A hepatitis C-vírus-fertőzés és kezelésének                     költségvonzata

The worldwide prevalence of hepatitis C infection is 2–3%. In addition to its individual consequences, it generates huge financial impact on national level. In particular, lack of recognition or late diagnosis of the disease is associated with high rate of liver cirrhosis related complications (hepatic encephalopathy, ascites, variceal bleeding, hepatocellular carcinoma) and/or demands liver transplantation. Loss of quality assisted life years and/or those spent in employment, reduced work productivity, as well as costs of antiviral therapy also contribute to the financial burden. The costs of new interferon-free therapies may exceed the prices of previous pegylated interferon based therapies with or without protease inhibitors; however, shorter treatment durations and extremely low rates of severe side-effects with much less related expenses can reduce total costs of these treatments. In addition to the moral obligations, published cost-effectiveness analyses conclude that early diagnosis and treatment of this primarily iatrogenic infection through organized screening programs and wide access to effective therapies may lead to long term financial benefit. Orv. Hetil., 2015, 156(21), 862–868.

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HEPATITIS C INFECTION IN PATIENTS WITH PRIMARY HYPOGAMMAGLOBULINEMIA AFTER TREATMENT WITH CONTAMINATED IMMUNE GLOBULIN

PEDIATRICS ◽

10.1542/peds.98.2.351a ◽

1996 ◽

Vol 98 (2) ◽

pp. 351-351

Author(s):

Robert A. Wood

Keyword(s):

Hepatitis C ◽

Immune Globulin ◽

Hcv Infection ◽

High Rate ◽

Hepatitis C Infection ◽

Progressive Course

Patients with hypogammaglobulinemia had a high rate of HCV infection after treatment with contaminated immune globulin. These patients experienced a severe and rapidly progressive course with their HCV infection and responses to interferon were poor.

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Work productivity among treatment-naïve patients with genotype 1 chronic hepatitis C infection receiving telaprevir combination treatment

Journal of Viral Hepatitis ◽

10.1111/jvh.12227 ◽

2014 ◽

Vol 22 (1) ◽

pp. 8-17 ◽

Cited By ~ 13

Author(s):

J. Aggarwal ◽

M. Vera-Llonch ◽

M. Donepudi ◽

E. Suthoff ◽

Z. Younossi ◽

...

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Chronic Hepatitis C ◽

Combination Treatment ◽

Work Productivity ◽

Genotype 1 ◽

Hepatitis C Infection ◽

Treatment Naïve

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Moving towards Universal Coverage of Direct-Acting Antiviral Therapies for Hepatitis C Infection in Canada: An Environmental Scan of Canadian Provinces and International Jurisdictions

Journal of Pharmacy & Pharmaceutical Sciences ◽

10.18433/jpps30220 ◽

2018 ◽

Vol 21 (1s) ◽

pp. 271s-308s ◽

Cited By ~ 3

Author(s):

Samantha Myers ◽

Gurleen Khosa ◽

I fan Kuo ◽

Donica Janzen ◽

Silvia Alessi-Severini

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Chronic Hepatitis C ◽

Financial Burden ◽

Universal Coverage ◽

Hepatitis C Infection ◽

Coverage Criteria ◽

Direct Acting Antiviral ◽

Canadian Provinces ◽

Direct Acting

Background: Direct-acting antivirals (DAAs) have become the standard treatment for patients with chronic hepatitis C infections because of their high cure rates and favourable side effect profiles; however, access to this new class of agents has been limited because of its high cost. Public payers across Canada have implemented strict criteria for drug coverage in order to contain expenditures. Efforts have been made to improve access to medication for this high-burden condition. Recent coverage criteria across national and international jurisdictions have been compared.Methods: Coverage criteria for several DAAs were reviewed by accessing Canadian provincial drug formularies. International coverage (e.g., Europe, Australia, United States, Egypt, India) was reviewed by searching available literature. Results: Coverage criteria vary across Canada. By April 2018, most Canadian jurisdictions had removed the stage 2 liver fibrosis requirement for patients to be eligible for coverage. Internationally, patients’ access to DAAs differs significantly. Many jurisdictions restrict DAA prescribing authority to specialists and request documentation of chronic hepatitis C. In the US, considerable gaps of coverage are identifiable and patients might face significant financial burden to receive treatment. Conclusion: DAAs appear to be generally accessible through public drug plans in Canada compared to other countries.

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Impact of Sofosbuvir-Based Regimens for Chronic Hepatitis C Infection: A Work Productivity Model from Mainland China

Value in Health ◽

10.1016/j.jval.2018.07.044 ◽

2018 ◽

Vol 21 ◽

pp. S6 ◽

Cited By ~ 2

Author(s):

X Ye ◽

X Xu ◽

Q Xie ◽

H Tang ◽

J Xuan

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Chronic Hepatitis C ◽

Mainland China ◽

Work Productivity ◽

Hepatitis C Infection

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Serology of Viral Infections and Tuberculosis Screening in an IBD Population Referred to a Tertiary Centre of Southern Italy

Gastroenterology Research and Practice ◽

10.1155/2017/4139656 ◽

2017 ◽

Vol 2017 ◽

pp. 1-9 ◽

Cited By ~ 1

Author(s):

Marco Ardesia ◽

Giuseppe Costantino ◽

Placido Mondello ◽

Angela Alibrandi ◽

Walter Fries

Keyword(s):

