Butterfly-Shaped Mark: A Variant Form of Nevus Flammeus Simplex

PEDIATRICS ◽  
1990 ◽  
Vol 85 (6) ◽  
pp. 1069-1071
Author(s):  
Aryeh Metzker ◽  
Raanan Shamir
Keyword(s):  
Variant Form ◽  
Simplex Distribution ◽  
First Time ◽  
Nevus Flammeus

A red-violet, rhomboid-shaped mark on the sacrum of 25 children is described. It is recognized, for the first time, as a part of the nevus flammeus simplex distribution; it is less common than the erythema nuchae or the facial salmon patch. It has the tendency to disappear more slowly than other forms of nevus flammeus simplex. No further investigations seem indicated.

scholarly journals LASER SURGERY FOR CUTANEOUS SIMPLE CAPILLARY MALFORMATIONS IN CHILDREN

2019 ◽  
Vol 22 (4) ◽  
pp. 235-242
Author(s):  
L. D. Shakina ◽  
I. V. Ponomarev ◽  
A. P. Fisenko ◽  
I. E. Smirnov
Keyword(s):  
Surgical Treatment ◽  
Laser Irradiation ◽  
Absorption Index ◽  
Copper Vapor Laser ◽  
Vapor Laser ◽  
Age Related ◽  
Advanced Stages ◽  
First Time ◽  
Nevus Flammeus

There are presented data on the epidemiology, pathogenesis, and diagnosis of cutaneous simple capillary malformations, described as Nevus simplex and Nevus flammeus (NF) in the Classification of Vascular Anomalies in a revision on May 2108. There are compared the efficacy and side effects of an application of laser irradiation of different wavelengths for the laser surgical treatment of NF in patients of various ages. There are described features of morphometry and angioarchitecture of the vascular bed of NF at the early and advanced stages of the disease. In order to substantiate the choice of the preferred laser irradiation settings, the peculiarities of absorption of the laser irradiation with different wavelengths by main cutaneous photothermophores (chromophores) are compared in children of various ages. For the first time, there are presented data on the age-related features of the absorption coefficient and the relevant absorption index for laser irradiation of different wavelengths. The maximum values of the absorption coefficients and the index of the relevance of the absorption of laser radiation with a wavelength of 578 nm by the main skin photothermophores indicate the greatest efficiency of the domestic copper vapor laser for the surgical treatment of NF in children of different ages.

scholarly journals Characterization of Neoplastic Cells in the Cystic Space of Invasive Micropapillary Carcinoma of the Canine Mammary Gland.

2020 ◽  
Author(s):  
Michele Angela Rodrigues ◽  
Andre L. Caldeira-Brant ◽  
Dawidson Assis Gomes ◽  
Tatiany L. Silveira ◽  
Hélio Chiarini-Garcia ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Stromal Cells ◽  
Ductal Carcinoma ◽  
Variant Form ◽  
Invasive Micropapillary Carcinoma ◽  
Micropapillary Carcinoma ◽  
Cystic Space ◽  
First Time ◽  
Canine Mammary Gland

Abstract Background: Invasive micropapillary carcinoma (IMPC) is a rare breast malignant tumor and a variant form of invasive ductal carcinoma that is an aggressive neoplasm of the canine mammary gland and the human breast. There is a progressed recognition of the importance of the tumor microenvironment in cancer development, but little is known about cell types expressed in the cystic space of canine IMPC. This study aimed to investigate the neoplastic and stromal cells surrounding the cystic space in IMPC. Methods: It was used immunohistochemistry (IHC), immunofluorescence (IF), super-resolution microscope and transmission electron microscopy (TEM) to access the localization and morphology of both stromal cells and epithelial cells in canine IMPC cystic areas.Results: Cells surrounding the cystic space in IMPC were positive for the mesenchymal marker's alpha-smooth muscle actin (aSMA), Vimentin, and S100A4. Furthermore, myoepithelial cell marker p63 was negative on IMPC. Tumoral reversal polarity was observed using MUC1 for the first time in IMPC from the canine mammary gland. MUC1 is known to have a role in lumen formation and has an inhibitory role in the cell to stroma interaction. TEM showed that cells lining the IMPC cystic space were modified myoepithelial cells. Conclusion: The present work demonstrates, for the first time, a characterization of the cystic space compound on IMPC from the canine mammary gland. These findings could be useful to understand better the cellular microenvironment in invasive tumors of the mammary gland to improve cancer treatment.

