Role of organic functionalities linked to alkoxysilane precursors in nanomaterials synthesis and their biomedical applications

2015 ◽  
Vol 1719 ◽  
Author(s):  
P. C. Pandey ◽  
Govind Pandey
Keyword(s):  
Salt Tolerance ◽  
Metal Ions ◽  
Metal Nanoparticles ◽  
Noble Metal ◽  
Biomedical Applications ◽  
Ph Sensitivity ◽  
Noble Metal Nanoparticles ◽  
Biological Interactions ◽  
Wide Range

ABSTRACTThe synthesis of biocompatible noble metal nanoparticles dispersible in a wide range of biological media with control of polycrystalinity and nanogeometry, pH sensitivity and salt tolerance has been a challenging requirements. The role of 3-aminopropyltrimethoxysilane (3-APTMS) and organic reducing reagents for real time synthesis of amphilic noble metal nanoparticles meeting these requirements are demonstrated justifying the following; (1) 3-APTMS capped noble metal ions are converted into respective metal nanoparticles in the presence of one of organic reducing agents i.e., cyclohexanone, tetrahydrofuran hydroperoxide (THF-HPO), formaldehyde, acetaldehyde, acetone, t-buty dimethyl keotone, 3-Glycidoxy-propyltrimethoxysilane (3-GPTMS); (2) 3-APTMS acts as micelle, promotes the interaction of metal ions with organic reducing agent, precisely controls the size of metal nanoparticles, pH sensititvity and salt tolerance and also provides a suitable medium for nanoparticles suspension, (3) the use of suitable organic reagent precisely controls the polarity of as made noble metal nanoparticles allowing specific biological interactions, and (4) 3-APTMS significantly increases the stability and controls the pH sensitivity and salt tolerance of metal nanoparticles. The as synthesized nanomaterials show potential viability in biomedical applications from many angles i.e. (a) as potential bioelectrocatalyst, (b) selective interaction with active proteins and cellular components, and (c) peroxidase mimetic.

Self-assembled calixarene aligned patterning of noble metal nanoparticles on graphene

Nanoscale ◽  
2014 ◽  
Vol 6 (9) ◽  
pp. 4517-4520 ◽  
Author(s):  
Xianjue Chen ◽  
Kasturi Vimalanathan ◽  
Wenzhe Zang ◽  
Ashley D. Slattery ◽  
Ramiz A. Boulos ◽  
...  
Keyword(s):  
Metal Ions ◽  
Metal Nanoparticles ◽  
Noble Metal ◽  
Phosphonic Acid ◽  
Hydrogen Gas ◽  
Noble Metal Nanoparticles ◽  
Self Assembled

Patterns of noble metal nanoparticles (NMNPs) of ruthenium and platinum are formed on p-phosphonic acid calix[8]arene stabilized graphene in water with hydrogen gas induced reduction of the metal ions.

Synthesis and characterization of bimetallic noble metal nanoparticles for biomedical applications

MRS Advances ◽  
2016 ◽  
Vol 1 (11) ◽  
pp. 681-691 ◽  
Author(s):  
Prem C. Pandey ◽  
Govind Pandey
Keyword(s):  
Metal Ions ◽  
Prussian Blue ◽  
Metal Nanoparticles ◽  
Noble Metal ◽  
Time Course ◽  
Bimetallic Nanoparticles ◽  
Reducing Agents ◽  
Noble Metal Nanoparticles ◽  
Ambient Conditions ◽  
Peroxidase Mimetic

ABSTRACTWe report herein a facile approach to synthesize processable bimetallic nanoparticles (Pd-Au/AuPd/Ag-Au/Au-Ag) decorated Prussian blue nanocomposite (PB-AgNP). The presence of cyclohexanone/formaldehyde facilitates the formation of functional bimetallic nanoparticles from 3-aminopropyltrimethoxysilane (3-APTMS) capped desired ratio of hetero noble metal ions. The use of 3-APTMS and cyclohexanone also enables the synthesis of polycrystalline Prussian blue nanoparticles (PBNPs). As synthesized PBNPs, Pd-Au/Au-Pd/Ag-Au/Au-Ag enable the formation of nano-structured composites displaying better catalytic activity than that recorded with natural enzyme. The nanomaterials have been characterized by Uv-Vis, FT-IR and Transmission Electron Microscopy (TEM) with following major findings: (1) 3-APTMS capped noble metal ions in the presence of suitable organic reducing agents i.e.; 3 glycidoxypropyltrimethoxysilane (GPTMS), cyclohexanone and formaldehyde; are converted into respective nanoparticles under ambient conditions, (2) the time course of synthesis and dispersibility of the nanoparticles are found as a function of organic reducing agents, (3) the use of formaldehyde and cyclohexanone in place of GPTMS with 3-APTMS outclasses the other two in imparting better stability of amphiphilic nanoparticles with reduced silanol content, (4) simultaneous synthesis of bimetallic nanoparticles under desired ratio of palladium/gold and silver/ gold cations are recorded, (5) the nanoparticles made from the use of 3-APTMS and cyclohexanone enable the formation of homogeneous nanocomposite with PBNP as peroxidase mimetic representing potential substitute of peroxidase enzyme. The peroxidase mimetic ability has been found to vary as a function of 3-APTMS concentration revealing the potential role of functional metal nanoparticles in bioanalytical applications.

