scholarly journals A Short Review on OSMF : Oral Submucous fibrosis

2020 ◽  
Vol 3 (09) ◽  
Author(s):  
Dr. Vishal Thakur ◽  
Dr. Supriya Jassal ◽  
Dr. Atul Kumar ◽  
Dr. Sadaf J Malik ◽  
Dr. Pallavi Sharma ◽  
...  
Keyword(s):  
Drug Therapy ◽  
Oral Cancer ◽  
Clinical Symptoms ◽  
Oral Submucous Fibrosis ◽  
Short Review ◽  
Tobacco Consumption ◽  
Band Formation ◽  
Premalignant Condition ◽  
Submucous Fibrosis ◽  
Fibrotic Band

Oral submucous fibrosis (OSMF) is a premalignant condition caused by betel chewing. OSMF is a premalignant condition that can lead to oral cancer. A risk that is further increased by concomitant tobacco consumption. OSMF is a diagnosis based on clinical symptoms and confirmation by histopathology. Major constituents of betel quid are arecoline from betel nuts and copper, which are responsible for fibroblast dysfunction and fibrotic band formation. Drug therapy include antifibrotic, anti-inflammatory, and antioxidants, homemade remedies including turmeric and tulsi . Prevention is most important in case of OSMF , because severe cases of OSMF are irreversible.

scholarly journals Mandibular Canal Widening and Bell’s Palsy: Sequelae of Perineural Invasion in Oral Cancer

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
Gopinath Thilak Parepady Sundar ◽  
Vishwanath Sherigar ◽  
Sameep S. Shetty ◽  
Shree Satya ◽  
Sourabh M. Gohil
Keyword(s):  
Oral Cancer ◽  
Perineural Invasion ◽  
Oral Submucous Fibrosis ◽  
Inferior Alveolar Nerve ◽  
Mandibular Canal ◽  
Distinct Disease ◽  
Nerve Tracts ◽  
Submucous Fibrosis ◽  
Neurological Disturbance ◽  
Shed Light

Perineural invasion is an underrecognized route of metastatic spread along the nerve bundles within the nerve sheath into the surrounding tissues. It hinders the ability to establish local control as tumour cells can traverse along nerve tracts well beyond the extent of any local invasion rendering them inoperable and unresectable. Perineural invasion is a marker of poor prognosis. Oral submucous fibrosis with oral cancer constitutes a clinicopathologically distinct disease. Our case highlights an enigmatic presentation of oral submucous fibrosis and its coexistence with oral cancer presenting with unusual neurological disturbance of the inferior alveolar nerve and facial nerve and diffuse widening of the mandibular canal. The objective of this case report is to enumerate the significance of perineural invasion in determining the course of the disease and necessitate the need for future studies that can shed light on molecular mediators and pathogenesis of perineural spread.

scholarly journals Immunohistochemical Analysis of Myofibroblasts Using α- SMA in Oral Submucous Fibrosis Turning into Malignancy- A Case Report and Review

2021 ◽  
pp. 192-198
Author(s):  
Swapan Kumar Purkait ◽  
. Abhinandan ◽  
Nimisha Priya ◽  
Sriyanshi Singh ◽  
Sneha Singh
Keyword(s):  
Case Report ◽  
Immunohistochemical Study ◽  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Immunohistochemical Analysis ◽  
Invasive Front ◽  
Premalignant Condition ◽  
Submucous Fibrosis ◽  
Very High ◽  
Premalignant Conditions

Oral submucous fibrosis is a premalignant condition, characterized by fibrosis in oral mucosa causing stiffness of mucosa and leading to reduced mouth opening. The malignant transformation of oral submucous fibrosis is very high among the rest of the premalignant conditions. Chronic chewing of arecanut causes production of myofibroblasts. These myofibroblasts plays an important role in neoangiogenesis as well as disintegration of the basement membrane at the tumor invasive front leading to carcinoma.  Here, we are doing an Immunohistochemical study using alpha SMA for proper microscopic visulizations of myofibroblastic activity in an OSF patient, encompassing the pathogenesis and malignant potentiality of the disease.

