Transcutaneous Bilirubinometry and Diagnostic Tests: "The Right Job for the Tool"

PEDIATRICS ◽  
2002 ◽  
Vol 110 (2) ◽  
pp. 407-408 ◽  
Author(s):  
R. E. Schumacher
Author(s):  
Bernardo Lopes ◽  
Marcella Q Salomão ◽  
Isaac C Ramos ◽  
Fernando Faria-Correia

ABSTRACT To describe a case of very asymmetric ectasia successfully treated by femtosecond laser-assisted intracorneal ring segment implantation, in which the diagnosis of unilateral ectasia in the right eye was based on the clinical findings including history, follow-up, and advanced diagnostic data. The patient's history was positive for ocular allergy with moderate- to-intense eye rubbing only in the right eye. The uncorrected distance visual acuity was 20/63 in the right eye and 20/32 in the left eye. The corrected distance visual acuity (CDVA) was 20/40 in the right eye (-1.75-4.00 × 35°) and 20/16 in the left eye (-0.50-0.25 × 115°). After femtosecond laser-assisted intracorneal ring segment implantation, the right eye improved CDVA to 20/20-1. Concerning ectasia/keratoconus diagnosis, the left eye remained stable over 1 year of follow-up with unremarkable topometric, tomographic, and biomechanical findings. Epithelial thickness mapping by spectral domain optical coherence tomography and very-high-frequency digital ultrasound demonstrated epithelial thickness within normal limits in the left eye. Advanced diagnostic methods along with clinical data enable the distinction from unilateral ectasia cases and subclinical (fruste) keratoconus. Literature review is also performed along with case presentation and discussion. How to cite this article Ramos IC, Reinstein DZ, Archer TJ, Gobbe M, Salomão MQ, Lopes B, Luz A, Faria-Correia F, Gatinel D, Belin MW, Ambrósio R Jr. Unilateral Ectasia characterized by Advanced Diagnostic Tests. Int J Kerat Ect Cor Dis 2016;5(1):40-51.


Sexual Health ◽  
2015 ◽  
Vol 12 (4) ◽  
pp. 336 ◽  
Author(s):  
Nils Reinton ◽  
Stig Ove Hjelmevoll ◽  
Håkon Håheim ◽  
Kjersti Garstad ◽  
Lisa Therese Mørch-Reiersen ◽  
...  

Background In 2014, and for the first time in Norway, a pharmacy chain started selling home sampling kits for Chlamydia trachomatis (C. trachomatis) detection. Direct-to-consumer diagnostic kits for C. trachomatis have been available in Norway from an Internet company since 2005. There has been little assessment of persons who purchase direct-to-consumer diagnostic tests for sexually transmissible infections (STIs) detection and if low-risk populations are being unnecessarily encouraged to buy these tests. Methods: The prevalence of C. trachomatis in customers who purchased home sampling kits from the pharmacy chain and from the commercial Internet Co. were compared to that of patients attending STI clinics and other free primary healthcare services. Prevalences of other STIs in pharmacy and Internet customers were also determined. Results: The prevalence of C. trachomatis among pharmacy customers was 11%, almost identical to the prevalence among Internet customers (12%). In comparison, the prevalence among patients attending STI clinics in Oslo was 7.2%, which is similar to the prevalence among patients who have been tested through primary healthcare services. The prevalence of Mycoplasma genitalium was two-fold less than that of C. trachomatis in the STI and primary physician population, and significantly less in the Internet and the pharmacy population. Neisseria gonorrhoeae was not detected in urine samples from pharmacy customers or from Internet customers. Conclusions: Both pharmacy and Internet C. trachomatis home-sampling kits seem to be purchased by the right risk population. Marketing of direct-to-consumer N. gonorrhoeae tests and possibly M. genitalium tests cannot be justified in Norway. Direct-to-consumer diagnostic tests should be actively utilised as part of national programs in preventing the spread of C. trachomatis.


