THE PEDIATRICIAN AND IATRIC INFECTIOUS DISEASE

PEDIATRICS ◽  
1973 ◽  
Vol 51 (4) ◽  
pp. 595-602
Author(s):  
Thomas H. Weller

The privilege of presenting the second R. Cannon Eley Memorial Lecture permits acknowledgment of personal indebtedness to an individual who was a pediatrician's pediatrician. In 1939, with a primary interest in infectious and parasitic disease, I was faced with the choice of an internship. The decision was not difficult for the superb teaching of communicable and infectious diseases by the group composed of Charles F. McKhann, R. Cannon Eley, Leroy Fothergill, and John Davies at the Children's had a magnetic quality and the diversified program of research on infectious agents then in progress was unique in Boston. In the McKhann-Eley laboratory, extraction of gamma-globulin from human placentas was to provide the first preparation for the prevention or modification of measles in the exposed child. From 1946 to 1963, when Cannon resigned his Children's and Harvard appointments to become Professor of Pediatrics at Brown University and Chairman of the Department of Pediatrics at Roger Williams Hospital in Providence, Rhode Island, he was our pediatrician. Thus our affection for Cannon and appreciation for his depth of clinical experience in the communicable disease field, stems from an association that transcended that customarily achieved between a senior staff man and his junior. As a consequence, we, perhaps more than others, had partial insight into Cannon's numerous unpublicized acts of kindness to generations of house staff and graduate students, as he assisted in the resolution of their personal crises, be they professional, economic or social. From the foregoing remarks it is apparent that the request to present this Eley lecture has evoked memories of my own years at the Children's, and in turn reflection on changes that have occurred in the interim in the teaching and handling of infectious diseases.

2022 ◽  
Vol 12 ◽  
Author(s):  
Hasnat Tariq ◽  
Sannia Batool ◽  
Saaim Asif ◽  
Mohammad Ali ◽  
Bilal Haider Abbasi

Virus-like particles (VLPs) are nanostructures that possess diverse applications in therapeutics, immunization, and diagnostics. With the recent advancements in biomedical engineering technologies, commercially available VLP-based vaccines are being extensively used to combat infectious diseases, whereas many more are in different stages of development in clinical studies. Because of their desired characteristics in terms of efficacy, safety, and diversity, VLP-based approaches might become more recurrent in the years to come. However, some production and fabrication challenges must be addressed before VLP-based approaches can be widely used in therapeutics. This review offers insight into the recent VLP-based vaccines development, with an emphasis on their characteristics, expression systems, and potential applicability as ideal candidates to combat emerging virulent pathogens. Finally, the potential of VLP-based vaccine as viable and efficient immunizing agents to induce immunity against virulent infectious agents, including, SARS-CoV-2 and protein nanoparticle-based vaccines has been elaborated. Thus, VLP vaccines may serve as an effective alternative to conventional vaccine strategies in combating emerging infectious diseases.


PEDIATRICS ◽  
1963 ◽  
Vol 32 (4) ◽  
pp. 640-645

Symposium on Pediatric Diagnosis A symposium on pediatric diagnosis will be held at the Roger Williams General Hospital, Providence, Rhode Island, October 23, 1963, 11:00 a.m. to 4:00 p.m. The program has been arranged by the Department of Pediatrics, and R. Cannon Eley, M.D., Professor of Pediatrics, Brown University. Guest speakers will be Edward D. B. Neuhauser, M.D., Alexander Nadas, M.D., and Harry Schwachman, M.D., all of Harvard Medical School; Arnold P. Gold, M.D., Columbia University; and Burr H. Curtis, M.D., Newington Hospital for Crippled Children.


