Photopolymerization-based additive manufacturing for the development of 3D porous scaffolds

2014 ◽  
pp. 149-201 ◽  
Author(s):  
B. Husár ◽  
M. Hatzenbichler ◽  
V. Mironov ◽  
R. Liska ◽  
J. Stampfl ◽  
...  
Keyword(s):  
Additive Manufacturing ◽  
Porous Scaffolds

scholarly journals Bioresorbable Magnesium-Based Alloys as Novel Biomaterials in Oral Bone Regeneration: General Review and Clinical Perspectives

2021 ◽  
Vol 10 (9) ◽  
pp. 1842
Author(s):  
Valentin Herber ◽  
Begüm Okutan ◽  
Georgios Antonoglou ◽  
Nicole G. Sommer ◽  
Michael Payer
Keyword(s):  
Additive Manufacturing ◽  
Bone Regeneration ◽  
Modulus Of Elasticity ◽  
Bone Repair ◽  
Clinical Results ◽  
Porous Scaffolds ◽  
General Review ◽  
Synthetic Materials ◽  
Bone Preservation

Bone preservation and primary regeneration is a daily challenge in the field of dental medicine. In recent years, bioresorbable metals based on magnesium (Mg) have been widely investigated due to their bone-like modulus of elasticity, their high biocompatibility, antimicrobial, and osteoconductive properties. Synthetic Mg-based biomaterials are promising candidates for bone regeneration in comparison with other currently available pure synthetic materials. Different alloys based on Mg were developed to fit clinical requirements. In parallel, advances in additive manufacturing offer the possibility to fabricate experimentally bioresorbable metallic porous scaffolds. This review describes the promising clinical results of resorbable Mg-based biomaterials for bone repair in osteosynthetic application and discusses the perspectives of use in oral bone regeneration.

A Review of Bone Graft Substitutes Made From HA-Polymer Composite Scaffolds and Fabrication Potential With Laser-Based Additive Manufacturing Processes

2015 ◽  
Author(s):  
Hera Wu ◽  
Shuting Lei
Keyword(s):  
Additive Manufacturing ◽  
Bone Graft ◽  
Three Dimensional ◽  
Bone Graft Substitute ◽  
Biological Properties ◽  
Porous Scaffolds ◽  
Composite Scaffolds ◽  
Bone Graft Substitutes ◽  
Manufacturing Technologies ◽  
High Level

Hydroxyapatite, a bioactive ceramic, has been combined with biodegradable polymers to create composite three-dimensional interconnected porous scaffolds for bone graft substitutes. The materials and fabrication methods of these composite scaffolds are reviewed. The resulting mechanical and biological properties of scaffolds produced from the combination of certain materials and fabrication methods are analyzed. Requirements for a bone graft substitute and third generation scaffolds with the addition of osteoinductive and osteogenic features to composite scaffolds including biomolecule delivery and cell seeding are also introduced. Finally, the benefits of using additive manufacturing technologies to enable high level of control over the design of interconnected pore structure are discussed.

scholarly journals Additive Manufacturing of Biopolymers for Tissue Engineering and Regenerative Medicine: An Overview, Potential Applications, Advancements, and Trends

2021 ◽  
Vol 2021 ◽  
pp. 1-20 ◽  
Author(s):  
Dhinakaran Veeman ◽  
M. Swapna Sai ◽  
P. Sureshkumar ◽  
T. Jagadeesha ◽  
L. Natrayan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
3D Printing ◽  
Regenerative Medicine ◽  
Tissue Regeneration ◽  
Three Dimensional ◽  
Porous Scaffolds ◽  
Wide Range ◽  
Potential Applications ◽  
Pharmaceutical Industries

As a technique of producing fabric engineering scaffolds, three-dimensional (3D) printing has tremendous possibilities. 3D printing applications are restricted to a wide range of biomaterials in the field of regenerative medicine and tissue engineering. Due to their biocompatibility, bioactiveness, and biodegradability, biopolymers such as collagen, alginate, silk fibroin, chitosan, alginate, cellulose, and starch are used in a variety of fields, including the food, biomedical, regeneration, agriculture, packaging, and pharmaceutical industries. The benefits of producing 3D-printed scaffolds are many, including the capacity to produce complicated geometries, porosity, and multicell coculture and to take growth factors into account. In particular, the additional production of biopolymers offers new options to produce 3D structures and materials with specialised patterns and properties. In the realm of tissue engineering and regenerative medicine (TERM), important progress has been accomplished; now, several state-of-the-art techniques are used to produce porous scaffolds for organ or tissue regeneration to be suited for tissue technology. Natural biopolymeric materials are often better suited for designing and manufacturing healing equipment than temporary implants and tissue regeneration materials owing to its appropriate properties and biocompatibility. The review focuses on the additive manufacturing of biopolymers with significant changes, advancements, trends, and developments in regenerative medicine and tissue engineering with potential applications.

