The effect of wet-cupping on the severity of migraine headaches: Randomized controlled clinical trial

Mohammad Zarei; Amir Tabatabaee; Mostafa Roshan Ravan

doi:10.15419/bmrat.v6i2.521

The effect of wet-cupping on the severity of migraine headaches: Randomized controlled clinical trial

Biomedical Research and Therapy ◽

10.15419/bmrat.v6i2.521 ◽

2019 ◽

Vol 6 (2) ◽

pp. 2992-2995

Author(s):

Mohammad Zarei ◽

Amir Tabatabaee ◽

Mostafa Roshan Ravan

Keyword(s):

Pain Intensity ◽

Controlled Clinical Trial ◽

Randomized Controlled Clinical Trial ◽

Control Groups ◽

Randomized Controlled ◽

Migraine Headaches ◽

Significant Difference ◽

Before And After ◽

The Mean ◽

And Control

Introduction: This study aimed to determine the effect of wet-cupping on pain intensity in patients with migraines. Method: 132 patients were diagnosed with migraines. Pain intensity was evaluated based on the visual analogue scale. After homogenizing the data, patients were randomly divided into two (wet-cupping and control) groups. Paired t-test, Kruskal-Wallis and Mann-Whitney tests were used to analyze the data. Results: The mean of pain intensity of wetcupping (7.61+/-1.29) and control (7.22+/-1.21) before the intervention showed no significant difference (p=0.401). There was a significant difference between the mean of pain relief intensity of wet-cupping (2.4+/-1.9) and control (0.6+/-0.8) groups before and after interventions (p<0.001). Conclusion: Wet-cupping is an effective tool to treat migraine headaches. Trial registration: Current Controlled Trials IRCT201110314495N2

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Evaluation of Dorema Ammoniacum and Acupuncture's Therapeutic Effects in Patients With Ischemic Stroke: A Randomized Controlled Clinical Trial

10.21203/rs.3.rs-45701/v1 ◽

2020 ◽

Author(s):

Mahsa Mehrpour ◽

Mahdi Yousefi ◽

Monavar AfzalAghaee ◽

Hasan Rakhshandeh ◽

Hoda Azizi ◽

...

Keyword(s):

Clinical Trial ◽

Ischemic Stroke ◽

Acupuncture Group ◽

Controlled Clinical Trial ◽

Randomized Controlled Clinical Trial ◽

Control Groups ◽

Randomized Controlled ◽

Significant Difference ◽

The Mean ◽

And Control

Abstract Aim: Stroke is the third prevalent cause of disability worldwide. This study aimed to evaluate the role of Dorema ammoniacum and acupuncture in the management of patients with stroke.Methods: In this randomized controlled clinical trial, patients with a recent ischemic stroke (within the first month of stroke) were investigated. The patients were divided into three groups. The first group was managed by acupuncture, while the second group received 1 g of Dorema ammoniacum (two 500 mg capsules per day) from ammoniacum gum. The two intervention groups also received standard treatment with routine medical therapy and physiotherapy. The final group was the control, which only received conventional treatment and physiotherapy. The patients were evaluated immediately before the interventions, and one month after the interventions, using the Modified Rankin Scale (mRS) and Modified National Institutes of Health Stroke Scale (mNIHSS).Results: There was a significant difference in the mean score of mNIHSS at the beginning and end of the study in all of the three studied groups (P<0.001). There were significant pre-treatment/post-treatment differences between the groups (P<0.001). After controlling for the effect of mNIHSS score at the beginning of the study and the follow-up visit, a significant difference was observed between the three groups regarding the mean mNIHSS score post-intervention (P<0.001). The results of the post-hoc test indicated a significant difference between the acupuncture and control groups, Dorema ammoniacum and control groups (P<0.001), acupuncture, and Dorema ammoniacum groups (P<0.001); the extent of reduction was greater in the acupuncture group. The mean mNIHSS scores of the acupuncture and Dorema ammoniacum groups were 1.82 and 1.04 lower than the control group's mean score, respectively. There was a significant difference in the mean mRS score at the beginning and end of the study in all three groups (P<0.001). However, the extent of reduction was greater in the acupuncture group.Conclusion: Acupuncture and Dorema ammoniacum may be beneficial if started within the first month of stroke incidence. However, acupuncture can cause a greater reduction in the mNIHSS score of stroke patients. Trial registration: Iranian Registry of Clinical Trials (IRCT20170227032797N2).Registered 5 March 2018 - Retrospectively registered, https://www.irct.ir/trial/25469

