scholarly journals Efficacy of adding Luvos® Healing Earth supplementation to mebeverine in improving symptoms and quality of life of patients with diarrhea-predominant irritable bowel syndrome: A randomized clinical trial

2018 ◽  
Vol 5 (10) ◽  
pp. 2776-2783
Author(s):  
Marjan Mokhtare ◽  
Mohammadreza Asadipanah ◽  
Mansour Bahardoust ◽  
Arezoo Chaharmahali ◽  
Masoomeh Khalighi Sikaroudi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Demographic Data ◽  
Gastrointestinal Disorder ◽  
Young Males ◽  
Significant Difference ◽  
Group A ◽  
Irritable Bowel ◽  
Group B

Introduction: Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder. Treatment can improve symptoms and social functioning in the patients. This study was designed to assess the effect of adding Luvos supplementation to mebeverine on improving symptoms and quality of life (QOL) in patients with diarrhea-predominant irritable bowel syndrome. Methods: Eighty patients with diarrhea-predominant IB, ages 18-65, were diagnosed by the Rome IV criteria and randomly assigned to the study. Forty patients (group A) received mebeverine (135 mg) twice a day (bid) plus Luvos®Healing Earth (1 sachet, bid). The other 41 patients (group B) received mebeverine (135 mg) bid for 4 weeks. Basic demographic data, Bristol score, symptom severity score, and QOL questionnaire were recorded at the start and completion of treatment. The data were analyzed by SPSS version 22. Results: Seventy one of the patients (35 and 36 patients in groups A and B, respectively) completed the study. The majority of the patients were young males, unmarried and highly educated. Diarrhea and QOL were both significantly improved in group A when compared to group B (P=0.036 and P=0.028, respectively). We did not find a significant difference (improvement) in abdominal pain or overall symptom score between group A (mebeverine + Luvos) compared to group B (mebeverine alone) (P=0.096 and P=0.071, respectively). Mild and tolerable adverse effects were observed in 2.8% (2/71) of the patients. Conclusion: According to our results, Luvos supplementation is safe, effective and well-tolerated in diarrhea-predominant irritable bowel syndrome patients. Further study with a larger sample size is recommended to evaluate the efficacy of this natural clay-like medicine.

scholarly journals A Cross-Sectional Study of the Association between Overnight Call and Irritable Bowel Syndrome in Medical Students

2012 ◽  
Vol 26 (5) ◽  
pp. 281-284 ◽  
Author(s):  
Malcolm Wells ◽  
Lee Roth ◽  
Morgan McWilliam ◽  
Kim Thompson ◽  
Nilesh Chande
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Medical Students ◽  
Demographic Data ◽  
Paper Copy ◽  
Gastrointestinal Symptoms ◽  
Cross Sectional ◽  
Significant Difference ◽  
Irritable Bowel

BACKGROUND: Shift work has been associated with irritable bowel syndrome (IBS), which includes gastrointestinal symptoms such as abdominal pain, constipation and diarrhea. Overnight call shifts also lead to a disruption of the endogenous circadian rhythm.HYPOTHESIS: Medical students who perform intermittent overnight call shifts will demonstrate a higher prevalence of IBS symptoms when compared with medical students who perform no overnight call shifts.METHODS: First- and second-year (preclinical) medical students have no overnight call requirements, whereas third- and fourth-year medical (clerkship) students do have overnight call requirements. All medical students at the Schulich School of Medicine and Dentistry (London, Ontario) were invited to complete an anonymous, web-based survey or an identical paper copy that included demographic data, the Rome III questionnaire and the IBS-Quality of Life measure (IBS-QOL). The prevalence of IBS symptoms and quality of life secondary to those symptoms were determined.RESULTS: Data were available for 247 medical students (110 pre-clinical students, 118 clerkship students and 19 excluded surveys). There was no significant difference in the presence of IBS between preclinical and clerkship students (21 of 110 [19.1%] versus 26 of 118 [22.0%]; P=0.58). The were no significant differences in mean (± SD) IBS-QOL score of those with IBS between preclinical (43.5±8.3) and clerkship students (45.7±13.8) (P=0.53).CONCLUSIONS: Participation in overnight call was not associated with the development of IBS or a lower quality of life secondary to IBS in medical students.

