FLUORIDE AS A NUTRIEN

PEDIATRICS ◽  
1972 ◽  
Vol 49 (3) ◽  
pp. 456-460
Author(s):  
L. J. Filer ◽  
Lewis A. Barness ◽  
Richard B. Goldbloom ◽  
Malcolm A. Holliday ◽  
Robert W. Miller ◽  
...  
Keyword(s):  
Drinking Water ◽  
Dental Caries ◽  
Tooth Enamel ◽  
Dental Fluorosis ◽  
Normal Component ◽  
Fluoride Content ◽  
Water Supplies ◽  
Calcified Tissues

The association of mottled enamel and dental fluorosis with community drinking water was detected before 1920 and was specifically related to the fluoride content of the water when Churchill, in 1931,1 was able to measure trace amounts of fluoride in drinking water. Also, in areas with communal water supplies naturally contaming increased amounts of fluoride, the occurrence of dental caries was lower than that seen in the general population.2 These observations and subsequent studies3 led to the practice of adding fluoride to communal waters, with a consequent significant reduclion in the incidence of dental caries. Nearly 90 million persons in 7,500 communities4 use water supplies containing an amount of fluoride effective in reducing the dental caries rate. Fluoride is present in the customary diet and in most potable water sources in amounts that vary from 0.1 to 0.5 parts per million (ppm).5 The average dietary intake of fluoride is approximately 0.5 mg daily from these two sources. In the temperate zone, fluoridated community water supplies are increased in fluoride content to a level of 1.0 ppm, thus providing, on the average, a total fluoride ingestion of 1.5 mg per day. A lesser level of fluoridation may be sufficient in warmer climates conducive to a higher water consumption. Fluoride is regarded as an essential nutrient6 and it is now well known to be effective in the maintenance of a tooth enamel that is more resistant to decay. Fluoride is a normal component of tooth enamel and bone. Studies in vivo and in vitro demonstrate that the calcified tissues of both enamel and bone are made up of a combination of hydroxy- and fluor-apatites of varying composition, depending on the abundance of fluoride at the site of formation.

Estimation of Fluoride Content of Drinking Water in Dharan

2020 ◽  
Vol 3 (1) ◽  
pp. 88-95
Author(s):  
Bandana Koirala ◽  
Surya Raj Niraula ◽  
Anup Ghimire
Keyword(s):  
Drinking Water ◽  
Dental Caries ◽  
Water Supply ◽  
Optimal Level ◽  
Fluoride Content ◽  
Water Supplies ◽  
Effective Measure ◽  
Guideline Value ◽  
Guideline Values ◽  
Significant Difference

Introduction: Fluoride when present in drinking water at optimal level has been shown to promote oral health by preventing tooth decay. Dental caries represents a health problem that impacts on the medical, functional, nutritional and psychological status of patients in all the age groups. Fluoridation of public water supply is a safe, economical and effective measure to prevent dental caries. Objective: To estimate the level of fluoride present in drinking water supplies in all the wards of Dharan and to compare the fluoride concentration of its different water supply sources. Methods: One hundred water samples were collected from the various sources (ground water and surface water) and its different reservoirs along with random samples of 2-7 from all the wards of Dharan. The samples were then taken to the SEAM-N-MMA laboratory, Biratnagar to be tested for fluoride using the photometric method. Microsoft excel for data entry and SPSS 11.5 version for analysis were used. Significance of the variables was examined by Chi-square test. Results: The results of this study showed that in 96% of the samples taken, fluoride level was below the optimal. Only few samples met the lower range guideline value of Nepal (0.5 mg/l). Also, there was significant difference (p< 0.002) between the surface and consumer level fluoride. Conclusion: The fluoride content in drinking water supplies of Dharan was found to be below optimal level as per the national and WHO guideline values.

scholarly journals Novel lactotransferrin-derived synthetic peptides suppress cariogenic bacteria in vitro and arrest dental caries in vivo

2021 ◽  
Vol 13 (1) ◽  
pp. 1943999
Author(s):  
Junyuan Luo ◽  
Zening Feng ◽  
Wentao Jiang ◽  
Xuelian Jiang ◽  
Yue Chen ◽  
...  
Keyword(s):  
Dental Caries ◽  
Synthetic Peptides ◽  
Cariogenic Bacteria

The potential reproductive effects of exposure of domestic ruminants to endocrine disrupting compounds

2002 ◽  
Vol 74 (1) ◽  
pp. 3-12 ◽  
Author(s):  
M.L. Boerjan ◽  
S. Freijnagel ◽  
S.M. Rhind ◽  
G.A.L. Meijer
Keyword(s):  
Drinking Water ◽  
Reproductive Function ◽  
Endocrine Disrupting Compounds ◽  
Laboratory Animals ◽  
Domestic Ruminants ◽  
Reproductive Effects ◽  
Endocrine Disrupting ◽  
Contaminated Food

