scholarly journals Modulation of placental protein expression of OLR1: implication in pregnancy-related disorders or pathologies

Reproduction ◽  
2008 ◽  
Vol 136 (4) ◽  
pp. 491-502 ◽  
Author(s):  
M Ethier-Chiasson ◽  
J-C Forest ◽  
Y Giguère ◽  
A Masse ◽  
C Marseille-Tremblay ◽  
...  
Keyword(s):  
Protein Expression ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Cholesterol Level ◽  
Plasma Cholesterol ◽  
Total Cholesterol Level ◽  
Low Density Lipoprotein ◽  
Ldl Receptor ◽  
Density Lipoprotein ◽  
Placental Protein

The lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (OLR1) is a newly described receptor for oxidatively modified LDL. The human pregnancy is associated with hyperlipidemia and oxidative stress. It has been reported that modification in maternal lipid profile can induce disturbance during pregnancy. In this study, we have evaluated the expression protein level of OLR1 in human term placenta of women having plasma cholesterol level lower to 7 mM or higher to 8 mM and women of gestational diabetes mellitus (GDM) by western blot analysis. The present study demonstrates that the maternal lipid profile is associated with placental protein expression of OLR1. A significant increase in the protein expression of OLR1 was observed in placenta of women with elevated plasmatic total cholesterol level (>8 mM). In addition, the placental protein expression of OLR1 is increased in mothers having the highest pre-pregnancy body mass index (BMI) and low (<7 mM) plasmatic total cholesterol level at term. Interestingly, the placental protein expression of OLR1 is increased in the presence of GDM pregnancies compared with normal lipids level pregnancies, without the modification of mRNA expression. In conclusion, placental OLR1 protein expression is associated with maternal lipid profile, pre-pregnancy BMI, and pathology of GDM.

scholarly journals Clinical Investigations of the Effect of Citrus unshiu Peel Pellet on Obesity and Lipid Profile

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Seongil Kang ◽  
Sangyeol Song ◽  
Joosang Lee ◽  
Hyekyung Chang ◽  
Sanghun Lee
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Cholesterol Level ◽  
Weight Control ◽  
Large Scale ◽  
Total Cholesterol Level ◽  
Experimental Studies ◽  
Density Lipoprotein ◽  
Citrus Unshiu ◽  
The Impact

Objectives. Several experimental studies have reported antiobesity and lipid-improving effects of Citrus unshiu. However, clinical studies on its effects are lacking. This study was designed to evaluate the impact of Citrus unshiu peel pellet (CUPP) on obesity and lipid profile. Methods. For 118 patients with body mass index (BMI) > 23 who took Citrus unshiu peel pellet (CUPP) for 4 weeks in a Public Health Center, laboratory and biometric readings before and after CUPP administration were analyzed. Results. Mean age of these subjects was 53.8±10.6 years (range: 18-75 years). There were 88 (74.6%) females in the study sample (n = 118). A significant (p < 0.01) decrease in BMI from 27.47±2.24 to 27.27±2.22 was observed in all subjects after CUPP treatment and 65.3% (N = 77) of them lost 1.03±0.83 kg of weight after 4 weeks of treatment. Total cholesterol level was significantly (p < 0.01) decreased from 204.0±37.4 mg/dL to 193.5±36.5 mg/dL. Significant (p < 0.05) decreases in levels of low-density lipoprotein, cholesterol, and triglyceride were also observed. Conclusions. These results suggest that CUPP in practice could help weight control and improve total cholesterol level. Findings of this study provide clinical foundation for future large-scale trials to establish clinical benefits of CUPP.

scholarly journals Familial hypercholesterolemia: etiopathogenesis, diagnosis, treatment and state of the problem in Ukraine

2019 ◽  
Vol 26 (4) ◽  
pp. 23-31
Author(s):  
O. I. Mitchenko ◽  
V. Y. Romanov ◽  
N. M. Chulaevska ◽  
K. O. Timokhova
Keyword(s):  
Total Cholesterol ◽  
Familial Hypercholesterolemia ◽  
Cholesterol Level ◽  
Total Cholesterol Level ◽  
Genetic Disorders ◽  
Low Density Lipoprotein ◽  
Coronary Vessels ◽  
Density Lipoprotein ◽  
Epidemiological Data ◽  
Membrane Receptors

