Metabolic Syndrome and C-Reactive Protein in American Adults: The Impact of Abdominal Obesity

Background. Hypercoagulation is one of the cardiovascular risk factors in patients with metabolic syndrome (MS). It results from various factors including hyperhomocysteinemia, endothelial dysfunction, non-enzymatic glycation of proteins etc.The aim of this study was to assess clinical correlates of thrombodynamics in insulin resistant and non insulin resistant men with metabolic syndrome.Methods. We investigated 79 patients with MS diagnosed in accordance with IDF criteria (2009). The main group consisted of 44 men with MS including insulin resistance. The control group consisted of 35 men with MS not including insulin resistance. In addition to routine clinical tests we performed thrombodynamics assay and measured serum levels of asymmetric dimethylarginine (ADMA) and homocysteine. Mann-Whitney U-test and Spearmen’s correlation coefficient (rs) were used for statistical analysis.Results. There was no significant difference between thrombodynamics parameters, ADMA and homocysteine levels between the two groups. In both groups thrombodynamics parameters had no correlations with body mass index, hemoglobin level, platelet count and serum ADMA level. In patients with insulin resistance clot density correlated positively with serum level of C-reactive protein (rs=0.621, p=0.007); average and initial rates of clot growth correlated positively with homocysteine level (rs=0.539, p=0.017, and rs=0.554, p=0.014, respectively). In patients with insulin resistance clot density and rates of clot growth were not interrelated with the above mentioned parameters.Conclusions. The results of the study suggest that insulin resistant men with MS are characterized by clinical correlates between thrombodynamics parameters, homocysteine and C-reactive protein levels while patients without insulin resistance have other, unestablished determinants of clot density and rates of clot growth.

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The Relationship between Metabolic Syndrome Risk Factors and High Sensitive C-reactive Protein in Abdominal Obesity Elderly Women

Korean Journal of Clinical Laboratory Science ◽

10.15324/kjcls.2017.49.2.121 ◽

2017 ◽

Vol 49 (2) ◽

pp. 121-127 ◽

Cited By ~ 2

Author(s):

Kyung-A Shin

Keyword(s):

Risk Factors ◽

Metabolic Syndrome ◽

Abdominal Obesity ◽

Elderly Women ◽

C Reactive Protein ◽

Reactive Protein ◽

The Relationship

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Impact of Inflammation on Atrial Fibrillation in patients with Metabolic Syndrome

10.21203/rs.3.rs-640552/v1 ◽

2021 ◽

Author(s):

Ylber Jani ◽

Kastriot Haxhirexha ◽

Nehat Baftiu ◽

Bekim Pocesta ◽

Atila Rexhepi ◽

...

Keyword(s):

Atrial Fibrillation ◽

Metabolic Syndrome ◽

Systemic Inflammation ◽

Left Atrial ◽

Cross Sectional Study ◽

C Reactive Protein ◽

Cross Sectional ◽

Structural Remodeling ◽

Reactive Protein ◽

The Impact

Abstract BACKGROUND: Inflammation have been involved in the pathogenesis of both metabolic syndrome(MS) and atrial fibrillation(AF). The magnitude of elevations in plasma C-reactive protein(CRP) a marker of inflammation, is probably related to atrial structural remodeling and impaired atrial function.In patient with MS,limited data exist regarding impact of plasma levels of inflammatory markers,such as C-reactive protein on the: type of AF and atrial structural and functional remodeling. OBJECTIVE: We set to analyze the impact of degree of systemic inflammation (assessed acrording to CRP levels),on the type of AF,atrial functional and structural remodeling in patients with MS.METHODS: We conducted an multicenter observational cross-sectional study. Recruited were 425 consecutive participants,with MS and AF(paroxysmal, persistent and permanent AF),who attended outpatient visits at 7 general cardiology Health Care Clinics, during 1 calendar year,stratified according CRP-levels:(211 participans with level of CRP ≥3mg/l, and 214, with level of CRP <3mg/l). RESULTS: Permanent type of AF, was more common in participans with CRP-levels ≥3mg/l(54.6% vs.20.5%,p= 0.000),whereas parhoxysmal AF, was more common in participans with CRP-levels of <3 mg/l (9.9% vs.52.3%,p=0.000).Patients who had CRP levels above the cut-off of 3 mg/l,had increased dimension of left atrium{(LA),(4.2±0.3 vs. 3.7±0.2,p=0.000)},higher prevalence of enlargement of LA {defined as left atrial volum index(LAVI) ≥29ml/m2(84.1% vs.48.5%,p=0.002)} and inverse relationship of LA function(defined as left atrial emptying fraction(LAEF <45%, (30.8±3.4 vs.41.9±2.6, p=0.00). There was observed significant association of CRP levels above the cut-off of 3 mg/l and: frequence of persistent AF(OR=8.824,95% CI 1.689-46.100), permanent AF(OR=13.955, 95%CI 2.676 -72.780),increased LA dimension (OR=3.817,95% CI 0.989 -1.544), and decreased LA function.{(expressed by: LAVI >29ml/m2OR=4.014, 95% CI 2.620-6.152),LAEF <45%(OR=3.323,95%CI 2.062 -5.351) and LAVI>29 + LAEF-reduced (OR=3.354,95% CI 1.693 - 6.646)}.CONCLUSIONS: In patients with Metabolic Syndrome,degree of systemic inflammation have significant impact on clinical presentation of Atrial Fibrillation,atrial functional and structural remodeling .