scholarly journals Noble Metal Nanoparticles-Based Colorimetric Biosensor for Visual Quantification: A Mini Review

Chemosensors ◽  
2019 ◽  
Vol 7 (4) ◽  
pp. 53 ◽  
Author(s):  
Lu Yu ◽  
Na Li
Keyword(s):  
Metal Nanoparticles ◽  
Noble Metal ◽  
Electrostatic Interactions ◽  
Organic Molecules ◽  
Chemical Reduction ◽  
Noble Metal Nanoparticles ◽  
Gold And Silver Nanoparticles ◽  
Local Surface Plasmon Resonance ◽  
Reliable Technique ◽  
Wide Range

Nobel metal can be used to form a category of nanoparticles, termed noble metal nanoparticles (NMNPs), which are inert (resistant to oxidation/corrosion) and have unique physical and optical properties. NMNPs, particularly gold and silver nanoparticles (AuNPs and AgNPs), are highly accurate and sensitive visual biosensors for the analytical detection of a wide range of inorganic and organic compounds. The interaction between noble metal nanoparticles (NMNPs) and inorganic/organic molecules produces colorimetric shifts that enable the accurate and sensitive detection of toxins, heavy metal ions, nucleic acids, lipids, proteins, antibodies, and other molecules. Hydrogen bonding, electrostatic interactions, and steric effects of inorganic/organic molecules with NMNPs surface can react or displacing capping agents, inducing crosslinking and non-crosslinking, broadening, or shifting local surface plasmon resonance absorption. NMNPs-based biosensors have been widely applied to a series of simple, rapid, and low-cost diagnostic products using colorimetric readout or simple visual assessment. In this mini review, we introduce the concepts and properties of NMNPs with chemical reduction synthesis, tunable optical property, and surface modification technique that benefit the development of NMNPs-based colorimetric biosensors, especially for the visual quantification. The “aggregation strategy” based detection principle of NMNPs colorimetric biosensors with the mechanism of crosslinking and non-crosslinking have been discussed, particularly, the critical coagulation concentration-based salt titration methodology have been exhibited by derived equations to explain non-crosslinking strategy be applied to NMNPs based visual quantification. Among the broad categories of NMNPs based biosensor detection analyses, we typically focused on four types of molecules (melamine, single/double strand DNA, mercury ions, and proteins) with discussion from the standpoint of the interaction between NMNPs surface with molecules, and DNA engineered NMNPs-based biosensor applications. Taken together, NMNPs-based colorimetric biosensors have the potential to serve as a simple yet reliable technique to enable visual quantification.

Electrochemical Sensors Based on Noble Metal Nanoparticles in Voltammetry

2021 ◽  
Vol 887 ◽  
pp. 54-59
Author(s):  
D.O. Perevezentseva ◽  
Eduard V. Gorchakov
Keyword(s):  
Metal Nanoparticles ◽  
Noble Metal ◽  
Electrochemical Sensors ◽  
Narrow Range ◽  
Spherical Shape ◽  
High Sensitivity ◽  
Noble Metal Nanoparticles ◽  
Wide Range ◽  
Sulfur Containing

Portable electrochemical sensors based on noble metal nanoparticles (МеNPs) for the quantitative determination of hydrogen peroxide (H2O2) and sulfur-containing amino acids (cysteine, methionine, glutathione) are discussed. These sensors have high sensitivity (pM), with low sample requirements (<50 μl). This article discusses methods for producing sensors based on silver and gold nanoparticles and their application in voltammetry. It is shown that the sensitivity of H2O2 determination on a sensor based on silver nanoparticles (AgNPs) depends on their size. Their size is determined by the reducing agent. Sensors based on AgNPs of spherical shape with the smallest size from 0.5 to 17.5 nm have the highest sensitivity for determining H2O2, but a narrow range of determined concentrations. Sensors on medium-sized AgNPs have optimal metrological characteristics. Their size is from 10 to 55 nm, less sensitive, but with a wide range of determined concentrations from 0.1 to 1 nm H2O2. The linearity of the range of glutathione concentrations is 1.0-10.0 pM. The linearity of the range of determined concentrations of methionine is 1–26 рМ.

scholarly journals Noble Metal Nanoparticles Stabilized by Hyper-Cross-Linked Polystyrene as Effective Catalysts in Hydrogenation of Arenes

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4687
Author(s):  
Elena S. Bakhvalova ◽  
Arina O. Pinyukova ◽  
Alexey V. Mikheev ◽  
Galina N. Demidenko ◽  
Mikhail G. Sulman ◽  
...  
Keyword(s):  
Metal Nanoparticles ◽  
Organic Solvents ◽  
Noble Metal ◽  
Noble Metal Nanoparticles ◽  
Batch Mode ◽  
High Importance ◽  
Ru Nanoparticles ◽  
Wide Range ◽  
Pharmaceutical Industries

This work is addressing the arenes’ hydrogenation—the processes of high importance for petrochemical, chemical and pharmaceutical industries. Noble metal (Pd, Pt, Ru) nanoparticles (NPs) stabilized in hyper-cross-linked polystyrene (HPS) were shown to be active and selective catalysts in hydrogenation of a wide range of arenes (monocyclic, condensed, substituted, etc.) in a batch mode. HPS effectively stabilized metal NPs during hydrogenation in different medium (water, organic solvents) and allowed multiple catalyst reuses.

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