scholarly journals COMPARISON BETWEEN THERAPEUTIC ULTRASOUND AND SCAR MOBILIZATION OVER PERSISTENT POSTNATAL DYSPAREUNIA

2017 ◽  
Vol 10 (9) ◽  
pp. 48
Author(s):  
Mariyam Farzana Sf ◽  
Ponmathi P ◽  
Sivakumar Pvr
Keyword(s):  
Quality Of Life ◽  
Analogue Scale ◽  
Therapeutic Ultrasound ◽  
Ultrasound Therapy ◽  
Age Group ◽  
Functional Index ◽  
Significant Difference ◽  
Group A ◽  
Group B

  Objective: Dyspareunia is known as the painful sexual intercourse. This study was conducted to compare the effectiveness between therapeutic ultrasound and scar mobilization in persistent postnatal dyspareunia.Methods: This is an experimental study. 30 subjects with superficial dyspareunia, age group between 25 and 35 years are taken in this study and 15 subjects in Group A were treated with ultrasound therapy, 15 subjects in Group B were treated with scar mobilization. Female sexual functional index questionnaire (FSFI) and visual analogue scale (VAS) were used as the outcome measure.Results: Results showed a significant difference in FSFI and VAS measurements in both the groups, but clinically Group A showed better improvement in pain and quality of life than Group B.Conclusion: There is no significant difference between ultrasound therapy and scar mobilization over the pain and quality of life in patients with persistent postnatal dyspareunia.

Septoplasty Improves Life Quality Related to Allergy in Patients with Septal Deviation and Allergic Rhinitis

2011 ◽  
Vol 145 (6) ◽  
pp. 910-914 ◽  
Author(s):  
Young Hyo Kim ◽  
Beom Joon Kim ◽  
Kang Hyun Bang ◽  
Yoonseok Hwang ◽  
Tae Young Jang
Keyword(s):  
Quality Of Life ◽  
Allergic Rhinitis ◽  
Clinical Course ◽  
Septal Deviation ◽  
Vas Score ◽  
Medication Score ◽  
Significant Difference ◽  
Group A ◽  
Group B

Objective. Evaluate the effect of septoplasty on the clinical course of allergic rhinitis by comparing (1) symptom change using the Visual Analogue Scale (VAS), (2) change of the medication score, and (3) improvement of the quality of life using a questionnaire. Study Design. Prospective pilot. Setting. Academic tertiary rhinological practice. Subjects and Methods. Sixty-two patients who had undergone septoplasty and turbinoplasty for septal deviation and allergic rhinitis were enrolled in group A. Twenty-six patients who had undergone only turbinoplasty for allergic rhinitis were enrolled in group B. The VAS score, the Average Rescue Medication Score (ARMS), and the Rhinasthma Questionnaire for the quality of life were all obtained from each patient. These parameters were compared before and after the surgery and between the groups. Results. Both groups showed significant improvement of the VAS score ( P < .001). When the change of VAS was compared between groups, there was a significant difference in group A only for nasal obstruction ( P = .047). Comparison of the ARMS between groups showed significant improvement in both groups after the surgery ( P < .01). However, there were no differences between the groups. The Rhinasthma score of group A was significantly lowered after the surgery (56.4 ± 13.2 to 34.1 ± 12.3, P < .001). The Rhinasthma score of group A was significantly lower than that of group B after the surgery ( P = .004). Conclusions. This is the first research about the potential effect of septoplasty on the clinical course of allergic rhinitis. Further studies are needed to elucidate the mechanisms underlying these effects.

scholarly journals Effects of calisthenics on exercise capacity, symptoms and quality of life in COPD

2020 ◽  
Vol 11 (4) ◽  
pp. 6296-6300
Author(s):  
Ganapathy Sankar U ◽  
Monisha R
Keyword(s):  
Quality Of Life ◽  
Exercise Capacity ◽  
Research Centre ◽  
Chronic Obstructive ◽  
College Hospital ◽  
Obstructive Pulmonary Disease ◽  
Significant Difference ◽  
Group A ◽  
Group B

Chronic Obstructive Pulmonary Disease (COPD) is the leading cause of death and disability in India. The study aims to evaluate the effects of CSC- COPD Sitting Calisthenics on exercise capacity, symptoms and quality of life. Twenty-five patients with COPD admitted in SRM Medical college hospital, and research centre (Department of respiratory medicine) were included in the study. After calculating the samples of 25 with excluding one drop outpatient, randomly assigned 12 patients in each group, group A (n = 12), group B (n = 12) and the patients in two groups received five sessions of intervention (CSC and CET) in the hospital stay. The results indicate that there is a significant improvement in exercise capacity in callisthenics group on day 5 (P &lt; 0.001). There was no significant difference found for modified Borg's scale on day 5 in callisthenics group. QOL showed a statistically significant difference in Group A, and the current study concludes that callisthenics is effective in improving exercise capacity and QOL in patients diagnosed with COPD.