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Effects of an intervention in eating habits and physical activity in Japanese-Brazilian women with a high prevalence of metabolic syndrome in Bauru, São Paulo State, Brazil

Cadernos de Saúde Pública ◽

10.1590/s0102-311x2008001400014 ◽

2008 ◽

Vol 24 (suppl 2) ◽

pp. s294-s302 ◽

Cited By ~ 8

Author(s):

Sandra Roberta G. Ferreira ◽

Suely G. A. Gimeno ◽

Amélia T. Hirai ◽

Helena Harima ◽

Luiza Matsumura ◽

...

Keyword(s):

Metabolic Syndrome ◽

Lifestyle Intervention ◽

Cardiometabolic Risk ◽

Eating Habits ◽

Protein Body ◽

C Reactive Protein ◽

Reactive Protein ◽

High Prevalence ◽

The Impact

We evaluated the impact of a lifestyle intervention on the cardiometabolic risk profile of women participating in the Study on Diabetes and Associated Diseases in the Japanese-Brazilian Population in Bauru. This was a non-controlled experimental study including clinical and laboratory values at baseline and after a 1-year intervention period. 401 Japanese-Brazilian women were examined (age 60.8±11.7 years), and 365 classified for metabolic syndrome (prevalence = 50.6%). Subjects with metabolic syndrome were older than those without (63.0±10.0 vs. 56.7±11.6 years, p < 0.01). After intervention, improvements in variables were found, except for C-reactive protein. Body mass index and waist circumference decreased, but adiposity reduction was more pronounced in the abdominal region (87.0±9.7 to 84.5±11.2cm, p < 0.001). Intervention-induced differences in total cholesterol, LDL, and post-challenge glucose were significant; women who lost more than 5% body weight showed a better profile than those who did not. The lifestyle intervention in Japanese-Brazilian women at high cardiometabolic risk improved anthropometric and laboratory parameters, but it is not known whether such benefits will persist and result in long-term reduction in cardiovascular events.

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Clinical correlates of thrombodynamics in men with metabolic syndrome: the impact of insulin resistance

Problems of Endocrinology ◽

10.14341/probl201662525-26 ◽

2016 ◽

Vol 62 (5) ◽

pp. 25-26

Author(s):

Ivan Y. Pchelin ◽

Natalia V. Hudiakova ◽

Alexander N. Shishkin

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Serum Levels ◽

Control Group ◽

C Reactive Protein ◽

Clinical Correlates ◽

Insulin Resistant ◽

Reactive Protein ◽

Significant Difference ◽

The Impact

Background. Hypercoagulation is one of the cardiovascular risk factors in patients with metabolic syndrome (MS). It results from various factors including hyperhomocysteinemia, endothelial dysfunction, non-enzymatic glycation of proteins etc.The aim of this study was to assess clinical correlates of thrombodynamics in insulin resistant and non insulin resistant men with metabolic syndrome.Methods. We investigated 79 patients with MS diagnosed in accordance with IDF criteria (2009). The main group consisted of 44 men with MS including insulin resistance. The control group consisted of 35 men with MS not including insulin resistance. In addition to routine clinical tests we performed thrombodynamics assay and measured serum levels of asymmetric dimethylarginine (ADMA) and homocysteine. Mann-Whitney U-test and Spearmen’s correlation coefficient (rs) were used for statistical analysis.Results. There was no significant difference between thrombodynamics parameters, ADMA and homocysteine levels between the two groups. In both groups thrombodynamics parameters had no correlations with body mass index, hemoglobin level, platelet count and serum ADMA level. In patients with insulin resistance clot density correlated positively with serum level of C-reactive protein (rs=0.621, p=0.007); average and initial rates of clot growth correlated positively with homocysteine level (rs=0.539, p=0.017, and rs=0.554, p=0.014, respectively). In patients with insulin resistance clot density and rates of clot growth were not interrelated with the above mentioned parameters.Conclusions. The results of the study suggest that insulin resistant men with MS are characterized by clinical correlates between thrombodynamics parameters, homocysteine and C-reactive protein levels while patients without insulin resistance have other, unestablished determinants of clot density and rates of clot growth.

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