Familial hypercholesterolemia (FH) is one of the most common, inherited autosomal dominant diseases. Most often, FH is caused by dominant mutation of the gene, responsible for the synthesis of low density lipoprotein (LDL) membrane receptors that remove LDL from the blood plasma. As a result, individuals with a mutation of this gene from birth have a significantly increased level of cholesterol LDL in the blood. FH mediates the accelerated development of cardiovascular disease of atherosclerotic genesis, especially coronary heart disease (CHD), so the level of cardiovascular mortality in the population of such patients is extremely high. The article focuses on the fact that the main threat of these lipid disorders is the early and rapid initiation of atherosclerotic lesions of coronary vessels: in patients with heterozygous FH with a total cholesterol level of 8–15 mmol/l, CHD usually manifests up to 55 and 60 years, whereas in homozygous patients with a total cholesterol level of 12–30 mmol/l, CHD manifests at the start of their life and if left untreated, death occurs by the age of 20 years. The major genetic disorders in familial hypercholesterolemia and the frequency of their detection in the population are characterized. There are definitions of clinical screening options for FH: targeted, opportunistic, universal, cascadic. A comprehensive view of the diagnosis of FH according to the Dutch Lipid Clinic Network (DLCN) is provided. The basic principles of non-medication and three-step medication treatment of FH are presented. The article presents a clinical case of the homozygous FH taking into account the peculiarities of the disease course, the results of laboratory and instrumental studies and step-by-step treatment in the department of dyslipidemia of M.D. Strazhesko Institute of Cardiology of NAMS of Ukraine. The epidemiological data of the Ukrainian population survey on the possible prevalence of FH in Ukraine are presented. The preliminary analysis of the Ukrainian registry of patients with FH as a national fragment of the international ScreenProFH Registry and the European Register EAS-FHSC is provided.

scholarly journals Pemberian air rebusan daun salam (Syzygium polyanthum) dapat menurunkan kadar kolesterol pada lansia dengan hiperkolesterolemia

2021 ◽  
Vol 15 (1) ◽  
pp. 39-47
Author(s):  
Widiyono Widiyono ◽  
Atik Aryani ◽  
Vitri Dyah Herawati
Keyword(s):  
Total Cholesterol ◽  
Cholesterol Level ◽  
Total Cholesterol Level ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
P Value ◽  
Low Density ◽  
Herbal Therapy ◽  
Paired Sample ◽  
Cholesterol Levels