Canatoxin, a toxic protein from jack beans (Canavalia ensiformis), is a variant form of urease (EC 3.5.1.5): biological effects of urease independent of its ureolytic activity

2001 ◽  
Vol 360 (1) ◽  
pp. 217-224 ◽  
Author(s):  
Cristian FOLLMER ◽  
Grace B. S. BARCELLOS ◽  
Russolina B. ZINGALI ◽  
Olga L. T. MACHADO ◽  
Elias W. ALVES ◽  
...  
Keyword(s):  
Blood Platelets ◽  
Biological Effects ◽  
Enzymic Activity ◽  
Variant Form ◽  
Native Form ◽  
Toxic Protein ◽  
Canavalia Ensiformis ◽  
Covalently Linked ◽  
First Time

Canatoxin is a toxic protein from Canavalia ensiformis seeds, lethal to mice (LD50 = 2mg/kg) and insects. Further characterization of canatoxin showed that its main native form (184kDa) is a non-covalently linked dimer of a 95kDa polypeptide containing zinc and nickel. Partial sequencing of internal peptides indicated homology with urease (EC 3.5.1.5) from the same seed. Canatoxin has approx. 30% of urease's activity for urea, and Km of 2–7mM. The proteins differ in their affinities for metal ions and were separated by affinity chromatography on a Zn2+ matrix. Similar to canatoxin, urease activates blood platelets and interacts with glycoconjugates. In contrast with canatoxin, no lethality was seen in mice injected with urease (10mg/kg). Pretreatment with p-hydroxymercuribenzoate irreversibly abolished the ureolytic activity of both proteins. On the other hand, p-hydroxymercuribenzoate-treated canatoxin was still lethal to mice, and both treated proteins were fully active in promoting platelet aggregation and binding to glycoconjugates. Taken together, our data indicate that canatoxin is a variant form of urease. Moreover, we show for the first time that these proteins display several biological effects that are unrelated to their enzymic activity for urea.

Annulate lamellae in the Sertoli cells of guinea pig testis after unilateral torsion of the spermatic cord

1984 ◽  
Vol 42 ◽  
pp. 196-197
Author(s):  
J. Chakraborty ◽  
A. P. Sinha Hikim ◽  
J. S. Jhunjhunwala
Keyword(s):  
Sertoli Cells ◽  
Guinea Pigs ◽  
Spermatic Cord ◽  
Present Report ◽  
Cell Types ◽  
Annulate Lamellae ◽  
Spermatogenic Cells ◽  
Electron Microscopic ◽  
Structural Details ◽  
First Time

Although the presence of annulate lamellae was noted in many cell types, including the rat spermatogenic cells, this structure was never reported in the Sertoli cells of any rodent species. The present report is based on a part of our project on the effect of torsion of the spermatic cord to the contralateral testis. This paper describes for the first time, the fine structural details of the annulate lamellae in the Sertoli cells of damaged testis from guinea pigs.One side of the spermatic cord of each of six Hartly strain adult guinea pigs was surgically twisted (540°) under pentobarbital anesthesia (1). Four months after induction of torsion, animals were sacrificed, testes were excised and processed for the light and electron microscopic investigations. In the damaged testis, the majority of seminiferous tubule contained a layer of Sertoli cells with occasional spermatogonia (Fig. 1). Nuclei of these Sertoli cells were highly pleomorphic and contained small chromatinic clumps adjacent to the inner aspect of the nuclear envelope (Fig. 2).