scholarly journals Nasolabial Flap in the Management of Oral Submucous Fibrosis

2016 ◽  
Vol 1 (1) ◽  
pp. 27-29
Author(s):  
Vaishali Jamdade ◽  
Amit LNU
Keyword(s):  
Surgical Treatment ◽  
Physical Therapy ◽  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Oral Carcinoma ◽  
Treatment Modalities ◽  
Nasolabial Flap ◽  
Mahatma Gandhi ◽  
Premalignant Condition ◽  
Submucous Fibrosis

ABSTRACT Oral submucous fibrosis (OSMF) is a premalignant condition associated with restricted mouth opening. Oral submucous fibrosis is poorly understood and unsatisfactorily treated disease. Serious complication is the risk of development of oral carcinoma. Different treatment modalities like medical, surgical, physical therapy or combination are used to improve the condition of the patient. Surgical treatment is usually indicated in late and irreversible stage of the disease. Successful use of nasolabial flap in the management of OSMF is presented. How to cite this article Jamdade V, Sharma S, Chitlangia P, Amit. Nasolabial Flap in the Management of Oral Submucous Fibrosis. J Mahatma Gandhi Univ Med Sci Tech 2016;1(1):27-29.

scholarly journals Oral submucous fibrosis: a premalignant condition in a 14-year-old Indian girl

2013 ◽  
Vol 2013 (dec12 1) ◽  
pp. bcr2013200786-bcr2013200786 ◽  
Author(s):  
A. Deshpande ◽  
S. Kiran ◽  
S. Dhillon ◽  
R. Mallikarjuna
Keyword(s):  
Oral Submucous Fibrosis ◽  
Indian Girl ◽  
Premalignant Condition ◽  
Submucous Fibrosis

scholarly journals Genetic Susceptibility and Protein Expression of Extracellular Matrix Turnover-Related Genes in Oral Submucous Fibrosis

2020 ◽  
Vol 21 (21) ◽  
pp. 8104
Author(s):  
Ru-Hsiu Cheng ◽  
Yi-Ping Wang ◽  
Julia Yu-Fong Chang ◽  
Yu-Hwa Pan ◽  
Mei-Chi Chang ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Oral Cancer ◽  
Genetic Susceptibility ◽  
Molecular Mechanisms ◽  
Lysyl Oxidase ◽  
Oral Submucous Fibrosis ◽  
Tissue Inhibitors Of Metalloproteinases ◽  
Contributing Factors ◽  
Plasminogen Activator Inhibitor 1 ◽  
Submucous Fibrosis

Betel quid (BQ) chewing increased the risk of oral cancer and oral submucous fibrosis (OSMF), an oral premalignant disorder (OPMD) with malignant transformation potential. BQ components such as areca nut (AN), trauma by coarse AN fiber, catechin, copper, alkaloids, stimulated reactive oxygen species (ROS), inflammation and cytotoxicity are suggested to be the contributing factors. They may induce tissue inflammation, proliferation of fibroblasts and collagen deposition, myofibroblast differentiation and contraction, collagen cross-links and inhibit collagen phagocytosis, finally leading to the development of OSMF and oral cancer. These events are mediated by BQ components-induced changes of extracellular matrix (ECM) turnover via regulation of TGF-β1, plasminogen activator inhibitor-1 (PAI-1), cystatin, lysyl oxidase (LOX) and tissue inhibitors of metalloproteinases (TIMPs) and metalloproteinases (MMPs). Genetic susceptibility is also involved in these disease processes. Further understanding the molecular mechanisms of BQ-induced OSMF and oral cancer can be helpful for future disease prevention and treatment.

Consumption of areca quid, cigarettes, and alcohol related to the comorbidity of oral submucous fibrosis and oral cancer

2007 ◽  
Vol 104 (5) ◽  
pp. 647-652 ◽  
Author(s):  
Pei-Shan Ho ◽  
Yi-Hsin Yang ◽  
Tien-Yu Shieh ◽  
I.-Yueh Huang ◽  
Yun-Kwan Chen ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Oral Submucous Fibrosis ◽  
Submucous Fibrosis
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