The effectiveness of Bay leaf (Syzygium polyanthum) to decrease blood total cholesterol level among elderly with HypercholesterolemiaBackground: Total cholesterol levels will gradually increase with age. In the elderly, uncontrolled cholesterol will be a risk factor for life-threatening diseases such as stroke and cardiovascular disease. Observing the adverse effects of hypercholesterolemia, appropriate intervention needed. The treatment of Hypercholesterolemia by using complementary herbal therapy as bay leaves. Bay leaves also contain quercetin, which is a flavonoid that plays a role in strong antioxidants because it can prevent oxidation of LDL (Low Density Lipoprotein). Flavonoids can also prevent fat deposition on the walls of blood vessels.Purpose : To determine the effect of bay leaf (Syzygium polyanthum)  on reducing the cholesterol levels among elderly with Hypercholesterolemia, Method: A quasi-experimental One Group pretest-posttest design without control. The sampling taken by purposive sampling. The number of samples of this study were 29 participants.The cholesterol levels measured using a GCU (Glucose Cholesterol Urid acid), which was calibrated and had good accuracy. The statistical test used is the Paired sample t-test. As for the making of a concoction of bay leaves at each dose of administration by; as much as 10 bay leaves boiled with 400ml of water until the remaining 200ml. 400 ml per day provide in morning and evening and the therapy takes out for 1 full a month and ends with a blood examination evaluation with GCU.Results : The analysis showing that there was a significant difference in the mean cholesterol levels before and after being given the bay leaf stew with a p value of 0.001, which means that there was an effect of the provision of bay leaf boiled water on reducing cholesterol levels.Conclusion: The bay leaf is a complementary herbal therapy that is cheap and can find everywhere in Indonesia also is a non-invasive treatment. This intervention expected as alternative a non-pharmacological therapeutic method in overcoming hypercholesterolemia in the elderly.Keywords: Bay leaf (Syzygium polyanthum); Total cholesterol level; Elderly; HypercholesterolemiaPendahuluan: Kadar kolestrol total akan meningkat secara bertahap seiring bertambahnya usia. Pada lansia, kolesterol yang tidak terkontrol akan menjadi berbagai faktor risiko penyakit yang mengancam jiwa seperti stroke dan penyakit kardiovaskuler. Mencermati dampak buruk dari hiperkolesterolemia maka diperlukan intervensi yang tepat. Mengatasi hiperkolesterolemia dapat dilakukan dengan pengunaan terapi komplementer herbal berupa pemberian air rebusan daun salam. Daun salam juga mengandung quercetin, yaitu Flavonoid yang berperan dalam antioksidan kuat karena mampu mencegah oksidasi LDL (Low Density Lipoprotein). Flavonoid juga dapat mencegah pengendapan lemak pada dinding pembuluh darah.Tujuan : Mengetahui pengaruh pemberian air rebusan dalam salam terhadap penurunan kadar kolesterol lanisa yang mengalami Hipercholesterolemia.Metode : Penelitian  quasy eksperimental dan menggunakan rancangan One Group pretest-posttest design without Control. Teknik pengambilan sampel dilakukan dengan secara purposive sampling. Jumlah sampel penelitiannya 29 partisipan. Kadar kolesterol pada partisipan diukur dengan menggunakan alat cek kolesterol GCU (Glukosa Colesterol Urid acid) yang sudah dikalibrasi dan memiliki akurasi yang baik. Uji statistic yang digunakan yakni uji Paired sample t-test. Adapun pembuatan ramuan daun salam pada setiap dosis pemberian dengan cara; rebus sebanyak 10 lembar daun salam dengan 400ml air hingga tersisa 200ml.400 ml per hari berikan pagi dan sore dan terapi berlangsung selama 1 bulan penuh dan diakhiri dengan evaluasi pemeriksaan darah dengan GCU.Hasil : Menunjukan bahwa ada perbedaan rerata kadar kolesterol yang bermakna sebelum dan sesudah diberikan rebusan daun salam dengan nilai p value 0,001 yang berarti ada pengaruh pemberian air rebusan daun salam terhadap penurunan kadar kolesterol.Simpulan: Pemberian rebusan air daun salam merupakan terapi komplementer herbal yang murah, mudah, dapat dilakukan dimanapun dan kapanpun dan merupakan tindakan non-invasif. Intervensi ini diharapkan dapat dimanfaatkan sebagai metode terapi non farmakalogi dalam mengatasi hiperkolesterolemia pada lansia.

scholarly journals Diabetic retinopathy with or without clinically significant macular edema: The influencing factors

2016 ◽  
Vol 7 (2) ◽  
pp. 142-147
Author(s):  
Barsha Suwal ◽  
Jeevan Kumar Shrestha ◽  
Sagun Narayan Joshi ◽  
Ananda Kumar Sharma
Keyword(s):  
Diabetic Retinopathy ◽  
Glycemic Control ◽  
Macular Edema ◽  
Total Cholesterol ◽  
Cholesterol Level ◽  
Total Cholesterol Level ◽  
Density Lipoprotein ◽  
Diabetic Patients ◽  
Clinically Significant Macular Edema ◽  
Clinically Significant

Introduction: Diabetic retinopathy is the commonest micro vascular complication in patients with diabetes and remains a leading cause of blindness in people of working age group. Objective: to determine the prevalence of clinically significant macular edema (CSME) and the influence of systemic risk factors Materials and methods: It is a hospital based comparative study conducted in 220 eyes of 110 diabetic patients. DR was graded according to International Clinical Diabetic Retinopathy Severity Scale and CSME was defined according to Early Treatment Diabetic Retinopathy Study (ETDRS) system. The patients were grouped as 1) CSME group (DR and CSME in one or both eyes) and 2) Non- CSME group(CSME in none of the eyes but with any grade of DR).Level of glycosylated hemoglobin (HbA1C), serum total cholesterol, triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL) and urine for albumin were studied in both groups. Results: CSME was present in 36% of 110 patients. Poor glycemic control and high total cholesterol level showed positive association with CSME (p<0.05). LDL and TG levels were higher and HDL lower in CSME group. However, no statistical significance was found. Conclusion: The CSME is significantly associated with poorer glycemic control and elevated total cholesterol level.