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The Effect of Distraction Techniques on Pain and Stress during Labor: A Randomized Controlled Clinical Trial

10.21203/rs.2.13303/v1 ◽

2019 ◽

Author(s):

Paria Amiri ◽

Mojgan Mirghafourvand ◽

Khalil Esmaeilpour ◽

Mahin Kamalifard ◽

Reyhaneh Ivanbagha

Keyword(s):

Intervention Group ◽

Active Phase ◽

Control Group ◽

Controlled Clinical Trial ◽

Fear Of Childbirth ◽

Control Groups ◽

Randomized Controlled ◽

Significant Difference ◽

The Mean ◽

And Control

Abstract Background The aim of this study was to determine the effect of distraction techniques on labor pain and stress (primary outcomes), fear of childbirth, and length of delivery stages (secondary outcomes). Methods A randomized controlled clinical trial was conducted on 68 pregnant women. Participants were allocated into two intervention and control groups by blocked randomization. Participants in the intervention group received distraction techniques in four sessions. Questionnaires of Fear of Childbirth (W-DEQ version A) and PSS once were completed before intervention and again at the 36th week for the W-DEQ and in the active phase for the PSS through interviews. The pain was assessed through VAS during active phase per hour. The length of delivery stages was recorded in the partograph chart. Data were analyzed by independent t-test and ANCOVA. Results The mean of perceived stress during labor in the intervention group was significantly less than that of the control group (AMD: -3.2; 95% CI: -0.8 to -6.0; P= 0.01). The mean (SD) of pain intensity was 6.2 (1.4) and 7.5 (1.4) in the intervention and control groups, respectively, which indicated a significant difference between the two groups (P<0.001). Although the mean score of fear in 36th week in the intervention group (29.1) was less than of the control group (39.1), there was no significant difference between the two groups (P= 0.170). Moreover, there was no statistically significant difference between the two groups in terms of the length of the delivery stages (P>0.05). Conclusion According to the results, distraction techniques can reduce the pain and stress of labor, but further studies are needed to reach a decisive conclusion.

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The Effect of Isometric Exercises on Primary Dysmenorrhea: A Randomized Controlled Clinical Trial

Galen Medical Journal ◽

10.31661/gmj.v4i1.168 ◽

2015 ◽

Vol 4 (1) ◽

pp. 26-32

Author(s):

Sara Azima ◽

Hajar Rajaei Bakhshayesh ◽

Keramatollah Abbasnia ◽

Maasumeh Kaviani ◽

Mehrab Sayadi

Keyword(s):

Clinical Trial ◽

Pain Intensity ◽

Repeated Measures ◽

Intervention Group ◽

Controlled Clinical Trial ◽

Primary Dysmenorrhea ◽

Randomized Controlled Clinical Trial ◽

Randomized Controlled ◽

Significant Difference ◽

Pharmacological Method

Background: Primary dysmenorrhea is the most common cyclic pelvic pain and is also the most common gynecological problem worldwide and affects quality of life. The present study aimed to investigate the effect of isometric exercises on intensity and duration of pain and level of anxiety in the students with primary dysmenorrhea.Materials and Methods: In this randomized controlled clinical trial, 68 students living in dormitories of Shiraz University with primary dysmenorrhea were randomly assigned to isometric exercises and control groups. The intervention group performed isometric exercises since the third day of the menstrual cycle for 8 weeks. Pain intensity was measured using Visual Analog Scale (VAS). In addition, the anxiety level was assessed using Spielberger questionnaire. The data were analyzed using independent t-test, repeated measures ANOVA, and Bonferroni Post hoc test at the end of the second and third months of the study. Besides, P<0.05 was considered as statistically significant.Results: Pain intensity and duration of pain was significantly reduced in exercises group (p<0.001). However, no significant difference was found between the two groups concerning the mean anxiety levels.Conclusion: Primary dysmenorrhea is a common complaint among young women. Isometric exercises seem to be an easy, non-pharmacological method for reducing primary dysmenorrheal.