2011 ◽  
Vol 1 (5) ◽  
pp. 1-2
Author(s):  
Lavkush Dwivedi

Infectious diseases and consequent immune imbalancesare major constraint in human health managementthroughout the world. However, in recentdecades enormous efforts have been made to elucidatethe immunomodulatory approaches againstinfectious diseases. Immunomodulation is a therapeuticapproach in which we try to intervene inauto regulating processes of the defense system toadjust the immune response at a desired level.The present special issue on cutting edge issues inImmunomodulation like Immune stimulation, Immunesuppression, Immune potentiating and immunereinforcement summarizes our current understandingof this complex mosaic. The accompanyingselection of recent articles from across theworld provides further insight into this topic. 


2015 ◽  
Vol 9 (09) ◽  
pp. 1033-1035 ◽  
Author(s):  
Rangan Srinivasaraghavan ◽  
Parameswaran Narayanan ◽  
Thandapani Kanimozhi

Infectious diseases are one of the major causes of morbidity and mortality in developing countries. Sometimes concurrent infections with multiple infectious agents may occur in one patient, which make the diagnosis and management a challenging task. The authors here present a case of co-infection of typhoid fever with dengue fever in a ten-year-old child and discuss the pertinent issues. The authors emphasize that the risk factors predicting the presence of such co-infections, if developed, will be immensely useful in areas where dengue outbreak occurs in the background of high transmission of endemic infections.


2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Alexandria Macmadu ◽  
Lauren Brinkley-Rubinstein ◽  
Ian Gonsher ◽  
Jennifer G. Clarke ◽  
Bradley W. Brockmann

Purpose The purpose of this paper is to describe the course, “Designing Education for Better Prisoner and Community Health,” which provided students with the knowledge, skills and resources needed to build real-world health education materials for persons who are criminal justice involved. Design/methodology/approach A multiphase engaged scholarship course was designed and implemented through the Brown University School of Public Health in Rhode Island, USA. Findings Students collaborated closely with instructors, subject matter experts and affected community members to develop highly tailored health education projects across six topic areas. The structure and outcomes of the paper are described with the hope that other instructors and institutions might replicate components of the model. Originality/value Engaged scholarship in public health can provide students with rich, collaborative learning experiences, and when executed effectively, these endeavors can provide underserved communities with robust and informed health education interventions and programs.


Author(s):  
H. G. Sandeep Patil ◽  
Ajit N. Babu ◽  
P. S. Ramkumar

Non-invasive medical measurements have expanded into several types of diagnostic and monitoring activities in health care delivery. They are being used in handling a number of non-infectious diseases such as diabetes, asthma, hypertension, congestive heart failure, cardiac arrhythmia, etc., as well as infectious diseases such as cholera, malaria, etc.. Non-Invasive Medical Devices (NIMDs) are naturally preferred over invasive methods considering patient convenience, reduced patient risk, increased speed, and operational simplicity. However non-invasive methods are often perceived to be less accurate than their invasive counterparts. Over the last decade, technological advances and mathematical techniques have improved significantly, challenging this perception across the board. The chapter will discuss this important transformation in health care diagnostics and monitoring. The chapter will also provide further insight into some of the currently available non-invasive measurement products and explore how futuristic techniques and technology trends which have great potential to transform healthcare into a significantly different paradigm than the one we experience today.


2020 ◽  
Vol 10 (2) ◽  
Author(s):  
Emmanuel Magesa ◽  
Kabwebwe Honore Mitonga ◽  
Penehafo Angula

Malaria continues to be a serious communicable disease whose impact on public health in Namibia is massive. Some improvement in reducing the number of malaria cases has been made in the country, but the sporadic availability of malaria diagnostic test kits (mRDT) continues to slow down government efforts to eliminate malaria in the country. Given the nature of current conditions, justification exists for a study to determine the factors associated with stock out of malaria rapid test kit (mRDT) in Namibia. Mixed method approach was employed, whereby in quantitative aspect, the study adopted a descriptive approach to acquire data from a period of five years retrospectively (2012 - 2016). To gain insight into qualitative aspects of the study, key informants at all levels of the supply chain in Oshana region were interviewed. Pharmaceutical knowledge of ordering mRDT is needed to prevent stock out of mRDT. It is a recommendation of this study that training is needed for staffs who are involved in ordering of pharmaceutical items.


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