2020 ◽  
Vol 2 (2) ◽  
pp. V2
Author(s):  
Ming-Ying Lan ◽  
Wei-Hsin Wang

This is a 37-year-old woman who presented with weight gain, a moon-shaped face, and muscle weakness for 4 months. Cushing’s disease was confirmed after a series of diagnostic tests. MRI demonstrated a pituitary macroadenoma with right cavernous sinus invasion and encasement of the right ICA. An endoscopic endonasal approach was performed, and gross-total resection could be achieved without injury of the cranial nerves. The Cushing’s syndrome improved gradually after the surgery. Histopathology revealed a corticotroph adenoma. In this surgical video, we demonstrate the strategies of tumor resection according to a surgical anatomy-based classification of the cavernous sinus from an endonasal perspective.The video can be found here: https://youtu.be/aNXFRdGfjpI.


Author(s):  
Rachel Archer ◽  
Simon Bates

Being able to discover students‟ conceptions and more importantly alternate- and misconceptions about a topic is vital in order to be able to assess and thus be able to improve student learning. It is well known that this can be achieved via the use of well-designed diagnostic tests, a widely used example of which is the Force Concept Inventory. Creating the right questions in order to form a reliable diagnostic test can be a lengthy and complicated process. This article reports work on a Development Project funded in 2008 to develop such a test for introductory Quantum Mechanics courses in both physics and chemistry. We present details of our methodology, which involves augmenting a „standard‟ multiple-choice question set with free-response boxes to determine the reasons for a student choosing a particular answer, and a self-assessment of their level of confidence in their choice. The responses from piloting this initial test in different institutions are used to inform the subsequent refinement of the test, as well as assessing the reliability and validity of the questions. We highlight examples of misconceptions that have been found during the development of the diagnostic tests.


2020 ◽  
Vol 11 (1) ◽  
pp. 90-95
Author(s):  
Goran Popović ◽  
Ranka Mirković ◽  
Dejan Bokonjić ◽  
Biljana Milinković ◽  
Tatjana Gavrilović-Elez

Introduction. Deja vu (franc. Déjà vu) is a phenomenon experienced by two thirds of all people. However, this phenomenon can follow aura during the temporal lobe epilepsy. It is believed that it originates from hippocampus, which plays a major role in generating epileptic discharges. Some authors emphasize that in these patients déjà vu phenomenon is not an aura but rather it sometimes refers to the attack itself. Method. In this case report, an eightyear-old girl suffering from repeated crisis of consciousness is described. Case report. The aim of the study was to present the case of an eightyearold girl who underwent three crisis of consciousness, headache behind the forehead as well as the repeated déjà vu phenomenon. The girl was hospitalized, after which medical history was taken and physical examination, as well as other diagnostic tests, were performed. EEG recording revealed an increased electrocortical epileptic activity above the right frontotemporal region. An antiepileptic therapy (Karbapin) leading to attack control was introduced. Conclusion. It is necessary to give temporal lobe epilepsy in children with déjà vu phenomenon serious consideration.


2021 ◽  
Vol 12 ◽  
Author(s):  
Sarah Hösli ◽  
Dominik Straumann

Ocular vestibular evoked myogenic potentials (oVEMPs), subjective visual vertical (SVV), and fundus photographically measured binocular cyclorotation (BCR) are diagnostic tests to assess utricular function in patients with vertigo or dizziness. In 138 patients with chronic vertigo or dizziness, we asked whether the asymmetry ratio of oVEMP (normal, right side pathological, left side pathological) could predict the SVV deviation (normal, rightward deviation, leftward deviation) or BCR (normal, cyclorotation to the right, cyclorotation to the left). There was no correlation between oVEMP and SVV and between oVEMP and BCR, while SVV and BCR correlated highly. Although both oVEMP and SVV measure aspects of utricular function, our findings demonstrate that oVEMP and SVV are not redundant and may reflect different utricular pathologies. The role of fundus photographic BCR may be relegated to only confirm unclear SVV results in vestibular diagnostic workup.