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The effect of delivery ball and warm shower on the childbirth experience of nulliparous women: A randomized controlled clinical trial

10.21203/rs.3.rs-903099/v1 ◽

2021 ◽

Author(s):

parvaneh sharifipour ◽

Masoomeh Kheirkhah ◽

Mojgan Rajati ◽

hamid haghani

Keyword(s):

Clinical Trial ◽

Pregnant Women ◽

Control Group ◽

Controlled Clinical Trial ◽

Control Groups ◽

Childbirth Experience ◽

Nulliparous Women ◽

Significant Difference ◽

The Mean ◽

And Control

Abstract Background Childbirth is a unique experience that affects women’s life. Therefore, this study was performed to determine the effect of delivery ball and warm shower on the childbirth experience of primiparous women. Methods This study is a clinical trial that was carried out on primiparous pregnant women referred to Motazedi Hospital in Kermanshah, Iran. Sampling was done by continuous method and pregnant women were divided into three groups of delivery ball-warm shower (n = 33), delivery ball (n = 33) and control (n = 33). Exercise with ball at the dilation of 4 cm was similar in the two groups of delivery ball-warm shower and delivery ball, but the first group also used warm shower at the dilatation of 7 cm. The control group only received the routine delivery care. Demographic information form consisting of pregnancy history and information about the mother and infant were completed and the childbirth experience questionnaire (CEQ) were completed by the women two hours after the childbirth. Results There was a statistically significant difference in the mean score of childbirth experience after the intervention between the two groups of delivery ball-warm shower and control (P = 0.001), and also between the delivery ball and control groups (P = 0.001). There was a statistically significant difference in the mean scores of professional support between the two groups of delivery ball-warm shower and control (P = 0.02) and also between the delivery ball and control groups (p = 0.02). There was a statistically significant difference in the mean scores of participation between the two groups of delivery ball-warm shower and control (P = 0.003) and also between the delivery ball and control groups (P = 0.01). There was also a statistically significant difference in the mean scores of sense of security between the two groups of delivery ball-warm shower and control (P = 0.01). Conclusion Delivery ball and warm shower were effective interventions to create a positive childbirth experience. This method was more effective than using delivery ball alone in childbirth experience. To achieve a positive experience of childbirth in mothers, the use of both intervention (delivery ball and warm shower) is recommended.

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Effect of an aged wearing suit on nursing student’s knowledge and attitude

BMC Nursing ◽

10.1186/s12912-021-00668-2 ◽

2021 ◽

Vol 20 (1) ◽

Author(s):

Zahra Mandegari Bamakan ◽

Khadijeh Nasiriani ◽

Farzan Madadizadeh ◽

Fatemeh Keshmiri

Keyword(s):

Nursing Students ◽

The Elderly ◽

Control Group ◽

Control Groups ◽

Significant Difference ◽

Before And After ◽

The Mean ◽

Knowledge And Attitude ◽

And Control ◽

Experimental Group

Abstract Background The knowledge and attitude of health care providers are important and influential factors in providing care services to the elderly and need to be considered during the training course. Simulation in geriatric nursing education can be an opportunity for learners to experience the restrictions of the elderly. The present study was conducted to determine the effect of training through simulation on the attitude and knowledge of nursing students in elderly care. Methods This study was quasi-experimental with two experimental and control groups of pre and post-test, which was conducted on 70 nursing students of the 5th semester (two groups of 35 people). For the experimental group, the elderly simulation suit was worn for two hours, which was designed by the researcher and created sensory, physical, and motor restrictions similar to the elderly for students. Before and after the study, Kogan’s attitudes toward older people scale and Palmore’s “facts on aging quiz” were completed by students. The data were analyzed using an independent t-test and paired t-test using SPSS version 16 software. Results The mean scores of students’ knowledge in the experimental and control groups had no significant difference at the beginning of the study (p < 0.05). But the mean scores of knowledge in the experimental group before and after the intervention was (9.2 ± 2.6) and (15.3 ± 3.5), respectively, and in the control group before and after the intervention was (10.4 ± 2.9) and (11.3 ± 2.6), respectively, which had a statistically significant difference (p = 0.0001). The mean scores of students’ attitudes in the experimental and control groups had no significant difference at the beginning of the study (p < 0.05). The mean scores of attitude in the experimental group before and after the intervention was (114.69 ± 8.4) and (157.31 ± 10.7), respectively and in the control group before and after the intervention was (113.34 ± 13.6) and (108.5 ± 16.6), respectively, which was significantly different (p = 0.0001). Conclusions Based on the findings, the experience of aging restrictions through simulation has improved the knowledge and attitude of nursing students towards the elderly. Nursing education requires the growth of attitudinal skills, individuals’ beliefs, and creating empathy among them, so creating simulation opportunities can assist nursing students in the educational processes.