Hepatitis C ◽

Hepatitis B ◽

Southern Italy ◽

Opportunistic Infections ◽

Immunosuppressive Agents ◽

Latent Tuberculosis ◽

Hepatitis C Infection ◽

Tuberculosis Screening ◽

Younger Patients ◽

Screening Programs

Background. With the introduction of more potent immunosuppressive agents in inflammatory bowel disease, prevention of opportunistic infections has become necessary by introducing screening programs. Prevalence of the most important infectious agents may vary in different geographical areas. The aim of our study was to assess the immune status for hepatitis B, varicella, mononucleosis, and cytomegalovirus infection together with the determination of the hepatitis C and tuberculosis status in Southern Italy. Methods. Prevalence of latent tuberculosis, together with serology of hepatitis B and C, Epstein-Barr virus, varicella zoster, and cytomegalovirus were collected by analysing retrospectively the clinical charts of IBD patients. Data were integrated with demographic and clinical features. Results. Data from 509 IBD patients divided in two age groups showed a prevalence of HBV infection in nonvaccinated patients of 9%. Seroprotection (HBsAb) in vaccinated IBD patients was lower (p<0.0001) compared with that in controls. Prevalences of herpesvirus infections fluctuate between 51% (CMV) and 85% (EBV) and 84% (VZV) in younger patients. Latent tuberculosis and hepatitis C infection were found only in patients > 37 years of age. Conclusions. In younger patients, high susceptibility rates for primary herpesvirus infections should determine the choice of treatment. Loss of HBV seroprotection in already vaccinated patients should be considered for booster vaccination programs.

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Hepatocellular Carcinoma in Pakistan: National Trends and Global Perspective

Gastroenterology Research and Practice ◽

10.1155/2016/5942306 ◽

2016 ◽

Vol 2016 ◽

pp. 1-10 ◽

Cited By ~ 10

Author(s):

Abu Bakar Hafeez Bhatti ◽

Faisal Saud Dar ◽

Anum Waheed ◽

Kashif Shafique ◽

Faisal Sultan ◽

...

Keyword(s):

Risk Factors ◽

Hepatocellular Carcinoma ◽

Hepatitis C ◽

National Level ◽

Global Perspective ◽

Definitive Treatment ◽

Adult Males ◽

Global Trends ◽

Screening Programs ◽

National Trends

Hepatocellular carcinoma (HCC) ranks second amongst all causes of cancer deaths globally. It is on a rise in Pakistan and might represent the most common cancer in adult males. Pakistan contributes significantly to global burden of hepatitis C, which is a known risk factor for HCC, and has one of the highest prevalence rates (>3%) in the world. In the absence of a national cancer registry and screening programs, prevalence of hepatitis and HCC only represents estimates of the real magnitude of this problem. In this review, we present various aspects of HCC in Pakistan, comparing and contrasting it with the global trends in cancer care. There is a general lack of awareness regarding risk factors of HCC in Pakistani population and prevalence of hepatitis C has increased. In addition, less common risk factors are also on a rise. Majority of patients present with advanced HCC and are not eligible for definitive treatment. We have attempted to highlight issues that have a significant bearing on HCC outcome in Pakistan. A set of strategies have been put forth that can potentially help reduce incidence and improve HCC outcome on national level.

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Ledipasvir/sofosbuvir regimens for chronic hepatitis C infection: Insights from a work productivity economic model from the United States

Hepatology ◽

10.1002/hep.27757 ◽

2015 ◽

Vol 61 (5) ◽

pp. 1471-1478 ◽

Cited By ~ 38

Author(s):

Zobair M. Younossi ◽

Yushan Jiang ◽

Nathaniel J. Smith ◽

Maria Stepanova ◽

Rachel Beckerman

Keyword(s):

United States ◽

Chronic Hepatitis ◽

Hepatitis C ◽

Chronic Hepatitis C ◽

Economic Model ◽

Work Productivity ◽

The United States ◽

Hepatitis C Infection

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Hepatitis B & C Viral Markers Status in Icteric Children at a Tertiary Care Hospital

Journal of Shaheed Suhrawardy Medical College ◽

10.3329/jssmc.v3i2.12075 ◽

2012 ◽

Vol 3 (2) ◽

pp. 35-37 ◽

Cited By ~ 2

Author(s):

Abdul Matin ◽

Md. Rafiqul Islam ◽

Md. Al-Amin Mridha ◽

Md. Golam Mowla ◽

Rita Khan ◽

...

Keyword(s):

Hepatitis C ◽

Hepatitis B ◽

Venous Blood ◽

Tertiary Care ◽

High Rate ◽

Seroprevalence Rate ◽

Care Hospital ◽

Age Group ◽

Hepatitis C Infection ◽

Medical University

Background: Hepatitis B (HBV) and Hepatitis C virus (HCV) can cause important morbidity and mortality and are major causes of acute and chronic liver disease worldwide.Objectives: This study was an attempt to evaluate the seroprevalence rate of hepatitis B and C in jaundiced children who were admitted at Bangabandhu Sheikh Mujib Medical University. This would be helpful to take measure for the prevention of hepatitis B and hepatitis C infection in paediatric age group. Methodology: A total of 50 admitted jaundiced children of either sex selected randomly were studied during July 2004 to June 2005 in the Department of Paediatrics of Bangabandhu Sheikh Mujib Medical University. Venous blood was tested for HBsAg and anti-HBcAb (IgM) and anti-HCV viral markers by ELISA.Results: The HBsAg test was positive among 24.0 %, Anti-HBcAb (IgM) test positive in 14.0 %. HBsAg was positive in 66.66% of male children and 33.33% of female children. Sero positivity was more in the 10 years age group. Conclusion: This study shows high rate of HBsAg and Anti- HBcAb IgM seropositivity among icteric sick children so, further studies with appropriate design & sample size to be conducted. J Shaheed Suhrawardy Med Coll, 2011;3 (2): 35-37 DOI: http://dx.doi.org/10.3329/jssmc.v3i2.12075

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