Diagnostic Tests for Lead Poisoning

PEDIATRICS ◽  
1962 ◽  
Vol 30 (6) ◽  
pp. 1013-1014
Author(s):  
B. D. DINMAN
Keyword(s):  
Diagnostic Test ◽  
Lead Poisoning ◽  
Mechanism Of Action ◽  
Diagnostic Tests ◽  
Body Burden ◽  
Present Knowledge ◽  
The Body ◽  
Sites Of Action

The report of Whitaker, Austin, and Nelson, "Edathamil Calcium Disodium (Versenate) Diagnostic Test for Lead Poisoning" (Pediatrics 29:384, 1962), comments upon the use of this agent and its mechanism of action in a manner which may lead to misapprehension concerning the potentialities of this agent. The authors state that this test is based upon the principle that "edathamil chelates lead in body stores, as well as circulating lead...." In view of our present knowledge concerning these sites of action of edathamil calcium disodium, it would appear that this is an overstatement of the efficacy of this agent in producing mobilization and subsquent excretion of the body burden of lead.

Effect of Sample Storage Conditions on Body Burden Analysis of Organic Contaminants in Unionid Mussels

1992 ◽  
Vol 27 (4) ◽  
pp. 833-844 ◽  
Author(s):  
Micheline Hanna
Keyword(s):  
Organic Contaminants ◽  
Body Burden ◽  
Storage Conditions ◽  
The Body ◽  
Sample Storage ◽  
Pcb Congeners ◽  
Unionid Mussels ◽  
Group A ◽  
The Difference ◽  
Group B

Abstract In order to quantitatively assess the effect of sample storage conditions on the body burden analysis of organic contaminants, a comparative analysis was carried out on the unionid mussel Elliptic complanata. The mussels were divided into two groups, each with distinct storage conditions, while Group A was kept in the freezer at −20°C, Group B was kept in the refrigerator for five days at 5°C. All the compounds present in the control were also present in Group B samples. Analysis of the organic contaminants in each of these two groups showed that for total PCB concentrations, the two treatments were not significantly different; however when compared individually 6 of the 13 PCB congeners showed significant differences. The observed differences were relatively small for individual PCB congeners (7.1 to 15.3%), higher for chlorobenzenes (10.5 to 36.4%), and yet higher for HCE (44.1%); the difference for HCE, although large is nevertheless not significant, even if only marginally so.

scholarly journals Decompression sickness risk in rats by microbial removal of dissolved gas

1998 ◽  
Vol 275 (3) ◽  
pp. R677-R682 ◽  
Author(s):  
Susan R. Kayar ◽  
Terry L. Miller ◽  
Meyer J. Wolin ◽  
Eugenia O. Aukhert ◽  
Milton J. Axley ◽  
...  
Keyword(s):  
Gas Chromatography ◽  
High Pressures ◽  
Decompression Sickness ◽  
Body Burden ◽  
The Body ◽  
Dissolved Gas ◽  
Hyperbaric Chamber ◽  
Methanobrevibacter Smithii ◽  
Water Rate ◽  
Microbial Removal

We present a method for reducing the risk of decompression sickness (DCS) in rats exposed to high pressures of H2. Suspensions of the human colonic microbe Methanobrevibacter smithii were introduced via a colonic cannula into the large intestines of the rats. While the rats breathed H2in a hyperbaric chamber, the microbe metabolized some of the H2diffusing into the intestine, converting H2and CO2to methane and water. Rate of release of methane from the rats, which was monitored by gas chromatography, varied with chamber H2pressure. This rate was higher during decompression than during compression, suggesting that during decompression the microbe was metabolizing H2stored in the rats’ tissues. Rats treated with M. smithii had a 25% (5 of 20) incidence of DCS, which was significantly lower ( P < 0.01) than the 56% (28 of 50) incidence of untreated controls, brought on by a standardized compression and decompression sequence. Thus using a microbe in the intestine to remove an estimated 5% of the body burden of H2reduced DCS risk by more than one-half. This method of biochemical decompression may potentially facilitate human diving.