Electron spectroscopic imaging and diffraction

1991 ◽  
Vol 49 ◽  
pp. 706-707
Author(s):  
M. Rühle ◽  
J. Mayer ◽  
J.C.H. Spence ◽  
J. Bihr ◽  
W. Probst ◽  
...  
Keyword(s):  
Materials Science ◽  
Electron Spectroscopic Imaging ◽  
Magnetic Filter ◽  
Magnetic Imaging ◽  
Illumination System ◽  
Probe Size ◽  
Diffraction Patterns ◽  
Fritz Haber ◽  
Koehler Illumination ◽  
First Time

A new Zeiss TEM with an imaging Omega filter is a fully digitized, side-entry, 120 kV TEM/STEM instrument for materials science. The machine possesses an Omega magnetic imaging energy filter (see Fig. 1) placed between the third and fourth projector lens. Lanio designed the filter and a prototype was built at the Fritz-Haber-Institut in Berlin, Germany. The imaging magnetic filter allows energy-filtered images or diffraction patterns to be recorded without scanning using efficient area detection. The energy dispersion at the exit slit (Fig. 1) results in ∼ 1.5 μm/eV which allows imaging with energy windows of ≤ 10 eV. The smallest probe size of the microscope is 1.6 nm and the Koehler illumination system is used for the first time in a TEM. Serial recording of EELS spectra with a resolution < 1 eV is possible. The digital control allows X,Y,Z coordinates and tilt settings to be stored and later recalled.

A Novel TEM Technique for Characterizing As-Grown CVD Diamond Films

1991 ◽  
Vol 49 ◽  
pp. 956-957 ◽  
Author(s):  
Z.L. Wang ◽  
J. Bentley ◽  
R.E. Clausing ◽  
L. Heatherly ◽  
L.L. Horton
Keyword(s):  
Diamond Films ◽  
Chemical Vapor ◽  
Growth Direction ◽  
Dark Field ◽  
Growth Surface ◽  
Specimen Preparation ◽  
Transmission Electron ◽  
Diffraction Patterns ◽  
First Time ◽  
Microstructural Studies

Microstructural studies by transmission electron microscopy (TEM) of diamond films grown by chemical vapor deposition (CVD) usually involve tedious specimen preparation. This process has been avoided with a technique that is described in this paper. For the first time, thick as-grown diamond films have been examined directly in a conventional TEM without thinning. With this technique, the important microstructures near the growth surface have been characterized. An as-grown diamond film was fractured on a plane containing the growth direction. It took about 5 min to prepare a sample. For TEM examination, the film was tilted about 30-45° (see Fig. 1). Microstructures of the diamond grains on the top edge of the growth face can be characterized directly by transmitted electron bright-field (BF) and dark-field (DF) images and diffraction patterns.

A microscopic marker experiment study on high temperature oxidation of Ni-Al alloy

1986 ◽  
Vol 44 ◽  
pp. 514-515
Author(s):  
Shou-kong Fan
Keyword(s):  
Transport Mechanism ◽  
High Temperature Oxidation ◽  
Transverse Section ◽  
Al Alloy ◽  
Metal Interface ◽  
Electron Microscopic ◽  
Temperature Oxidation ◽  
Analytical Electron ◽  
Microscopic Studies ◽  
First Time

Transmission and analytical electron microscopic studies of scale microstructures and microscopic marker experiments have been carried out in order to determine the transport mechanism in the oxidation of Ni-Al alloy. According to the classical theory, the oxidation of nickel takes place by transport of Ni cations across the scale forming new oxide at the scale/gas interface. Any markers deposited on the Ni surface are expected to remain at the scale/metal interface after oxidation. This investigation using TEM transverse section techniques and deposited microscopic markers shows a different result,which indicates that a considerable amount of oxygen was transported inward. This is the first time that such fine-scale markers have been coupled with high resolution characterization instruments such as TEM/STEM to provide detailed information about evolution of oxide scale microstructure.

