scholarly journals Macronutrients and caloric intake in health and longevity

2015 ◽  
Vol 226 (1) ◽  
pp. R17-R28 ◽  
Author(s):  
Samantha M Solon-Biet ◽  
Sarah J Mitchell ◽  
Rafael de Cabo ◽  
David Raubenheimer ◽  
David G Le Couteur ◽  
...  
Keyword(s):  
Caloric Restriction ◽  
Dietary Intervention ◽  
Critical Role ◽  
Caloric Intake ◽  
Nutrient Sensing ◽  
Current Understanding ◽  
Nutritional Interventions ◽  
Wide Range ◽  
The Impact ◽  
The Relationship

Both lifespan and healthspan are influenced by nutrition, with nutritional interventions proving to be robust across a wide range of species. However, the relationship between nutrition, health and aging is still not fully understood. Caloric restriction is the most studied dietary intervention known to extend life in many organisms, but recently the balance of macronutrients has been shown to play a critical role. In this review, we discuss the current understanding regarding the impact of calories and macronutrient balance in mammalian health and longevity, and highlight the key nutrient-sensing pathways that mediate the effects of nutrition on health and ageing.

scholarly journals Hyaluronan and the Fascial Frontier

2021 ◽  
Vol 22 (13) ◽  
pp. 6845
Author(s):  
Rebecca L. Pratt
Keyword(s):  
Nerve Fibers ◽  
The Body ◽  
Water Volume ◽  
Cell Behavior ◽  
Connective Tissues ◽  
Wide Range ◽  
The World ◽  
Extracellular Microenvironment ◽  
The Impact ◽  
The Relationship

The buzz about hyaluronan (HA) is real. Whether found in face cream to increase water volume loss and viscoelasticity or injected into the knee to restore the properties of synovial fluid, the impact of HA can be recognized in many disciplines from dermatology to orthopedics. HA is the most abundant polysaccharide of the extracellular matrix of connective tissues. HA can impact cell behavior in specific ways by binding cellular HA receptors, which can influence signals that facilitate cell survival, proliferation, adhesion, as well as migration. Characteristics of HA, such as its abundance in a variety of tissues and its responsiveness to chemical, mechanical and hormonal modifications, has made HA an attractive molecule for a wide range of applications. Despite being discovered over 80 years ago, its properties within the world of fascia have only recently received attention. Our fascial system penetrates and envelopes all organs, muscles, bones and nerve fibers, providing the body with a functional structure and an environment that enables all bodily systems to operate in an integrated manner. Recognized interactions between cells and their HA-rich extracellular microenvironment support the importance of studying the relationship between HA and the body’s fascial system. From fasciacytes to chronic pain, this review aims to highlight the connections between HA and fascial health.

scholarly journals Causal Inference, International Law, And Maritime Disputes

AJIL Unbound ◽  
2021 ◽  
Vol 115 ◽  
pp. 389-393
Author(s):  
Benjamin J. Appel
Keyword(s):  
Causal Inference ◽  
International Law ◽  
Law Of The Sea ◽  
International Courts ◽  
Legal Scholarship ◽  
Wide Range ◽  
Maritime Disputes ◽  
Empirical Tests ◽  
The Impact ◽  
The Relationship

Sara Mitchell and Andrew Owsiak's examination of the impact of UN Convention on the Law of the Sea (UNCLOS) and Article 287 declarations on the peaceful resolution of maritime disputes significantly advances the literature on the relationship between international law/international courts and maritime issues. To their credit, the authors employ a wide range of empirical tests in the article to provide readers with confidence in the empirical results. Nonetheless, there are some important limitations in their approach. Drawing on insights from the causal inference literature, I argue that Mitchell and Owsiak's empirical analyses suffer from two biases that both (1) raise concerns about the causal relationships identified in the article, and (2) suggest some important scope conditions in its empirical findings. I investigate the biases and propose suggestions for legal scholarship to produce more credible results.