Laser additive manufacturing of Zn porous scaffolds: Shielding gas flow, surface quality and densification

2019 ◽  
Vol 35 (2) ◽  
pp. 368-376 ◽  
Author(s):  
Peng Wen ◽  
Yu Qin ◽  
Yanzhe Chen ◽  
Maximilian Voshage ◽  
Lucas Jauer ◽  
...  
Keyword(s):  
Additive Manufacturing ◽  
Surface Quality ◽  
Gas Flow ◽  
Porous Scaffolds ◽  
Shielding Gas ◽  
Laser Additive Manufacturing ◽  
Flow Surface

scholarly journals Up-Cycling of LCD Glass by Additive Manufacturing of Porous Translucent Glass Scaffolds

Materials ◽  
2021 ◽  
Vol 14 (17) ◽  
pp. 5083
Author(s):  
Arish Dasan ◽  
Paulina Ożóg ◽  
Jozef Kraxner ◽  
Hamada Elsayed ◽  
Elena Colusso ◽  
...  
Keyword(s):  
Additive Manufacturing ◽  
Viscous Flow ◽  
Porous Ceramic ◽  
Porous Scaffolds ◽  
Organic Additives ◽  
Burn Out ◽  
Ceramic Components ◽  
High Transition ◽  
Manufacturing Technologies ◽  
Highly Porous

Additive manufacturing technologies, compared to conventional shaping methods, offer great opportunities in design versatility, for the manufacturing of highly porous ceramic components. However, the application to glass powders, later subjected to viscous flow sintering, involves significant challenges, especially in shape retention and in the achievement of a substantial degree of translucency in the final products. The present paper disclosed the potential of glass recovered from liquid crystal displays (LCD) for the manufacturing of highly porous scaffolds by direct ink writing and masked stereolithography of fine powders mixed with suitable organic additives, and sintered at 950 °C, for 1–1.5 h, in air. The specific glass, featuring a relatively high transition temperature (Tg~700 °C), allowed for the complete burn-out of organics before viscous flow sintering could take place; in addition, translucency was favored by the successful removal of porosity in the struts and by the resistance of the used glass to crystallization.

scholarly journals Fabrication of 3D-Printed Biodegradable Porous Scaffolds Combining Multi-Material Fused Deposition Modeling and Supercritical CO2 Techniques

Nanomaterials ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 1080 ◽  
Author(s):  
Raúl Sanz-Horta ◽  
Carlos Elvira ◽  
Alberto Gallardo ◽  
Helmut Reinecke ◽  
Juan Rodríguez-Hernández
Keyword(s):  
Additive Manufacturing ◽  
Supercritical Co2 ◽  
Fused Deposition Modeling ◽  
Poly Lactic Acid ◽  
Porous Scaffolds ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
3D Printed ◽  
Internal Pore ◽  
A Current

The fabrication of porous materials for tissue engineering applications in a straightforward manner is still a current challenge. Herein, by combining the advantages of two conventional methodologies with additive manufacturing, well-defined objects with internal and external porosity were produced. First of all, multi-material fused deposition modeling (FDM) allowed us to prepare structures combining poly (ε-caprolactone) (PCL) and poly (lactic acid) (PLA), thus enabling to finely tune the final mechanical properties of the printed part with modulus and strain at break varying from values observed for pure PCL (modulus 200 MPa, strain at break 1700%) and PLA (modulus 1.2 GPa and strain at break 5–7%). More interestingly, supercritical CO2 (SCCO2) as well as the breath figures mechanism (BFs) were additionally employed to produce internal (pore diameters 80–300 µm) and external pores (with sizes ranging between 2 and 12 μm) exclusively in those areas where PCL is present. This strategy will offer unique possibilities to fabricate intricate structures combining the advantages of additive manufacturing (AM) in terms of flexibility and versatility and those provided by the SCCO2 and BFs to finely tune the formation of porous structures.

scholarly journals Geometric Modeling of Cellular Materials for Additive Manufacturing in Biomedical Field: A Review

2018 ◽  
Vol 2018 ◽  
pp. 1-14 ◽  
Author(s):  
Gianpaolo Savio ◽  
Stefano Rosso ◽  
Roberto Meneghello ◽  
Gianmaria Concheri
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
Geometric Modeling ◽  
Solid Freeform Fabrication ◽  
Cellular Materials ◽  
Point Of View ◽  
Porous Scaffolds ◽  
Freeform Fabrication ◽  
Geometric Point ◽  
Manufacturing Technologies

Advances in additive manufacturing technologies facilitate the fabrication of cellular materials that have tailored functional characteristics. The application of solid freeform fabrication techniques is especially exploited in designing scaffolds for tissue engineering. In this review, firstly, a classification of cellular materials from a geometric point of view is proposed; then, the main approaches on geometric modeling of cellular materials are discussed. Finally, an investigation on porous scaffolds fabricated by additive manufacturing technologies is pointed out. Perspectives in geometric modeling of scaffolds for tissue engineering are also proposed.

Additive Manufacturing of 3D Aerogels and Porous Scaffolds: A Review

2021 ◽  
pp. 2103410
Author(s):  
Halil Tetik ◽  
Ying Wang ◽  
Xiao Sun ◽  
Daxian Cao ◽  
Nasrullah Shah ◽  
...  
Keyword(s):  
Additive Manufacturing ◽  
Porous Scaffolds
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