scholarly journals On diagnostic tests of contact break for contact circuits

2020 ◽  
Vol 30 (2) ◽  
pp. 103-116 ◽  
Author(s):  
Kirill A. Popkov
Keyword(s):  
Boolean Function ◽  
Diagnostic Test ◽  
Boolean Functions ◽  
Diagnostic Tests ◽  
Almost All

AbstractWe prove that, for n ⩾ 2, any n-place Boolean function may be implemented by a two-pole contact circuit which is irredundant and allows a diagnostic test with length not exceeding n + k(n − 2) under at most k contact breaks. It is shown that with k = k(n) ⩽ 2n−4, for almost all n-place Boolean functions, the least possible length of such a test is at most 2k + 2.

scholarly journals Comparison of three rapid influenza diagnostic tests with digital readout systems and one conventional rapid influenza diagnostic test

2017 ◽  
Vol 32 (2) ◽  
pp. e22234 ◽  
Author(s):  
Sook Won Ryu ◽  
In Bum Suh ◽  
Se-Min Ryu ◽  
Kyu Sung Shin ◽  
Hyon-Suk Kim ◽  
...  
Keyword(s):  
Diagnostic Test ◽  
Diagnostic Tests ◽  
Digital Readout

scholarly journals Clinical overlap between malaria and pneumonia: can malaria rapid diagnostic test play a role?

2011 ◽  
Vol 5 (03) ◽  
pp. 199-203 ◽  
Author(s):  
Kingsley Nnanna Ukwaja ◽  
Olufemi B Aina ◽  
Ademola A Talabi
Keyword(s):  
Diagnostic Test ◽  
Rapid Diagnostic Test ◽  
Diagnostic Tests ◽  
Health Centre ◽  
Rapid Diagnostic Tests ◽  
Case Definition ◽  
Sub Saharan Africa ◽  
Malaria Rapid Diagnostic Test ◽  
Chi Square ◽  
Symptom Overlap

Introduction: Malaria and pneumonia account for 40% of mortality among children under five years of age in sub-Saharan Africa. Due to lack of diagnostic facilities, their management is based on the integrated management of childhood illnesses (IMCI) strategy. Symptoms of malaria and pneumonia overlap in African children, necessitating dual IMCI classifications at health centres and treatment with both antibiotics and antimalarials. This study determined the prevalence of malaria-pneumonia symptom overlap and confirmed the diagnosis of malaria in these cases using a rapid diagnostic test. Methodology: Consecutive consultations of 1,216 children (two months to five years old) were documented over a three-month period in a comprehensive health centre. Malaria rapid diagnostic tests were conducted only for children who had symptom overlap. Results: Of the 1,216 children enrolled, 1,090 (90%) reported cough or fever. Among the children fulfilling the malaria case definition, 284 (30%) also met the pneumonia case definition. Twenty-three percent (284) of all children enrolled met the criteria for both malaria and pneumonia. However, only 130 (46%) of them had a positive result for malaria using a malaria rapid diagnostic test. During a malaria-pneumonia overlap, female children (chi-square 5.9, P = 0.01) and children ≥ one year (chi-square 4.8, P = 0.003) were more likely to seek care within two days of fever. Conclusion: Dual treatment with antimalarials and antibiotics in children with malaria-pneumonia overlap may result in unnecessary over-prescription of antimalarial medications. Use of rapid diagnostic tests in their management can potentially avoid over-prescribing of malaria medications.

scholarly journals ANALISIS MISKONSEPSI SISWA MENGGUNAKAN THREE TIER DIAGNOSTIC TEST BERBASIS OPEN ENDED QUESTION

2021 ◽  
Vol 9 (3) ◽  
pp. 276-291
Author(s):  
Mawaddah Mawaddah ◽  
Yandi Heryandi
Keyword(s):  
Data Collection ◽  
Diagnostic Test ◽  
Diagnostic Tests ◽  
Research Method ◽  
False Negative ◽  
Large Percentage ◽  
Sampling Techniques ◽  
Research Subjects ◽  
False Negatives ◽  
Clinical Interviews

