/recurrent disease, 71% of patients achieved a successful ablation. In these intermediate-risk patients, the probability of subsequent recurrence is low and most recurrence occurred in those with already abnormal findings at the first control.

scholarly journals Is prophylactic central neck dissection necessary for cN0 differentiated thyroid cancer patients at initial treatment? A meta-analysis of the literature

2017 ◽  
Vol 37 (1) ◽  
pp. 1-8
Author(s):  
J. Liang ◽  
Z. Li ◽  
F. Fang ◽  
T. Yu ◽  
C. Leone
Keyword(s):  
Thyroid Cancer ◽  
Cancer Patients ◽  
Differentiated Thyroid Cancer ◽  
Web Of Science ◽  
Meta Analysis ◽  
Central Neck Dissection ◽  
Cochrane Library ◽  
Central Neck ◽  
Sono Stati ◽  
Prophylactic Central Neck Dissection

Le metastasi ai linfonodi del compartimento centrale del collo sono comuni nei pazienti affetti da carcinoma differenziato della tiroide (DTC). La gestione dei pazienti con stadiazione preoperatoria cN0 è ancora dibattuta. L’obiettivo di questo lavoro è stato quello di analizzare le differenze in merito a ricorrenza e complicanze chirurgiche tra tiroidectomia (TT) isolata e TT associata a svuotamento linfonodale profilattico del compartimento centrale del collo (pCND) come trattamenti iniziali di pazienti con DTC cN0, e di valutare l’importanza clinica del pCND per questi pazienti. I database PubMed, Ovid, Cochrane Library e Web of Science sono stati analizzati scrupolosamente, e sono stati identificati ventitré articoli per un totale di 6823 pazienti. La qualità di evidenza è stata valutata tramite lo score di Jadad e tramite la Newcastle-Ottawa Quality assessment scale. I risultati hanno mostrato che i pazienti sottoposti a TT e pCND, se paragonati ai pazienti sottoposti a TT isolata, hanno avuto un tasso significativamente più alto di lesioni transitorie del nervo laringeo inferiore (p = 0,023), di ipocalcemia transitoria (p < 0,01) e di ipocalcemia permanente (p < 0,01). Inoltre è stato rilevato un trend in diminuzione per quel che riguarda il tasso di ricorrenza nei pazienti sottoposti a TT e pCND (p < 0,01). La tiroidectomia totale associata allo svuotamento del compartimento centrale del collo come trattamento iniziale per quei pazienti con cN0 potrebbe ridurre il rischio di ricorrenza di malattia, ma aumenta l’incidenza di alcune complicanze. Si rendono necessari ulteriori studi di maggior qualità metodologica.

Abstract WMP106: Soluble CD163 as a Prognostic Marker for Perihematomal Edema Formation and Functional Outcomes in Intracerebral Hemorrhage

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Meaghan Roy-O’Reilly ◽  
Davis So ◽  
Glenda Torres ◽  
Liang Zhu ◽  
Jaroslaw Aronowski ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Functional Outcomes ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Tissue Injury ◽  
Enzyme Linked Immunosorbent Assay ◽  
Healthy Controls ◽  
Edema Formation ◽  
Soluble Cd163 ◽  
Perihematomal Edema

Introduction: Macrophages are the predominant cell capable of removing toxic hemoglobin at sites of tissue injury, and CD163 has been recognized as the hemoglobin scavenger receptor present on the macrophage cell surface. In this study, we explored the levels of soluble CD163 (sCD163) in patients with intracerebral hemorrhage (ICH) to ascertain whether sCD163 was associated with clinicoradiologic features and long-term functional outcomes. Methods: Our ICH cohort was comprised of 50 patients with moderate-sized basal ganglia hematomas. We collected serial serum and cerebrospinal fluid (CSF) at pre-specified timepoints (24 hours, 48 hours, 3-5 days, 6-8 days, and greater than 10 days post-ictus). We also obtained samples from 10 healthy controls. Levels of sCD163 were measured by enzyme-linked immunosorbent assay. A linear mixed model was used to compare sCD163 values among various groups, using a Bonferroni correction for multiple test adjustment. The method of generalized estimating equations was used to determine associations with dichotomized outcomes (modified Rankin Scale score 0-3 versus 4-6). Results: Compared to healthy controls, serum sCD163 was higher in the ICH patients (40.6 versus 128.4 ng/mL). Within the ICH cohort, early values (24 hours to 5 days post-ictus) of serum sCD163 were significantly higher in patients who elaborated minimal perihematomal edema (PHE) (200.3 in patients with less than 10 mL PHE versus 71.8; p = 0.046). 6 to greater than 10 days post-ictus, sCD163 levels tailed off for patients with less PHE whereas levels rose in patients with greater PHE. Continued subacute elevation of sCD163, particularly in the CSF, was highly associated with poorer outcomes, both at discharge and at 90 days (p < 0.001). These associations were independent of age, gender, peak hematoma volume, and ICH score; there was a statistically significant association of CSF sCD163 values with degree of intraventricular hemorrhage (p = 0.04). Conclusions: sCD163 may be a dynamic marker in ICH, with acute levels distinguishing edema patterns and subacute levels predicting functional outcome. Further studies are needed to confirm these findings and explore the pathophysiology behind these observations.