scholarly journals Hypercholesterolemia Due to Lipoprotein X: Case Report and Thematic Review

2019 ◽  
Vol 12 ◽  
pp. 117955141987868 ◽  
Author(s):  
Laura Kattah ◽  
Andrés Gómez ◽  
Sebastián Gutiérrez ◽  
Kathalina Puerto ◽  
Eiman D Moreno-Pallares ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Cholesterol Acyltransferase ◽  
Ldl Receptor ◽  
Lipoprotein Metabolism ◽  
Density Lipoprotein ◽  
Definitive Treatment ◽  
Primary Biliary Cholangitis ◽  
Low Density ◽  
Hepatic Diseases

The liver is a key organ in lipid and lipoprotein metabolism, hence hepatic diseases often manifest as lipid disturbances. Cholestatic liver diseases are frequently associated with an important increase in total cholesterol at the expense of lipoprotein X (LpX), an abnormal lipoprotein isolated and characterized in the 1960s to 1970s in patients with obstructive jaundice. Lipoprotein X is rich in phospholipids, albumin, and free cholesterol, has a density similar to low-density lipoprotein (LDL), and a size similar to very low-density lipoprotein (VLDL), which has hampered its detection through routine laboratory tests. Unlike LDL, LpX has no apoB-100, so it is not removed from circulation via the LDL receptor, and it is not clear whether or not it can be atherogenic. Although LpX was initially described in patients with cholestasis, it has also been found in patients with genetic deficiency of lecithin-cholesterol acyltransferase (LCAT), in patients who receive lipid-rich parenteral nutrition and most recently in patients with graft versus host disease of the liver. In the presence of LpX, plasma total cholesterol can rise up to 1000 mg/dL, which may lead to the development of skin xanthomas and hyperviscosity syndrome. Treatment of LpX-dependent hypercholesterolemia with conventional hypolipidemic drugs is frequently ineffective, and definitive treatment relies on correction of the underlying cause of cholestasis. Here, we present the case of a patient with LpX-dependent hypercholesterolemia in the context of primary biliary cholangitis.

scholarly journals Efek ekstrak daun sirsak (Annona muricata Linn) terhadap profil lipid tikus putih jantan (Rattus Norvegicus)

2014 ◽  
Vol 3 (1) ◽  
pp. 7-12 ◽  
Author(s):  
Indrawati Wurdianing ◽  
SA Nugraheni ◽  
Zen Rahfiludin
Keyword(s):  
Treatment Group ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Cholesterol Level ◽  
Ldl Cholesterol ◽  
Total Cholesterol Level ◽  
Wilcoxon Test ◽  
Control Group ◽  
Annona Muricata ◽  
The Mean

Background: Lipid profile effects is a risk factor for Coronary Heart Disease. Soursop leaves (Annona muricata L) isa traditional medicine plant containing metabolic compounds that contribute to the improvement of the lipid profile.Objective: To determine the effects of soursop leaves extract on lipid profile (total cholesterol, LDL cholesterol, HDLcholesterol and triglyceride).Methods: An experimental study using randomized pre-posttest with control group design. Sample consisted of 28 maleWistar rats, were divided into four groups. The control group (K) was only given High Fat High Cholesterol (HFHC)diet and treatment groups (P1, P2, P3) were given a HFHC diet plus Annona muricata L extract with doses of 100, 200and 300 mg/kgBB per day for 28 days respectively. Data were analyzed by Wilcoxon test, Kruskal-Wallis and MannWhitney.Results: The mean total cholesterol level significantly decreased in the treatment group P1 (p = 0.028) from 60.7 mg/dl(47.6-75.3) to 45.5 mg/dl (38.4-62.4). Mean HDL cholesterol level significantly increased in the treatment group P2(p=0.043) from 26.0 mg/dl (19.7-35.3) to 27.9 mg/dl (18.8-38.0). The mean levels of LDL cholesterol and triglyceridedecreased but not significantly.Conclusion: The administration of Annona muricata L extract can decrease total cholesterol and increase HDLcholesterol significantly.

scholarly journals Alterations in Lipids and Adipocyte Hormones in Female-to-Male Transsexuals