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Comparison of Complications and Safety of Hemorrhoidectomy with Ligasureand Hemorrhoidectomy with Ferguson: A Randomized Controlled Clinical Trial Study

Journal of Surgery and Trauma ◽

10.32592/jsurgery.2021.9.2.102 ◽

2021 ◽

pp. 50-56

Keyword(s):

Clinical Trial ◽

Surgical Techniques ◽

Controlled Clinical Trial ◽

Randomized Controlled Clinical Trial ◽

Significance Level ◽

Exact Test ◽

Randomized Controlled ◽

Surgical Methods ◽

The Mean ◽

And Control

Introduction: Hemorrhoid is one of the most common anorectal diseases which affects 5% of the general population. Complications and pain are inevitable after all surgeries with different intensities and degrees.Management and control of these complications is one of the most important aspects of postoperative care. There are surgical techniques and interventions for the treatment and control of pain after hemorrhoid. According to the contradictory results of the studies on surgical methods, the present study aimed to compare the effectiveness, complications, and safety of hemorrhoidectomy with Ligasureand Ferguson hemorrhoidectomy. Methods: The study sample in this randomized controlled clinical trial studyincluded54 patientswhowere randomly divided into two groupsofLigasureandFerguson surgery. Prior to the surgery, patients were educated abouttheVisual Analogue Scale(VAS).Patients underwent general anesthesia and the same surgeon performed the surgery in both groups. Immediately after the surgery (oncethe patient regainedconsciousness and understoodthe environment), 6, 12, and 24 hours after the surgery, patients’ pain and complications were assessed.The collected data were analyzed using SPSS software (version 18)through independent t-test, Mann-Whitney, Friedman, Chi-square and Fisher’s exact test at a significance level of α=0.05. Results: The mean bleeding during the surgery was significantly lower in the Ligasuregroupthan the Ferguson group. The mean pain at 0, 6, 12, and 24 hafterthe surgery was not significantly different between the two groups.Postoperative complications were significantly higher in the Ligasuregroup than the Ferguson group. Conclusion: Ligasurehemorrhoidectomy is not superior to the Ferguson method in terms of analgesia up to 24 h after the surgery; however, this method of surgeryis preferable to the Ferguson method in terms of bleeding during the surgery.

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The effect of prenatal counseling on breastfeeding self-efficacy and frequency of breastfeeding problems in mothers with previous unsuccessful breastfeeding: A randomized controlled clinical trial

10.21203/rs.2.14118/v3 ◽

2020 ◽

Author(s):

fahimeh sehhatie shafaei ◽

mojgan mirghafourvand ◽

shiva havizari

Keyword(s):