Market ranking and network structure: pathway to dominance

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Yasaman Sarabi ◽  
Matthew Smith ◽  
Heather McGregor ◽  
Dimitris Christopoulos
Keyword(s):  
Firm Value ◽  
Critical Role ◽  
Firm Characteristics ◽  
Interlocking Directorates ◽  
Content Type ◽  
Network Autocorrelation ◽  
The Uk ◽  
Market Capitalisation ◽  
The Impact ◽  
The Relationship

PurposeThe relationship between interlocking directorates and firm performance has been increasingly debated, with a focus on whether firm's centrality in interlock networks is associated with performance. The purpose of this study is to examine not only how a firm's position in this network is associated with performance but also how the performance of network partners can impact a firm's performance. This study examines how firms effectively utilise the interlock network to achieve the goal of higher market capitalisation – termed market capitalisation rank (MCR).Design/methodology/approachThe premise of the study is the UK FTSE 350 firms from 2014 to 2018. The paper makes use of a temporal network autocorrelation model to examine how firm characteristics, the structural position in the interlock network and the performance of network partners affect MCR over time.FindingsThe analysis indicates that firms with ties (via the interlock network) to firms with high market capitalisation are more likely to enhance their own MCR, highlighting network partners have the opportunity to play a critical role in a firm's dominance strategy to optimise firm value.Originality/valueThe value of this research is that it does not only look at the impact of a firm's position in the network on performance, but the impact of the performance of network partners on a firm's market performance as well.

Impact of corporate social responsibility (CSR) awareness, affordability and management system sophistication on CSR performance

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Anura De Zoysa ◽  
Nobyuki Takaoka ◽  
Yuqian Zhang
Keyword(s):  
Corporate Social Responsibility ◽  
Social Responsibility ◽  
Management System ◽  
Structural Equation ◽  
Critical Role ◽  
Content Type ◽  
Japanese Firms ◽  
Corporate Social ◽  
The Impact ◽  
The Relationship

PurposeThis paper aims to examine the impact of three key factors — corporate social responsibility (CSR) awareness, CSR affordability and CSR management system (CSRMS) sophistication—on the CSR performance of Japanese firms.Design/methodology/approachUsing responses to 36 items developed on the Global CSR standard of ISO26000, two CSR indexes were constructed to assess the CSR management system sophistication and performance of Japanese firms. The relationship between the three key variables (CSR awareness, affordability and management system sophistication) and CSR performance was then examined through a partial least squares (PLS)-based structural equation model. Data were collected through a questionnaire survey of 146 firms.FindingsThe results of the study found a positive relationship between CSR performance and three exogenous variables (CSR awareness, affordability and management system sophistication). Furthermore, the study found that CSRMS sophistication played a mediating role in the relationship between CSR performance and firms' CSR awareness and affordability.Research limitations/implicationsThe study was limited to examining the CSR practices of a major province in Japan, which may hinder the generalisation of the findings to the rest of the country. Moreover, the data used for assessing the variables in this study were self-reported by the participating firms, in addition to being cross-sectional. The findings of this study clarified areas that policymakers, including Japan's business associations–Keidanren and Keizai Doyukai, and other relevant parties need to focus on for further improving CSR performances of Japanese firms.Originality/valueThis study highlights the role CSR awareness, affordability and CSRMS sophistication play in improving CSR performance. On the one hand, it identifies the critical role CSRMS plays in mediating the relationship among CSR performance, awareness and affordability. On the other hand, it advances CSR theory providing insight for practitioners to generate positive CSR outcomes.

