ANTIOXIDANT ENZYME DEPLETION AND NITRIC OXIDE ALTERATIONS: RELATIONSHIP WITH THE RISK FACTORS IN ANGIOGRAPHICALLY DIAGNOSED CORONARY HEART DISEASE

1999 ◽  
pp. 52-56
Author(s):  
Bulent Sözmen ◽  
Fevziye Uysal ◽  
Dervi Gazitepe ◽  
Leyla Aslan ◽  
Eser Yildirim Sözmen
Keyword(s):  
Nitric Oxide ◽  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Antioxidant Enzyme

scholarly journals Dose Response of Almonds on Coronary Heart Disease Risk Factors: Blood Lipids, Oxidized Low-Density Lipoproteins, Lipoprotein(a), Homocysteine, and Pulmonary Nitric Oxide

Circulation ◽  
2002 ◽  
Vol 106 (11) ◽  
pp. 1327-1332 ◽  
Author(s):  
David J.A. Jenkins ◽  
Cyril W.C. Kendall ◽  
Augustine Marchie ◽  
Tina L. Parker ◽  
Philip W. Connelly ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Blood Lipids ◽  
Disease Risk ◽  
Low Density Lipoproteins ◽  
Low Density ◽  
Heart Disease Risk Factors ◽  
Heart Disease Risk

scholarly journals The Risk Factors of Coronary Heart Disease and its Relationship with Endothelial Nitric Oxide Synthase

2021 ◽  
Vol 9 (B) ◽  
pp. 451-456
Author(s):  
Eka Fithra Elfi ◽  
Eva Decroli ◽  
Ellyza Nasrul ◽  
Yanwirasti Yanwirasti ◽  
Eryati Darwin
Keyword(s):  
Nitric Oxide ◽  
Risk Factors ◽  
Coronary Heart Disease ◽  
Risk Factor ◽  
Heart Disease ◽  
Laboratory Finding ◽  
Control Group ◽  
Cardiology Department ◽  
History Of ◽  
Endothelial Nitric Oxide

BACKGROUND: Coronary heart disease (CHD) is the leading cause of death and start with injury to the endothelium of a coronary artery. The common feature of endothelial dysfunction is a decrease of nitric oxide (NO) bioavailability that regulated by endothelial NO synthase (eNOS) activity. AIM: The aim of our study was to study the relationship between risk factors of CHD patients with the level of eNOS. METHODS: Thirty-seven outpatients in cardiology department of the regional public hospital diagnosed as CHD were included in our study. Thirty healthy individuals were included as the control group. Risk factors of CHD were identified according to anamnesis and laboratory finding. eNOS was measured by ELISA methods. RESULTS: Endothelial NOS levels were significantly higher in the CHD when compared to the controls (p < 0.05). The most dominant risk factor for CHD is overweight, and followed by dyslipidemia, smoking, hypertension, history of CHD, and diabetes mellitus. eNOS in CHD patients who had one risk factor was 37.598 ± 0.1541 ng/ml, two risk factors 42.154 ± 22.329 ng/ml, three risk factors 25.329 ± 6.083 ng/ml, four risk factors 22.483 ± 4.022 ng/ml, and five risk factors 15.994 ± 4.774 ng/ml. There were significant differences in the average eNOS levels based on the number of risk factors (p < 0.05), and a tendency that more risk factors in CHD patients, the lower the average level of eNOS. CONCLUSION: In our study, eNOS levels showed highly significant relation with CHD and related to the number of risk factors those the CHD patients had.

Sign in / Sign up

Export Citation Format

Share Document