This study aims to: (1) find out the misconceptions experienced by students in the material of similarity and congruence by using three-tier diagnostic tests based on open-ended questions. (2) find out the large percentage of students' misconceptions on the similarity and congruence material using a three-tier diagnostic test based on open-ended questions. The research method used was descriptive qualitative. The data collection instruments used were clinical interviews and three-tier diagnostic tests based on open-ended questions. This study was conducted in the SMP Negeri 2 Palimanan. The research subjects were selected using purposive sampling techniques so that 33 students were selected from 330 students. The results of the analysis of the three-tier diagnostic test based on open-ended questions showed that (1) the misconceptions that occurred in the material of similarity and congruence of 2D shapes included pure misconceptions, false positives, and false negatives. (2) the percentage of misconceptions experienced in the material of similarity and congruence 2D shapes as a whole was 50.2% with a large percentage of pure misconceptions 32.4%, false-positive 15.6%, and false-negative 2.2%

scholarly journals Human Body Burden of Heavy Metals and Health Consequences of Pb Exposure in Guiyu, an E-Waste Recycling Town in China

2021 ◽  
Vol 18 (23) ◽  
pp. 12428
Author(s):  
Wenlong Huang ◽  
Xiaoling Shi ◽  
Kusheng Wu
Keyword(s):  
Heavy Metals ◽  
Body Burden ◽  
Local Environment ◽  
Waste Recycling ◽  
The Body ◽  
Health Consequences ◽  
Long Term Effects ◽  
Adaptive Immune ◽  
Pb Exposure

Guiyu accommodates millions of tons of e-waste from overseas and domestic sources each year and is notorious for its e-waste dismantling industry. As a consequence, Guiyu has been described as “the world’s most toxic place” and “junk town”. Informal e-waste recycling activities have caused severe pollution to the local environment and are associated with extensive health problems to the residents. This review provides updated insights on the body burden of heavy metals derived from e-waste and health outcomes resulted from lead (Pb) exposure. The review identified that Guiyu has been highly contaminated by heavy metals, especially Pb. Excessive exposure to Pb has been associated with multi-system and long-term effects in neonates and children, covering nervous, cardiovascular, adaptive immune, and hematologic systems as well as chromosome and DNA damage. Our review indicates strong associations that emphasize the need to develop strong regulations for prevention of exposure and health consequences in Guiyu and similar sites around the world.

Lead toxicosis in cats—a review

2003 ◽  
Vol 5 (5) ◽  
pp. 249-255 ◽  
Author(s):  
TE Knight ◽  
MSA Kumar
Keyword(s):  
Diagnostic Tests ◽  
Aminolevulinic Acid ◽  
Clinical Signs ◽  
Body Burden ◽  
Blood Lead ◽  
Good Prognosis ◽  
Metabolic Effects ◽  
Neuronal Necrosis ◽  
The Individual ◽  
High Index Of Suspicion

Although the incidence of lead toxicosis in small animals continues to decrease, it remains a significant malady. We have reviewed the literature of the past 45 years, which revealed 70 cases involving cats. Sources, signs, diagnosis, pathology and treatment of feline lead toxicosis are reviewed. In 84% of these cases the source of lead was old paint usually from home renovation. The most common signs in cats are anorexia, vomiting, and seizures. The younger individuals seem more likely to show CNS signs. Since signs are often vague, lead toxicosis may be significantly under diagnosed in cats. The gold standard of diagnostic tests is blood lead concentration, although it does not necessarily correlate with total body burden of lead or with metabolic effects including clinical signs. Diagnostic tests including erythropoietic protoporphyrin (EPP), urine aminolevulinic acid, and others are discussed. Gross findings on necropsy are few and include a yellow-brown discoloration of the liver often with a nutmeg-like appearance. Histological examination may reveal pathognomonic inclusion bodies in liver and renal tissues. Characteristic histological changes in the CNS include neuronal necrosis and demyelination. Treatment of lead toxicosis in cats, as in any species, involves removing the exposure, decontaminating the individual and the environment, supportive care and chelation therapy. The most recently available chelator is succimer (meso 2,3-dimercaptosuccinic acid). Succimer given orally is well tolerated and has a wide margin of safety. A high index of suspicion of lead toxicosis is warranted in cats since they often present with vague and non-specific signs. With any consistent history owners need to be asked about home renovation. Early diagnosis and treatment affords a good prognosis.

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