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
Prakash Chandra ◽  
Sukhdeep S. Basra ◽  
Tai C. Chen ◽  
Vin Tangpricha
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Statistical Significance ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Testosterone Therapy ◽  
Serum Leptin ◽  
Atherogenic Lipid Profile

Testosterone therapy in men and women results in decreased high-density lipoprotein cholesterol (HDL) and increased low-density lipoprotein cholesterol (LDL). We sought to determine whether testosterone therapy has this same effect on lipid parameters and adipocyte hormones in female-to-male (FTM) transsexuals. Twelve FTM transsexuals provided a fasting lipid profile including serum total cholesterol, HDL, LDL, and triglycerides prior to and after 1 year of testosterone therapy (testosterone enanthate or cypionate 50–125 mg IM every two weeks). Subjects experienced a significant decrease in mean serum HDL (52±11to40±7 mg/dL)(P<.001). The mean LDL(P=.316), triglyceride(P=.910), and total cholesterol(P=.769)levels remained unchanged. In a subset of subjects, we measured serum leptin levels which were reduced by 25% but did not reach statistical significance(P=.181)while resistin levels remained unchanged. We conclude that testosterone therapy in FTM transsexuals can promote an increased atherogenic lipid profile by lowering HDL and possibly reduce serum leptin levels. However, long-term studies are needed to determine whether decreases in HDL result in adverse cardiovascular outcomes.

Paradoxical Hypercholesterolemia in an Otherwise Healthy Adult Man

2019 ◽  
Author(s):  
Peter A Mcpherson
Keyword(s):  
Cholesterol Level ◽  
Total Cholesterol Level ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Red Yeast Rice ◽  
Transfer Protein ◽  
Cholesterol Levels ◽  
Red Yeast ◽  
High High Density Lipoprotein

AbstractHypercholesterolemia is characterized by serum cholesterol levels greater than 5 mmol per L. However, the distribution of cholesterol among lipoprotein classes has a significant bearing on diagnosis: high–low-density lipoprotein (LDL) cholesterol suggests familial hypercholesterolemia, whereas high–high-density lipoprotein (HDL) cholesterol is associated with hyperalphalipoproteinemia. On routine screening, a 23-year-old man presented with a total cholesterol level of 7.6 mmol per L but was subsequently found to have an HDL cholesterol level of 5.6 mmol per L. The clinical picture was confounded by his use of red yeast rice extract, a popular health supplement with hypolipidemic effects. In this case individual, the use of red yeast rice extract caused a hyperlipidemic state, ostensibly through downregulation of cholesteryl ester transfer protein. This case emphasizes the extended role of laboratory medicine in complex cases of hyperlipidemia.

scholarly journals Lipid Profile of Children with Malaria byPlasmodium vivax

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Rosa Maria Dias ◽  
Jose Luiz Fernandes Vieira ◽  
Bianca da Conceição Cabral ◽  
Isameriliam Rosaulem Pereira da Silva ◽  
Laelia Maria Barra Feio Brasil ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Signs And Symptoms ◽  
Low Density ◽  
Lipid Levels ◽  
Colorimetric Measurements ◽  
History Of ◽  
Lipid Abnormalities

Background. Changes in lipid profile are commonly reported in adult patients with malaria. However, a few studies evaluated lipid abnormalities in children continuously exposed toP. vivax.Objective. To evaluate lipid abnormalities in children withP. vivaxinfection and to assess if parasite count or the history of malaria correlates with lipid levels at admission.Methods. A total of 75 children were included in the study, from which 43 were slide confirmed infection byP. vivax. Serial blood samples were collected at admission and, on days 7 and 14, evaluated for the colorimetric measurements of triglycerides, very low-density lipoprotein (VLDL), total cholesterol, high-density lipoprotein (HDL), and low-density lipoprotein (LDL).Results. The levels of total cholesterol, LDL, and HDL were significantly lower in malaria cases. The levels of VLDL and triglycerides were significantly higher in children with malaria. Such changes were transient and were not associated with parasite counting as well as with the history of malaria of patients.Conclusion. There are significant lipid abnormalities in children with low level ofP. vivaxinfection and mild signs and symptoms of the disease, which are not associated with parasitaemia and previous episodes of disease.

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