scholarly journals A study to compare the effectiveness of core strengthening exercises for phase I and phase II of menstrual cycle in primary dysmenorrhea subjects

Biomedicine ◽  
2021 ◽  
Vol 41 (2) ◽  
pp. 315-317
Author(s):  
S Zainab ◽  
P. Nithyashree ◽  
R Jumanah ◽  
M Kamalakannan ◽  
Suganthirababu Prathap ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Menstrual Cycle ◽  
Phase I ◽  
Phase Ii ◽  
Primary Dysmenorrhea ◽  
Significant Difference ◽  
Strengthening Exercises ◽  
Group A ◽  
Group B

Introduction and Aim:The common gynaecological problem among females found to be Dysmenorrhea, which is a cramping pain in the lower abdomen occurring at menstruation in the absence of any identifiable pelvic disease with a prevalence rate of 60%-90%. The consequences of primary dysmenorrhea affect quality of life (QOL) and limitations in daily activities as well as absenteeism. There is no open literature on which phase of the menstrual cycle is better to exercise in and is more effective. The aim of this study was to compare the effectiveness of core strengthening exercises for Phase I and Phase II of menstrual cycle in primary dysmenorrhea subjects and find out which phase is best to exercise in.   Materials and Methods: A total of 150 subjects were selected using convenient sampling technique based on inclusion and exclusion criteria and randomly allotted into 2 groups (group A and group B)containing 75 subjects each. Group A (Phase I follicular phase)and group B (Phase II luteal phase) performed core strengthening exercise protocol for a duration of 3 menstrual cycles (12 weeks). Working ability, location, intensity, days of pain, dysmenorrhea (WaLIDD) score as well as EQ 5-D 5-L (Euroql5 dimension 5 level quality of life questionnaire) values were obtained before and after the intervention.   Results: An unpaired t-test of the post-test mean values of phase I and II groups show that there is a significant difference between the two groups(p-value<0.0001)   Conclusion: From the results,it can be concluded that there is a significant difference in effectiveness of core strengthening exercises between phase I and phase II and thus exercising in Phase I is most effective.  

scholarly journals Effect of long-term adjuvant temozolomide chemotherapy on primary glioblastoma patient survival

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Bin Huang ◽  
Zuan Yu ◽  
Risheng Liang
Keyword(s):  
Quality Of Life ◽  
Survival Rate ◽  
Concurrent Chemoradiotherapy ◽  
Patient Survival ◽  
Cox Regression Analysis ◽  
Significant Difference ◽  
Group A ◽  
Group B

Abstract Objective Glioblastoma multiforme (GBM) is the most common primary malignant central nervous system (CNS) tumor. The Stupp regimen is the standard treatment, although the optimal number of temozolomide (TMZ) treatment cycles remains controversial. We compared the effects of standard 6 cycles versus > 6 cycles of TMZ chemotherapy post-surgery with concurrent chemoradiotherapy on primary GBM patient survival. Patients and methods We performed a single center retrospective study of GBM patients that underwent total resection, concurrent chemoradiotherapy, and at least 6 cycles of adjuvant TMZ chemotherapy from June 2011 to August 2018. Patients were divided into 2 groups based on adjuvant TMZ treatment plan: Group A(n = 27): standard 6-cycle adjuvant TMZ therapy and Group B(n = 26): > 6 cycles of adjuvant TMZ therapy. Primary endpoints were progression-free survival (PFS) and overall survival (OS). Continuous variables were analyzed by ANOVA, and the Kaplan-Meier method was used to evaluate PFS and OS. Univariate and multivariate COX analyses determined correlation between survival rates and covariates. We used The Mini Mental State Examination (MMSE) and Karnofsky Performance Status (KPS) to assess patients’ neurocognitive function and quality of life. Results After follow-up, median PFS was 15 months in in Group A (95%CI 9.5–20.5) and 20.1 months in Group B (95%CI 15.9–24.4). Group A median OS was 19.4 months (95%CI 15.5–23.2), compared to 25.6 months in Group B (95%CI 20.4–30.8). The 2-year survival rate of Groups A and B was 36% was 66%, respectively (P = 0.02). and 5-year survival was 7% in both. Multivariate COX regression analysis showed association between patient PFS and long-period adjuvant chemotherapy, but not OS. There were no significant difference in disability or quality of life during treatment with Stupp protocol, but differences in MMSE and KPS were in favour of the Groups B after year 1 of the treatment (P < 0.05). Conclusions Long-term adjuvant TMZ chemotherapy was beneficial for PFS and 2-year survival rate in GBM patients, and improved their quality of life contemporarily. But OS was not significantly improved.