Self Efficacy ◽

Intervention Group ◽

Control Group ◽

Controlled Clinical Trial ◽

Randomized Controlled Clinical Trial ◽

Prenatal Counseling ◽

Control Groups ◽

Randomized Controlled ◽

Breastfeeding Problems ◽

And Control

Abstract Background: Breastfeeding is one of the most important interfering factors in infants’ health. Monitoring mothers’ performance and providing them with the feedback helps to increase their self-efficacy, interest in learning, and level of performance. The present research evaluates the effect of prenatal counseling on the breastfeeding self-efficacy and frequency of breastfeeding problems in mothers with previous unsuccessful breastfeeding.Methods: This randomized controlled clinical trial was conducted on 108 pregnant women with unsuccessful breastfeeding in Tabriz health centers during 2017-2018. The participants were randomly assigned to intervention and control groups. The intervention group had four prenatal counseling sessions and the controls only received routine care. Then, the mothers who gave birth to their children received a counseling session up to 4 months after the delivery. The Breastfeeding Self-Efficacy (BSES) questionnaire and the frequency of breast feeding problems checklist on the 15th day, and 2nd and 4th month were completed both by the intervention and control groups.Results: The mean (SD) of breastfeeding self-efficacy was 119.3 (10.5), 128.3 (8.3) and 133.8 (10.3) in the intervention group and 105.3 (16.1), 105.7 (19.7) and 109.4 (24.7) in the control group on the 15th day, 2nd and 4th month after the delivery, respectively. There was a significant difference in terms of breastfeeding self-efficacy between intervention and control group on the 15th day (p<0.001), and 2nd (p<0.001) and 4th (p<0.001) month after the delivery. The frequency of breastfeeding problems on the 15th (p=0.008), 2nd (p<0.001) and 4th (p<0.001) after the delivery was significantly different in most cases of the intervention group when compared to the controls.Conclusion: The results indicated that prenatal counseling can increase mothers’ breastfeeding self-efficacy and solves most breastfeeding problems during postpartum period.Trial registration: IRCT20100109003027N19

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The effect of distraction techniques on pain and stress during labor: a randomized controlled clinical trial

BMC Pregnancy and Childbirth ◽

10.1186/s12884-019-2683-y ◽

2019 ◽

Vol 19 (1) ◽

Author(s):

Paria Amiri ◽

Mojgan Mirghafourvand ◽

Khalil Esmaeilpour ◽

Mahin Kamalifard ◽

Reyhaneh Ivanbagha

Keyword(s):

Intervention Group ◽

Active Phase ◽

Labor Pain ◽

Control Group ◽

Controlled Clinical Trial ◽

Fear Of Childbirth ◽

Control Groups ◽

Significant Difference ◽

The Mean ◽

And Control

Abstract Background Pain control and the stress associated with labor and delivery are among the most important issues of health care system. Use of distraction techniques during childbirth is reported to reduce pain and stress of labor. However, there is a limited publication that looked on the effect of distraction techniques on labor pain and stress. Thus, the aim of this study was to determine the effect of distraction techniques on labor pain and stress (primary outcomes), fear of childbirth, length of delivery stages, first minute Apgar score and oxytocin consumption (secondary outcomes). Methods A randomized controlled clinical trial was conducted on 68 pregnant women. Participants were allocated into two groups (intervention and control groups) by blocked randomization. Participants in the intervention group received distraction techniques in four sessions. Questionnaires of Fear of Childbirth (W-DEQ version A) and PSS once were completed before intervention and again at the 36th week for the W-DEQ and in the active phase for the PSS through interviews. The pain was assessed through VAS during active phase per hour. The length of delivery stages was recorded in the partograph chart. Data were analyzed by independent t-test and ANCOVA. Results The mean of perceived stress during labor in the intervention group was significantly less than that of the control group (AMD: -3.2; 95% CI: − 0.8 to − 6.0; P = 0.01). The mean (SD) of pain intensity during labor was less than in the intervention and control groups compare to the control group (6.2 vs 7.5; P < 0.001). There was no significant difference between the two groups in terms of fear of childbirth score (AMD: 5.3; 95% CI: 13.0 to − 6.0; P = − 2.3). Moreover, there was no statistically significant difference between the two groups in terms of the active phase of labor (P = 0.504), second stage of delivery (P = 0.928), total length of delivery (P = 0.520), Apgar score (P = 1.000) and frequency of oxytocin consumption (P = 0.622). Conclusion According to the results, distraction techniques can reduce the pain and stress of labor, but further studies by using the distraction techniques are needed to reach a decisive conclusion. Trial registration IRCT2017042910324N39; Name of registry: Iranian Registry of Clinical Trials; Registered 11 September 2017. URL of registry: https://fa.irct.ir/user/trial/10814/view. Date of enrolment of the first participant to the trial: September 2017.