Direct imaging of charge transfer

1996 ◽  
Vol 54 ◽  
pp. 680-681
Author(s):  
Yimei Zhu ◽  
J. Tafto
Keyword(s):  
Charge Transfer ◽  
Electron Diffraction ◽  
Scattering Amplitude ◽  
High Temperature Superconductors ◽  
Charge Carriers ◽  
Image Charge ◽  
Net Charge ◽  
Long Time ◽  
Electron Holes ◽  
First Time

The electron holes confined to the CuO2-plane are the charge carriers in high-temperature superconductors, and thus, the distribution of charge plays a key role in determining their superconducting properties. While it has been known for a long time that in principle, electron diffraction at low angles is very sensitive to charge transfer, we, for the first time, show that under a proper TEM imaging condition, it is possible to directly image charge in crystals with a large unit cell. We apply this new way of studying charge distribution to the technologically important Bi2Sr2Ca1Cu2O8+δ superconductors.Charged particles interact with the electrostatic potential, and thus, for small scattering angles, the incident particle sees a nuclei that is screened by the electron cloud. Hence, the scattering amplitude mainly is determined by the net charge of the ion. Comparing with the high Z neutral Bi atom, we note that the scattering amplitude of the hole or an electron is larger at small scattering angles. This is in stark contrast to the displacements which contribute negligibly to the electron diffraction pattern at small angles because of the short g-vectors.

Recent developments in low-voltage SEM of polymers

1993 ◽  
Vol 51 ◽  
pp. 866-867
Author(s):  
S.J. Krause ◽  
W.W. Adams
Keyword(s):  
Low Voltage ◽  
Chromatic Aberration ◽  
Thermal Electron ◽  
Analytical Technique ◽  
Recent Developments ◽  
Beam Currents ◽  
New Generation ◽  
First Time ◽  
Voltage Scanning ◽  
Beam Damage

Over the past decade low voltage scanning electron microscopy (LVSEM) of polymers has evolved from an interesting curiosity to a powerful analytical technique. This development has been driven by improved instrumentation and in particular, reliable field emission gun (FEG) SEMs. The usefulness of LVSEM has also grown because of an improved theoretical and experimental understanding of sample-beam interactions and by advances in sample preparation and operating techniques. This paper will review progress in polymer LVSEM and present recent results and developments in the field.In the early 1980s a new generation of SEMs produced beam currents that were sufficient to allow imaging at low voltages from 5keV to 0.5 keV. Thus, for the first time, it became possible to routinely image uncoated polymers at voltages below their negative charging threshold, the "second crossover", E2 (Fig. 1). LVSEM also improved contrast and reduced beam damage in sputter metal coated polymers. Unfortunately, resolution was limited to a few tenths of a micron due to the low brightness and chromatic aberration of thermal electron emission sources.

Communication Sciences and Disorders PhD Graduates' Perceptions of Their PhD Program

2020 ◽  
Vol 5 (2) ◽  
pp. 463-478
Author(s):  
Elizabeth Crais ◽  
Melody Harrison Savage
Keyword(s):  
Detailed Examination ◽  
Career Expectations ◽  
Doctoral Preparation ◽  
Creative Solutions ◽  
Phd Education ◽  
Doctor Of Philosophy ◽  
First Time ◽  
Students Success ◽  
Phd Program

Purpose The shortage of doctor of philosophy (PhD)–level applicants to fill academic and research positions in communication sciences and disorders (CSD) programs calls for a detailed examination of current CSD PhD educational practices and the generation of creative solutions. The intended purposes of the article are to encourage CSD faculty to examine their own PhD program practices and consider the perspectives of recent CSD PhD graduates in determining the need for possible modifications. Method The article describes the results of a survey of 240 CSD PhD graduates and their perceptions of the challenges and facilitators to completing a PhD degree; the quality of their preparation in research, teaching, and job readiness; and ways to improve PhD education. Results Two primary themes emerged from the data highlighting the need for “matchmaking.” The first time point of needed matchmaking is prior to entry among students, mentors, and expectations as well as between aspects of the program that can lead to students' success and graduation. The second important matchmaking need is between the actual PhD preparation and the realities of the graduates' career expectations, and those placed on graduates by their employers. Conclusions Within both themes, graduate's perspectives and suggestions to help guide future doctoral preparation are highlighted. The graduates' recommendations could be used by CSD PhD program faculty to enhance the quality of their program and the likelihood of student success and completion. Supplemental Material https://doi.org/10.23641/asha.11991480

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