scholarly journals High prevalence of irritable bowel syndrome-type symptoms in microscopic colitis: implications for treatment

2018 ◽  
Vol 11 ◽  
pp. 175628481878360 ◽  
Author(s):  
John S. Kane ◽  
Andrew J. Irvine ◽  
Yannick Derwa ◽  
Olorunda Rotimi ◽  
Alexander C. Ford
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Psychological Health ◽  
Short Form ◽  
Demographic Data ◽  
Depression Scale ◽  
Microscopic Colitis ◽  
Irritable Bowel ◽  
The Impact

Background: Patients with microscopic colitis (MC) often present with abdominal pain and diarrhoea, and previous data suggest that there may be overlap between MC and irritable bowel syndrome (IBS). We evaluated the prevalence of IBS-type symptoms in patients with MC, and assess the impact of these symptoms on psychological health and quality of life. Methods: We conducted a cross-sectional survey of individuals with a histological diagnosis of MC, collecting demographic data, Rome III IBS-type symptoms, and mood, somatization, and quality of life data. Results: In total, 151 (31.6%) of 478 individuals with a new diagnosis of MC completed questionnaires, 52 (34.4%) of whom reported IBS-type symptoms. The commonest histological subtype was collagenous colitis (51.7%, n = 78), followed by lymphocytic colitis (39.1%, n = 59). Individuals with IBS-type symptoms had significantly higher levels of anxiety [Hospital Anxiety and Depression Scale (HADS) anxiety score 8.6 versus 5.1, p < 0.001], depression (HADS depression score 6.2 versus 3.6, p = 0.001), and somatoform-type behaviour (Patient Health Questionnaire 15 score 12.7 versus 8.0, p < 0.001) compared with individuals who did not. Those with IBS-type symptoms scored significantly worse across all domains of the 36-item Short Form questionnaire, except for physical functioning. Conclusions: More than one third of individuals with MC reported IBS-type symptoms, although whether this is due to ongoing inflammation is unclear. These individuals had higher levels of anxiety, depression, and somatization, and impaired quality of life. Identifying concomitant IBS in individuals with MC may have important implications for management decisions.

Efficacy and safety of Achillea wilhelmsii C. Koch capsules on symptom severity and quality of life in patients with irritable bowel syndrome: a randomized, placebo-controlled clinical trial

2019 ◽  
Vol 16 (4) ◽  
Author(s):  
Padide Derakhshande ◽  
Seyed Jafar Navabi ◽  
Yalda Shokoohinia ◽  
Hojjat Rouhi-Broujeni ◽  
Fateme Deris ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Trial ◽  
Irritable Bowel Syndrome ◽  
Symptom Severity ◽  
Significant Difference ◽  
Before And After ◽  
The Mean ◽  
Achillea Wilhelmsii ◽  
Irritable Bowel

Abstract Background Irritable bowel syndrome (IBS) is one of the most common digestive diseases. The aim of this clinical trial was to determine the effectiveness of Achillea wilhelmsii C. Koch on the symptom severity and quality of life (QOL) in patients with IBS. Methods The patients were randomized into two groups of 45 each. The QOL and symptom severity of the patients were evaluated at baseline and at completion of the treatments by means of IBS-QOL and IBS severity index. Results The mean severity of clinical symptoms in the Achillea wilhelmsii C. Koch receiving groups before and after the treatment was 282.56 ± 103.57 and 178.06 ± 88.40, and in the placebo group was 265.93 ± 93.56 and 197.74 ± 106.26, respectively. The mean QOL in the Achillea wilhelmsii C. Koch receiving group before and after treatment was 51.49 ± 11.98 and 50.44 ± 13.39 and in the placebo group was 60.71 ± 11.97 and 58.39 ± 11.67, respectively. In both groups, there was a significant difference in the recovery rate in each group (p<0.05). However, the mean difference between the two groups before and after intervention was not significantly different (p>0.05). Also, no patient reported any adverse events during the trial. Although the symptom severity and QOL in both groups were improved compared to those before intervention, there was no significant difference between the two groups. Conclusion It is recommended to conduct future studies with larger sample size and longer treatment periods, and also investigate the efficacy on the IBS subtypes, separately.