AbstractChemical compounds that mimic or block some of the actions of the steroid hormone oestradiol, have created public concern primarily because of potential adverse reproductive effects in wildlife and humans. Many studies, in vivo and in vitro, have revealed abnormal reproductive function following exposure to these compounds. The number of chemicals known to have the potential to modulate endocrine functions is increasing. In contrast to humans and wildlife, the potential reproductive effects of exposure of domestic animals to endocrine disrupting compounds (EDC) have been studied little. The aim of this overview is to evaluate the possible contribution of EDC to reproductive failure in domestic ruminants.Sources and classes of EDC are discussed as well as their structure and the modes of hormone disruption. Endocrine disrupting agents may interfere with the reproductive processes of both males and females at several points of the reproductive cycle and through a range of physiological mechanisms. Extrapolating from the results obtained with laboratory animals, the mechanisms whereby infertility in domestic ruminants might be expressed by exposure to EDC through contaminated food and drinking water are addressed.A preliminary risk assessment is included and it is concluded that under certain circumstances there may be a significantly enhanced intake of oestrogenic hormones and EDC through sewage-contaminated water or soil-contaminated herbage. The physiological consequences for domestic ruminants of EDC ingestion, at the rates estimated, are largely unknown. However, the levels of exposure to oestrogenic hormones and phthalates in grazing ruminants are such that when studying fertility problems in high-yielding dairy cattle the impacts of exposure to endocrine disruptors via the food and drinking water cannot be neglected.

scholarly journals Intraoral Fluoride-Releasing Devices: A Literature Review

2012 ◽  
Vol 3 (4) ◽  
pp. 350-354 ◽  
Author(s):  
Jagjit Singh ◽  
Gurminder Singh ◽  
Ramandeep Singh Gambhir ◽  
Daljit Kapoor ◽  
Heena Kakar
Keyword(s):  
Dental Caries ◽  
Literature Review ◽  
Fluoride Concentration ◽  
Risk Groups ◽  
High Caries Risk ◽  
Release Devices ◽  
Topical Fluorides

ABSTRACT Dental caries still continues to be a problem for majority of the individuals and it can be a serious problem for medically compromised, developmentally disabled and elderly individuals. Water fluoridation, systemic and topical fluorides are used for past many years to supply supplemental fluoride in order to combat dental caries. The latest fluoride research is investigating the use of slow-release devices for the long-term intraoral provision of fluoride. The present review addresses two main types of intraoral fluoride-releasing devices like the copolymer membrane device, glass device containing fluoride and some variations of these devices. These devices can significantly increase the salivary fluoride concentration without substantially affecting the urinary fluoride levels. A significant number of studies have confirmed that intraoral fluoride-releasing devices have great potential for use in preventing dental caries in children, high-caries-risk groups, and irregular dental attenders in addition to a number of other applications. As most of the studies done on these devices are in vitro and in vivo studies, more well-designed clinical trials are necessary to evaluate the results so that these devices can be used clinically. How to cite this article Gambhir RS, Kapoor D, Singh G, Singh J, Kakar H. Intraoral Fluoride-Releasing Devices: A Literature Review. World J Dent 2012;3(4):350-354.

scholarly journals Taurine Attenuates Carcinogenicity in Ulcerative Colitis-Colorectal Cancer Mouse Model

2020 ◽  
Vol 2020 ◽  
pp. 1-7 ◽  
Author(s):  
Guifeng Wang ◽  
Ning Ma ◽  
Feng He ◽  
Shosuke Kawanishi ◽  
Hatasu Kobayashi ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Drinking Water ◽  
Mouse Model ◽  
Histopathological Examination ◽  
Tumor Formation ◽  
Water Model ◽  
Control Group ◽  
Ki 67

Taurine (2-aminoethane-sulfonic acid) is a type of amino acids and has numerous physiological and therapeutic functions, including anti-inflammation. However, there are few studies on the anticancer action of taurine. Our previous studies have demonstrated that taurine exhibits an apoptosis-inducing effect on human nasopharyngeal carcinoma cells in vitro. In this study, we have investigated whether taurine has an anticancer effect, using azoxymethane (AOM)/sulfate sodium (DSS)- induced mouse model for colon carcinogenesis. All mice, except those in control group, received a single intraperitoneal injection of AOM and DSS in the drinking water for 7 days twice, with 1-week interval. After the first DSS treatment, mice were given distilled water (model group) or taurine in the drinking water (taurine group) ad libitum. No tumor was observed in the control group. Taurine significantly suppressed AOM+DSS-induced tumor formation. Histopathological examination revealed AOM/DSS treatment induced colon cancer in all mice (8/8, 100%), and taurine significantly inhibited the progression of colon cancer (4/9, 44.4%). Taurine significantly attenuated cell proliferation in cancer tissues detected by Ki-67 staining. Taurine significantly increased the levels of an apoptosis marker cleaved caspase-9 and tumor suppressor protein PTEN. This is the first study that demonstrated that taurine significantly reduced carcinogenicity in vivo using AOM/DSS-induced colon cancer mouse model.