Comparison of Completion Thyroidectomy and Primary Total Surgery for Differentiated Thyroid Cancer: A Meta-Analysis

2015 ◽  
Vol 38 (10) ◽  
pp. 528-531 ◽  
Author(s):  
Yu-Jie Li ◽  
Yao-Zong Wang ◽  
Zhan-Bo Yi ◽  
Liang-Liang Chen ◽  
Xiao-Dong Zhou
Keyword(s):  
Thyroid Cancer ◽  
Differentiated Thyroid Cancer ◽  
Meta Analysis ◽  
Completion Thyroidectomy

scholarly journals Circulating thyroid stimulating hormone receptor messenger RNA and differentiated thyroid cancer: A diagnostic meta-analysis

Oncotarget ◽  
2016 ◽  
Vol 8 (4) ◽  
pp. 6623-6629 ◽  
Author(s):  
Zhen-Zhen Zhang ◽  
Qiang Chen ◽  
Chao-Yue Kong ◽  
Zhan-Ming Li ◽  
Li-Shun Wang
Keyword(s):  
Thyroid Cancer ◽  
Hormone Receptor ◽  
Messenger Rna ◽  
Differentiated Thyroid Cancer ◽  
Meta Analysis ◽  
Thyroid Stimulating Hormone ◽  
Stimulating Hormone

Bivariate Random-effects Meta-analysis of Sensitivity and Specificity with SAS PROC GLIMMIX

2010 ◽  
Vol 49 (01) ◽  
pp. 54-64 ◽  
Author(s):  
J. Menke
Keyword(s):  
Sensitivity And Specificity ◽  
Random Effects ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Meta Analysis ◽  
Empirical Evaluation ◽  
Test Accuracy ◽  
Random Effects Model ◽  
Operating Characteristics ◽  
Meta Analyses

Summary Objectives: Meta-analysis allows to summarize pooled sensitivities and specificities from several primary diagnostic test accuracy studies. Often these pooled estimates are indirectly obtained from a hierarchical summary receiver operating characteristics (HSROC) analysis. This article presents a generalized linear random-effects model with the new SAS PROC GLIMMIX that obtains the pooled estimates for sensitivity and specificity directly. Methods: Firstly, the formula of the bivariate random-effects model is presented in context with the literature. Then its implementation with the new SAS PROC GLIMMIX is empirically evaluated in comparison to the indirect HSROC approach, utilizing the published 2 x 2 count data of 50 meta-analyses. Results: According to the empirical evaluation the meta-analytic results from the bivariate GLIMMIX approach are nearly identical to the results from the indirect HSROC approach. Conclusions: A generalized linear mixed model with PROC GLIMMIX offers a straightforward method for bivariate random-effects meta-analysis of sensitivity and specificity.

scholarly journals PSVIII-10 Effects of enzyme supplementation in corn distiller’s dried grains with solubles (DDGS) diets on growth performance in broilers: a meta-analysis

2020 ◽  
Vol 98 (Supplement_3) ◽  
pp. 211-211
Author(s):  
Jae-Cheol Jang ◽  
Zhikai Zeng ◽  
Pedro E Urriola ◽  
Gerald C Shurson
Keyword(s):  
Growth Performance ◽  
Fixed Effects ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Meta Analysis ◽  
Growth Responses ◽  
Exogenous Enzymes ◽  
The Mean ◽  
Enzyme Supplementation ◽  
Mean Differences

Abstract The objective of this study was to conduct a meta-analysis to quantitatively summarize the growth responses of broilers fed cDDGS and the efficacy of various types of dietary enzyme supplementation. A total of 12 publications with 69 observations were included in the database. Individual observations were analyzed using a multivariable linear mixed model. The mean differences (MD) of BWG, FI, and gain efficiency (G/F) were calculated by subtracting either the enzyme response in corn-soybean meal (CSB) or CSB+cDDGS based diets to the control, and was expressed as a percentage (MD = (enzyme – control)/control ×100%). A type of exogenous enzymes (xylanase; protease; carbohydrases; cocktail = proteases + carbohydrases), and feeding phase (starter = d 0 to d 21; finisher = d 21 to d 42 or 49; overall = d 0 to d 42 or more) were included as fixed effects. Dietary enzyme inclusion showed significant improvement on BWG (3.19%, P &lt; 0.01) and G/F (5.69%, P &lt; 0.01) in broilers fed cDDGS diet. However, no significant enzyme responses were observed in broilers fed CSB diet on growth performance. Broilers fed cDDGS diet had increased (P &lt; 0.01) BWG with the addition of protease (3.32 %) and cocktail (3.27 %), whereas addition of xylanased improved (P &lt; 0.01) G/F by (3.56 %) and carbohydrases (1.90 %). Broilers fed cDDGS diet with enzyme supplementation showed greater improvement in BWG (3.71 %, P &lt; 0.01) and G/F (3.78 %, P &lt; 0.01) at finisher phase compared with starter phase. Likewise, Broilers fed CSB diet with enzyme supplementation increased BWG (9.40 %, P &lt; 0.01) and G/F (3.11 %, P &lt; 0.01) at finisher phase. In conclusion, supplementation of xylanase and carbohydrases in cDDGS diet improved G/F, and the enzyme response can be maximized when fed during the finisher phase diet compared with the starter phase diet.

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