Author(s):  
Moritz Lambers ◽  
Oliver Bruder ◽  
Heinrich Wieneke ◽  
Kai Nassenstein

Abstract Background The incidence of recognized cardiopulmonary cement embolism in the context of percutaneous vertebroplasty varies between 0-23%. In most cases, only small fragments embolize in the pulmonary arteries or the right heart cavities. The latter can cause potential harm by right ventricular perforation. Case summary A 57-year-old patient was admitted to our department of cardiology due to exertional dyspnoea and chest pain. In the course of further diagnostic tests a huge cement embolus was accidentally discovered in the right ventricle. The unusual size and length and the threat of ventricular perforation make this case so unique. Discussion Large cement embolisms in kyphoplasty settings are possible and associated with the risk of fulminant complications.


2020 ◽  
Vol 1 (2) ◽  
pp. 74-91
Author(s):  
Supriyanto

This study aims to describe the location, type, and factors causing students to make mistakes in solving the story of the comparison. And to arrange alternative learning so that errors do not happen again. The determination of research subjects based on the results of the analysis of student work outcomes on the question of diagnostic tests provided. With diagnostic tests can be known location and type of student error, while to determine the factors causing the error obtained from an interviews with the subject of research. From the research, it is known that the research subjects made mistake in every step of problem-solving that is: understanding the problem, devising a plan, carrying out the plan, and looking back and make a conclusion. The types of mistakes made by the students are as follows: 1) the error of facts: incomplete in writing what is known about, 2) misconceptions: not making the right plan, wrong in determining the percentage of a value, wrong in comparing, Determining the values ​​compared, wrong in determining the type of comparison, 3) principle error: incorrect in using formulas to determine percentages, and incorrect in determining unknown values ​​in comparison, and 4) operation errors: errors in simplifying fractions. Factors that cause errors are a lack of thorough students in reading and understanding problems, difficulties in using and analyzing information on the problem, the existence of a misconception about the comparison. Based on the characteristics of factors causing mistakes made by students, then Problem Based Learning is one effective way to embed the concept of comparison and familiarize students in solving math problems.


2021 ◽  
Vol 135 (20) ◽  
pp. 2423-2428
Author(s):  
Stephen T. Holgate

Abstract The SARS-CoV-2 pandemic has shown the importance of medical research in responding to the urgent prevention and health needs to combat the devastating disease, COVID-19, that this β-coronavirus unleashed. Equally, it has demonstrated the importance of interdisciplinary working to translate scientific discovery into public and patient benefit. As we come to adjust to live with this new virus, it is important to look back and see what lessons we have learnt in the way scientific medical discoveries can be more effectively and rapidly moved into public benefit. Clinical Science has had a long and distinguished history with this Journal bearing the same name and being an important contributor to the rapidly increasing use of human pathobiological data to gain mechanistic understanding of disease mechanisms leading to new diagnostic tests and treatments. The recognition that many complex diseases engage multiple causal pathways that may vary from patient to patient, and at different times across the lifecourse, has led to the emergence of stratified or precision medicine in which the right treatment is given to the right patient at the right time and, in doing so, minimise ‘non-responders’ and off-target side effects. Applications of omics technologies, the digitalisation of biology and the applications of machine learning and artificial intelligence (AI) are accelerating disease insights at pace with translation of discoveries into new diagnostic tests and treatments. The future of clinical science, as it morphs into translational medicine, is now creating unique possibilities where even the most intractable diseases are now open to being conquered.


Author(s):  
J. Anthony VanDuzer

SummaryRecently, there has been a proliferation of international agreements imposing minimum standards on states in respect of their treatment of foreign investors and allowing investors to initiate dispute settlement proceedings where a state violates these standards. Of greatest significance to Canada is Chapter 11 of the North American Free Trade Agreement, which provides both standards for state behaviour and the right to initiate binding arbitration. Since 1996, four cases have been brought under Chapter 11. This note describes the Chapter 11 process and suggests some of the issues that may arise as it is increasingly resorted to by investors.


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