scholarly journals Natural fluoride levels from public water supplies in Piauí State, Brazil

2009 ◽  
Vol 14 (6) ◽  
pp. 2215-2220 ◽  
Author(s):  
Josiene Saibrosa da Silva ◽  
Wallesk Gomes Moreno ◽  
Franklin Delano Soares Forte ◽  
Fábio Correia Sampaio
Keyword(s):  
Drinking Water ◽  
Water Supply ◽  
Urban Areas ◽  
Urban Population ◽  
Dental Fluorosis ◽  
Fluoride Concentration ◽  
Public Water Supply ◽  
Water Supplies ◽  
Two Samples ◽  
High Prevalence

The aim of this work was to determine the natural fluoride concentrations in public water supplies in Piauí State, Brazil, in order to identify cities in risk for high prevalence of dental fluorosis. For each city, two samples of drinking water were collected in the urban area: one from the main public water supply and another from a public or residential tap from the same source. Fluoride analyses were carried out in duplicate using a specific ion electrode and TISAB II. From a total of 222 cities in Piauí, 164 (73.8%) samples were analyzed. Urban population in these towns corresponds to 92.5% of the whole state with an estimated population of 1,654,563 inhabitants from the total urban population (1,788,590 inhabitants). A total of 151 cities showed low fluoride levels (<0.30 mg/L) and 13 were just below optimum fluoride concentration in the drinking water (0.31-0.59 mg/L). High natural fluoride concentration above 0.81 mg/L was not observed in any of the surveyed cities. As a conclusion, most of the cities in Piauí have low fluoride concentration in the drinking water. The risk for a high prevalence of dental fluorosis in these urban areas due to natural fluoride in the water supplies is very unlikely. Thus, surveys about the dental fluorosis prevalence in Piauí should be related with data about the consumption of fluoridated dentifrices and other fluoride sources.

scholarly journals Symbiotic Relationship between Streptococcus mutans and Candida albicans Synergizes Virulence of Plaque BiofilmsIn Vivo

2014 ◽  
Vol 82 (5) ◽  
pp. 1968-1981 ◽  
Author(s):  
Megan L. Falsetta ◽  
Marlise I. Klein ◽  
Punsiri M. Colonne ◽  
Kathleen Scott-Anne ◽  
Stacy Gregoire ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Dental Caries ◽  
Streptococcus Mutans ◽  
Bacterial Pathogen ◽  
Single Species ◽  
Content Type ◽  
3 Dimensional ◽  
Biofilm Development

ABSTRACTStreptococcus mutansis often cited as the main bacterial pathogen in dental caries, particularly in early-childhood caries (ECC).S. mutansmay not act alone;Candida albicanscells are frequently detected along with heavy infection byS. mutansin plaque biofilms from ECC-affected children. It remains to be elucidated whether this association is involved in the enhancement of biofilm virulence. We showed that the ability of these organisms together to form biofilms is enhancedin vitroandin vivo. The presence ofC. albicansaugments the production of exopolysaccharides (EPS), such that cospecies biofilms accrue more biomass and harbor more viableS. mutanscells than single-species biofilms. The resulting 3-dimensional biofilm architecture displays sizeableS. mutansmicrocolonies surrounded by fungal cells, which are enmeshed in a dense EPS-rich matrix. Using a rodent model, we explored the implications of this cross-kingdom interaction for the pathogenesis of dental caries. Coinfected animals displayed higher levels of infection and microbial carriage within plaque biofilms than animals infected with either species alone. Furthermore, coinfection synergistically enhanced biofilm virulence, leading to aggressive onset of the disease with rampant carious lesions. Ourin vitrodata also revealed that glucosyltransferase-derived EPS is a key mediator of cospecies biofilm development and that coexistence withC. albicansinduces the expression of virulence genes inS. mutans(e.g.,gtfB,fabM). We also found thatCandida-derived β1,3-glucans contribute to the EPS matrix structure, while fungal mannan and β-glucan provide sites for GtfB binding and activity. Altogether, we demonstrate a novel mutualistic bacterium-fungus relationship that occurs at a clinically relevant site to amplify the severity of a ubiquitous infectious disease.

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