An Empirical Analysis of FII Movement and Currency Value in India

2015 ◽  
pp. 207-217
Author(s):  
Saurabh Sen ◽  
Ruchi L. Sen
Keyword(s):  
Exchange Rate ◽  
Exchange Rates ◽  
Critical Role ◽  
Institutional Investment ◽  
Currency Futures ◽  
Overall Performance ◽  
Foreign Institutional Investors ◽  
Us Dollar ◽  
The Impact ◽  
The Relationship

India opened its stock market to foreign investors in September 1992 and has received portfolio investment from foreigners in the form of foreign institutional investment in equities and other markets including derivatives. It has emerged as one of the most influential groups to play a critical role in the overall performance of the Indian economy. The liberalization of FII flows into the Indian capital market since 1993 has had a significant impact on the economy. With increased volatility in exchange rate and to mitigate the risk arising out of excess volatility, currency futures were introduced in India in 2008, which is considered a second important structural change. This chapter examines the impact of the Foreign Institutional Investors (FIIs) on the exchange rate and analyzes the relationship between FII and Indian Rupee-US Dollar exchange rates.

Reappraising the Impact of Offending on Victimization: A Propensity Score Matching Approach

2017 ◽  
Vol 62 (8) ◽  
pp. 2374-2390
Author(s):  
Chad Posick
Keyword(s):  
Propensity Score ◽  
Propensity Score Matching ◽  
Property Crime ◽  
Experimental Methods ◽  
Wide Range ◽  
Sample Data ◽  
Quasi Experimental ◽  
The Life Course ◽  
The Impact ◽  
The Relationship

Existing evidence clearly supports an empirical connection between offending and victimization. Often called the “victim–offender overlap,” this relationship holds for both sexes, across the life course, and across a wide range of countries and cultural environments. In addition, the relationship is sustained regardless of the study sample and statistical methods applied in the analyses of the sample data. However, there has yet to be a study that examines this relationship for violent and property crime using quasi-experimental methods accounting for a wide range of potential confounders including individual differences and cultural contexts. This study subjects the victim–offender relationship to testing through propensity score matching for both violent and property crimes using an international dataset. The results show that previous violent and theft offending increases the odds of victimization when matching on individual and contextual factors. This finding supports previous literature and suggests that delinquent behavior may act as a “switch” that exposes one to subsequent violent and theft victimization.

scholarly journals Inflammation in Obesity-Related Complications in Children: The Protective Effect of Diet and Its Potential Role as a Therapeutic Agent

Biomolecules ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1324
Author(s):  
Valeria Calcaterra ◽  
Corrado Regalbuto ◽  
Debora Porri ◽  
Gloria Pelizzo ◽  
Emanuela Mazzon ◽  
...  
Keyword(s):  
Dietary Intervention ◽  
Critical Role ◽  
Overweight And Obesity ◽  
Alcoholic Fatty Liver ◽  
Nutrition And Diet ◽  
Pediatric Overweight ◽  
Healthy Growth ◽  
The Impact

Obesity is a growing health problem in both children and adults, impairing physical and mental state and impacting health care system costs in both developed and developing countries. It is well-known that individuals with excessive weight gain frequently develop obesity-related complications, which are mainly known as Non-Communicable Diseases (NCDs), including cardiovascular disease, type 2 diabetes mellitus, metabolic syndrome, non-alcoholic fatty liver disease, hypertension, hyperlipidemia and many other risk factors proven to be associated with chronic inflammation, causing disability and reduced life expectancy. This review aims to present and discuss complications related to inflammation in pediatric obesity, the critical role of nutrition and diet in obesity-comorbidity prevention and treatment, and the impact of lifestyle. Appropriate early dietary intervention for the management of pediatric overweight and obesity is recommended for overall healthy growth and prevention of comorbidities in adulthood.

The Role of Unabsorbed Slack in Internal and Collaborative Innovation Processes — A Resource-Based Framework

2016 ◽  
Vol 13 (03) ◽  
pp. 1640007 ◽  
Author(s):  
Ulrich Lichtenthaler
Keyword(s):  
Critical Role ◽  
Slack Resources ◽  
Fine Grained ◽  
Collaborative Innovation ◽  
Relationship Of ◽  
The Impact ◽  
The Relationship ◽  
Unabsorbed Slack ◽  
Innovation Processes