scholarly journals Comparison between the Effects of Acupuncture Relative to Other Controls on Irritable Bowel Syndrome: A Meta-Analysis

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Haizhen Zheng ◽  
Rixin Chen ◽  
Xiaofeng Zhao ◽  
Guanhui Li ◽  
Yi Liang ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Western Medicine ◽  
Meta Analysis ◽  
Sham Acupuncture ◽  
Cochrane Library ◽  
Significant Difference ◽  
Irritable Bowel

Background. Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder with recurrent abdominal pain and altered defecation habits. We here attempted to determine the effect of acupuncture on IBS. Methods. Randomized controlled trials (RCTs) published in CNKI, VIP, Wanfang, PubMed, Cochrane Library, EMBASE, Web of science, and ClinicalTrials.gov till July 17, 2019 were searched. Outcomes were total efficacy rates, overall IBS symptom scores, or global quality of life scores. Standardized mean difference (SMD) with 95% confidence intervals (CI) and risk ratio (RR) with 95% CI were calculated for meta-analysis. Results. We included 41 RCTs involving 3440 participants for analysis. 8 RCTs compared acupuncture with sham acupuncture, among which 3 trials confirmed the biological effects of acupuncture, especially in treating abdominal pain, discomfort, and stool frequency. No significant difference was found when acupuncture was compared with sham acupuncture, in terms of effects on IBS symptoms and quality of life (SMD = 0.18, 95% CI −0.26∼0.63, P=0.42; SMD = −0.10, 95% CI −0.31∼0.11, P=0.35), but the pooled efficacy rate data showed a better outcome for true acupuncture (RR = 1.22, 95% CI 1.01∼1.47, P=0.04), which was not supported by sensitivity analysis. Acupuncture was more effective relative to western medicine in alleviating IBS symptoms (RR = 1.17, 95% CI 1.12∼1.23, I2 = 0%, P<0.00001), whose effect might last 3 months. Besides, acupuncture as an adjunct to western medicine, Chinese medications, or tuina was superior over the single latter treatment (RR = 1.68, 95% CI 1.18 to 2.40, P=0.004; 1.19, 1.03 to 1.36, P=0.02; 1.36, 1.08 to 1.72, P=0.009, respectively), with high heterogeneities. Conclusions. Relative to sham controls, acupuncture showed no superiority for treating IBS, while the advantage over western medicine was significant. Acupuncture could be used as an adjunct in clinical settings to improve efficacy. Future high-quality and large-sample-size studies with adequate quantity-effect design need to be conducted.

scholarly journals Aerobic training versus strength exercises on muscle strength and quality of life for children with acute lymphoblastic leukemia

2020 ◽  
Vol 25 (1) ◽  
Author(s):  
Doaa Mohamed ◽  
Faten Abd Alazim ◽  
Elham Salem ◽  
Nesreen Ali ◽  
Dina Elgalaly
Keyword(s):  
Quality Of Life ◽  
Acute Lymphoblastic Leukemia ◽  
Muscle Strength ◽  
Training Program ◽  
Aerobic Training ◽  
Lymphoblastic Leukemia ◽  
Significant Difference ◽  
Group A ◽  
Group B

Abstract Background The treatment for children and adolescents with acute lymphoblastic leukemia (ALL) can lead to multiple adverse effects, including poor physical capacity and muscle weakness. This study aimed to determine which is more effective, aerobic exercises or modified strength training program, on muscle strength and quality of life (QOL) for children with ALL. Results In terms of muscle strength, there was a significant difference (P < 0.05) in selected group of muscles elbow flexors, shoulder abductors, hip flexors, knee extensors, and ankle dorsiflexors at both sides in group B compared with group A, whereas there was no significant difference (P > 0.05) between groups on QOL. Conclusion The outcomes of the study showed that there was a significant difference in the selected group of muscles at both sides in group B compared with group A; thus, the modified strength training program is more effective for muscle strength of children with ALL than aerobic training, but there was no significant difference between them on QOL. Trial registration The clinical trial registered in clinicaltrials.gov with an identifier number NCT03147365

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