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The Effect of Distraction Techniques on Pain and Stress during Labor: A Randomized Controlled Clinical Trial

10.21203/rs.2.13303/v2 ◽

2019 ◽

Author(s):

Paria Amiri ◽

Mojgan Mirghafourvand ◽

Khalil Esmaeilpour ◽

Mahin Kamalifard ◽

Reyhaneh Ivanbagha

Keyword(s):

Intervention Group ◽

Active Phase ◽

Labor Pain ◽

Control Group ◽

Controlled Clinical Trial ◽

Fear Of Childbirth ◽

Control Groups ◽

Significant Difference ◽

The Mean ◽

And Control

Abstract Background: Pain control and the stress associated with labor and delivery are among the most important issues of health care system. Use of distraction techniques during childbirth is reported to reduce pain and stress of labor. However, there is a limited publication that looked on the effect of distraction techniques on labor pain and stress. Thus, the aim of this study was to determine the effect of distraction techniques on labor pain and stress (primary outcomes), fear of childbirth, length of delivery stages, first minute Apgar score and oxytocin consumption (secondary outcomes). Methods: A randomized controlled clinical trial was conducted on 68 pregnant women. Participants were allocated into two groups (intervention and control groups) by blocked randomization. Participants in the intervention group received distraction techniques in four sessions. Questionnaires of Fear of Childbirth (W-DEQ version A) and PSS once were completed before intervention and again at the 36th week for the W-DEQ and in the active phase for the PSS through interviews. The pain was assessed through VAS during active phase per hour. The length of delivery stages was recorded in the partograph chart. Data were analyzed by independent t-test and ANCOVA . Results: The mean of perceived stress during labor in the intervention group was significantly less than that of the control group (AMD: -3.2; 95% CI: -0.8 to -6.0; P= 0.01). The mean (SD) of pain intensity during labor was less than in the intervention and control groups compare to the control group (6.2 vs 7.5; P<0.001). There was no significant difference between the two groups in terms of fear of childbirth score (AMD: 5.3; 95% CI: 13.0 to -6.0; P= -2.3). Moreover, there was no statistically significant difference between the two groups in terms of the active phase of labor (P= 0.504), second stage of delivery (P= 0.928), total length of delivery (P= 0.520), Apgar score (P= 1.000) and frequency of oxytocin consumption (P= 0.622). Conclusion: According to the results, distraction techniques can reduce the pain and stress of labor, but further studies by using the distraction techniques are needed to reach a decisive conclusion .

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Increase of PlGF (Placental Growth Factor) Level After Administration of Dydrogesterone in Pregnancy

KnE Medicine ◽

10.18502/kme.v1i1.530 ◽

2016 ◽

Vol 1 (1) ◽

Cited By ~ 1

Author(s):

Dewi Karlina Rusly

Keyword(s):

Folic Acid ◽

Controlled Clinical Trial ◽

Randomized Controlled ◽

Significant Difference ◽

Before And After ◽

Group A ◽

Study Population ◽

The Mean ◽

Group B ◽

In Pregnancy

Aim: To observe the effect of Dydrogesterone administration in pregnancy on PlGF levelMethods: This is a randomized controlled clinical trial. Study population has been divided into two groups. Group A consists of 20 women who receive only Folic acid 5 mg a day for 4 weeks time. Group B consists of 20 women who receive Dydrogesterone 2x10 mg a day and Folic acid 5 mg a day for 4 weeks. PlGF has been measured twice. First measurement was done before drug administration, while the second measurement has been done during 18th weeks of pregnancy. The changes on PlGF level before and after treatment from each group has been analyzed using SPSS 17.Results: 40 pregnant women have been recruited for this study. There are no differences based on the patient’s age, number of pregnancy and parity, gestational age and body weight between each group. The mean levels of PlGF in both groups before intervention shows no significant difference (p = 0091 or p> 0.05), 40.80 pg/mL vs. 25.95 pg / mL. The mean levels of PlGF in group A after 4 weeks administration of Folic acid is 89.60 pg / mL. It shows the escalation of 48.8 pg / mL. The elevation of PlGF level in group A shows significant difference (p = 0.000 or p <0.05) after 4 weeks Folic acid treatment.The mean levels of PlGF in group B after 4 weeks administration of Dydrogesterone and Folic acid is 212.15 pg / mL. It shows the escalation of 186.20 pg / mL. The elevation of PlGF level in group B shows significant difference (p = 0.000 or p <0.05) after 4 weeks Dydrogesterone and Folic acid treatment.Conclusion: Dydrogesterone treatment can increase the level of PlGF.

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