Extant research has highlighted the critical role of unabsorbed slack resources in internal innovation processes. In recent years, many firms have continued to open up their innovation processes to actively collaborate with external partners. In light of a limited understanding of the determinants of collaborative innovation, we provide new theoretical arguments about the relationship of unabsorbed slack resources with internal and collaborative innovation processes. Specifically, we draw on resource-based and competence-based logic and develop a conceptual framework for intraorganizational and interorganizational innovation with propositions for the impact of unabsorbed slack resources on internal and external knowledge acquisition and commercialization processes. The arguments underscore the critical role of excess resources in collaborative innovation, and they highlight the need for a fine-grained examination of the impact of unabsorbed slack resources in innovation processes. The arguments are particularly important in light of a renewed interest in essential enablers and barriers to collaborative innovation processes.

scholarly journals What drives the evolution of hunter–gatherer subsistence technology? A reanalysis of the risk hypothesis with data from the Pacific Northwest

2011 ◽  
Vol 366 (1567) ◽  
pp. 1129-1138 ◽  
Author(s):  
Mark Collard ◽  
Briggs Buchanan ◽  
Jesse Morin ◽  
Andre Costopoulos
Keyword(s):  
Pacific Northwest ◽  
Northwest Coast ◽  
Contact Period ◽  
Hunter Gatherers ◽  
The Pacific ◽  
Wide Range ◽  
Relevant Variables ◽  
The Impact ◽  
The Relationship

Recent studies have suggested that the decisions that hunter–gatherers make about the diversity and complexity of their subsistence toolkits are strongly affected by risk of resource failure. However, the risk proxies and samples employed in these studies are potentially problematic. With this in mind, we retested the risk hypothesis with data from hunter–gatherer populations who lived in the northwest coast and plateau regions of the Pacific Northwest during the early contact period. We focused on these populations partly because the northwest coast and plateau differ in ways that can be expected to lead to differences in risk, and partly because of the availability of data for a wide range of risk-relevant variables. Our analyses suggest that the plateau was a more risky environment than the northwest coast. However, the predicted differences in the number and complexity of the populations' subsistence tools were not observed. The discrepancy between our results and those of previous tests of the risk hypothesis is not due to methodological differences. Rather, it seems to reflect an important but hitherto unappreciated feature of the relationship between risk and toolkit structure, namely that the impact of risk is dependent on the scale of the risk differences among populations.

scholarly journals Impact of hypocaloric dietary intervention on ovulation in obese women with PCOS

Reproduction ◽  
2017 ◽  
Vol 153 (1) ◽  
pp. R15-R27 ◽  
Author(s):  
Brittany Y Jarrett ◽  
Marla E Lujan
Keyword(s):  
Weight Loss ◽  
Dietary Intervention ◽  
Polycystic Ovary ◽  
Reproductive Function ◽  
Antral Follicle ◽  
Reproductive Age ◽  
Obese Women ◽  
Dietary Interventions ◽  
Wide Range ◽  
The Impact

Polycystic ovary syndrome (PCOS) is a common cause of ovulatory dysfunction affecting women of reproductive age. Obesity and insulin resistance are thought to potentiate disruptions in antral follicle development that result in chronic anovulation, and as such, have become important therapeutic targets of dietary interventions aimed at weight loss. Caloric restriction has been shown to promote sporadic ovulation in obese women with PCOS, but improvements have occurred across a wide range of patients and little has been garnered about the factors that distinguish responders from non-responders. Further, few studies have evaluated the likelihood for modest weight loss to restore normal ovulatory cyclicity in PCOS. Consensus regarding the impact of dietary intervention on ovulation has been limited by variability in the measures used to characterize and report ovulatory status across studies. In response, this review provides an assessment of the evidence surrounding the effectiveness of hypocaloric dietary intervention to normalize ovulatory function in PCOS. The impact of physiological vs methodological factors on the evaluation of ovulatory status is discussed, and recommendations to strengthen future studies in this area are provided. Ultimately, further research is needed to understand the optimal dietary or lifestyle approaches that promote ovulation and sustained improvements in reproductive function in PCOS.

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